DK1401825T3 - Thiophenderivater som antivirale midler mod flavivirus-infektion - Google Patents
Thiophenderivater som antivirale midler mod flavivirus-infektionInfo
- Publication number
- DK1401825T3 DK1401825T3 DK02742563T DK02742563T DK1401825T3 DK 1401825 T3 DK1401825 T3 DK 1401825T3 DK 02742563 T DK02742563 T DK 02742563T DK 02742563 T DK02742563 T DK 02742563T DK 1401825 T3 DK1401825 T3 DK 1401825T3
- Authority
- DK
- Denmark
- Prior art keywords
- antiviral agents
- thiophene derivatives
- flavivirus infection
- flavivirus
- infection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29673101P | 2001-06-11 | 2001-06-11 | |
PCT/CA2002/000876 WO2002100851A2 (en) | 2001-06-11 | 2002-06-11 | Thiophene derivatives as antiviral agents for flavivirus infection |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1401825T3 true DK1401825T3 (da) | 2009-11-09 |
Family
ID=23143308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02742563T DK1401825T3 (da) | 2001-06-11 | 2002-06-11 | Thiophenderivater som antivirale midler mod flavivirus-infektion |
Country Status (25)
Country | Link |
---|---|
US (2) | US6881741B2 (no) |
EP (3) | EP2206709A3 (no) |
JP (2) | JP4544857B2 (no) |
KR (1) | KR100900304B1 (no) |
CN (2) | CN100509797C (no) |
AP (1) | AP1753A (no) |
AT (1) | ATE438637T1 (no) |
AU (2) | AU2002344854B2 (no) |
BR (1) | BR0210357A (no) |
CA (1) | CA2450007C (no) |
CY (1) | CY1109497T1 (no) |
CZ (1) | CZ20033368A3 (no) |
DE (1) | DE60233227D1 (no) |
DK (1) | DK1401825T3 (no) |
EA (1) | EA007484B1 (no) |
ES (1) | ES2330313T3 (no) |
MX (1) | MXPA03011452A (no) |
NO (1) | NO331721B1 (no) |
OA (1) | OA12622A (no) |
PL (2) | PL395097A1 (no) |
PT (1) | PT1401825E (no) |
SI (1) | SI1401825T1 (no) |
SK (1) | SK288015B6 (no) |
WO (1) | WO2002100851A2 (no) |
ZA (1) | ZA200309590B (no) |
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
KR100900304B1 (ko) * | 2001-06-11 | 2009-06-02 | 바이로켐 파마 인코포레이티드 | 플라비 바이러스 감염용 항바이러스제로서의 티오펜 유도체 |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US7166639B2 (en) * | 2001-10-04 | 2007-01-23 | Smithkline Beecham Corporation | NF-κB inhibitors |
JP2005531608A (ja) * | 2002-06-06 | 2005-10-20 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
US7179836B2 (en) * | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
TW200418863A (en) * | 2002-10-17 | 2004-10-01 | Upjohn Co | Novel anthelmintic and insecticidal compositions |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
NZ540799A (en) * | 2002-12-10 | 2008-09-26 | Virochem Pharma Inc | Compounds and methods for the treatment or prevention of flavivirus infections |
ES2345438T3 (es) * | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
US20040192707A1 (en) * | 2002-12-10 | 2004-09-30 | Laval Chan Chun Kong | Compounds and methods for the treatment or prevention of Flavivirus infections |
US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
WO2004056797A1 (en) * | 2002-12-23 | 2004-07-08 | 4Sc Ag | Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7173004B2 (en) | 2003-04-16 | 2007-02-06 | Bristol-Myers Squibb Company | Macrocyclic isoquinoline peptide inhibitors of hepatitis C virus |
US7112601B2 (en) | 2003-09-11 | 2006-09-26 | Bristol-Myers Squibb Company | Cycloalkyl heterocycles for treating hepatitis C virus |
