DK1007654T3 - In vitro peptid- eller proteinekspressionsbibliotek - Google Patents

In vitro peptid- eller proteinekspressionsbibliotek

Info

Publication number
DK1007654T3
DK1007654T3 DK98905520T DK98905520T DK1007654T3 DK 1007654 T3 DK1007654 T3 DK 1007654T3 DK 98905520 T DK98905520 T DK 98905520T DK 98905520 T DK98905520 T DK 98905520T DK 1007654 T3 DK1007654 T3 DK 1007654T3
Authority
DK
Denmark
Prior art keywords
protein
dna
encoding
expressed
property
Prior art date
Application number
DK98905520T
Other languages
Danish (da)
English (en)
Inventor
Elizabeth Haggard-Ljungquist
Bjorn H Lindqvist
David Andrews
Morten Isaksen
Original Assignee
Isogenica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isogenica Ltd filed Critical Isogenica Ltd
Application granted granted Critical
Publication of DK1007654T3 publication Critical patent/DK1007654T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK98905520T 1997-02-18 1998-02-18 In vitro peptid- eller proteinekspressionsbibliotek DK1007654T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9703369.0A GB9703369D0 (en) 1997-02-18 1997-02-18 Process
PCT/GB1998/000518 WO1998037186A1 (en) 1997-02-18 1998-02-18 In vitro peptide or protein expression library

Publications (1)

Publication Number Publication Date
DK1007654T3 true DK1007654T3 (da) 2005-09-19

Family

ID=10807887

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98905520T DK1007654T3 (da) 1997-02-18 1998-02-18 In vitro peptid- eller proteinekspressionsbibliotek

Country Status (14)

Country Link
US (1) US7416847B1 (es)
EP (1) EP1007654B1 (es)
JP (1) JP4644321B2 (es)
AT (1) ATE297462T1 (es)
AU (1) AU744791B2 (es)
CA (1) CA2282497C (es)
DE (2) DE1007654T1 (es)
DK (1) DK1007654T3 (es)
ES (1) ES2241117T3 (es)
GB (1) GB9703369D0 (es)
IL (2) IL131435A0 (es)
NO (1) NO322653B1 (es)
PT (1) PT1007654E (es)
WO (1) WO1998037186A1 (es)

