ATE488586T1 - In vitro peptid-expressionsbank - Google Patents
In vitro peptid-expressionsbankInfo
- Publication number
- ATE488586T1 ATE488586T1 AT03793896T AT03793896T ATE488586T1 AT E488586 T1 ATE488586 T1 AT E488586T1 AT 03793896 T AT03793896 T AT 03793896T AT 03793896 T AT03793896 T AT 03793896T AT E488586 T1 ATE488586 T1 AT E488586T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide expression
- vitro peptide
- library
- expression bank
- making
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000338 in vitro Methods 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220759A GB0220759D0 (en) | 2002-09-06 | 2002-09-06 | Display library |
| GB0304521A GB0304521D0 (en) | 2003-02-27 | 2003-02-27 | Display library |
| GB0304657A GB0304657D0 (en) | 2003-02-28 | 2003-02-28 | Display library |
| PCT/GB2003/003860 WO2004022746A1 (en) | 2002-09-06 | 2003-09-05 | In vitro peptide expression libraray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488586T1 true ATE488586T1 (de) | 2010-12-15 |
Family
ID=31982028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03793896T ATE488586T1 (de) | 2002-09-06 | 2003-09-05 | In vitro peptid-expressionsbank |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7842476B2 (de) |
| EP (2) | EP2385118A1 (de) |
| JP (1) | JP4664677B2 (de) |
| KR (1) | KR101051245B1 (de) |
| CN (1) | CN100351375C (de) |
| AT (1) | ATE488586T1 (de) |
| AU (1) | AU2003260786B2 (de) |
| CA (1) | CA2497496C (de) |
| DE (1) | DE60335000D1 (de) |
| DK (1) | DK1534830T3 (de) |
| IL (1) | IL166903A (de) |
| NO (1) | NO332949B1 (de) |
| PT (1) | PT1534830E (de) |
| WO (1) | WO2004022746A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418651D0 (en) * | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| GB0505420D0 (en) * | 2005-03-16 | 2005-04-20 | Isogenica Ltd | Stable ligand selection method |
| GB0515115D0 (en) * | 2005-07-22 | 2005-08-31 | Isogenica Ltd | Peptide characterisation |
| GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| WO2010011944A2 (en) * | 2008-07-25 | 2010-01-28 | Wagner Richard W | Protein screeing methods |
| BRPI0919881B1 (pt) | 2008-10-31 | 2021-09-08 | Centocor Ortho Biotech Inc | Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação |
| ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
| GB201000352D0 (en) | 2010-01-11 | 2010-02-24 | Isogenica Ltd | Antimicrobial peptides |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| CN103096910A (zh) | 2010-04-27 | 2013-05-08 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011150279A2 (en) | 2010-05-27 | 2011-12-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| JP5997134B2 (ja) | 2010-04-30 | 2016-09-28 | ヤンセン バイオテツク,インコーポレーテツド | 安定したフィブロネクチンドメイン組成物、方法及び用途 |
| WO2011139986A2 (en) * | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| CA2797799C (en) | 2010-05-03 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| WO2011140135A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| CA2797977C (en) | 2010-05-03 | 2019-08-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| AU2011248100B2 (en) | 2010-05-04 | 2017-01-19 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
| CA2798139C (en) | 2010-05-04 | 2019-09-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103096914B (zh) | 2010-05-17 | 2015-08-12 | Atyr医药公司 | 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2800281C (en) | 2010-06-01 | 2021-01-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CN103124561B (zh) | 2010-07-12 | 2017-05-03 | Atyr 医药公司 | 与天冬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| US20130202576A1 (en) | 2010-07-12 | 2013-08-08 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| GB201013284D0 (en) | 2010-08-06 | 2010-09-22 | Isogenica Ltd | Scaffold peptides |
