MX358827B - Supercóntigos de proteína basados en repeticiones de fibronectina tipo iii con superficies de unión alternativas. - Google Patents
Supercóntigos de proteína basados en repeticiones de fibronectina tipo iii con superficies de unión alternativas.Info
- Publication number
- MX358827B MX358827B MX2014003744A MX2014003744A MX358827B MX 358827 B MX358827 B MX 358827B MX 2014003744 A MX2014003744 A MX 2014003744A MX 2014003744 A MX2014003744 A MX 2014003744A MX 358827 B MX358827 B MX 358827B
- Authority
- MX
- Mexico
- Prior art keywords
- protein scaffolds
- type iii
- fibronectin type
- alternative binding
- based protein
- Prior art date
Links
- 102000002090 Fibronectin type III Human genes 0.000 title abstract 3
- 108050009401 Fibronectin type III Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Abstract
La presente invención se refiere a los supercóntigos de proteína y genotecas de supercóntigos basadas en una repetición defibronectina tipo III (FN3) con un diseño de superficie de unión alternativa, ácidos nucleicos aislados que codifican los supercóntigos de proteína, vectores, células huésped, y métodos para preparar los mismos son útiles en la generación de moléculas terapéuticas y en el tratamiento y diagnóstico de enfermedades y trastornos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161539670P | 2011-09-27 | 2011-09-27 | |
PCT/US2012/057436 WO2013049275A1 (en) | 2011-09-27 | 2012-09-27 | Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014003744A MX2014003744A (es) | 2014-08-22 |
MX358827B true MX358827B (es) | 2018-09-05 |
Family
ID=47911927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014003744A MX358827B (es) | 2011-09-27 | 2012-09-27 | Supercóntigos de proteína basados en repeticiones de fibronectina tipo iii con superficies de unión alternativas. |
Country Status (13)
Country | Link |
---|---|
US (3) | US9200273B2 (es) |
EP (3) | EP4151785A1 (es) |
JP (3) | JP6440496B2 (es) |
KR (2) | KR102035713B1 (es) |
CN (2) | CN110725009B (es) |
AU (2) | AU2016269407A1 (es) |
BR (1) | BR112014007469B1 (es) |
CA (1) | CA2849774C (es) |
EA (1) | EA035150B1 (es) |
ES (1) | ES2928578T3 (es) |
IL (3) | IL277891B2 (es) |
MX (1) | MX358827B (es) |
WO (1) | WO2013049275A1 (es) |
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WO2014124017A1 (en) | 2013-02-06 | 2014-08-14 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
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KR102472862B1 (ko) | 2014-03-20 | 2022-12-05 | 브리스톨-마이어스 스큅 컴퍼니 | 혈청 알부민-결합 피브로넥틴 유형 iii 도메인 |
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2012
- 2012-09-27 EP EP22190632.4A patent/EP4151785A1/en active Pending
- 2012-09-27 WO PCT/US2012/057436 patent/WO2013049275A1/en active Application Filing
- 2012-09-27 IL IL277891A patent/IL277891B2/en unknown
- 2012-09-27 CA CA2849774A patent/CA2849774C/en active Active
- 2012-09-27 ES ES18210289T patent/ES2928578T3/es active Active
- 2012-09-27 MX MX2014003744A patent/MX358827B/es active IP Right Grant
- 2012-09-27 EP EP18210289.7A patent/EP3540100B8/en active Active
- 2012-09-27 US US13/628,393 patent/US9200273B2/en active Active
- 2012-09-27 KR KR1020147010760A patent/KR102035713B1/ko active IP Right Grant
- 2012-09-27 BR BR112014007469-0A patent/BR112014007469B1/pt active IP Right Grant
- 2012-09-27 JP JP2014533701A patent/JP6440496B2/ja active Active
- 2012-09-27 CN CN201911042902.0A patent/CN110725009B/zh active Active
- 2012-09-27 KR KR1020197030620A patent/KR102142385B1/ko active IP Right Grant
- 2012-09-27 EP EP12834641.8A patent/EP2761066B1/en active Active
- 2012-09-27 EA EA201490703A patent/EA035150B1/ru unknown
- 2012-09-27 CN CN201280046708.XA patent/CN103827361A/zh active Pending
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2014
- 2014-03-19 IL IL231585A patent/IL231585B/en active IP Right Grant
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2015
- 2015-08-10 US US14/822,335 patent/US9897612B2/en active Active
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2016
- 2016-12-05 AU AU2016269407A patent/AU2016269407A1/en not_active Abandoned
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2017
- 2017-01-26 JP JP2017011974A patent/JP6445600B2/ja active Active
- 2017-12-18 US US15/845,657 patent/US10571472B2/en active Active
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2018
- 2018-06-21 AU AU2018204514A patent/AU2018204514B2/en active Active
- 2018-11-29 JP JP2018223449A patent/JP6722263B2/ja active Active
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2019
- 2019-09-19 IL IL26947019A patent/IL269470A/en unknown
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