Families Citing this family (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2233878C2 (ru) 1997-01-21 2004-08-10 Дзе Дженерал Хоспитал Корпорейшн Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US8207093B2 (en) 1997-01-21 2012-06-26 The General Hospital Corporation Selection of proteins using RNA-protein fusions
DK1019496T3 (da) 1997-07-07 2005-01-10 Medical Res Council In vitro-sorteringsmetode
CA2337490C (en) 1998-08-17 2012-01-03 Phylos, Inc. Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
KR20010099821A (ko) 1998-12-02 2001-11-09 추후기재 Ｄｎａ-단백질 융합체 및 그의 용도
IL146015A0 (en) 1999-06-01 2002-07-25 Phylos Inc Methods for producing 5'-nucleic acid-protein conjugates
EP1226149A4 (en) * 1999-10-01 2003-05-14 Zhongping Yu COMPOSITIONS AND METHODS FOR IDENTIFYING NUCLEIC ACID POLYPETIDES AND MOLECULES
JP2003520050A (ja) * 2000-01-24 2003-07-02 フィロス インク． タンパク質分析のための高感度多重化診断アッセイ法
GB2360282A (en) * 2000-03-17 2001-09-19 Bioinvent Int Ab Making and using micro-arrays of biological materials
WO2002022826A2 (en) * 2000-09-14 2002-03-21 Xencor, Inc. Methods and compositions for the construction and use of fusion libraries
US20030124537A1 (en) * 2000-12-14 2003-07-03 Yuan-Chin Liu Procaryotic libraries and uses
AU2002251999A1 (en) * 2001-02-22 2002-09-12 Xencor Methods and compositions for the construction and use of fusion libraries using computational protein design methods
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
IL157794A0 (en) 2001-03-07 2004-03-28 Childrens Medical Center Method to screen peptide display libraries using minicell display
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
EP2385118A1 (en) 2002-09-06 2011-11-09 Isogenica Limited In vitro peptide expression library
WO2004056995A1 (en) * 2002-12-23 2004-07-08 Affitech As Process for producing an in vitro peptide expression library
EP1762617A1 (en) 2003-01-07 2007-03-14 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
AU2004254552B2 (en) 2003-01-29 2008-04-24 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
ES2808687T3 (es) 2003-08-08 2021-03-01 Sangamo Therapeutics Inc Métodos y composiciones para escisión dirigida y recombinación
US20070134796A1 (en) 2005-07-26 2007-06-14 Sangamo Biosciences, Inc. Targeted integration and expression of exogenous nucleic acid sequences
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
AU2004286198C1 (en) 2003-08-18 2011-02-24 Medimmune, Llc Humanization of antibodies
DE502004006204D1 (de) * 2003-10-01 2008-03-27 Eth Zuerich Verfahren zur in vitro evolution von polypeptiden
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP4926054B2 (ja) 2004-07-20 2012-05-09 シムフォゲン・アクティーゼルスカブ 抗−ＲｈＤ組換えポリクローナル抗体及び製造方法
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP5153613B2 (ja) 2005-03-18 2013-02-27 メディミューン，エルエルシー 抗体のフレームワーク・シャッフル
US20090263900A1 (en) 2008-04-14 2009-10-22 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
EP2363205A3 (en) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (en) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Microfluidic Devices
ATE536371T1 (de) 2006-05-25 2011-12-15 Sangamo Biosciences Inc Verfahren und zusammensetzungen zur gendeaktivierung
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
CA2660485C (en) 2006-08-11 2016-04-12 Sangamo Biosciences, Inc. Zinc finger nuclease-mediated homologous recombination
KR101520507B1 (ko) 2006-12-14 2015-05-29 다우 아그로사이언시즈 엘엘씨 최적화된 비-정규 아연 손가락 단백질
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US20100105571A1 (en) 2007-03-27 2010-04-29 Carl Arne Krister Borrebaeck Protein Signature/Markers for the Detection of Adenocarcinoma
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8110379B2 (en) 2007-04-26 2012-02-07 Sangamo Biosciences, Inc. Targeted integration into the PPP1R12C locus
EP2152872B1 (en) 2007-05-25 2010-09-15 Symphogen A/S Method for manufacturing a recombinant polyclonal protein
WO2009009086A2 (en) 2007-07-12 2009-01-15 Sangamo Biosciences, Inc. Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut 8) gene expression
JP5763341B2 (ja) 2007-09-27 2015-08-12 サンガモ バイオサイエンシーズ， インコーポレイテッド 生物学的活性のあるヌクレアーゼの迅速なインビボ同定法
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
