DK176046B1 - Fremgangsmåde til fremstilling af 5-amino-2,4,6-triiodisophthalsyre-dichlorid ved chlorering med thionylchlorid i nærværelse af en katalysator - Google Patents
Fremgangsmåde til fremstilling af 5-amino-2,4,6-triiodisophthalsyre-dichlorid ved chlorering med thionylchlorid i nærværelse af en katalysator Download PDFInfo
- Publication number
- DK176046B1 DK176046B1 DK199701303A DK130397A DK176046B1 DK 176046 B1 DK176046 B1 DK 176046B1 DK 199701303 A DK199701303 A DK 199701303A DK 130397 A DK130397 A DK 130397A DK 176046 B1 DK176046 B1 DK 176046B1
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- process according
- triiodisophthalic acid
- thionyl chloride
- acid dichloride
- Prior art date
Links
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 title claims description 42
- 238000000034 method Methods 0.000 title claims description 25
- FBJVWRITWDYUAC-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl chloride Chemical compound NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I FBJVWRITWDYUAC-UHFFFAOYSA-N 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000003054 catalyst Substances 0.000 title description 7
- 238000005660 chlorination reaction Methods 0.000 title description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 47
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 claims description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 150000005621 tetraalkylammonium salts Chemical class 0.000 claims description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 6
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical group CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 5
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical group 0.000 claims description 3
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- 150000001649 bromium compounds Chemical class 0.000 claims description 2
- ROIPBPWWXWOVSW-UHFFFAOYSA-N bromo(chloro)methanesulfonic acid Chemical group OS(=O)(=O)C(Cl)Br ROIPBPWWXWOVSW-UHFFFAOYSA-N 0.000 claims description 2
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims description 2
- 229960004647 iopamidol Drugs 0.000 claims description 2
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims description 2
- 229940011051 isopropyl acetate Drugs 0.000 claims description 2
- SBHRWOBHKASWGU-UHFFFAOYSA-M tridodecyl(methyl)azanium;chloride Chemical class [Cl-].CCCCCCCCCCCC[N+](C)(CCCCCCCCCCCC)CCCCCCCCCCCC SBHRWOBHKASWGU-UHFFFAOYSA-M 0.000 claims description 2
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims 1
- 229960004537 ioversol Drugs 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000011541 reaction mixture Substances 0.000 description 8
- 230000003197 catalytic effect Effects 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000010533 azeotropic distillation Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000193 iodinated contrast media Substances 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 238000010626 work up procedure Methods 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- TZEBLZRSPJJCOS-UHFFFAOYSA-N 2,4,6-triiodo-5-(methylamino)benzene-1,3-dicarbonyl chloride Chemical compound CNC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I TZEBLZRSPJJCOS-UHFFFAOYSA-N 0.000 description 1
- KNDAEDDIIQYRHY-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(piperazin-1-ylmethyl)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)CN1CCNCC1 KNDAEDDIIQYRHY-UHFFFAOYSA-N 0.000 description 1
- GSFNQBFZFXUTBN-UHFFFAOYSA-N 2-chlorothiophene Chemical compound ClC1=CC=CS1 GSFNQBFZFXUTBN-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 150000001348 alkyl chlorides Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- -1 dichloride 5-amino-2,4,6-triiodisophthalic acid dichloride Chemical compound 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M isovalerate Chemical compound CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- ZUZLIXGTXQBUDC-UHFFFAOYSA-N methyltrioctylammonium Chemical compound CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC ZUZLIXGTXQBUDC-UHFFFAOYSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI951004 | 1995-05-18 | ||
| ITMI951004A IT1275429B (it) | 1995-05-18 | 1995-05-18 | Processo per la preparazione di un intermedio utile nella sintesi di composti organici |
| EP9602009 | 1996-05-10 | ||
