DK1414370T3 - Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling - Google Patents

Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling

Info

Publication number
DK1414370T3
DK1414370T3 DK02744588T DK02744588T DK1414370T3 DK 1414370 T3 DK1414370 T3 DK 1414370T3 DK 02744588 T DK02744588 T DK 02744588T DK 02744588 T DK02744588 T DK 02744588T DK 1414370 T3 DK1414370 T3 DK 1414370T3
Authority
DK
Denmark
Prior art keywords
cross
linked gelatin
preparation
methods
powder
Prior art date
Application number
DK02744588T
Other languages
English (en)
Inventor
Zhen Qian
Edward A Osawa
Cary J Reich
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Application granted granted Critical
Publication of DK1414370T3 publication Critical patent/DK1414370T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK02744588T 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling DK1414370T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/908,464 US7435425B2 (en) 2001-07-17 2001-07-17 Dry hemostatic compositions and methods for their preparation
PCT/US2002/020022 WO2003007845A1 (en) 2001-07-17 2002-06-21 Dry hemostatic compositions and methods for their preparation

Publications (1)

Publication Number Publication Date
DK1414370T3 true DK1414370T3 (da) 2007-04-30

Family

ID=25425842

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07005206T DK1803417T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf
DK02744588T DK1414370T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK07005206T DK1803417T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf

Country Status (16)