US8399218B2 (en) 2007-09-27 2013-03-19 Dow Agrosciences, Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
CA2703045C (en) 2007-10-25 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
WO2009134409A2 (en) 2008-04-30 2009-11-05 Sanbio, Inc. Neural regenerating cells with alterations in dna methylation
AU2009260888B2 (en) 2008-05-28 2014-09-11 Sangamo Therapeutics, Inc. Compositions for linking DNA-binding domains and cleavage domains
CA2893175C (en) 2008-06-10 2016-09-06 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
KR101759586B1 (ko) 2008-08-22 2017-07-19 상가모 테라퓨틱스, 인코포레이티드 표적화된 단일가닥 분할 및 표적화된 통합을 위한 방법 및 조성물
AU2009311697B2 (en) 2008-10-29 2014-12-18 Sangamo Therapeutics, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
JP5882058B2 (ja) 2008-11-07 2016-03-09 ファブラス エルエルシー 組合せ抗体ライブラリー及びその使用
CN102625655B (zh) 2008-12-04 2016-07-06 桑格摩生物科学股份有限公司 使用锌指核酸酶在大鼠中进行基因组编辑
JP2012511926A (ja) 2008-12-17 2012-05-31 ダウ・アグロサイエンス・エル・エル・シー Ｚｐ１５遺伝子座内への標的組込み
WO2010090744A1 (en) 2009-02-04 2010-08-12 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathies
WO2010107493A2 (en) 2009-03-20 2010-09-23 Sangamo Biosciences, Inc. Modification of cxcr4 using engineered zinc finger proteins
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
US9834787B2 (en) 2009-04-09 2017-12-05 Sangamo Therapeutics, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
JP5798116B2 (ja) 2009-06-30 2015-10-21 サンガモ バイオサイエンシーズ， インコーポレイテッド 生物活性のあるヌクレアーゼの迅速なスクリーニングおよびヌクレアーゼ修飾細胞の単離
EP2451837B1 (en) 2009-07-08 2015-03-25 Cellular Dynamics International, Inc. Modified ips cells having a mutant form of human immunodeficiency virus (hiv) cellular entry gene
WO2011016840A2 (en) 2009-07-28 2011-02-10 Sangamo Biosciences, Inc. Methods and compositions for treating trinucleotide repeat disorders
NZ598457A (en) * 2009-08-03 2014-06-27 Recombinetics Inc Methods and compositions for targeted gene modification
EP3428289B1 (en) 2009-08-11 2020-05-20 Sangamo Therapeutics, Inc. Organisms homozygous for targeted modification
US8586526B2 (en) 2010-05-17 2013-11-19 Sangamo Biosciences, Inc. DNA-binding proteins and uses thereof
AU2010294192A1 (en) 2009-09-10 2012-04-05 Lonza Biologics Plc Method and system for polypeptide purification
EP2486409A1 (en) 2009-10-09 2012-08-15 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
KR101813981B1 (ko) 2009-10-22 2018-01-04 다우 아그로사이언시즈 엘엘씨 지방산 생합성에 포함된 식물 유전자를 표적하는 조작된 징크 핑거 단백질
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
JP5902631B2 (ja) 2010-01-22 2016-04-13 ダウ アグロサイエンシィズ エルエルシー 標的化ゲノム変更
CA2788850C (en) 2010-02-09 2019-06-25 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
BR112012027532A2 (pt) 2010-04-26 2020-10-13 Sangamo Biosciences, Inc. edição de genoma de um locus rosa usando nucleases de dedo de zinco.
DK2566972T3 (da) 2010-05-03 2020-02-17 Sangamo Therapeutics Inc Sammensætninger til at forbinde zinkfinger-moduler
GB201009798D0 (en) 2010-06-11 2010-07-21 Immunovia Ab Method,array and use thereof
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
US8945868B2 (en) 2010-07-21 2015-02-03 Sangamo Biosciences, Inc. Methods and compositions for modification of a HLA locus
CN103168101A (zh) 2010-07-23 2013-06-19 西格马-奥尔德里奇有限责任公司 使用靶向核酸内切酶和单链核酸的基因组编辑
GB201014837D0 (en) 2010-09-07 2010-10-20 Immunovia Ab Biomarker signatures and uses thereof
AU2011312562B2 (en) 2010-09-27 2014-10-09 Sangamo Therapeutics, Inc. Methods and compositions for inhibiting viral entry into cells
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012051343A1 (en) 2010-10-12 2012-04-19 The Children's Hospital Of Philadelphia Methods and compositions for treating hemophilia b
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
GB201018014D0 (en) 2010-10-26 2010-12-08 Senzagen Ab Analytical methods and arrays for use in the same
EP2466310A1 (en) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Means and methods for detecting double-strand breaks
CA2821547A1 (en) 2010-12-29 2012-07-05 Sigma-Aldrich Co. Llc Cells having disrupted expression of proteins involved in adme and toxicology processes
US9267123B2 (en) 2011-01-05 2016-02-23 Sangamo Biosciences, Inc. Methods and compositions for gene correction
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
