ATE488586T1 - In vitro peptid-expressionsbank - Google Patents
In vitro peptid-expressionsbankInfo
- Publication number
- ATE488586T1 ATE488586T1 AT03793896T AT03793896T ATE488586T1 AT E488586 T1 ATE488586 T1 AT E488586T1 AT 03793896 T AT03793896 T AT 03793896T AT 03793896 T AT03793896 T AT 03793896T AT E488586 T1 ATE488586 T1 AT E488586T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide expression
- vitro peptide
- library
- expression bank
- making
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000338 in vitro Methods 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220759A GB0220759D0 (en) | 2002-09-06 | 2002-09-06 | Display library |
| GB0304521A GB0304521D0 (en) | 2003-02-27 | 2003-02-27 | Display library |
| GB0304657A GB0304657D0 (en) | 2003-02-28 | 2003-02-28 | Display library |
| PCT/GB2003/003860 WO2004022746A1 (en) | 2002-09-06 | 2003-09-05 | In vitro peptide expression libraray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488586T1 true ATE488586T1 (de) | 2010-12-15 |
Family
ID=31982028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03793896T ATE488586T1 (de) | 2002-09-06 | 2003-09-05 | In vitro peptid-expressionsbank |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7842476B2 (de) |
| EP (2) | EP1534830B1 (de) |
| JP (1) | JP4664677B2 (de) |
| KR (1) | KR101051245B1 (de) |
| CN (1) | CN100351375C (de) |
| AT (1) | ATE488586T1 (de) |
| AU (1) | AU2003260786B2 (de) |
| CA (1) | CA2497496C (de) |
| DE (1) | DE60335000D1 (de) |
| DK (1) | DK1534830T3 (de) |
| IL (1) | IL166903A (de) |
| NO (1) | NO332949B1 (de) |
| PT (1) | PT1534830E (de) |
| WO (1) | WO2004022746A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418651D0 (en) * | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| GB0505420D0 (en) * | 2005-03-16 | 2005-04-20 | Isogenica Ltd | Stable ligand selection method |
| GB0515115D0 (en) | 2005-07-22 | 2005-08-31 | Isogenica Ltd | Peptide characterisation |
| GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| WO2010011944A2 (en) | 2008-07-25 | 2010-01-28 | Wagner Richard W | Protein screeing methods |
| BRPI0919881B1 (pt) | 2008-10-31 | 2021-09-08 | Centocor Ortho Biotech Inc | Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação |
| US20120004185A1 (en) | 2009-02-27 | 2012-01-05 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| GB201000352D0 (en) | 2010-01-11 | 2010-02-24 | Isogenica Ltd | Antimicrobial peptides |
| WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| AU2011248521B2 (en) | 2010-04-27 | 2017-03-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl tRNA synthetases |
| WO2011139799A2 (en) | 2010-04-27 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011139907A2 (en) | 2010-04-29 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| DK3569256T3 (da) | 2010-04-30 | 2022-08-15 | Janssen Biotech Inc | Stabiliserede fibronectin-domænesammensætninger, fremgangsmåder og anvendelser |
| US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
| CN103140233B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| WO2011140132A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| WO2011139988A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| EP2566492B1 (de) | 2010-05-04 | 2016-10-26 | aTyr Pharma, Inc. | Innovative entdeckung therapeutischer zusammensetzungen im zusammenhang mit proteinfragmenten von glutamyl-prolyl-trna-synthetasen |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