| PCT/EP1996/002009 WO1996036590A1 (en) | 1995-05-18 | 1996-05-10 | Process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination with thionyl chloride in the presence of a catalyst |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK130397A DK130397A (da) | 1997-11-17 |
| DK176046B1 true DK176046B1 (da) | 2006-02-20 |
Family
ID=11371619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199701303A DK176046B1 (da) | 1995-05-18 | 1996-05-10 | Fremgangsmåde til fremstilling af 5-amino-2,4,6-triiodisophthalsyre-dichlorid ved chlorering med thionylchlorid i nærværelse af en katalysator |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5663432A (nl) |
| JP (1) | JP3865405B2 (nl) |
| AU (1) | AU5895096A (nl) |
| BE (1) | BE1009466A3 (nl) |
| CA (1) | CA2221278C (nl) |
| CH (1) | CH691534A5 (nl) |
| CZ (1) | CZ287815B6 (nl) |
| DE (1) | DE19681399B4 (nl) |
| DK (1) | DK176046B1 (nl) |
| FR (1) | FR2734262B1 (nl) |
| GB (1) | GB2315751B (nl) |
| HU (1) | HUP9801142A3 (nl) |
| IE (1) | IE80674B1 (nl) |
| IL (1) | IL118062A (nl) |
| IT (1) | IT1275429B (nl) |
| NL (1) | NL1003127C2 (nl) |
| NO (1) | NO310286B1 (nl) |
| SE (1) | SE520616C2 (nl) |
| WO (1) | WO1996036590A1 (nl) |
| ZA (1) | ZA963788B (nl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101307010B (zh) * | 2008-07-12 | 2011-05-25 | 厦门大学 | 碘佛醇的合成方法 |
| PT105770B (pt) * | 2011-06-24 | 2013-07-08 | Hovione Farmaciencia S A | Novo intermediário e seu uso na preparação de agente de contrate triiodado |
| AU2013357598B2 (en) | 2012-12-11 | 2017-12-21 | Bracco Imaging Spa | Continuous process for the preparation of (S)-2-acetyloxypropionic acid chloride |
| KR102358241B1 (ko) | 2014-06-10 | 2022-02-04 | 브라코 이미징 에스.피.에이. | (s)-2-아세틸옥시프로피온산 및 그것의 유도체의 제조 방법 |
| CN108026017B (zh) * | 2015-10-02 | 2021-09-21 | 日本瑞翁株式会社 | 酰卤溶液的制造方法、混合溶液及单酯化合物的制造方法 |
| WO2017130871A1 (ja) | 2016-01-26 | 2017-08-03 | 日本ゼオン株式会社 | 酸ハライド溶液の製造方法、及びモノエステル化合物の製造方法 |
| US10342232B1 (en) | 2018-10-24 | 2019-07-09 | The United States Of America As Represented By The Secretary Of The Navy | Iodinated polymers for biological agent defeat |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR825418A (fr) * | 1936-08-10 | 1938-03-03 | Bosch Robert | Pompe à combustibles liquides |
| US3655752A (en) * | 1969-06-20 | 1972-04-11 | Sterling Drug Inc | Isomers of 2 4 6-trihalo-n n n' n'-tetraalkylisophthalamides |
| CH608189A5 (nl) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
| FR2541676A1 (fr) * | 1983-02-25 | 1984-08-31 | Guerbet Sa | Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| CA2124559A1 (en) * | 1991-12-03 | 1993-06-10 | Mills Thomas Kneller | Nonionic x-ray contrast agents, compositions and methods |
| IT1271107B (it) * | 1994-11-29 | 1997-05-26 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di composti organici |
-
1995
- 1995-05-18 IT ITMI951004A patent/IT1275429B/it active IP Right Grant
-
1996
- 1996-04-29 IL IL11806296A patent/IL118062A/xx not_active IP Right Cessation
- 1996-05-09 FR FR9605773A patent/FR2734262B1/fr not_active Expired - Lifetime
- 1996-05-10 HU HU9801142A patent/HUP9801142A3/hu unknown
- 1996-05-10 CH CH02665/97A patent/CH691534A5/de not_active IP Right Cessation
- 1996-05-10 AU AU58950/96A patent/AU5895096A/en not_active Abandoned
- 1996-05-10 CZ CZ19973633A patent/CZ287815B6/cs not_active IP Right Cessation
- 1996-05-10 CA CA002221278A patent/CA2221278C/en not_active Expired - Lifetime
- 1996-05-10 JP JP53453196A patent/JP3865405B2/ja not_active Expired - Lifetime
- 1996-05-10 GB GB9724181A patent/GB2315751B/en not_active Expired - Lifetime
- 1996-05-10 DK DK199701303A patent/DK176046B1/da not_active IP Right Cessation
- 1996-05-10 DE DE19681399T patent/DE19681399B4/de not_active Expired - Lifetime
- 1996-05-10 WO PCT/EP1996/002009 patent/WO1996036590A1/en active IP Right Grant
- 1996-05-13 ZA ZA963788A patent/ZA963788B/xx unknown
- 1996-05-15 NL NL1003127A patent/NL1003127C2/nl not_active IP Right Cessation
- 1996-05-17 IE IE960350A patent/IE80674B1/en not_active IP Right Cessation
- 1996-05-17 US US08/649,490 patent/US5663432A/en not_active Expired - Lifetime
- 1996-05-20 BE BE9600446A patent/BE1009466A3/fr not_active IP Right Cessation
-
1997
- 1997-11-17 SE SE9704190A patent/SE520616C2/sv unknown
- 1997-11-17 NO NO19975260A patent/NO310286B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |
Expiry date: 20171117 |