ATE415136T1 - Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellung - Google Patents
Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE415136T1 ATE415136T1 AT07005206T AT07005206T ATE415136T1 AT E415136 T1 ATE415136 T1 AT E415136T1 AT 07005206 T AT07005206 T AT 07005206T AT 07005206 T AT07005206 T AT 07005206T AT E415136 T1 ATE415136 T1 AT E415136T1
- Authority
- AT
- Austria
- Prior art keywords
- cross
- linked gelatin
- production
- methods
- powder
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/908,464 US7435425B2 (en) | 2001-07-17 | 2001-07-17 | Dry hemostatic compositions and methods for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE415136T1 true ATE415136T1 (de) | 2008-12-15 |
Family
ID=25425842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02744588T ATE358455T1 (de) | 2001-07-17 | 2002-06-21 | Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellung |
AT07005206T ATE415136T1 (de) | 2001-07-17 | 2002-06-21 | Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02744588T ATE358455T1 (de) | 2001-07-17 | 2002-06-21 | Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellung |
Country Status (16)
Country | Link |
---|---|
US (4) | US7435425B2 (de) |
EP (2) | EP1414370B1 (de) |
JP (1) | JP4316374B2 (de) |
KR (1) | KR100904582B1 (de) |
CN (2) | CN101284146B (de) |
AT (2) | ATE358455T1 (de) |
AU (1) | AU2002345846B2 (de) |
BR (1) | BRPI0211258B8 (de) |
CA (1) | CA2453592C (de) |
DE (2) | DE60219319T2 (de) |
DK (2) | DK1803417T3 (de) |
ES (2) | ES2284883T3 (de) |
HK (2) | HK1060277A1 (de) |
MX (1) | MXPA04000514A (de) |
PT (2) | PT1414370E (de) |
WO (1) | WO2003007845A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
US7435425B2 (en) | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US6066325A (en) * | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
AU2003302906B2 (en) | 2002-12-11 | 2009-04-02 | Ferrosan Medical Devices A/S | Gelatine-based materials as swabs |
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US8440225B2 (en) * | 2003-08-07 | 2013-05-14 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
US20060019868A1 (en) * | 2004-01-30 | 2006-01-26 | Pendharkar Sanyog M | Hemostatic compositions and devices |
US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
AR054637A1 (es) * | 2004-01-30 | 2007-07-11 | Ferrosan As | Aerosoles y composiciones hemostaticas |
US7109163B2 (en) * | 2004-01-30 | 2006-09-19 | Ethicon, Inc. | Hemostatic compositions and devices |
US8119160B2 (en) * | 2004-06-29 | 2012-02-21 | Ethicon, Inc. | Hemostatic compositions and devices |
US8021684B2 (en) | 2004-07-09 | 2011-09-20 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
FR2881651A1 (fr) * | 2005-02-09 | 2006-08-11 | Urodelia Sa | Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique |
JP5475283B2 (ja) * | 2005-07-28 | 2014-04-16 | カーネギー メロン ユニバーシティ | 生体適合性ポリマーおよび使用方法 |
EP2366402A1 (de) * | 2005-12-16 | 2011-09-21 | OxThera, Inc., | Zusammensetzungen und Verfahren zur Oxalatreduktion |
CN101454030B (zh) | 2006-05-31 | 2013-06-26 | 巴克斯特国际公司 | 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法 |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
CN101854960B (zh) | 2006-12-15 | 2014-06-25 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
US8133484B2 (en) | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
US20100143447A1 (en) * | 2006-12-19 | 2010-06-10 | Ferrosan A/S | Wound or tissue dressing comprising lactic acid bacteria |
DE102007038125A1 (de) | 2007-08-03 | 2009-02-05 | Aesculap Ag | Kombination zum Verkleben von biologischen Geweben |
TWI461227B (zh) | 2007-10-30 | 2014-11-21 | Baxter Int | 再生生物功能性膠原生物基質用來治療內臟或體壁缺陷的用途 |