| JP6027965B2 (ja) | 2010-05-17 | 2016-11-16 | エータイアー ファーマ, インコーポレイテッド | ロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103096913B (zh) | 2010-05-27 | 2017-07-18 | Atyr 医药公司 | 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP5906237B2 (ja) | 2010-06-01 | 2016-04-20 | エータイアー ファーマ, インコーポレイテッド | リジルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| KR20130102534A (ko) | 2010-07-12 | 2013-09-17 | 에이티와이알 파마, 인코포레이티드 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| JP5991973B2 (ja) | 2010-07-12 | 2016-09-14 | エータイアー ファーマ, インコーポレイテッド | アスパルチルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| GB201013284D0 (en) | 2010-08-06 | 2010-09-22 | Isogenica Ltd | Scaffold peptides |
| US9029506B2 (en) | 2010-08-25 | 2015-05-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases |
| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| US9753040B2 (en) | 2010-12-01 | 2017-09-05 | Mitsubishi Tanabe Pharma Corporation | Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| WO2013049275A1 (en) | 2011-09-27 | 2013-04-04 | Janssen Biotech, Inc. | Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces |
| US20130090247A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for identification of binding pharmacophores |
| US20130090266A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for optimization of peptide screening |
| US20130090265A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| US9688978B2 (en) | 2011-12-29 | 2017-06-27 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetase-Fc conjugates |
| GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
| HRP20182128T1 (hr) | 2012-11-21 | 2019-02-08 | Janssen Biotech, Inc. | Bispecifična egfr/c-met protutijela |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| CN114717206A (zh) | 2013-03-15 | 2022-07-08 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| WO2015057545A2 (en) | 2013-10-14 | 2015-04-23 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type iii domain binding molecules |
| US20180245070A1 (en) | 2015-02-27 | 2018-08-30 | The University Of Hong Kong | Dna display and methods thereof |
| US10662248B2 (en) | 2015-04-06 | 2020-05-26 | Subdomain Llc | De novo binding domain containing polypeptides and uses thereof |
| AU2016258174B2 (en) | 2015-05-06 | 2022-01-20 | Janssen Biotech, Inc. | Prostate specific membrane antigen binding fibronectin type III domains |
| JP7111627B2 (ja) | 2016-06-03 | 2022-08-02 | ヤンセン バイオテツク,インコーポレーテツド | 血清アルブミン結合フィブロネクチンiii型ドメイン |
| EP3471750A4 (de) | 2016-06-21 | 2020-02-26 | Janssen Biotech, Inc. | Cysteinmanipulierte fibronectin-typ-iii-domänenbindungsmoleküle |
| BR112019004711A2 (pt) | 2016-09-14 | 2019-05-28 | Janssen Biotech Inc | receptores de antígeno quiméricos compreendendo domínios de fibronectina tipo iii específicos para bcma e usos dos mesmos |
| BR112019012154A2 (pt) | 2016-12-14 | 2019-11-12 | Janssen Biotech, Inc. | domínios do tipo iii da fibronectina de ligação a cd8a |
| EP3554535A4 (de) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | Pd-l1-bindende fibronectin-typ iii-domänen |
| EP3554561B1 (de) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137-bindende fibronectin-typ-iii-domänen |
| JP2020511519A (ja) | 2017-03-22 | 2020-04-16 | リサーチ コーポレーション テクノロジーズ インコーポレイテッド | 操作された安定なch2ポリペプチド |
| EP3612215B1 (de) | 2017-04-20 | 2024-08-28 | aTyr Pharma, Inc. | Zusammensetzungen zur behandlung von lungenentzündungen |
| CA3074317C (en) | 2017-08-25 | 2024-06-18 | Janssen Biotech, Inc. | Fc.gamma.rii binding fibronectin type iii domains, their conjugates and multispecific molecules comprising them |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| WO2021076546A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| US12351619B2 (en) | 2019-12-18 | 2025-07-08 | Aro Biotherapeutics Company | Serum albumin-binding fibronectin type III domains and uses thereof |