Country Link
US (4) US7435425B2 (da)
EP (2) EP1414370B1 (da)
JP (1) JP4316374B2 (da)
KR (1) KR100904582B1 (da)
CN (2) CN101284146B (da)
AT (2) ATE358455T1 (da)
AU (1) AU2002345846B2 (da)
BR (1) BRPI0211258B8 (da)
CA (1) CA2453592C (da)
DE (2) DE60230079D1 (da)
DK (2) DK1803417T3 (da)
ES (2) ES2284883T3 (da)
HK (2) HK1060277A1 (da)
MX (1) MXPA04000514A (da)
PT (2) PT1803417E (da)
WO (1) WO2003007845A1 (da)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1573295A2 (en) * 2002-12-11 2005-09-14 Ferrosan A/S Gelatine-based materials as swabs
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
EP1713521B1 (en) * 2004-01-30 2010-07-28 Ferrosan A/S Haemostatic sprays and compositions
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
RU2369408C2 (ru) * 2004-07-09 2009-10-10 Ферросан А/С Гемостатическая композиция, включающая гиалуроновую кислоту
FR2881651A1 (fr) * 2005-02-09 2006-08-11 Urodelia Sa Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique
EP1934288A2 (en) * 2005-07-28 2008-06-25 Carnegie Mellon University Biocompatible polymers and methods of use
WO2007075447A2 (en) * 2005-12-16 2007-07-05 Oxthera, Inc. Compositions and methods for oxalate reduction
CN101454030B (zh) * 2006-05-31 2013-06-26 巴克斯特国际公司 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US8133484B2 (en) 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
EP2111239B1 (en) 2006-12-15 2013-03-06 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
RU2009127718A (ru) * 2006-12-19 2011-01-27 Ферросан А/С (Dk) Раневой или тканевой перевязочный материал, содержащий молочнокислые бактерии
DE102007038125A1 (de) 2007-08-03 2009-02-05 Aesculap Ag Kombination zum Verkleben von biologischen Geweben
EP2214734B1 (en) 2007-10-30 2017-12-13 Baxter International Inc. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
EP2222159B1 (en) * 2007-11-20 2018-02-21 Pioneer Surgical Orthobiologics, Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
EP2259803B2 (en) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
WO2009123903A1 (en) 2008-04-03 2009-10-08 Zymogenetics, Inc. Hemostatic microspheres
CN102124058B (zh) 2008-06-18 2014-05-28 生命连结有限公司 改进的交联组合物
US8110208B1 (en) 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PL2442835T3 (pl) * 2009-06-16 2015-07-31 Baxter Int Gąbka hemostatyczna
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
WO2011079336A1 (en) 2009-12-16 2011-07-07 Baxter International Inc. Hemostatic sponge
EP2515957B1 (en) 2009-12-22 2015-07-29 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
CN103037845B (zh) 2010-06-01 2015-11-25 巴克斯特国际公司 用于制备干燥、稳定的止血组合物的方法
KR101814841B1 (ko) 2010-06-01 2018-01-03 백스터 인터내셔널 인코포레이티드 건조 및 안정한 지혈 조성물의 제조 방법
BR112012030457B1 (pt) 2010-06-01 2021-03-09 Baxter International Inc. processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática
CN103118713B (zh) 2010-08-05 2016-06-01 生命连结有限公司 干组合物伤口敷料及粘合剂
US10086043B2 (en) 2011-04-03 2018-10-02 The General Hospital Corporation Efficient protein expression in vivo using modified RNA (MOD-RNA)
US9149511B2 (en) * 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
US20130096082A1 (en) 2011-10-11 2013-04-18 Baxter Healthcare S.A. Hemostatic compositions
US20130090291A1 (en) 2011-10-11 2013-04-11 Baxter Healthcare S.A. Hemostatic compositions
CN103998068B (zh) 2011-10-11 2016-05-25 巴克斯特国际公司 止血组合物
AU2012318257B2 (en) 2011-10-11 2015-10-01 Baxter Healthcare S.A. Hemostatic compositions
UY34414A (es) * 2011-10-27 2013-04-30 Baxter Int Composiciones hemostáticas
TW201332567A (zh) 2011-10-27 2013-08-16 Baxter Int 止血組成物
US8940317B2 (en) 2011-12-23 2015-01-27 Pioneer Surgical Technology Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith
RU2657955C2 (ru) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Контейнер под давлением, содержащий гемостатическую пасту
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
EP3177330A4 (en) 2014-08-08 2018-01-17 The Brigham and Women's Hospital, Inc. Elastic biopolymer and use as a tissue adhesive
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
WO2016149615A1 (en) 2015-03-19 2016-09-22 The Brigham And Women's Hospital, Inc. Polypeptide compositions and methods of using the same
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
AU2016313773B2 (en) 2015-09-01 2020-11-26 Baxter International Inc. Hemostatic material
EP3413940A4 (en) 2016-02-08 2020-07-15 The Brigham and Women's Hospital, Inc. BIOADHESIVE FOR CORNEAL REPAIR
CN105879109A (zh) * 2016-03-31 2016-08-24 武汉华同信生物科技有限公司 一种医用胶粘剂及其制备方法
KR20180027126A (ko) * 2016-09-06 2018-03-14 (주)한국비엠아이 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
CA3076826A1 (en) 2017-11-03 2019-05-09 Baxter International Inc. Polymeric compositions, delivery devices, and methods
US20210001003A1 (en) * 2017-11-28 2021-01-07 Baxter International Inc. Wound-treating absorbent
CN111787958A (zh) 2017-12-29 2020-10-16 巴克斯特国际公司 喷雾干燥凝血酶以及使用和制造喷雾干燥凝血酶的方法
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
EP4218839B1 (en) 2019-07-12 2024-09-11 Cilag GmbH Haemostatic sheet
JPWO2021261080A1 (da) * 2020-06-26 2021-12-30
JP2024502848A (ja) 2021-01-08 2024-01-23 シラグ・ゲーエムベーハー・インターナショナル 生体吸収性封止粉末
CN113144277B (zh) * 2021-04-13 2022-06-14 武汉理工大学 一种可注射流体明胶及其制备方法和应用
CN113209357B (zh) * 2021-05-14 2023-02-17 南方科技大学 复合止血粉
JP2024534444A (ja) * 2021-09-16 2024-09-20 エシコン・インコーポレイテッド 組織経路封止用組成物のためのキット
CN117298327B (zh) * 2023-11-15 2024-10-01 北京帝康医药投资管理有限公司 一种止血微球颗粒及其制备方法和应用