| CN103108650A (zh) | 2010-08-25 | 2013-05-15 | Atyr医药公司 | 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2012048125A2 (en) | 2010-10-06 | 2012-04-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| EP2647704B1 (de) | 2010-12-01 | 2017-11-01 | Mitsubishi Tanabe Pharma Corporation | Polynukleotidkonstrukt zur präsentation von fab in einem zellulären übersetzungssystem sowie verfahren zur herstellung und zum screening von fab damit |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| BR112014007469B1 (pt) | 2011-09-27 | 2022-06-14 | Janssen Biotech, Inc | Método de fabricação de uma biblioteca de domínios de módulo de fibronectina tipo iii (fn3), biblioteca e método para obter um arcabouço de proteína |
| US20130090266A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for optimization of peptide screening |
| US20130090265A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices |
| US20130090247A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for identification of binding pharmacophores |
| WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| AU2012368189B2 (en) | 2011-12-29 | 2017-08-31 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetase-Fc conjugates |
| GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
| ES2831374T3 (es) | 2012-11-21 | 2021-06-08 | Janssen Biotech Inc | Anticuerpos de EGFR/c-Met biespecíficos |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| US9587235B2 (en) | 2013-03-15 | 2017-03-07 | Atyr Pharma, Inc. | Histidyl-tRNA synthetase-Fc conjugates |
| KR20160067966A (ko) | 2013-10-14 | 2016-06-14 | 얀센 바이오테크 인코포레이티드 | 시스테인 조작된 피브로넥틴 iii형 도메인 결합 분자 |
| CN107614703A (zh) | 2015-02-27 | 2018-01-19 | 香港大学 | Dna展示及其方法 |
| WO2016164308A1 (en) | 2015-04-06 | 2016-10-13 | Subdomain, Llc | De novo binding domain containing polypeptides and uses thereof |
| EA201792441A2 (ru) | 2015-05-06 | 2018-06-29 | Янссен Байотек, Инк. | Домены фибронектина типа iii, связывающиеся с простатспецифическим мембранным антигеном |
| WO2017210425A1 (en) * | 2016-06-03 | 2017-12-07 | Janssen Biotech, Inc. | Serum albumin-binding fibronectin type iii domains |
| AU2017281083B2 (en) | 2016-06-21 | 2022-01-27 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type III domain binding molecules |
| MA46236A (fr) | 2016-09-14 | 2019-07-24 | Janssen Biotech Inc | Récepteurs antigéniques chimériques comprenant des domaines de la fibronectine de type iii spécifiques du bcma, et utilisations correspondantes |
| BR112019012154A2 (pt) | 2016-12-14 | 2019-11-12 | Janssen Biotech, Inc. | domínios do tipo iii da fibronectina de ligação a cd8a |
| EP3554535A4 (de) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | Pd-l1-bindende fibronectin-typ iii-domänen |
| EP3554561B1 (de) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137-bindende fibronectin-typ-iii-domänen |
| CA3057619A1 (en) | 2017-03-22 | 2018-09-27 | Research Corporation Technologies, Inc. | Engineered stable ch2 polypeptides |
| CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
| CA3074317C (en) | 2017-08-25 | 2024-06-18 | Janssen Biotech, Inc. | Fc.gamma.rii binding fibronectin type iii domains, their conjugates and multispecific molecules comprising them |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| US12491255B2 (en) | 2019-10-14 | 2025-12-09 | Aro Biotherapeutics Company | EPCAM binding fibronectin type III domains |
| WO2021076546A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
| CA3161723A1 (en) | 2019-12-18 | 2021-06-24 | Karyn O'neil | Serum albumin-binding fibronectin type iii domains and uses thereof |
| IL307582A (en) | 2021-04-14 | 2023-12-01 | Aro Biotherapeutics Company | CD71-binding domains of the fibronectin type |