AP2287A (en) | 2003-10-14 | 2011-10-31 | Intermune Inc | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication. |
PT1677827E (pt) * | 2003-10-27 | 2009-03-13 | Vertex Pharma | Associações para o tratamento do vhc |
EP1944042A1 (en) * | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinations for HCV treatment |
DE10359791A1 (de) * | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
EP2626354A1 (en) | 2004-02-20 | 2013-08-14 | Boehringer Ingelheim International GmbH | Viral polymerase inhibitors |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
DE102005028077A1 (de) * | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
CA2596393C (en) | 2004-12-30 | 2014-09-23 | Janssen Pharmaceutica N.V. | 4-(benzyl)-piperazine-1-carboxylic acid phenylamide derivatives and related compounds as modulators of fatty acid amide hydrolase for the treatment of anxiety, pain and other conditions |
JP2008540370A (ja) | 2005-05-04 | 2008-11-20 | エフ.ホフマン−ラ ロシュ アーゲー | ヘテロ環式抗ウイルス化合物 |
AU2011205048B2 (en) * | 2005-05-13 | 2013-05-02 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
DE602006003661D1 (de) | 2005-06-06 | 2008-12-24 | Lilly Co Eli | Ampa-rezeptoren-verstärker |
CA2633569A1 (en) | 2005-12-12 | 2007-06-21 | Genelabs Technologies, Inc. | N-(5-membered heteroaromatic ring)-amido anti-viral compounds |
PE20070814A1 (es) * | 2005-12-22 | 2007-08-16 | Smithkline Beecham Corp | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) |
GB0526255D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
CN101490058A (zh) * | 2006-07-14 | 2009-07-22 | 健亚生物科技公司 | 抗病毒剂 |
WO2008017688A1 (en) * | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
US20110172230A1 (en) * | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
AU2007306405A1 (en) | 2006-10-10 | 2008-04-17 | Medivir Ab | HCV nucleoside inhibitor |
WO2008043791A2 (en) * | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
JP5290186B2 (ja) | 2006-11-15 | 2013-09-18 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染症の治療または予防用のチオフェン類似体 |
ATE524465T1 (de) * | 2006-11-17 | 2011-09-15 | Glaxosmithkline Llc | 2-carboxy-thiophen-derivate als viruzide |
GB0707092D0 (en) * | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
CA2686051A1 (en) | 2007-05-04 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of hcv infection |
US20090062294A1 (en) * | 2007-05-25 | 2009-03-05 | Richard Apodaca | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
GB0712393D0 (en) * | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
US8178699B2 (en) * | 2008-07-30 | 2012-05-15 | Pfizer Inc. | Modulators of CCR9 receptor and methods of use thereof |
TWI392673B (zh) * | 2008-08-27 | 2013-04-11 | Calcimedica Inc | 調控細胞內鈣離子濃度之化合物 |
WO2010031832A2 (en) * | 2008-09-18 | 2010-03-25 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative |
WO2010039801A2 (en) | 2008-10-02 | 2010-04-08 | The J. David Gladstone Institutes | Methods of treating hepatitis c virus infection |
WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
CA2745119A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
CN104163816A (zh) | 2008-12-03 | 2014-11-26 | 普雷西迪奥制药公司 | Hcv ns5a的抑制剂 |
CN102245604A (zh) * | 2008-12-23 | 2011-11-16 | 雅培制药有限公司 | 抗病毒化合物 |
EP2367824B1 (en) | 2008-12-23 | 2016-03-23 | AbbVie Inc. | Anti-viral derivatives of pyrimidine |
WO2010101967A2 (en) * | 2009-03-04 | 2010-09-10 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole hcv polymerase inhibitors |