EP2694554A1 (en) 2011-04-08 2014-02-12 Gilead Biologics, Inc. Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
ES2671733T3 (es) 2011-06-30 2018-06-08 Sigma Aldrich Co. Llc Células deficientes en ácido CMP-N-acetilneuramínico hidroxilasa y/o glucoproteína alfa-1,3-galactosil transferasa
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
JP6072788B2 (ja) 2011-07-25 2017-02-01 サンガモ バイオサイエンシーズ， インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子（ｃｆｔｒ）遺伝子を改変するための方法および組成物
CA3186126A1 (en) 2011-09-21 2013-03-28 Sangamo Biosciences, Inc. Methods and compositions for regulation of transgene expression
US20130090265A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices
US20130090266A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for optimization of peptide screening
US20130090247A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for identification of binding pharmacophores
EP2771457B1 (en) 2011-10-27 2017-11-22 Sangamo Therapeutics, Inc. Methods and compositions for modification of the hprt locus
EP2780460B1 (en) 2011-11-16 2018-07-11 Sangamo Therapeutics, Inc. Modified dna-binding proteins and uses thereof
GB201122325D0 (en) 2011-12-23 2012-02-01 Cytoguide As Novel formulations
WO2013106515A1 (en) 2012-01-11 2013-07-18 Sigma-Aldrich Co. Llc Production of recombinant proteins with simple glycoforms
US20130195817A1 (en) 2012-01-27 2013-08-01 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
EP2820127B1 (en) 2012-02-28 2018-09-26 Sigma Aldrich Co. LLC Targeted histone acetylation
MX359327B (es) 2012-02-29 2018-09-25 Sangamo Biosciences Inc Composiciones y sus usos para tratar y prevenir la enfermedad de huntington.
GB2500243A (en) * 2012-03-15 2013-09-18 Isogenica Ltd Identifying members of immobilised peptide libraries comprising protein-DNA complexes
GB201207297D0 (en) 2012-04-26 2012-06-06 Senzagen Ab Analytical methods and arrays for use in the same
US9523098B2 (en) 2012-05-02 2016-12-20 Dow Agrosciences Llc Targeted modification of malate dehydrogenase
EP2847338B1 (en) 2012-05-07 2018-09-19 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration of transgenes
EP2872154B1 (en) 2012-07-11 2017-05-31 Sangamo BioSciences, Inc. Methods and compositions for delivery of biologics
EP3196301B1 (en) 2012-07-11 2018-10-17 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of monogenic diseases
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
CA3171494A1 (en) 2012-08-29 2014-03-06 Sangamo Biosciences, Inc. Cells genetically modified within the bcl11a gene by a nuclease and various aspects related thereto
US9937205B2 (en) 2012-09-04 2018-04-10 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
UA119135C2 (uk) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб отримання трансгенної рослини
UA118090C2 (uk) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
EP3406715B1 (en) 2012-09-07 2023-12-13 Corteva Agriscience LLC Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
DK2906684T3 (da) 2012-10-10 2020-09-28 Sangamo Therapeutics Inc T-celle-modificerende forbindelser og anvendelser deraf
AU2013355327A1 (en) 2012-12-05 2015-06-11 Sangamo Therapeutics, Inc. Methods and compositions for regulation of metabolic disorders
BR102013032200A2 (pt) 2012-12-13 2015-11-24 Dow Agrosciences Llc direcionamento preciso de um gene para um locus específico em milho
EP2963113B1 (en) 2013-02-14 2019-11-06 Osaka University Method for isolating specific genomic region using molecule binding specifically to endogenous dna sequence
EP2958996B1 (en) 2013-02-25 2019-10-16 Sangamo Therapeutics, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
AU2014235968B2 (en) 2013-03-21 2018-05-24 Ospedale San Raffaele Srl Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
GB201305940D0 (en) 2013-04-02 2013-05-15 Immunovia Ab Methods and arrays for use in the same
AU2014248208C1 (en) 2013-04-05 2023-04-27 Corteva Agriscience Llc Methods and compositions for integration of an exogenous sequence within the genome of plants
EP2994531B1 (en) 2013-05-10 2018-03-28 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
CA2910489A1 (en) 2013-05-15 2014-11-20 Sangamo Biosciences, Inc. Methods and compositions for treatment of a genetic condition