EP3338549A1 (de) * | 2007-11-20 | 2018-06-27 | Pioneer Surgical Orthobiologics, Inc. | Kryokonservierung von zellen mittels kreuzvernetzter bioaktiver hydrogel-matrixpartikel |
US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
AU2009232000B2 (en) | 2008-04-03 | 2014-12-11 | Baxter International Inc. | Hemostatic microspheres |
AU2009261559B2 (en) | 2008-06-18 | 2014-01-16 | Lifebond Ltd | Improved cross-linked compositions |
US8110208B1 (en) | 2009-03-30 | 2012-02-07 | Biolife, L.L.C. | Hemostatic compositions for arresting blood flow from an open wound or surgical site |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
AU2010262058B2 (en) | 2009-06-16 | 2013-08-29 | Baxter Healthcare S.A. | Hemostatic sponge |
US20110081398A1 (en) * | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
US8968785B2 (en) * | 2009-10-02 | 2015-03-03 | Covidien Lp | Surgical compositions |
US20110081701A1 (en) * | 2009-10-02 | 2011-04-07 | Timothy Sargeant | Surgical compositions |
CA2784432C (en) | 2009-12-16 | 2019-01-15 | Baxter Healthcare S.A. | Hemostatic sponge |
CN102711853B (zh) | 2009-12-22 | 2015-05-20 | 生命连结有限公司 | 用于控制交联基质的性质的酶交联剂的改性 |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
GB201008404D0 (en) * | 2010-05-20 | 2010-07-07 | Fujifilm Mfg Europe Bv | Hemostatic compositions |
CN102917691A (zh) | 2010-06-01 | 2013-02-06 | 巴克斯特国际公司 | 用于生产干燥、稳定的止血组合物的方法 |
KR20130083393A (ko) * | 2010-06-01 | 2013-07-22 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
CA2801116C (en) | 2010-06-01 | 2019-02-12 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
DK2600910T3 (en) | 2010-08-05 | 2016-04-04 | Lifebond Ltd | Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS |
JP2014511694A (ja) | 2011-04-03 | 2014-05-19 | ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル | 修飾型rna(mod−rna)を使用する効率的なインビボタンパク質発現 |
US9149511B2 (en) * | 2011-06-30 | 2015-10-06 | Ethicon, Inc. | Procoagulant peptides and their derivatives and uses therefor |
CA2851321C (en) | 2011-10-11 | 2020-07-07 | Baxter International Inc. | Hemostatic compositions |
US20130096082A1 (en) | 2011-10-11 | 2013-04-18 | Baxter Healthcare S.A. | Hemostatic compositions |
ES2938566T3 (es) | 2011-10-11 | 2023-04-12 | Baxter Int | Composiciones hemostaticas |
JP6195567B2 (ja) | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 止血組成物 |
US20130108671A1 (en) * | 2011-10-27 | 2013-05-02 | Baxter Healthcare S.A. | Hemostatic compositions |
TW201332567A (zh) | 2011-10-27 | 2013-08-16 | Baxter Int | 止血組成物 |
MX352601B (es) | 2011-12-23 | 2017-11-30 | Pioneer Surgical Tech | Matriz continua con particulas osteoconductoras dispersadas en ella, método para formarla y método para regenerar hueso con ella. |
CA2865349C (en) | 2012-03-06 | 2021-07-06 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
EP2977066A3 (de) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Trockene blutstillende zusammensetzung |
BR112015030612B1 (pt) | 2013-06-21 | 2020-07-21 | Ferrosan Medical Devices A/S | método para preparar uma composição seca |
EP3470094B1 (de) * | 2013-12-11 | 2020-07-22 | Ferrosan Medical Devices A/S | Trockenzusammensetzung mit extrusionsverstärker |
US10814032B2 (en) | 2014-08-08 | 2020-10-27 | The Brigham And Women's Hospital, Inc. | Elastic biopolymer and use as a tissue adhesive |
CA2960309A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
RU2705905C2 (ru) | 2014-12-24 | 2019-11-12 | Ферросан Медикал Дивайсиз А/С | Шприц для удерживания и смешивания первого и второго веществ |
US10723783B2 (en) | 2015-03-19 | 2020-07-28 | The Brigham And Women's Hospital, Inc. | Polypeptide compositions and methods of using the same |