JP2012520884A (ja) | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
KR20110131312A (ko) | 2009-03-27 | 2011-12-06 | 프레시디오 파마슈티칼스, 인코포레이티드 | 융합된 고리 c형 간염 억제제 |
MX2011010905A (es) * | 2009-04-15 | 2011-11-01 | Abbott Lab | Compuestos antivirales. |
WO2010141809A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
EP2337781B1 (en) | 2009-06-11 | 2014-07-23 | AbbVie Bahamas Ltd. | Anti-viral compounds to treat hcv infection |
CN102471327A (zh) * | 2009-07-21 | 2012-05-23 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
WO2011031669A1 (en) | 2009-09-09 | 2011-03-17 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
CA2780044A1 (en) | 2009-11-14 | 2011-05-19 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to hcv treatment |
EP2504329A1 (en) | 2009-11-25 | 2012-10-03 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
CA2772285A1 (en) | 2009-12-02 | 2011-06-09 | F. Hoffmann-La Roche Ag | Biomarkers for predicting sustained response to hcv treatment |
MX2012007420A (es) | 2009-12-24 | 2012-07-23 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones de flavivirus. |
PT2523950T (pt) | 2010-01-15 | 2017-06-01 | Gilead Sciences Inc | Inibidores dos vírus flaviridae |
AP2012006413A0 (en) * | 2010-01-15 | 2012-08-31 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
TW201130502A (en) | 2010-01-29 | 2011-09-16 | Vertex Pharma | Therapies for treating hepatitis C virus infection |
CA2794181A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
AU2011232331A1 (en) | 2010-03-24 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of Flavivirus infections |
WO2011119860A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
WO2011119858A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
US8877707B2 (en) | 2010-05-24 | 2014-11-04 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
US20130157258A1 (en) | 2010-06-15 | 2013-06-20 | Vertex Pharmaceuticals Incorporated | Hcv ns5b protease mutants |
CA2803248A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
JP2013531011A (ja) | 2010-06-28 | 2013-08-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染の処置または予防のための化合物および方法 |
WO2012006070A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2012010663A1 (en) * | 2010-07-22 | 2012-01-26 | Novartis Ag | 2,3,5-trisubstituted thiophene compounds and uses thereof |
WO2012020036A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Hepatitis c virus inhibitors |
JP2013534249A (ja) | 2010-08-17 | 2013-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス科ウイルス感染の処置または予防のための化合物および方法 |
WO2012058125A1 (en) | 2010-10-26 | 2012-05-03 | Presidio Pharmaceuticals, Inc. | Inhibitors of hepatitis c virus |
WO2012083105A1 (en) | 2010-12-17 | 2012-06-21 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
EP2681208B1 (en) * | 2011-03-03 | 2016-05-18 | Denovamed Inc. | Antimicrobial/adjuvant compounds |
CA2831978A1 (en) * | 2011-03-03 | 2012-09-07 | Universitat Des Saarlandes | Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2012175581A1 (en) | 2011-06-24 | 2012-12-27 | F. Hoffmann-La Roche Ag | Antiviral compounds |
PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
AU2012286853A1 (en) | 2011-07-26 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Thiophene compounds |