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507244A (en) * 1947-04-14 1950-05-09 Upjohn Co Surgical gelatin dusting powder and process for preparing same
CH264752A (de) * 1947-06-03 1949-10-31 Hoffmann La Roche Verfahren zur Herstellung von Trägern für Arzneimittel.
US3089315A (en) 1961-09-25 1963-05-14 Gen Electric Convertible self-contained cooling unit for air conditioning
SE420565B (sv) 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
US4013078A (en) 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
US4006220A (en) 1975-06-04 1977-02-01 Gottlieb Sheldon K Compositions and methods useful for repairing depressed cutaneous scars
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
DE2843963A1 (de) 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4179400A (en) 1978-05-09 1979-12-18 W. R. Grace & Co. Process for preparing catalytic solutions of sulfonium salts
AT359653B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT359652B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DE3036033A1 (de) 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
US4300494A (en) 1979-09-26 1981-11-17 Shell Oil Company Thermal insulated intake ports
US4292972A (en) * 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
US4443332A (en) * 1980-07-14 1984-04-17 Oros Company Cross flow solid-to-solid heat transfer apparatus
DE3105624A1 (de) 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
EP0086627B1 (en) 1982-02-12 1985-08-28 Unitika Ltd. Anti-cancer device
US4482386A (en) 1982-03-26 1984-11-13 Warner-Lambert Company Method of conditioning a water swellable hydrocolloid
US4543332A (en) * 1982-03-29 1985-09-24 Miles Laboratories, Inc. Method for the preparation of spherical microorganism cell aggregates
US4540410A (en) * 1982-11-16 1985-09-10 Serono Pharmaceutical Partners Lyophilized compositions, preparation and use thereof
DE3466702D1 (en) 1983-07-14 1987-11-12 Hitachi Chemical Co Ltd Gelatin spherical gels and production thereof
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4515637A (en) 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
AT389815B (de) 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4837285A (en) 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
JPS6144825A (ja) 1984-08-09 1986-03-04 Unitika Ltd 止血剤
GB8422950D0 (en) 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US5178883A (en) 1984-11-29 1993-01-12 Regents Of The University Of Minnesota Method for promoting hair growth
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
IL78826A (en) 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5300494A (en) 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4832686A (en) 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4885161A (en) 1987-03-11 1989-12-05 Medi-Tech International Corporation Wound dressings in gelled paste form
CA1305069C (en) 1987-03-11 1992-07-14 John Cornell Wound dressings in sheet or gelled paste form
US5080893A (en) 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5350573A (en) 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5447966A (en) 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US4925677A (en) 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5041292A (en) 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5135751A (en) 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US4891359A (en) 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
DE3903672C1 (da) 1989-02-08 1990-02-01 Lohmann Gmbh & Co Kg
DE69004098T2 (de) 1989-08-10 1994-08-04 Gore & Ass Medizinisches spendesystem für gewebeklebstoffkomponenten.
US5196185A (en) 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (ja) 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5306501A (en) 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
US5595735A (en) 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5209776A (en) 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5108421A (en) 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
ZA918168B (en) 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
US5129882A (en) 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
JPH06500802A (ja) 1991-06-14 1994-01-27 アムジエン・インコーポレーテツド コラーゲンフィルムによるタンパクのドラッグ・デリバリー
AT398079B (de) 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AU666712B2 (en) 1992-02-28 1996-02-22 Cohesion Technologies, Inc. Injectable ceramic compositions and methods for their preparation and use
