DK1137663T3 - Oprensning af Echinocandin-cyclopeptidforbindelser - Google Patents
Oprensning af Echinocandin-cyclopeptidforbindelserInfo
- Publication number
- DK1137663T3 DK1137663T3 DK99965156T DK99965156T DK1137663T3 DK 1137663 T3 DK1137663 T3 DK 1137663T3 DK 99965156 T DK99965156 T DK 99965156T DK 99965156 T DK99965156 T DK 99965156T DK 1137663 T3 DK1137663 T3 DK 1137663T3
- Authority
- DK
- Denmark
- Prior art keywords
- acetic acid
- fermentation
- products
- purification
- echinocandin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11152498P | 1998-12-09 | 1998-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1137663T3 true DK1137663T3 (da) | 2007-01-08 |
Family
ID=22339024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99965156T DK1137663T3 (da) | 1998-12-09 | 1999-12-08 | Oprensning af Echinocandin-cyclopeptidforbindelser |
Country Status (17)
Country | Link |
---|---|
US (1) | US6506726B1 (xx) |
EP (1) | EP1137663B1 (xx) |
JP (1) | JP2003511345A (xx) |
KR (1) | KR20010101151A (xx) |
CN (1) | CN1337968A (xx) |
AT (1) | ATE338059T1 (xx) |
AU (1) | AU766091B2 (xx) |
BR (1) | BR9916101A (xx) |
CA (1) | CA2353930A1 (xx) |
DE (1) | DE69933046T2 (xx) |
DK (1) | DK1137663T3 (xx) |
ES (1) | ES2272096T3 (xx) |
IL (1) | IL143563A0 (xx) |
PT (1) | PT1137663E (xx) |
RU (1) | RU2001118849A (xx) |
WO (1) | WO2000034315A2 (xx) |
ZA (1) | ZA200104621B (xx) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
JP4936595B2 (ja) * | 1999-03-03 | 2012-05-23 | イーライ リリー アンド カンパニー | ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物 |
DE60030415T2 (de) | 1999-03-03 | 2007-08-30 | Eli Lilly And Co., Indianapolis | Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b |
CN1345230A (zh) | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 口服ecb药物制剂和药物组合物的制备方法 |
CN1345333A (zh) | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 棘白菌素/糖类复合物 |
US6991800B2 (en) * | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
AU2005265960B8 (en) * | 2004-06-29 | 2012-01-12 | Reliance Life Sciences Pvt Ltd | Process for improvement of virus-safe biological fluids |
DE102004060750A1 (de) * | 2004-12-15 | 2006-07-13 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Deacylierung von Lipopeptiden |
TW200826957A (en) * | 2006-10-16 | 2008-07-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Purification processes for echinocandin-type compounds |
US9394340B2 (en) | 2009-03-24 | 2016-07-19 | Cadila Healthcare Limited | Purification process for lipopeptides |
CN102219832B (zh) | 2010-04-15 | 2013-08-21 | 上海天伟生物制药有限公司 | 一种氮杂环六肽或其盐的纯化方法 |
CN102336817B (zh) * | 2010-07-16 | 2016-06-15 | 浙江震元制药有限公司 | 棘球白素b母核的分离方法 |
WO2012041218A1 (zh) * | 2010-09-29 | 2012-04-05 | 上海天伟生物制药有限公司 | 一种环脂肽化合物或其盐的纯化方法 |
KR101514904B1 (ko) * | 2010-09-30 | 2015-04-23 | 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 | 사이클릭 리포펩타이드 화합물 또는 그의 염의 정제방법 |
CN102153616A (zh) * | 2010-12-27 | 2011-08-17 | 浙江海正药业股份有限公司 | 一种环己肽类化合物及其盐的分离纯化方法 |
CN106279369B (zh) | 2011-03-03 | 2020-02-11 | 奇达拉治疗公司 | 抗真菌剂及其应用 |
EP2699327B1 (en) | 2011-04-20 | 2015-07-01 | Xellia Pharmaceuticals ApS | Method for purification of micafungin |
CN102952178B (zh) * | 2011-08-24 | 2016-04-27 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度棘白霉素类化合物的制备方法 |
SI2827710T1 (sl) | 2012-03-19 | 2020-04-30 | Cidara Therapeutics, Inc. | Režimi odmerjanja za spojine razreda ehinokandin |
CN103483427A (zh) * | 2012-06-09 | 2014-01-01 | 浙江海正药业股份有限公司 | 一种棘白菌素类化合物的纯化方法 |
CN103910783B (zh) * | 2014-04-23 | 2016-07-06 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度棘白霉素b母核的制备方法 |
EP3058958B1 (en) | 2015-02-23 | 2018-09-19 | Selectchemie AG | Anidulafungin composition |
CN108883152A (zh) | 2016-01-08 | 2018-11-23 | 奇达拉治疗公司 | 防止和治疗肺孢子虫感染的方法 |
JP7224916B2 (ja) | 2016-03-16 | 2023-02-20 | シダラ セラピューティクス インコーポレーテッド | 真菌感染の処置のための投薬レジメン |
CN106248857A (zh) * | 2016-07-15 | 2016-12-21 | 广西医科大学 | 利用薄层层析快速检测植物环肽的方法 |
US11197909B2 (en) | 2017-07-12 | 2021-12-14 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of fungal infections |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4293489A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
US4293482A (en) | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | A-30912A Nucleus |
US4320052A (en) | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
US4304716A (en) | 1979-12-13 | 1981-12-08 | Eli Lilly And Company | S 31794/F-1 Nucleus |
US4874843A (en) | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
EP0294990A3 (en) * | 1987-06-10 | 1990-05-09 | Eli Lilly And Company | Chromatographic purification process |
US5166135A (en) | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