US9180193B2 (en) | 2011-10-10 | 2015-11-10 | Hoffmann-La Roche Inc. | Antiviral compounds |
CN103059042B (zh) * | 2011-10-18 | 2015-10-07 | 银杏树药业(苏州)有限公司 | 噻吩类衍生物及其在药学中的用途 |
US9364484B2 (en) | 2011-12-06 | 2016-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating viral diseases |
JP5923181B2 (ja) | 2011-12-16 | 2016-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Hcvns5aの阻害剤 |
KR101687084B1 (ko) | 2011-12-20 | 2016-12-15 | 리보사이언스 엘엘씨 | Hcv rna 복제의 억제제로서 4'-아지도, 3'-플루오로 치환된 뉴클레오시드 유도체 |
JP5982007B2 (ja) | 2011-12-20 | 2016-08-31 | リボサイエンス・エルエルシー | Hcvrna複製の阻害薬としての2’,4’−ジフルオロ−2’−メチル置換されたヌクレオシド誘導体 |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
BR112014015582A8 (pt) | 2012-02-24 | 2017-07-04 | Hoffmann La Roche | compostos antivirais |
NZ630805A (en) | 2012-03-22 | 2016-01-29 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
ES2684396T3 (es) | 2012-08-31 | 2018-10-02 | Novadrug, Llc | Heterociclil carboxamidas para tratar enfermedades víricas |
BR112015017414A2 (pt) | 2013-01-23 | 2017-07-11 | Hoffmann La Roche | derivados de triazol antivirais |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
BR112015021429A2 (pt) | 2013-03-05 | 2017-07-18 | Hoffmann La Roche | compostos antivirais |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
JP2016519146A (ja) | 2013-05-16 | 2016-06-30 | リボサイエンス・エルエルシー | 4’−アジド,3’−デオキシ−3’−フルオロ置換ヌクレオシド誘導体 |
MX2015015782A (es) | 2013-05-16 | 2016-06-02 | Riboscience Llc | Derivados de nucleosido 4'-fluoro-2'-metil sustituido. |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
ES2932383T3 (es) | 2014-04-17 | 2023-01-18 | Merck Sharp & Dohme Llc | Complejo de tanato de sitagliptina |
EP3166637B1 (en) * | 2014-07-10 | 2020-01-29 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
CA2969699A1 (en) * | 2014-12-05 | 2016-06-09 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use |
TWI731854B (zh) | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | C型肝炎病毒聚合酶之抑制劑 |
WO2019060740A1 (en) | 2017-09-21 | 2019-03-28 | Riboscience Llc | 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION |
EP3759091A1 (en) * | 2018-03-01 | 2021-01-06 | Thomas Helledays stiftelse för medicinsk forskning | Substituted benzodiazoles and use thereof in therapy |
KR20210018806A (ko) | 2018-05-09 | 2021-02-18 | 코크리스탈 파마, 아이엔씨. | Hcv의 치료를 위한 병용 요법 |
CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3076817A (en) | 1963-02-05 | New j-amino-thiophene-z | ||
DE1055077B (de) | 1956-02-08 | 1959-04-16 | Bayerische Schrauben Und Feder | Telephonkabelsteckverbinder |
DE1055007B (de) | 1957-08-29 | 1959-04-16 | Dr Hans Fiesselmann | Verfahren zur Herstellung von 3-Aminothiophen-2-carbonsaeureestern und den entsprechenden freien Carbonsaeuren |
US3470151A (en) * | 1966-05-17 | 1969-09-30 | Beecham Group Ltd | Furyl- and thienyl-penicillins and salts thereof |
JPS499465B1 (no) | 1967-07-07 | 1974-03-05 | ||
US3823161A (en) | 1970-05-07 | 1974-07-09 | Exxon Research Engineering Co | Aminothiophene derivatives |
US3852293A (en) | 1972-06-21 | 1974-12-03 | Uniroyal Inc | 4-phenyl-2-(3-pyridyl)-thiazole carboxamides |
AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
DD146952A1 (de) | 1979-11-09 | 1981-03-11 | Karl Gewald | Verfahren zur herstellung von substituierten 3-amino-4-cyan-5-phenylthiophenen |
JPS57116077A (en) | 1981-01-12 | 1982-07-19 | Kanebo Ltd | Thieno(3,2-b)pyridinecarboxylic acid derivative |