EP3039136B8 (en) 2013-08-28 2020-12-16 Sangamo Therapeutics, Inc. Compositions for linking dna-binding domains and cleavage domains
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
EP3057432B1 (en) 2013-10-17 2018-11-21 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
CA3194037A1 (en) 2013-10-17 2015-04-23 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
NZ719477A (en) 2013-11-11 2022-05-27 Sangamo Therapeutics Inc Methods and compositions for treating huntington’s disease
GB201319878D0 (en) 2013-11-11 2013-12-25 Immunovia Ab Method, Array and use thereof
PL3068881T3 (pl) 2013-11-13 2019-08-30 Children's Medical Center Corporation Regulacja ekspresji genów, w której pośredniczą nukleazy
HUE051628T2 (hu) 2013-12-09 2021-03-01 Sangamo Therapeutics Inc Eljárások és kompozíciók genom-manipulálására
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
DK3102673T3 (da) 2014-02-03 2020-07-06 Sangamo Therapeutics Inc Fremgangsmåder og sammensætninger til behandling af beta-talassæmi
AU2015218576B2 (en) 2014-02-24 2020-02-27 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration
US10377990B2 (en) 2014-03-04 2019-08-13 Sigma-Aldrich Co. Llc Viral resistant cells and uses thereof
AU2015231353B2 (en) 2014-03-18 2020-11-05 Sangamo Therapeutics, Inc. Methods and compositions for regulation of zinc finger protein expression
US9522936B2 (en) 2014-04-24 2016-12-20 Sangamo Biosciences, Inc. Engineered transcription activator like effector (TALE) proteins
EP3142707A4 (en) 2014-05-13 2018-02-21 Sangamo Therapeutics, Inc. Methods and compositions for prevention or treatment of a disease
EP3152319A4 (en) 2014-06-05 2017-12-27 Sangamo BioSciences, Inc. Methods and compositions for nuclease design
GB201410226D0 (en) 2014-06-09 2014-07-23 Immunovia Ab Methods and arrays for use in the same
NZ728159A (en) 2014-07-14 2018-08-31 Univ Washington State Nanos2 knock-out that ablates germline cells
WO2016014837A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Gene editing for hiv gene therapy
US9816074B2 (en) 2014-07-25 2017-11-14 Sangamo Therapeutics, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
US9616090B2 (en) 2014-07-30 2017-04-11 Sangamo Biosciences, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
WO2016044416A1 (en) 2014-09-16 2016-03-24 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
EP3247366A4 (en) 2015-01-21 2018-10-31 Sangamo Therapeutics, Inc. Methods and compositions for identification of highly specific nucleases
CA2981077A1 (en) 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
US10808020B2 (en) 2015-05-12 2020-10-20 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
EP3322297A4 (en) 2015-07-13 2019-04-17 Sangamo Therapeutics, Inc. RELEASE METHOD AND COMPOSITIONS FOR NUCLEASE-DERIVED GENOMINE ENGINEERING
RU2018107842A (ru) 2015-08-06 2019-09-09 Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури Устойчивые к патогенам животные, имеющие модифицированные гены cd163
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
GB201516801D0 (en) 2015-09-22 2015-11-04 Immunovia Ab Method, array and use thereof
CA2999888C (en) 2015-09-24 2024-04-09 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
CN108472365A (zh) 2015-10-30 2018-08-31 艾丽塔生物治疗剂公司 用于肿瘤转导的组合物和方法
MA43135A (fr) 2015-10-30 2018-09-05 Aleta Biotherapeutics Inc Compositions et méthodes pour le du traitement du cancer
US10639383B2 (en) 2015-11-23 2020-05-05 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
CA3008382A1 (en) 2015-12-18 2017-06-22 Sangamo Therapeutics, Inc. Targeted disruption of the mhc cell receptor
US11352631B2 (en) 2015-12-18 2022-06-07 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
US20170202931A1 (en) 2016-01-15 2017-07-20 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of neurologic disease
EP3411056A4 (en) 2016-02-02 2019-10-02 Sangamo Therapeutics, Inc. COMPOUNDS FOR NETWORKING DNA BINDING DOMAINS AND SPLITTING DOMAINS
CN108884493B (zh) 2016-03-23 2022-07-19 森扎基因有限责任公司 分析方法和其中使用的阵列
GB201700138D0 (en) 2017-01-05 2017-02-22 Senzagen Ab Analytical methods and arrays for use in the same
GB201608192D0 (en) 2016-05-10 2016-06-22 Immunovia Ab Method, array and use thereof
GB201609950D0 (en) 2016-06-07 2016-07-20 Immunovia Ab Biomarkers signatures and uses thereof
