DK0644944T3 - Adeno-associeret virus med inverterede repeterede slutsekvenser som promotor for in vivo overførsel af et funktionelt CFTR-gen - Google Patents

Adeno-associeret virus med inverterede repeterede slutsekvenser som promotor for in vivo overførsel af et funktionelt CFTR-gen

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Publication number
DK0644944T3
DK0644944T3 DK93916425T DK93916425T DK0644944T3 DK 0644944 T3 DK0644944 T3 DK 0644944T3 DK 93916425 T DK93916425 T DK 93916425T DK 93916425 T DK93916425 T DK 93916425T DK 0644944 T3 DK0644944 T3 DK 0644944T3
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DK
Denmark
Prior art keywords
vector
promoter
gene
adeno
associated virus
Prior art date
Application number
DK93916425T
Other languages
Danish (da)
English (en)
Inventor
Barrie J Carter
Terrence Flotte
Sandra Afione
Rikki Solow
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of DK0644944T3 publication Critical patent/DK0644944T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4712—Cystic fibrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93916425T 1992-06-02 1993-06-02 Adeno-associeret virus med inverterede repeterede slutsekvenser som promotor for in vivo overførsel af et funktionelt CFTR-gen DK0644944T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/891,962 US5587308A (en) 1992-06-02 1992-06-02 Modified adeno-associated virus vector capable of expression from a novel promoter
PCT/US1993/005310 WO1993024641A2 (en) 1992-06-02 1993-06-02 Adeno-associated virus with inverted terminal repeat sequences as promoter

Publications (1)

Publication Number Publication Date
DK0644944T3 true DK0644944T3 (da) 2002-05-13

Family

ID=25399130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93916425T DK0644944T3 (da) 1992-06-02 1993-06-02 Adeno-associeret virus med inverterede repeterede slutsekvenser som promotor for in vivo overførsel af et funktionelt CFTR-gen

Country Status (11)

Country Link
US (5) US5587308A (es)
EP (2) EP0644944B1 (es)
AT (2) ATE209254T1 (es)
AU (1) AU673367B2 (es)
CA (1) CA2136441C (es)
DE (2) DE69331194T2 (es)
DK (1) DK0644944T3 (es)
ES (1) ES2168096T3 (es)
HK (1) HK1014549A1 (es)
PT (1) PT644944E (es)
WO (1) WO1993024641A2 (es)

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US5587308A (en) * 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter

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US6165781A (en) 2000-12-26
DE69331194D1 (de) 2002-01-03
US5989540A (en) 1999-11-23
WO1993024641A2 (en) 1993-12-09
HK1014549A1 (en) 1999-09-30
EP1164195A3 (en) 2005-11-23
EP1164195A2 (en) 2001-12-19
DE69334343D1 (de) 2010-11-18
EP1164195B1 (en) 2010-10-06
ATE209254T1 (de) 2001-12-15
EP0644944B1 (en) 2001-11-21
US5990279A (en) 1999-11-23
AU673367B2 (en) 1996-11-07
PT644944E (pt) 2002-05-31
ATE483817T1 (de) 2010-10-15
CA2136441C (en) 2007-04-24
CA2136441A1 (en) 1993-12-09
ES2168096T3 (es) 2002-06-01
US5866696A (en) 1999-02-02
US5587308A (en) 1996-12-24
AU4598193A (en) 1993-12-30
WO1993024641A3 (en) 1994-05-11
DE69331194T2 (de) 2002-07-25
EP0644944A1 (en) 1995-03-29

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