US4666502A (en) | 1982-02-09 | 1987-05-19 | Sandoz Ltd. | Herbicidal N-thienyl-chloroacetamides |
ATE26720T1 (de) | 1982-09-09 | 1987-05-15 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazin-derivate. |
GB8515207D0 (en) | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
JPS63126884A (ja) | 1986-11-17 | 1988-05-30 | Sankyo Co Ltd | オキサゾロチエノピリミジン誘導体 |
GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
DD263055A1 (de) | 1987-07-28 | 1988-12-21 | Univ Dresden Tech | Verfahren zur herstellung substituierter 3-amino-5-phenyl-thiophene |
DE3932052A1 (de) | 1989-09-26 | 1991-04-04 | Basf Ag | Oxazol- bzw. thiazolcarbonsaeureamide |
ATE127122T1 (de) | 1990-06-23 | 1995-09-15 | Basf Ag | Dicarbonsäureimide als herbizide. |
DE4023048A1 (de) | 1990-07-20 | 1992-01-23 | Basf Ag | Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
JP2574085B2 (ja) | 1991-10-28 | 1997-01-22 | 株式会社トクヤマ | 3−アミノ−2−チオフェンカルボン酸誘導体の製造方法 |
FR2689129B1 (fr) | 1992-03-27 | 1995-05-12 | Atochem Elf Sa | Nouveaux dérivés de l'acide 3-mercapto-2-thénoique et leurs procédés de préparation. |
JPH0625221A (ja) | 1992-07-10 | 1994-02-01 | Tokuyama Soda Co Ltd | 3−アミノ−2−チオフェンカルボン酸誘導体の製造方法 |
DE4244069A1 (de) | 1992-12-24 | 1994-06-30 | Hoechst Ag | Cephalosporinsalze und Verfahren zu deren Herstellung |
JPH0748360A (ja) | 1993-05-31 | 1995-02-21 | Yoshitomi Pharmaceut Ind Ltd | ビフェニルテトラゾール誘導体 |
JPH0718360A (ja) | 1993-07-07 | 1995-01-20 | Sumitomo Light Metal Ind Ltd | 耐摩耗性に優れたTi−Al系金属間化合物部材及びその製造方法 |
EP0658559A1 (de) | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
KR970705560A (ko) | 1995-08-02 | 1997-10-09 | 호아껭 우리아치 토렐로 | 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity) |
ATE198593T1 (de) | 1995-08-02 | 2001-01-15 | Uriach & Cia Sa J | Pyrimidonderivate mit antifungaler wirkung |
WO1998008839A1 (en) | 1996-08-26 | 1998-03-05 | Eli Lilly And Company | Combinatorial process for preparing substituted thiophene libraries |
JP4000608B2 (ja) | 1996-11-07 | 2007-10-31 | トヨタ自動車株式会社 | 水素製造充填装置および電気自動車 |
TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
NZ336898A (en) | 1997-04-28 | 2001-10-26 | Texas Biotechnology Corp | Sulfonamides for treatment of endothelin-mediated disorders |
EP1019040B1 (en) | 1997-05-23 | 2004-09-29 | Bayer Corporation | Aryl ureas for the treatment of inflammatory or immunomodulatory diseases |
AU7585598A (en) * | 1997-05-23 | 1998-12-11 | Bayer Corporation | Raf kinase inhibitors |
US6344476B1 (en) | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
WO1999011647A1 (fr) | 1997-09-02 | 1999-03-11 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes thiophene condenses et leur utilisation en medecine |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
US20070244120A1 (en) | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
AU2003204708B2 (en) | 1997-12-22 | 2006-05-25 | Bayer Healthcare Llc | Inhibition of Raf Kinase using Substituted Heterocyclic Ureas |
US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
US20050119332A1 (en) | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
US6262044B1 (en) | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
US6214879B1 (en) | 1998-03-24 | 2001-04-10 | Virginia Commonwealth University | Allosteric inhibitors of pyruvate kinase |
US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