| AU2022258584A1 (en) | 2021-04-14 | 2023-10-12 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| WO2022221505A2 (en) | 2021-04-14 | 2022-10-20 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0185192B1 (ko) | 1989-10-05 | 1999-04-01 | 제임스 더블유. 데이비 | 신규의 유전자 및 폴리펩티드의 무세포 합성 및 분리 |
| EP0823486A3 (de) * | 1991-06-27 | 2004-02-11 | Genelabs Technologies, Inc. | Verfahren zur Hemmung der Bindung von DNA-Bindungsproteinen mit Duplex-DNA |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| US6620587B1 (en) * | 1997-05-28 | 2003-09-16 | Discerna Limited | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
| EP1496120B1 (de) | 1997-07-07 | 2007-03-28 | Medical Research Council | Ein in vitro Sortierverfahren |
| GB9718455D0 (en) * | 1997-09-02 | 1997-11-05 | Mcgregor Duncan P | Chimeric binding peptide library screening method |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| CA2367212A1 (en) | 1999-04-01 | 2000-10-12 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| JP3750020B2 (ja) | 2000-12-07 | 2006-03-01 | 学校法人慶應義塾 | C末端修飾タンパク質およびその製造方法、ならびに、c末端修飾タンパク質の製造に用いる修飾剤および翻訳テンプレート、ならびに、c末端修飾タンパク質を用いたタンパク質相互作用の検出方法 |
| JP4963142B2 (ja) | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| WO2003014734A1 (fr) | 2001-08-07 | 2003-02-20 | Keio University | Procede de detection d'une interaction entre une substance et une proteine, procede d'analyse de la proteine interagissant avec la substance et procede de formation d'un complexe contenant la substance et la proteine interagissant avec cette substance |
| US20060156511A1 (en) * | 2005-01-19 | 2006-07-20 | Li Yuan J | Caster |
-
2003
- 2003-09-05 AT AT03793896T patent/ATE488586T1/de active
- 2003-09-05 DK DK03793896.6T patent/DK1534830T3/da active
- 2003-09-05 PT PT03793896T patent/PT1534830E/pt unknown
- 2003-09-05 CA CA2497496A patent/CA2497496C/en not_active Expired - Fee Related
- 2003-09-05 EP EP03793896A patent/EP1534830B1/de not_active Expired - Lifetime
- 2003-09-05 US US10/526,479 patent/US7842476B2/en not_active Expired - Lifetime
- 2003-09-05 JP JP2004533653A patent/JP4664677B2/ja not_active Expired - Fee Related
- 2003-09-05 WO PCT/GB2003/003860 patent/WO2004022746A1/en not_active Ceased
- 2003-09-05 KR KR1020057003832A patent/KR101051245B1/ko not_active Expired - Lifetime
- 2003-09-05 EP EP10010747A patent/EP2385118A1/de not_active Withdrawn
- 2003-09-05 DE DE60335000T patent/DE60335000D1/de not_active Expired - Lifetime
- 2003-09-05 AU AU2003260786A patent/AU2003260786B2/en not_active Ceased
- 2003-09-05 CN CNB038211343A patent/CN100351375C/zh not_active Expired - Lifetime
-
2005
- 2005-02-15 IL IL166903A patent/IL166903A/en active IP Right Grant
- 2005-04-05 NO NO20051685A patent/NO332949B1/no not_active IP Right Cessation
-
2010
- 2010-10-21 US US12/909,420 patent/US8679781B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2497496A1 (en) | 2004-03-18 |
| DK1534830T3 (da) | 2011-02-14 |
| JP4664677B2 (ja) | 2011-04-06 |
| CN1681924A (zh) | 2005-10-12 |
| DE60335000D1 (de) | 2010-12-30 |
| JP2005537795A (ja) | 2005-12-15 |
| EP1534830B1 (de) | 2010-11-17 |
| CN100351375C (zh) | 2007-11-28 |
| US20060035232A1 (en) | 2006-02-16 |
| EP2385118A1 (de) | 2011-11-09 |
| KR101051245B1 (ko) | 2011-07-21 |
| KR20050057216A (ko) | 2005-06-16 |
| PT1534830E (pt) | 2011-01-31 |
| EP1534830A1 (de) | 2005-06-01 |
| AU2003260786A1 (en) | 2004-03-29 |
| CA2497496C (en) | 2012-05-15 |
| NO20051685L (no) | 2005-06-06 |
| US20120149591A1 (en) | 2012-06-14 |
| NO332949B1 (no) | 2013-02-04 |
| US8679781B2 (en) | 2014-03-25 |
| WO2004022746A1 (en) | 2004-03-18 |
| HK1072957A1 (en) | 2005-09-16 |
| US7842476B2 (en) | 2010-11-30 |
| AU2003260786B2 (en) | 2008-03-13 |
| IL166903A (en) | 2012-06-28 |
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