EP0632820B1 (en) 1992-02-28 2000-05-17 Collagen Corporation High concentration homogenized collagen compositions
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
CA2134071C (en) 1992-04-23 1999-04-27 Sew Wah Tay Apparatus and method for sealing vascular punctures
IL105529A0 (en) 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
WO1993024476A1 (en) 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5385606A (en) 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5413571A (en) 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5428022A (en) 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
DE4227681C2 (de) 1992-08-21 1995-05-18 Becker & Co Naturinwerk Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung
ATE206602T1 (de) 1992-11-12 2001-10-15 Neville Alleyne Einrichtung zum schutz des herzens
US5667839A (en) 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
WO1994027630A1 (fr) 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base
FR2715309B1 (fr) 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5674275A (en) 1994-04-06 1997-10-07 Graphic Controls Corporation Polyacrylate and polymethacrylate ester based hydrogel adhesives
US5531759A (en) 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5658592A (en) 1994-05-13 1997-08-19 Kuraray Co., Ltd. Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
GB9415739D0 (en) 1994-07-30 1994-09-21 Scimat Ltd Gel wound dressing
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5931165A (en) 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
DE69636289T2 (de) 1995-12-18 2007-05-10 Angiodevice International Gmbh Vernetzten polymerisatmassen und verfahren für ihre verwendung
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5748318A (en) * 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
JP2000510357A (ja) 1996-04-04 2000-08-15 イムノ・アクチエンゲゼルシャフト コラーゲンを基にした止血スポンジ
US5902832A (en) 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
CN1157355A (zh) * 1996-10-21 1997-08-20 山西省化学纤维研究所 止血纤维组成及其气体牵伸法纺丝工艺
US6458386B1 (en) * 1997-06-03 2002-10-01 Innogenetics N.V. Medicaments based on polymers composed of methacrylamide-modified gelatin
US5908054A (en) * 1997-06-16 1999-06-01 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
WO1999013902A1 (en) 1997-09-16 1999-03-25 Integra Lifesciences Corporation Product for promoting dural or meningeal tissue growth comprising collagen
US6179872B1 (en) 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US6227394B1 (en) 1998-06-09 2001-05-08 Asahi Glass Company Ltd. Glass bulb for a cathode ray tube and a method for producing a cathode ray tube
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US6328229B1 (en) 1998-12-18 2001-12-11 Cohesion Technologies, Inc. Low volume mixing spray head for mixing and dispensing of two reactive fluid components
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6312474B1 (en) 1999-09-15 2001-11-06 Bio-Vascular, Inc. Resorbable implant materials
US6221109B1 (en) 1999-09-15 2001-04-24 Ed. Geistlich Söhne AG fur Chemische Industrie Method of protecting spinal area
CN1114728C (zh) * 2000-04-21 2003-07-16 中国石油化工集团公司 止血纤维及其制造方法
AU2001291092B2 (en) 2000-09-18 2007-08-23 Organogenesis Inc. Bioengineered flat sheet graft prosthesis and its use
CZ20032199A3 (cs) 2001-01-25 2003-12-17 Nycomed Pharma As Suspenze obsahující fibrinogen, trombin a alkohol, způsob přípravy této suspenze, způsob pokrytí nosiče touto suspenzí, způsob vysušení pokrytí nosiče a pokrytá kolagenová houba
AU2002300450B2 (en) 2001-08-10 2007-04-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen Carrier of Therapeutic Genetic Material, and Method
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
WO2004108179A1 (en) 2003-06-05 2004-12-16 Baxter International Inc. Compositions for repairing and regenerating human dura mater
JP2007516740A (ja) 2003-11-10 2007-06-28 アンジオテック インターナショナル アーゲー 医療移植片（ｉｍｐｌａｎｔｓ）および瘢痕化抑制剤
US20080091277A1 (en) 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
US8246990B2 (en) 2005-05-04 2012-08-21 Suprapolix B.V. Hydrogen bonded hydrogels
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
CN101454030B (zh) 2006-05-31 2013-06-26 巴克斯特国际公司 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
EP2214734B1 (en) 2007-10-30 2017-12-13 Baxter International Inc. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PL2442835T3 (pl) 2009-06-16 2015-07-31 Baxter Int Gąbka hemostatyczna