GB201609951D0 (en) 2016-06-07 2016-07-20 Immunovia Ab Biomarkers signatures and uses thereof
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
MA45455A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Procédé d'identification d'épitopes peptidiques, molécules qui se lient à de tels épitopes et utilisations associées
CN109863143B (zh) 2016-07-13 2021-10-15 威泰克斯制药公司 提高基因组编辑效率的方法、组合物和试剂盒
KR20190031306A (ko) 2016-07-21 2019-03-25 맥스시티 인코포레이티드 게놈 dna를 변경하기 위한 방법 및 조성물
KR102455249B1 (ko) 2016-08-24 2022-10-17 상가모 테라퓨틱스, 인코포레이티드 가공된 표적 특이적 뉴클레아제
KR102572759B1 (ko) 2016-08-24 2023-08-29 상가모 테라퓨틱스, 인코포레이티드 조작된 뉴클레아제를 이용하는 유전자 발현의 조절
JP6929354B2 (ja) 2016-09-24 2021-09-01 アブビトロ， エルエルシー 親和性−オリゴヌクレオチドコンジュゲートおよびその使用
CN110022904B (zh) 2016-10-20 2024-04-19 桑格摩生物治疗股份有限公司 用于治疗法布里病的方法和组合物
WO2018081775A1 (en) 2016-10-31 2018-05-03 Sangamo Therapeutics, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
CN110249051A (zh) 2016-12-08 2019-09-17 凯斯西储大学 增强功能性髓鞘产生的方法和组合物
US20190390241A1 (en) 2017-01-24 2019-12-26 Sigma-Aldrich Co. Llc Viral resistant cells and culture systems
GB201706464D0 (en) 2017-04-24 2017-06-07 Senzagen Ab Analytical methods and arrays for use in the same
AU2018261366A1 (en) 2017-05-03 2019-10-31 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CTFR) gene
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
CA3079748A1 (en) 2017-11-09 2019-05-16 Sangamo Therapeutics, Inc. Genetic modification of cytokine inducible sh2-containing protein (cish) gene
US11891426B2 (en) 2017-12-15 2024-02-06 Aleta Biotherapeutics Inc. CD19 variants
US20210060028A1 (en) 2018-01-17 2021-03-04 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
US20200361877A1 (en) 2018-01-17 2020-11-19 Vertex Pharmaceuticals Incorporated Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
MA51619A (fr) 2018-01-17 2021-04-14 Vertex Pharma Inhibiteurs de la protéine kinase dépendante de l'adn
US11401512B2 (en) 2018-02-08 2022-08-02 Sangamo Therapeutics, Inc. Engineered target specific nucleases
JP7332622B2 (ja) 2018-04-18 2023-08-23 サンガモ セラピューティクス， インコーポレイテッド ハンチンチン（ｈｔｔ）の調節のためのジンクフィンガータンパク質組成物
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
AU2019326408A1 (en) 2018-08-23 2021-03-11 Sangamo Therapeutics, Inc. Engineered target specific base editors
AU2019344927A1 (en) 2018-09-18 2021-04-01 Sangamo Therapeutics, Inc. Programmed cell death 1 (PD1) specific nucleases
CN113260715A (zh) 2019-01-03 2021-08-13 森扎基因有限责任公司 识别能够诱发呼吸道致敏的试剂的方法和用于该方法的阵列和分析试剂盒
JP7523449B2 (ja) 2019-01-11 2024-07-26 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
CN112805026A (zh) 2019-02-06 2021-05-14 桑格摩生物治疗股份有限公司 用于治疗i型黏多糖贮积症的方法
US20200316116A1 (en) 2019-04-02 2020-10-08 Sangamo Therapeutics, Inc. Method for the treatment of beta-thalassemia
WO2020252381A2 (en) 2019-06-13 2020-12-17 Allogene Therapeutics, Inc. Anti-talen antibodies and uses thereof
JP2023525510A (ja) 2020-05-06 2023-06-16 セレクティス ソシエテ アノニム 治療用タンパク質の送達のために細胞を遺伝子改変する方法
CA3177093A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof
BR112023000327A2 (pt) 2020-07-16 2023-01-31 Acuitas Therapeutics Inc Lipídeos catiônicos para o uso em nanopartículas lipídicas
WO2022046760A2 (en) 2020-08-25 2022-03-03 Kite Pharma, Inc. T cells with improved functionality
US20240000051A1 (en) 2020-11-16 2024-01-04 Pig Improvement Company Uk Limited Influenza a-resistant animals having edited anp32 genes
AU2022343268A1 (en) 2021-09-08 2024-03-28 Flagship Pioneering Innovations Vi, Llc Methods and compositions for modulating a genome
CN118401257A (zh) 2021-11-09 2024-07-26 美国安进公司 用于产生抗体肽缀合物的方法
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023168397A1 (en) 2022-03-04 2023-09-07 Sigma-Aldrich Co. Llc Metabolic selection via the asparagine biosynthesis pathway
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024073692A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the glycine-formate biosynthesis pathway
WO2024073686A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the serine biosynthesis pathway
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
WO2024156899A1 (en) 2023-01-27 2024-08-02 Biomerieux Modified immuno-molecular assay for faster biomarker detection