CN107771093B (zh) | 2015-07-03 | 2021-06-15 | 弗罗桑医疗设备公司 | 用于混合两种组分和用于在存储条件下保持真空的注射器 |
MX2018002649A (es) | 2015-09-01 | 2018-06-20 | Baxter Int | Material hemostatico. |
US11058800B2 (en) | 2016-02-08 | 2021-07-13 | Massachusetts Eye And Ear Infirmary | Bioadhesive for corneal repair |
CN105879109A (zh) * | 2016-03-31 | 2016-08-24 | 武汉华同信生物科技有限公司 | 一种医用胶粘剂及其制备方法 |
KR20180027126A (ko) * | 2016-09-06 | 2018-03-14 | (주)한국비엠아이 | 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물 |
US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
MX2020004180A (es) | 2017-11-03 | 2020-08-03 | Baxter Int | Composiciones polimericas, dispositivos de administracion y sus metodos. |
CA3079753A1 (en) * | 2017-11-28 | 2019-06-06 | Baxter International Inc. | Wound-treating absorbent |
MX2020006856A (es) | 2017-12-29 | 2020-08-24 | Baxter Int | Trombina secada por aspersion y metodos de uso y preparacion de trombina secada por aspersion. |
ES2968412T3 (es) | 2018-05-09 | 2024-05-09 | Ferrosan Medical Devices As | Método para preparar una composición hemostática |
US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
ES2961107T3 (es) | 2019-07-12 | 2024-03-08 | Cilag Gmbh Int | Polvo hemostático |
JPWO2021261080A1 (de) * | 2020-06-26 | 2021-12-30 | ||
CN116744983A (zh) | 2021-01-08 | 2023-09-12 | 西拉格国际有限公司 | 生物可吸收性密封粉末 |
CN113144277B (zh) * | 2021-04-13 | 2022-06-14 | 武汉理工大学 | 一种可注射流体明胶及其制备方法和应用 |
CN113209357B (zh) * | 2021-05-14 | 2023-02-17 | 南方科技大学 | 复合止血粉 |
EP4401801A1 (de) * | 2021-09-16 | 2024-07-24 | Ethicon, Inc. | Kit für zusammensetzung zur gewebetraktabdichtung |
CN117298327A (zh) * | 2023-11-15 | 2023-12-29 | 北京帝康医药投资管理有限公司 | 一种止血微球颗粒及其制备方法和应用 |
Family Cites Families (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2507244A (en) | 1947-04-14 | 1950-05-09 | Upjohn Co | Surgical gelatin dusting powder and process for preparing same |
CH264752A (de) | 1947-06-03 | 1949-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Trägern für Arzneimittel. |
US3089315A (en) | 1961-09-25 | 1963-05-14 | Gen Electric | Convertible self-contained cooling unit for air conditioning |
SE420565B (sv) | 1974-06-06 | 1981-10-19 | Pharmacia Ab | Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel |
US4013078A (en) * | 1974-11-25 | 1977-03-22 | Feild James Rodney | Intervertebral protector means |
US4006220A (en) | 1975-06-04 | 1977-02-01 | Gottlieb Sheldon K | Compositions and methods useful for repairing depressed cutaneous scars |
US4164559A (en) * | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
US4265233A (en) * | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
US4179400A (en) | 1978-05-09 | 1979-12-18 | W. R. Grace & Co. | Process for preparing catalytic solutions of sulfonium salts |
AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
DE3036033A1 (de) | 1980-09-24 | 1982-05-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung |
US4300494A (en) | 1979-09-26 | 1981-11-17 | Shell Oil Company | Thermal insulated intake ports |
US4292972A (en) | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
US4443332A (en) * | 1980-07-14 | 1984-04-17 | Oros Company | Cross flow solid-to-solid heat transfer apparatus |
DE3105624A1 (de) * | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
US4482386A (en) | 1982-03-26 | 1984-11-13 | Warner-Lambert Company | Method of conditioning a water swellable hydrocolloid |
US4543332A (en) | 1982-03-29 | 1985-09-24 | Miles Laboratories, Inc. | Method for the preparation of spherical microorganism cell aggregates |
US4540410A (en) | 1982-11-16 | 1985-09-10 | Serono Pharmaceutical Partners | Lyophilized compositions, preparation and use thereof |