US6689754B1 (en) | 1998-04-10 | 2004-02-10 | G. D. Searle & Co. | Heterocyclic glycyl β-alanine derivatives |
PT957099E (pt) | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
US6858223B2 (en) * | 1998-06-23 | 2005-02-22 | Altana Pharma Ag | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) |
DE69912432D1 (de) * | 1998-06-29 | 2003-12-04 | Iaf Biochem Int | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
US7101878B1 (en) | 1998-08-20 | 2006-09-05 | Agouron Pharmaceuticals, Inc. | Non-peptide GNRH agents, methods and intermediates for their preparation |
CZ2001523A3 (cs) * | 1998-08-20 | 2002-05-15 | Agouron Pharmaceuticals, Inc. | Nepeptidová GnRH činidla, způsob jejich přípravy a meziprodukty pro jejich výrobu |
DE19903398A1 (de) * | 1999-01-29 | 2000-08-10 | Hassan Jomaa | Verwendung von Thiadiazolderivaten zur prophylaktischen und therapeutischen Behandlung von Infektionen |
EP1152759A2 (en) | 1999-02-09 | 2001-11-14 | 3-Dimensional Pharmaceuticals, Inc. | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR |
DE60014603T2 (de) * | 1999-03-12 | 2006-02-16 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel |
EP1163236B1 (en) | 1999-03-12 | 2005-11-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
JP2001010957A (ja) | 1999-04-28 | 2001-01-16 | Sankyo Co Ltd | 肝障害の予防または抑制剤 |
DE19920247A1 (de) * | 1999-05-03 | 2000-11-16 | Hassan Jomaa | Arzneimittel mit einem Gehalt an Verbindungen mit einem Stickstoff-Sauerstoff-Heterocyclus als Wirkstoff und ihre Verwendung |
HN2000000051A (es) * | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
GB9929552D0 (en) | 1999-12-14 | 2000-02-09 | Proteus Molecular Design | Compounds |
AU7446600A (en) | 1999-10-01 | 2001-05-10 | Japan Energy Corporation | Novel diarylamide derivatives and use thereof as medicines |
AU764826B2 (en) * | 1999-11-29 | 2003-08-28 | Novartis Ag | Pesticidal N-heteroaryl alpha-alkoximino-carboxamides |
DE10002424A1 (de) * | 2000-01-20 | 2001-07-26 | Siemens Ag | Di(het)arylaminothiophen-Derivate |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
JP2001354658A (ja) | 2000-06-15 | 2001-12-25 | Taisho Pharmaceut Co Ltd | ヒドロキシホルムアミジン化合物及びその塩並びにそれらを含む医薬 |
US6414013B1 (en) * | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
WO2002028353A2 (en) | 2000-10-05 | 2002-04-11 | Smithkline Beecham Corporation | Phosphate transport inhibitors |
PL362930A1 (en) * | 2000-11-08 | 2004-11-02 | Syngenta Participations Ag | Pyrrolcarboxamides and pyrrolcarbothioamides and their agrochemical uses |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US6892279B2 (en) * | 2000-11-30 | 2005-05-10 | Mosaid Technologies Incorporated | Method and apparatus for accelerating retrieval of data from a memory system with cache by reducing latency |
DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
WO2002064598A1 (en) | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors |
WO2002070662A2 (en) | 2001-03-02 | 2002-09-12 | Gpc Biotech Ag | Three hybrid assay system |
US20040102324A1 (en) | 2002-02-28 | 2004-05-27 | Annis Gary David | Heterocyclic diamide invertebrate pest control agents |
CA2440834A1 (en) | 2001-03-13 | 2002-09-19 | Queen's University At Kingston | Anti-epileptogenic agents |
US6734207B2 (en) * | 2001-04-20 | 2004-05-11 | Parker Hughes Institute | Cytotoxic compounds |