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8824592D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Purification process
DE69032483T2 (de) * 1989-10-05 1998-11-26 Optein, Inc., Seattle, Wash. Zellfreie synthese und isolierung von genen und polypeptiden
WO1992002536A1 (en) * 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
WO1993003172A1 (en) * 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5627024A (en) * 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US7138511B1 (en) * 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6100035A (en) * 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements

Also Published As

Publication number Publication date
AU6108698A (en) 1998-09-09
CA2282497A1 (en) 1998-08-27
DE69830497D1 (de) 2005-07-14
EP1007654A1 (en) 2000-06-14
JP4644321B2 (ja) 2011-03-02
NO322653B1 (no) 2006-11-13
IL131435A (en) 2008-06-05
AU744791B2 (en) 2002-03-07
IL131435A0 (en) 2001-01-28
NO993953L (no) 1999-10-18
ATE297462T1 (de) 2005-06-15
NO993953D0 (no) 1999-08-17
GB9703369D0 (en) 1997-04-09
ES2241117T3 (es) 2005-10-16
CA2282497C (en) 2007-04-24
EP1007654B1 (en) 2005-06-08
PT1007654E (pt) 2005-08-31
US7416847B1 (en) 2008-08-26
DE69830497T2 (de) 2006-03-16
JP2001512474A (ja) 2001-08-21
DE1007654T1 (de) 2000-10-05
WO1998037186A1 (en) 1998-08-27

Similar Documents

Publication Publication Date Title
DK1007654T3 (da) In vitro peptid- eller proteinekspressionsbibliotek
DE60335000D1 (de) In vitro peptid-expressionsbank
GB2338237A (en) In vitro peptide or protein expression library
DK0527839T3 (da) Rekombinant bibliotekscreeningsfremgangsmåder
DK0542770T3 (da) Randomiseret bio-oligomer-bibliotek, en fremgangsmåde til syntese deraf og en fremgangsmåde til anvendelse deraf
PT859841E (pt) Bibliotecas de proteinas/ (poli) peptidos
AU2001268173A1 (en) Microarrays for performing proteomic analyses
WO2002055718A3 (en) Assembly and screening of highly complex and fully human antibody repertoire in yeast
ATE311443T1 (de) Methoden zur durchforstung (screenen) von proteinen
EA200100160A1 (ru) Новые способы идентификации биомолекул лигандов и мишеней
DE69534920D1 (de) Src SH3 BINDENDE PEPTIDE UND VERFAHREN ZU IHRER ISOLIERUNG UND VERWENDUNG
WO2002036773A3 (en) Nod2 nucleic acids and proteins
WO2001036644A3 (en) Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
DE69637484D1 (de) Vektoren/DNA-Sequenzen aus humanen kombinatorischen Antikörper-Bibliotheken
WO2001081412A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding the same, and uses thereof
WO2002046406A3 (en) Human transporter proteins, nucleic acid molecules encoding them,and uses thereof
WO2002022678A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2002057310A3 (en) Human transporter proteins, nucleic acid molecules encoding them, and uses thereof
WO2002024910A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding them, and uses thereof
WO2005011576A3 (en) Digital chromatography
WO2001088136A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2002048363A3 (en) Human transporter proteins, nucleic acid molecules encoding them, and uses thereof
WO2002024749A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding them, and uses thereof
WO2002064629A3 (en) Isolated human transporter proteins, nucleic acid molecules encoding them and uses thereof