Also Published As

Publication number Publication date
ES2317600T3 (es) 2009-04-16
CA2453592A1 (en) 2003-01-30
US8092820B2 (en) 2012-01-10
ATE358455T1 (de) 2007-04-15
AU2002345846B2 (en) 2007-08-23
US20070248685A1 (en) 2007-10-25
US7547446B2 (en) 2009-06-16
US20090227779A1 (en) 2009-09-10
EP1414370A4 (en) 2005-11-09
DE60219319D1 (de) 2007-05-16
WO2003007845A1 (en) 2003-01-30
US20080286376A1 (en) 2008-11-20
US20030064109A1 (en) 2003-04-03
ATE415136T1 (de) 2008-12-15
EP1803417A1 (en) 2007-07-04
BR0211258A (pt) 2004-07-27
CN101284146B (zh) 2013-05-08
US7435425B2 (en) 2008-10-14
BRPI0211258B1 (pt) 2015-06-02
BRPI0211258B8 (pt) 2021-07-27
CN1555249A (zh) 2004-12-15
WO2003007845A9 (en) 2004-04-01
DE60230079D1 (de) 2009-01-08
ES2284883T3 (es) 2007-11-16
KR20040025698A (ko) 2004-03-24
US8383141B2 (en) 2013-02-26
JP2005500102A (ja) 2005-01-06
PT1803417E (pt) 2008-12-31
JP4316374B2 (ja) 2009-08-19
DE60219319T2 (de) 2008-01-03
EP1414370B1 (en) 2007-04-04
MXPA04000514A (es) 2005-03-07
EP1414370A1 (en) 2004-05-06
DK1803417T3 (da) 2009-03-16
CA2453592C (en) 2009-10-06
CN101284146A (zh) 2008-10-15
EP1803417B1 (en) 2008-11-26
KR100904582B1 (ko) 2009-06-25
PT1414370E (pt) 2007-05-31
CN100402096C (zh) 2008-07-16
HK1060277A1 (en) 2004-08-06
HK1103342A1 (en) 2007-12-21

Similar Documents

Publication Publication Date Title
DK1414370T3 (da) Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling
ATE428406T1 (de) Bioadhäsive zusammensetzung
WO2003020117A3 (en) Tissue repair compositions and methods for their manufacture and use
JP2012528593A5 (da)
DE68914110D1 (de) Hämostastische Collagenpastenmaterialzusammensetzung.
PL346462A1 (en) Application of polysaccharides or thier derivatives obtained by gelation and subsequent grinding combined with drying with superheated steam or hot gas as a component of building material mixes
MXPA02011741A (es) Eteres de celulosa con disolucion retardada y un procedimiento para su fabricacion.
IS5646A (is) Aðferð til að breyta prótínbyggingu fóðurtaflna, fóðurkúlna eða annarra fóðurköggla sem fengið hafalokalögun til að ná fram stöðugleika í lögun, og fóðurmassa í samræmi við það sem aðferðin segir til um
SE8504700L (sv) Hydraulisk cementkomposition med fordrojd bindning for cementering vid hog temperatur och hogt tryck
FI910378A0 (fi) Foerfarande foer framstaellning av stabiliserad aspartamingrediens foer tuggummi, vilken aspartamingrediens frigoers snabbt.
PL348610A1 (en) Wood preservative formulations
BR9711148A (pt) Granulados compreendendo composto solÚvel em gua e celulose
WO2001001968A3 (en) Methods and compositions for regulating gut motility and food intake
ES2221811B1 (es) Yeso de construccion y procedimiento y usos correspondientes.
MD1186G2 (ro) Procedeu de uscare a prunelor
EA200401279A1 (ru) Способ обработки древесины, древесной муки и тому подобного, оборудование для обработки древесины и продукция, изготовленная из модифицированной древесины и древесной муки
HUP9903220A1 (hu) Gyorsrizs és előállításának módszerei
JPS6427560A (en) Pot pourri molded body
ES2148181T3 (es) Composiciones que controlan el ciclo celular y procedimiento para su utilizacion.
RU96119888A (ru) Вяжущее
RU2000100724A (ru) Композиция, обладающая общеукрепляющим, стимулирующим и радиопротекторным действием (варианты)
CY1112104T1 (el) Μεθοδος για την προετοιμασια ενος παρασκευασματος πρωτεϊνης που στεγνωνει με κυλινδρο
JPS5234456A (en) Contious drying method of band shape veneer
JPS51111745A (en) Dry dehumidifier
KR960020705A (ko) 동결건조법을 이용한 치즈 분말 및 이의 제조방법