US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
KR100900304B1 (ko) * | 2001-06-11 | 2009-06-02 | 바이로켐 파마 인코포레이티드 | 플라비 바이러스 감염용 항바이러스제로서의 티오펜 유도체 |
CA2449999C (en) | 2001-06-11 | 2012-07-31 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
JP2003073357A (ja) | 2001-09-03 | 2003-03-12 | Mitsubishi Pharma Corp | アミド化合物を含有するRhoキナーゼ阻害剤 |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
US7166639B2 (en) * | 2001-10-04 | 2007-01-23 | Smithkline Beecham Corporation | NF-κB inhibitors |
US7285557B2 (en) | 2001-10-15 | 2007-10-23 | Smithkline Beecham P.L.C. | Pyrimidinones as melanin concentrating hormone receptor 1 |
US7220777B2 (en) | 2001-10-15 | 2007-05-22 | Smithkline Beecham P.L.C. | Lactam derivatives as antagonists for human 11cby receptors |
TWI281916B (en) * | 2001-10-25 | 2007-06-01 | Lilly Co Eli | Antitumor compounds and methods |
AU2002352443A1 (en) * | 2001-12-21 | 2003-07-15 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
WO2003068223A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
US20030220336A1 (en) | 2002-04-05 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method of treating mucus hypersecretion |
JP2005538953A (ja) * | 2002-05-28 | 2005-12-22 | 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド | 新規チオフェンアミジン、それらの組成物、および補体媒介疾患および病気を治療する方法 |
US7179836B2 (en) * | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
CN1155679C (zh) | 2002-09-20 | 2004-06-30 | 华南理工大学 | 含低聚噻吩骨格的液晶化合物及其制备方法 |
CN1705645A (zh) | 2002-10-24 | 2005-12-07 | 默克专利有限公司 | 作为raf-激酶抑制剂的亚甲基脲衍生物 |
US20050075331A1 (en) | 2003-10-06 | 2005-04-07 | Pratt John K. | Anti-infective agents |
US20040097492A1 (en) | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
MXPA05004670A (es) | 2002-11-01 | 2005-08-18 | Abbott Lab | Agentes anti-infecciones. |
US7902203B2 (en) | 2002-11-01 | 2011-03-08 | Abbott Laboratories, Inc. | Anti-infective agents |
US20040162285A1 (en) | 2002-11-01 | 2004-08-19 | Pratt John K. | Anti-infective agents |
US20040192707A1 (en) | 2002-12-10 | 2004-09-30 | Laval Chan Chun Kong | Compounds and methods for the treatment or prevention of Flavivirus infections |
ES2345438T3 (es) | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
US7098241B2 (en) * | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
DE10359791A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
AU2005228899A1 (en) | 2004-03-30 | 2005-10-13 | Novartis Vaccines And Diagnostics, Inc. | Substituted thiophene derivatives as anti-cancer agents |
DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
-
2002
- 2002-06-11 KR KR1020037016240A patent/KR100900304B1/ko not_active IP Right Cessation
- 2002-06-11 EA EA200400022A patent/EA007484B1/ru not_active IP Right Cessation
- 2002-06-11 CZ CZ20033368A patent/CZ20033368A3/cs unknown
- 2002-06-11 AU AU2002344854A patent/AU2002344854B2/en not_active Ceased
- 2002-06-11 MX MXPA03011452A patent/MXPA03011452A/es active IP Right Grant
- 2002-06-11 CA CA2450007A patent/CA2450007C/en not_active Expired - Fee Related
- 2002-06-11 PT PT02742563T patent/PT1401825E/pt unknown
- 2002-06-11 SI SI200230851T patent/SI1401825T1/sl unknown
- 2002-06-11 DK DK02742563T patent/DK1401825T3/da active
- 2002-06-11 PL PL395097A patent/PL395097A1/pl unknown
- 2002-06-11 EP EP09167203A patent/EP2206709A3/en not_active Withdrawn