| US12239710B2 (en) | 2021-04-14 | 2025-03-04 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| WO2026073047A1 (en) | 2024-09-27 | 2026-04-02 | Applied Biomedical Science Institute | Methods of screening and expressing cis-display libraries of disulfide-rich polypeptides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
| EP0823486A3 (de) * | 1991-06-27 | 2004-02-11 | Genelabs Technologies, Inc. | Verfahren zur Hemmung der Bindung von DNA-Bindungsproteinen mit Duplex-DNA |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| GB9703369D0 (en) * | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| ATE250668T1 (de) * | 1997-05-28 | 2003-10-15 | Discerna Ltd | Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen |
| ES2283936T3 (es) | 1997-07-07 | 2007-11-01 | Medical Research Council | Procedimiento de clasificacion in vitro. |
| GB9718455D0 (en) * | 1997-09-02 | 1997-11-05 | Mcgregor Duncan P | Chimeric binding peptide library screening method |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| EP1163339A1 (de) | 1999-04-01 | 2001-12-19 | Innogenetics N.V. | Eine polypeptidstruktur zur verwendung als gerüst |
| JP3750020B2 (ja) | 2000-12-07 | 2006-03-01 | 学校法人慶應義塾 | C末端修飾タンパク質およびその製造方法、ならびに、c末端修飾タンパク質の製造に用いる修飾剤および翻訳テンプレート、ならびに、c末端修飾タンパク質を用いたタンパク質相互作用の検出方法 |
| JP4963142B2 (ja) | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| WO2003014734A1 (fr) | 2001-08-07 | 2003-02-20 | Keio University | Procede de detection d'une interaction entre une substance et une proteine, procede d'analyse de la proteine interagissant avec la substance et procede de formation d'un complexe contenant la substance et la proteine interagissant avec cette substance |
| US20060156511A1 (en) * | 2005-01-19 | 2006-07-20 | Li Yuan J | Caster |
-
2003
- 2003-09-05 US US10/526,479 patent/US7842476B2/en not_active Expired - Lifetime
- 2003-09-05 AU AU2003260786A patent/AU2003260786B2/en not_active Ceased
- 2003-09-05 CN CNB038211343A patent/CN100351375C/zh not_active Expired - Lifetime
- 2003-09-05 CA CA2497496A patent/CA2497496C/en not_active Expired - Fee Related
- 2003-09-05 EP EP10010747A patent/EP2385118A1/de not_active Withdrawn
- 2003-09-05 JP JP2004533653A patent/JP4664677B2/ja not_active Expired - Fee Related
- 2003-09-05 DE DE60335000T patent/DE60335000D1/de not_active Expired - Lifetime
- 2003-09-05 AT AT03793896T patent/ATE488586T1/de active
- 2003-09-05 EP EP03793896A patent/EP1534830B1/de not_active Expired - Lifetime
- 2003-09-05 PT PT03793896T patent/PT1534830E/pt unknown
- 2003-09-05 KR KR1020057003832A patent/KR101051245B1/ko not_active Expired - Lifetime
- 2003-09-05 DK DK03793896.6T patent/DK1534830T3/da active
- 2003-09-05 WO PCT/GB2003/003860 patent/WO2004022746A1/en not_active Ceased
-
2005
- 2005-02-15 IL IL166903A patent/IL166903A/en active IP Right Grant
- 2005-04-05 NO NO20051685A patent/NO332949B1/no not_active IP Right Cessation
-
2010
- 2010-10-21 US US12/909,420 patent/US8679781B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003260786B2 (en) | 2008-03-13 |
| CN100351375C (zh) | 2007-11-28 |
| CN1681924A (zh) | 2005-10-12 |
| NO20051685L (no) | 2005-06-06 |
| US8679781B2 (en) | 2014-03-25 |
| EP1534830B1 (de) | 2010-11-17 |
| US7842476B2 (en) | 2010-11-30 |
| NO332949B1 (no) | 2013-02-04 |
| EP1534830A1 (de) | 2005-06-01 |
| US20060035232A1 (en) | 2006-02-16 |
| CA2497496C (en) | 2012-05-15 |
| PT1534830E (pt) | 2011-01-31 |
| HK1072957A1 (en) | 2005-09-16 |
| WO2004022746A1 (en) | 2004-03-18 |
| KR20050057216A (ko) | 2005-06-16 |
| IL166903A (en) | 2012-06-28 |
| EP2385118A1 (de) | 2011-11-09 |
| KR101051245B1 (ko) | 2011-07-21 |
| US20120149591A1 (en) | 2012-06-14 |
| JP4664677B2 (ja) | 2011-04-06 |
| AU2003260786A1 (en) | 2004-03-29 |
| CA2497496A1 (en) | 2004-03-18 |
| DK1534830T3 (da) | 2011-02-14 |
| DE60335000D1 (de) | 2010-12-30 |
| JP2005537795A (ja) | 2005-12-15 |
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