DE3466702D1 (en) | 1983-07-14 | 1987-11-12 | Hitachi Chemical Co Ltd | Gelatin spherical gels and production thereof |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4515637A (en) * | 1983-11-16 | 1985-05-07 | Seton Company | Collagen-thrombin compositions |
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US4600574A (en) * | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
JPS6144825A (ja) * | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
GB8422950D0 (en) * | 1984-09-11 | 1984-10-17 | Warne K J | Hydrogel |
JPS61122222A (ja) * | 1984-11-19 | 1986-06-10 | Koken:Kk | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
US5178883A (en) * | 1984-11-29 | 1993-01-12 | Regents Of The University Of Minnesota | Method for promoting hair growth |
US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US4600533A (en) | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
US5007916A (en) * | 1985-08-22 | 1991-04-16 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
IE59361B1 (en) * | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
IL78826A (en) * | 1986-05-19 | 1991-05-12 | Yissum Res Dev Co | Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
US5300494A (en) * | 1986-06-06 | 1994-04-05 | Union Carbide Chemicals & Plastics Technology Corporation | Delivery systems for quaternary and related compounds |
US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
CA1305069C (en) | 1987-03-11 | 1992-07-14 | John Cornell | Wound dressings in sheet or gelled paste form |
US4885161A (en) | 1987-03-11 | 1989-12-05 | Medi-Tech International Corporation | Wound dressings in gelled paste form |
US5080893A (en) * | 1988-05-31 | 1992-01-14 | University Of Florida | Method for preventing surgical adhesions using a dilute solution of polymer |
US5017229A (en) * | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US5350573A (en) * | 1988-05-31 | 1994-09-27 | University Of Florida Research Foundation, Inc. | Method and composition for preventing surgical adhesions |
US5140016A (en) * | 1988-05-31 | 1992-08-18 | University Of Florida | Method and composition for preventing surgical adhesions using a dilute solution of polymer |
US5447966A (en) * | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
US5041292A (en) * | 1988-08-31 | 1991-08-20 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US5135751A (en) * | 1988-11-16 | 1992-08-04 | Mediventures Incorporated | Composition for reducing postsurgical adhesions |
US5126141A (en) * | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
US5614587A (en) * | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
DE3903672C1 (de) * | 1989-02-08 | 1990-02-01 | Lohmann Gmbh & Co Kg | |
WO1991001711A1 (en) | 1989-08-10 | 1991-02-21 | W.L. Gore & Associates, Inc. | A medical dispensing system for tissue adhesive components |
US5196185A (en) * | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
US5061274A (en) | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
US5134229A (en) * | 1990-01-12 | 1992-07-28 | Johnson & Johnson Medical, Inc. | Process for preparing a neutralized oxidized cellulose product and its method of use |
JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
US5306501A (en) * | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
US5209776A (en) * | 1990-07-27 | 1993-05-11 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5192300A (en) * | 1990-10-01 | 1993-03-09 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
US5108421A (en) | 1990-10-01 | 1992-04-28 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
