DE69922964T2 - Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe - Google Patents

Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe Download PDF

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Publication number
DE69922964T2
DE69922964T2 DE69922964T DE69922964T DE69922964T2 DE 69922964 T2 DE69922964 T2 DE 69922964T2 DE 69922964 T DE69922964 T DE 69922964T DE 69922964 T DE69922964 T DE 69922964T DE 69922964 T2 DE69922964 T2 DE 69922964T2
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DE
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Prior art keywords
ranolazine
use according
pharmaceutical composition
formulation
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69922964T
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German (de)
English (en)
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DE69922964D1 (de
Inventor
A. Andrew WOLFF
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Roche Palo Alto LLC
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CV Therapeutics Inc
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Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of DE69922964D1 publication Critical patent/DE69922964D1/de
Application granted granted Critical
Publication of DE69922964T2 publication Critical patent/DE69922964T2/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DE69922964T 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe Expired - Lifetime DE69922964T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9980498P 1998-09-10 1998-09-10
US99804P 1998-09-10
US09/321,522 US6303607B1 (en) 1998-09-10 1999-05-27 Method for administering a sustained release ranolanolazine formulation
US321522 1999-05-27
PCT/US1999/020968 WO2000013687A2 (en) 1998-09-10 1999-09-09 Sustained release ranolazine formulations

Publications (2)

Publication Number Publication Date
DE69922964D1 DE69922964D1 (de) 2005-02-03
DE69922964T2 true DE69922964T2 (de) 2005-12-08

Family

ID=26796494

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69901570T Expired - Lifetime DE69901570T2 (de) 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe
DE122008000065C Pending DE122008000065I1 (de) 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe
DE69922964T Expired - Lifetime DE69922964T2 (de) 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69901570T Expired - Lifetime DE69901570T2 (de) 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe
DE122008000065C Pending DE122008000065I1 (de) 1998-09-10 1999-09-09 Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe

Country Status (33)

Country Link
US (14) US6303607B1 (uk)
EP (3) EP1109558B1 (uk)
JP (2) JP3745621B2 (uk)
KR (1) KR100475759B1 (uk)
CN (2) CN1211086C (uk)
AR (3) AR022085A1 (uk)
AT (2) ATE285774T1 (uk)
AU (4) AU760435B2 (uk)
BR (2) BR9913626A (uk)
CA (2) CA2343376C (uk)
CY (1) CY2008020I2 (uk)
CZ (2) CZ301375B6 (uk)
DE (3) DE69901570T2 (uk)
DK (2) DK1109558T3 (uk)
ES (2) ES2234302T3 (uk)
FR (1) FR09C0001I2 (uk)
GE (1) GEP20053420B (uk)
HK (2) HK1040060A1 (uk)
HU (2) HU224215B1 (uk)
IL (6) IL141892A0 (uk)
LU (1) LU91504I2 (uk)
MX (2) MXPA01002599A (uk)
NL (1) NL300371I2 (uk)
NO (4) NO319434B1 (uk)
NZ (2) NZ510384A (uk)
PL (3) PL202207B1 (uk)
PT (2) PT1109558E (uk)
RU (2) RU2207856C2 (uk)
SI (2) SI1109558T1 (uk)
TR (2) TR200101262T2 (uk)
TW (1) TWI241911B (uk)
UA (2) UA67793C2 (uk)
WO (2) WO2000013687A2 (uk)

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US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
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WO2002007716A2 (en) * 2000-07-21 2002-01-31 Cv Therapeutics, Inc. Method for treating angina
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US20080109040A1 (en) * 2002-04-04 2008-05-08 Luiz Belardinelli Method of treating arrhythmias
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ATE419840T1 (de) 2002-04-09 2009-01-15 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
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GEP20053420B (en) 2005-01-25
EP1096937B9 (en) 2007-02-28
NO20011191L (no) 2001-04-30
US6617328B2 (en) 2003-09-09
HUP0103844A2 (hu) 2002-04-29
AU2008207707A1 (en) 2008-09-25
CZ2001880A3 (cs) 2001-08-15
PL196263B1 (pl) 2007-12-31
TWI241911B (en) 2005-10-21
CN1354665A (zh) 2002-06-19
NO20011192L (no) 2001-04-30
US20030099705A1 (en) 2003-05-29
NO20011191D0 (no) 2001-03-08
DK1109558T3 (da) 2002-08-26
NO2009005I1 (no) 2009-03-16
FR09C0001I1 (uk) 2009-02-27
ES2177346T3 (es) 2002-12-01
NO320986B1 (no) 2006-02-20
NL300371I2 (nl) 2009-10-01
CA2342390C (en) 2006-08-29
AU744071B2 (en) 2002-02-14
CN1211086C (zh) 2005-07-20
AR053440A2 (es) 2007-05-09
NL300371I1 (nl) 2009-02-02
US6864258B2 (en) 2005-03-08
PL202207B1 (pl) 2009-06-30
JP3745621B2 (ja) 2006-02-15
CY2008020I1 (el) 2010-07-28
IL141893A (en) 2008-08-07
JP2002524416A (ja) 2002-08-06
EP1527779A1 (en) 2005-05-04
ATE285774T1 (de) 2005-01-15
US6852724B2 (en) 2005-02-08
PL347073A1 (en) 2002-03-11
WO2000013686A2 (en) 2000-03-16
NZ510384A (en) 2002-10-25
US20040029890A1 (en) 2004-02-12
IL141892A0 (en) 2002-03-10
WO2000013687A3 (en) 2000-06-29
US20060217397A1 (en) 2006-09-28
BR9913553A (pt) 2001-10-23
RU2207856C2 (ru) 2003-07-10
SI1096937T1 (en) 2005-04-30
CZ301375B6 (cs) 2010-02-03
HUP0104088A2 (hu) 2002-05-29
EP1096937A2 (en) 2001-05-09
DK1096937T3 (da) 2005-05-09
ATE217794T1 (de) 2002-06-15
US20040097514A1 (en) 2004-05-20
US20050059667A1 (en) 2005-03-17
HU224215B1 (hu) 2005-06-28
AU6142599A (en) 2000-03-27
US6525057B2 (en) 2003-02-25
PL196668B1 (pl) 2008-01-31
PL348249A1 (en) 2002-05-20
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8381 Inventor (new situation)

Inventor name: WOLFF, A., ANDREW, SAN FRANCISCO, US

Inventor name: LANGRIDGE, JOHN RICHARD, SINT OEDENRODE, NL

Inventor name: BAKER, FIONA, DUNFERMLINE, GB

8327 Change in the person/name/address of the patent owner

Owner name: ROCHE PALO ALTO LLC, PALO ALTO, CALIF., US