DK173802B1 (da) | 1988-09-12 | 2001-11-05 | Merck & Co Inc | Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner |
US5310726A (en) | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
DK0460882T3 (da) | 1990-06-07 | 1996-08-26 | Lilly Co Eli | Lipopeptiddeacylase |
FI912873A (fi) | 1990-06-18 | 1991-12-19 | Fujisawa Pharmaceutical Co | Ny polypeptidfoerening och foerfarande foer dess framstaellning. |
US5965525A (en) | 1992-03-19 | 1999-10-12 | Eli Lilly And Company | Cyclic peptide antifungal agents |
NZ299314A (en) | 1992-03-19 | 2001-09-28 | Lilly Co Eli | Cyclic peptide for inhibiting parasitic and antifungal activity |
US5541160A (en) | 1994-04-04 | 1996-07-30 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
US5646111A (en) | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
US5618787A (en) | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
US5786325A (en) | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
US5629290A (en) | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
US5652213A (en) | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
US5629289A (en) | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
AU1851797A (en) | 1996-02-01 | 1997-08-22 | Eli Lilly And Company | Cyclic peptide antifungal agents |
US5696084A (en) | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
AU8687798A (en) | 1997-08-04 | 1999-02-22 | Eli Lilly And Company | Cyclic peptide antifungal agents |
EP0931834A3 (en) | 1997-12-23 | 2002-06-26 | Eli Lilly And Company | Echinocandin binding domain of 1,3-Beta-glucan synthase |
US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
CA2340676A1 (en) | 1998-08-20 | 2000-03-02 | Eli Lilly And Company | Ring modified cyclic peptide analogs |
AU763351B2 (en) | 1998-08-28 | 2003-07-17 | Eli Lilly And Company | Reversible boronate complexes of 1,2-(cis)-diol cyclic-peptides |
WO2000024694A1 (en) | 1998-10-28 | 2000-05-04 | Eli Lilly And Company | Photochemical process for making 1-deoxy-2-keto derivatives |
CA2354055A1 (en) | 1998-12-16 | 2000-06-22 | Eli Lilly And Company | Cyclic peptide antifungal agents having a sugar substituent |
JP2002535248A (ja) | 1998-12-16 | 2002-10-22 | イーライ リリー アンド カンパニー | 環式ペプチド抗真菌剤 |
CN1345333A (zh) | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 棘白菌素/糖类复合物 |
CN1345230A (zh) | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 口服ecb药物制剂和药物组合物的制备方法 |
JP4936595B2 (ja) | 1999-03-03 | 2012-05-23 | イーライ リリー アンド カンパニー | ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物 |
DE60030415T2 (de) | 1999-03-03 | 2007-08-30 | Eli Lilly And Co., Indianapolis | Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b |
-
1999
- 1999-12-08 CN CN99815515A patent/CN1337968A/zh active Pending
- 1999-12-08 WO PCT/US1999/029008 patent/WO2000034315A2/en active IP Right Grant
- 1999-12-08 AT AT99965156T patent/ATE338059T1/de not_active IP Right Cessation
- 1999-12-08 EP EP99965156A patent/EP1137663B1/en not_active Expired - Lifetime
- 1999-12-08 CA CA002353930A patent/CA2353930A1/en not_active Abandoned
- 1999-12-08 KR KR1020017007161A patent/KR20010101151A/ko not_active Application Discontinuation
- 1999-12-08 DE DE69933046T patent/DE69933046T2/de not_active Expired - Fee Related
- 1999-12-08 IL IL14356399A patent/IL143563A0/xx unknown
- 1999-12-08 PT PT99965156T patent/PT1137663E/pt unknown
- 1999-12-08 AU AU31132/00A patent/AU766091B2/en not_active Ceased
- 1999-12-08 ES ES99965156T patent/ES2272096T3/es not_active Expired - Lifetime
- 1999-12-08 JP JP2000586757A patent/JP2003511345A/ja not_active Abandoned
- 1999-12-08 US US09/857,924 patent/US6506726B1/en not_active Expired - Fee Related
- 1999-12-08 RU RU2001118849/04A patent/RU2001118849A/ru not_active Application Discontinuation
- 1999-12-08 BR BR9916101-0A patent/BR9916101A/pt not_active IP Right Cessation
- 1999-12-08 DK DK99965156T patent/DK1137663T3/da active
-
2001
- 2001-06-06 ZA ZA200104621A patent/ZA200104621B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE338059T1 (de) | 2006-09-15 |
WO2000034315A2 (en) | 2000-06-15 |
PT1137663E (pt) | 2006-12-29 |
AU766091B2 (en) | 2003-10-09 |
DE69933046D1 (de) | 2006-10-12 |
BR9916101A (pt) | 2002-06-04 |
EP1137663A2 (en) | 2001-10-04 |
WO2000034315A3 (en) | 2000-12-28 |
RU2001118849A (ru) | 2003-08-10 |
ZA200104621B (en) | 2002-06-06 |
JP2003511345A (ja) | 2003-03-25 |
EP1137663B1 (en) | 2006-08-30 |
WO2000034315A8 (en) | 2000-10-26 |
AU3113200A (en) | 2000-06-26 |
IL143563A0 (en) | 2002-04-21 |
DE69933046T2 (de) | 2007-09-13 |
CN1337968A (zh) | 2002-02-27 |
US6506726B1 (en) | 2003-01-14 |
KR20010101151A (ko) | 2001-11-14 |
CA2353930A1 (en) | 2000-06-15 |
ES2272096T3 (es) | 2007-04-16 |
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