NO302481B1 (no) * | 1990-10-16 | 1998-03-09 | Takeda Chemical Industries Ltd | Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring |
US5129882A (en) * | 1990-12-27 | 1992-07-14 | Novoste Corporation | Wound clotting device and method of using same |
US5690675A (en) | 1991-02-13 | 1997-11-25 | Fusion Medical Technologies, Inc. | Methods for sealing of staples and other fasteners in tissue |
AU654574B2 (en) * | 1991-06-14 | 1994-11-10 | Amgen, Inc. | Collagen film drug delivery for proteins |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
WO1993016657A1 (en) | 1992-02-28 | 1993-09-02 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
DK0632820T3 (da) * | 1992-02-28 | 2000-10-02 | Collagen Corp | Højkoncentrerede, homogeniserede collagensammensætninger |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
EP0637226A4 (de) * | 1992-04-23 | 1995-06-14 | Scimed Life Systems Inc | Vorrichtung und verfahren zum verschliessen von vaskularen punktionen. |
IL105529A0 (en) * | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
US5385606A (en) * | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
US5413571A (en) * | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
US5428022A (en) * | 1992-07-29 | 1995-06-27 | Collagen Corporation | Composition of low type III content human placental collagen |
US5514379A (en) * | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
DE4227681C2 (de) | 1992-08-21 | 1995-05-18 | Becker & Co Naturinwerk | Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung |
DE69330909T2 (de) * | 1992-11-12 | 2002-06-20 | Neville Alleyne | Einrichtung zum schutz des herzens |
US5667839A (en) * | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
WO1994027630A1 (fr) | 1993-05-31 | 1994-12-08 | Kaken Pharmaceutical Co., Ltd. | Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base |
FR2715309B1 (fr) * | 1994-01-24 | 1996-08-02 | Imedex | Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé. |
US5674275A (en) | 1994-04-06 | 1997-10-07 | Graphic Controls Corporation | Polyacrylate and polymethacrylate ester based hydrogel adhesives |
US5531759A (en) * | 1994-04-29 | 1996-07-02 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5658592A (en) * | 1994-05-13 | 1997-08-19 | Kuraray Co., Ltd. | Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane |
GB9415739D0 (en) | 1994-07-30 | 1994-09-21 | Scimat Ltd | Gel wound dressing |
US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
US5931165A (en) * | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
US5580923A (en) | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
WO1997022371A1 (en) * | 1995-12-18 | 1997-06-26 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
US5748318A (en) | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
HUP9903586A3 (en) | 1996-04-04 | 2003-02-28 | Baxter Ag | Hemostatic sponge based on collagen |
US5902832A (en) * | 1996-08-20 | 1999-05-11 | Menlo Care, Inc. | Method of synthesizing swollen hydrogel for sphincter augmentation |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US6063061A (en) | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
US7320962B2 (en) * | 1996-08-27 | 2008-01-22 | Baxter International Inc. | Hemoactive compositions and methods for their manufacture and use |
US7871637B2 (en) * | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
US6706690B2 (en) * | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
CN1157355A (zh) * | 1996-10-21 | 1997-08-20 | 山西省化学纤维研究所 | 止血纤维组成及其气体牵伸法纺丝工艺 |
ES2243000T3 (es) * | 1997-06-03 | 2005-11-16 | Innogenetics N.V. | Nuevos medicamentos basados en polimeros compuestos de gelatina modificada con metacrilamina. |