- 2002-06-11 WO PCT/CA2002/000876 patent/WO2002100851A2/en active Application Filing
- 2002-06-11 DE DE60233227T patent/DE60233227D1/de not_active Expired - Lifetime
- 2002-06-11 CN CNB028157680A patent/CN100509797C/zh not_active Expired - Fee Related
- 2002-06-11 AP APAP/P/2003/002932A patent/AP1753A/en active
- 2002-06-11 ES ES02742563T patent/ES2330313T3/es not_active Expired - Lifetime
- 2002-06-11 US US10/166,031 patent/US6881741B2/en not_active Expired - Fee Related
- 2002-06-11 EP EP02742563A patent/EP1401825B1/en not_active Expired - Lifetime
- 2002-06-11 PL PL367080A patent/PL208713B1/pl not_active IP Right Cessation
- 2002-06-11 JP JP2003503618A patent/JP4544857B2/ja not_active Expired - Fee Related
- 2002-06-11 SK SK1520-2003A patent/SK288015B6/sk not_active IP Right Cessation
- 2002-06-11 BR BR0210357-5A patent/BR0210357A/pt not_active IP Right Cessation
- 2002-06-11 CN CN200910139375A patent/CN101624391A/zh active Pending
- 2002-06-11 AT AT02742563T patent/ATE438637T1/de active
- 2002-06-11 EP EP10185737A patent/EP2363396A1/en not_active Withdrawn
- 2002-06-11 OA OA1200300320A patent/OA12622A/en unknown
-
2003
- 2003-12-10 NO NO20035485A patent/NO331721B1/no not_active IP Right Cessation
- 2003-12-10 ZA ZA200309590A patent/ZA200309590B/en unknown
-
2005
- 2005-01-26 US US11/042,442 patent/US7985769B2/en not_active Expired - Fee Related
-
2009
- 2009-02-05 AU AU2009200430A patent/AU2009200430B2/en not_active Ceased
- 2009-10-22 CY CY20091101100T patent/CY1109497T1/el unknown
-
2010
- 2010-04-28 JP JP2010103706A patent/JP5412370B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1401825T3 (da) | Thiophenderivater som antivirale midler mod flavivirus-infektion | |
DK1397364T3 (da) | Hidtil ukendte pyrrolderivater som farmaceutiske midler | |
NO20041560L (no) | 1,6-nafthyridinderivater som antidiabetiske midler | |
ATE319451T1 (de) | Tetrahydrochinolin-derivate | |
NO20023828L (no) | Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer | |
ATE312827T1 (de) | 3-substituierte-4-pyrimidonderivate | |
NO20050426L (no) | Arylkarbonylderivater som terapeutiske midler | |
DK1257276T3 (da) | Antivirale azaindolderivater | |
NO20050665L (no) | Pyrrolidonderivater som MAOE inhibitoere | |
NO20042279L (no) | Kinazolinderivater som antitumormidler | |
NO20042288L (no) | Kinazolinderivater som antitumormidler | |
NO20034439D0 (no) | Benzamidinderivater | |
NO20022888L (no) | Lipopeptider som antibakterielle midler | |
DK1456206T3 (da) | Azaindolylalkylaminderivater som 5-hydroxytryptamin-6-ligander | |
NO20022887L (no) | Lipopeptider som antibakterielle midler | |
DK1578750T3 (da) | Kationiske porphyrinderivater som antibakterielle midler | |
NO20033618D0 (no) | Ftalayinon-piperidino-derivater som PDE-4-inhibitorer | |
DK1455779T3 (da) | Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander | |
DK1178986T3 (da) | Furanonderivater som inhibitorer af cathepsin S | |
ATE459598T1 (de) | Sulfonamidderivate | |
NO20043794L (no) | Benzensulfonamidderivater som antipsykotiske midler | |
NO20040860L (no) | Farmasoytisk sammensetning som innbefatter lumiracoxib | |
NO20034647D0 (no) | Hydroksyclylalkoksy-, alkyloksy- og -alkylaminobenzazol- derivater som 5-hydroksytryptamin-6-ligander | |
DE60223031D1 (de) | Arylpiperazin gebundene tetrahydroindolonderivate | |
DE60235304D1 (de) | Druckmaschinenrakel |