US5908054A (en) | 1997-06-16 | 1999-06-01 | Fusion Medical Technologies, Inc. | Fluid dispersion and delivery assembly and method |
ATE306935T1 (de) | 1997-09-16 | 2005-11-15 | Integra Lifesciences Corp | Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen |
US5997895A (en) | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
US6179872B1 (en) * | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
US6227394B1 (en) * | 1998-06-09 | 2001-05-08 | Asahi Glass Company Ltd. | Glass bulb for a cathode ray tube and a method for producing a cathode ray tube |
US6110484A (en) * | 1998-11-24 | 2000-08-29 | Cohesion Technologies, Inc. | Collagen-polymer matrices with differential biodegradability |
US6328229B1 (en) | 1998-12-18 | 2001-12-11 | Cohesion Technologies, Inc. | Low volume mixing spray head for mixing and dispensing of two reactive fluid components |
US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
US6312474B1 (en) | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
CN1114728C (zh) * | 2000-04-21 | 2003-07-16 | 中国石油化工集团公司 | 止血纤维及其制造方法 |
MXPA03002414A (es) | 2000-09-18 | 2004-07-08 | Organogenesis Inc | Protesis con injerto de hoja plana tratada por bioingenieria y su uso. |
AU2002255220B2 (en) | 2001-01-25 | 2007-05-31 | Topaz Investment As | Carrier with solid fibrinogen and solid thrombin |
AU2002300450B2 (en) | 2001-08-10 | 2007-04-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Collagen Carrier of Therapeutic Genetic Material, and Method |
ATE315413T1 (de) | 2003-06-05 | 2006-02-15 | Baxter Int | Zubereitungen zur wiederherstellung und regeneration humaner dura mater |
US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US20050181977A1 (en) * | 2003-11-10 | 2005-08-18 | Angiotech International Ag | Medical implants and anti-scarring agents |
US20080091277A1 (en) * | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
ATE512200T1 (de) | 2005-05-04 | 2011-06-15 | Suprapolix Bv | Hydrogele mit wasserstoffbrückenbindungen |
WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
CN101454030B (zh) * | 2006-05-31 | 2013-06-26 | 巴克斯特国际公司 | 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法 |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
TWI461227B (zh) * | 2007-10-30 | 2014-11-21 | Baxter Int | 再生生物功能性膠原生物基質用來治療內臟或體壁缺陷的用途 |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
AU2010262058B2 (en) | 2009-06-16 | 2013-08-29 | Baxter Healthcare S.A. | Hemostatic sponge |
-
2001
- 2001-07-17 US US09/908,464 patent/US7435425B2/en not_active Expired - Lifetime
-
2002
- 2002-06-21 ES ES02744588T patent/ES2284883T3/es not_active Expired - Lifetime
- 2002-06-21 MX MXPA04000514A patent/MXPA04000514A/es active IP Right Grant
- 2002-06-21 EP EP02744588A patent/EP1414370B1/de not_active Expired - Lifetime
- 2002-06-21 CN CN2008101081388A patent/CN101284146B/zh not_active Expired - Lifetime
- 2002-06-21 BR BRPI0211258A patent/BRPI0211258B8/pt not_active IP Right Cessation
- 2002-06-21 PT PT02744588T patent/PT1414370E/pt unknown
- 2002-06-21 ES ES07005206T patent/ES2317600T3/es not_active Expired - Lifetime
- 2002-06-21 EP EP07005206A patent/EP1803417B1/de not_active Expired - Lifetime
- 2002-06-21 KR KR1020047000565A patent/KR100904582B1/ko active IP Right Grant
- 2002-06-21 AT AT02744588T patent/ATE358455T1/de active
- 2002-06-21 DK DK07005206T patent/DK1803417T3/da active
- 2002-06-21 DE DE60219319T patent/DE60219319T2/de not_active Expired - Lifetime
- 2002-06-21 DE DE60230079T patent/DE60230079D1/de not_active Expired - Lifetime
- 2002-06-21 CN CNB028182073A patent/CN100402096C/zh not_active Expired - Lifetime
- 2002-06-21 AT AT07005206T patent/ATE415136T1/de active
- 2002-06-21 PT PT07005206T patent/PT1803417E/pt unknown
- 2002-06-21 WO PCT/US2002/020022 patent/WO2003007845A1/en active IP Right Grant
- 2002-06-21 JP JP2003513454A patent/JP4316374B2/ja not_active Expired - Fee Related
- 2002-06-21 DK DK02744588T patent/DK1414370T3/da active
- 2002-06-21 CA CA002453592A patent/CA2453592C/en not_active Expired - Lifetime
- 2002-06-21 AU AU2002345846A patent/AU2002345846B2/en not_active Expired
-
2004
- 2004-05-10 HK HK04103248A patent/HK1060277A1/xx not_active IP Right Cessation
-
2007
- 2007-06-21 US US11/766,516 patent/US7547446B2/en not_active Expired - Lifetime
- 2007-10-09 HK HK07110882A patent/HK1103342A1/xx not_active IP Right Cessation
-
2008
- 2008-07-21 US US12/176,945 patent/US8383141B2/en not_active Expired - Lifetime
-
2009
- 2009-05-19 US US12/468,316 patent/US8092820B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE415136T1 (de) | Trockene hämostatische zusammensetzungen und verfahren zu ihrer herstellung | |
DE60138362D1 (de) | Bioadhäsive zusammensetzung | |
WO2003020117A3 (en) | Tissue repair compositions and methods for their manufacture and use | |
ATE253898T1 (de) | Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen | |
DE69737834D1 (de) | Folienzusammensetzungen aus Polymerisat zur Herstellung von Kapseln | |
BR9808516A (pt) | Processo para a produção de composições de gel de baixa densidade | |
DE69901538D1 (de) | Kombination aus microfasern und mineralteilchen, herstellung und verwendungen | |
AU3697397A (en) | Supplementation of cellulose nanofibrils with carboxycellulose which has a low degree of substitution | |
FR2767070B1 (fr) | Composition visqueuses aqueuses, limpides ou non, pour la fabrication de capsules molles et de capsules dures, et procede de fabrication de films pour de telles capsules | |
DE69942641D1 (de) | Verfahren zur Herstellung von 1,1,1,3,3-Pentafluorpropan | |
DE60003912T2 (de) | Verfahren zur herstellung von konditionierungstüchern | |
DE69325948D1 (de) | Entfernung von Antikörpern aus von Blut stammenden Zusammensetzungen unter Erhalt von Gerinnungsfaktoren | |
DE19983660T1 (de) | Verfahren zur Aufreinigung von Lösungsmitteln, die bei der Herstellung von pharmazeutischen Zusammensetzungen nützlich sind | |
ATE95984T1 (de) | Verfahren zur herstellung von einem mit schneller freisetzung stabilisierten aspartambestandteil fuer kaugummis. | |
DE69520023D1 (de) | Verfahren zur Herstellung von Polyhydroxycarbonsäure | |
ATE84675T1 (de) | Verfahren, um ueberhitzte milch zur herstellung von fermentiertem kaese geeignet zu machen. | |
EP0133699A3 (de) | Zusammensetzungen zur Ausrüstung von Papier mit zeitweiliger Nassstärke | |
ATE248214T1 (de) | Verfahren zur herstellung von cogranulaten, hieraus erhaltene cogranulate und verwendung als komponente in waschmittelzusammensetzungen | |
WO2002066568A8 (en) | Compositions for pre-treating shoes and methods and articles employing same | |
DE69915301D1 (de) | Verfahren zur herstellung einer körnigen porösen trockenen gelzusammensetzung von sucralfate | |
BR9800801A (pt) | Composição aquosa, pó de polímero e processos para preparar o mesmo, para preparar emulsões de polímero e para modificar uma composição de cimento. | |
WO2002016338A8 (fr) | Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant | |
JPS57119972A (en) | Water-swelling, water-stopping material | |
DE60005613D1 (de) | Verfahren zur Herstellung von Dimethylcyanamid | |
RU93021441A (ru) | Состав для получения абразивного инструмента |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1803417 Country of ref document: EP |