DE69736185T2 - Zusammensetzung eines polynucleotid-impfstoffes für katzen - Google Patents
Zusammensetzung eines polynucleotid-impfstoffes für katzen Download PDFInfo
- Publication number
- DE69736185T2 DE69736185T2 DE69736185T DE69736185T DE69736185T2 DE 69736185 T2 DE69736185 T2 DE 69736185T2 DE 69736185 T DE69736185 T DE 69736185T DE 69736185 T DE69736185 T DE 69736185T DE 69736185 T2 DE69736185 T2 DE 69736185T2
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- Prior art keywords
- vaccine
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- virus
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9609337A FR2751223B1 (fr) | 1996-07-19 | 1996-07-19 | Formule de vaccin polynucleotidique felin |
| FR9609337 | 1996-07-19 | ||
| PCT/FR1997/001315 WO1998003660A1 (fr) | 1996-07-19 | 1997-07-15 | Formule de vaccin polynucleotidique felin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69736185D1 DE69736185D1 (de) | 2006-08-03 |
| DE69736185T2 true DE69736185T2 (de) | 2007-04-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69736185T Expired - Lifetime DE69736185T2 (de) | 1996-07-19 | 1997-07-15 | Zusammensetzung eines polynucleotid-impfstoffes für katzen |
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| EP (1) | EP0934416B1 (enExample) |
| JP (1) | JP2001500112A (enExample) |
| KR (1) | KR100687509B1 (enExample) |
| AR (1) | AR007861A1 (enExample) |
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| BR (2) | BR9710497B1 (enExample) |
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| CZ (2) | CZ304126B6 (enExample) |
| DE (1) | DE69736185T2 (enExample) |
| FR (1) | FR2751223B1 (enExample) |
| NZ (1) | NZ333781A (enExample) |
| PL (1) | PL191551B1 (enExample) |
| RU (1) | RU2312676C2 (enExample) |
| WO (1) | WO1998003660A1 (enExample) |
| ZA (1) | ZA976286B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2223029A1 (en) | 1997-02-12 | 1998-08-12 | Akzo Nobel Nv | Canine parvovirus dna vaccines |
| EP0863151A1 (en) * | 1997-02-12 | 1998-09-09 | Akzo Nobel N.V. | "Canine parvovirus dna vaccines" |
| US6770282B1 (en) * | 1998-10-23 | 2004-08-03 | Heska Corporation | Cationic lipid-mediated enhancement of nucleic acid immunization of cats |
| BR0011732B1 (pt) * | 1999-06-10 | 2014-02-04 | Vacinas de dna para animais de companhia e de esporte | |
| FR2794648B1 (fr) * | 1999-06-10 | 2003-03-07 | Merial Sas | Vaccins adn pour animaux de compagnie et de sport |
| EP1074625A3 (en) * | 1999-06-14 | 2002-01-02 | Pfizer Products Inc. | DNA vaccine against feline immunodeficiency virus |
| AU6683400A (en) * | 1999-07-08 | 2001-01-30 | Mologen Forschungs-, Entwicklungs- Und Vertriebs Gmbh | Vaccine against lentiviral infections, such as the feline immune deficiency virus of the cat |
| US6541458B1 (en) | 1999-07-16 | 2003-04-01 | Merial | Feline calicivirus genes and vaccines in particular recombinant vaccines |
| FR2796396A1 (fr) * | 1999-07-16 | 2001-01-19 | Merial Sas | Gene de calicivirus felin et vaccin recombine les incorporant |
| FR2796397B1 (fr) * | 1999-07-16 | 2006-09-01 | Merial Sas | Genes de calicivirus felin et vaccins notamment vaccins recombines |
| US7078388B2 (en) | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
| FR2829498B1 (fr) * | 2001-09-11 | 2003-11-28 | Merial Sas | Igf-1 comme adjuvant de vaccin felin, notamment contre les retrovirus felins |
| DE50304603D1 (de) * | 2002-09-23 | 2006-09-21 | Mologen Ag | Impfstoff gegen infektionen mit onkoviren, wie dem felinen leukosevirus der katze |
| EP2390352A1 (en) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
| US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
| EP1689858B1 (en) | 2003-11-13 | 2013-05-15 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
| MXPA06009452A (es) | 2004-02-19 | 2007-03-15 | Univ Alberta | Polimorfismos del promotor de leptin y sus usos. |
| SI1881845T1 (sl) | 2005-04-25 | 2010-06-30 | Merial Ltd | Cepiva proti virusu Nipah |
| US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
| EP1951751B1 (en) | 2005-11-14 | 2017-11-01 | Merial, Inc. | Gene therapy for renal failure |
| US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
| US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
| KR101445903B1 (ko) | 2007-05-02 | 2014-09-29 | 메리얼 리미티드 | 향상된 발현 및 안정성을 갖는 dna 플라스미드 |
| JP5797636B2 (ja) | 2009-04-03 | 2015-10-21 | メリアル リミテッド | ニューカッスル病ウイルスをベクターとするトリワクチン |
| JP5913316B2 (ja) | 2010-08-31 | 2016-04-27 | メリアル リミテッド | ニューカッスル病ウイルスをベクターとするヘルペスウイルスワクチン |
| WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
| EP2694677A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
| AU2012240246A1 (en) | 2011-04-04 | 2013-05-09 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
| US9216213B2 (en) | 2011-04-20 | 2015-12-22 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
| KR102007444B1 (ko) | 2011-04-25 | 2019-08-06 | 어드밴스드 바이오사이언스 라보라토리즈, 인코포레이티드 | 절단형 hiv 피막 단백질(env), 이와 관련된 방법 및 조성물 |
| ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
| US10166188B2 (en) | 2011-08-12 | 2019-01-01 | Merial, Inc. | Method for vacuum-assisted preservation of biologics including vaccines |
| WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
| WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
| HK1216006A1 (zh) | 2013-03-12 | 2016-10-07 | Boehringer Ingelheim Animal Health USA Inc. | 反向遺傳學施馬倫貝格病毒疫苗組合物,和其使用方法 |
| US10010499B2 (en) | 2014-11-03 | 2018-07-03 | Merial Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
| RU2586504C1 (ru) * | 2015-04-29 | 2016-06-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный аграрный университет имени Н.И. Вавилова" | Набор синтетических олигонуклеотидных праймеров и способ его применения для индикации вирусов иммунодефицита и лейкемии кошек в клиническом материале методом мультиплексной полимеразной цепной реакции |
| WO2016210094A1 (en) | 2015-06-23 | 2016-12-29 | Merial, Inc. | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof |
| FR3044017B1 (fr) * | 2015-11-24 | 2019-05-03 | Glaxosmithkline Intellectual Property Development Limited | Procede de transfection transitoire pour la production retrovirale |
| ES2939617T3 (es) * | 2015-11-24 | 2023-04-25 | Glaxosmithkline Ip Dev Ltd | Líneas celulares estables para producción retroviral |
| CN112921122A (zh) * | 2021-03-26 | 2021-06-08 | 广西大学 | 猫常见病毒多重pcr快速检测试剂盒及其引物组 |
| CN112921123B (zh) * | 2021-04-06 | 2022-11-04 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 快速检测猫杯状病毒的方法及检测用引物和试剂盒 |
| CN115894716B (zh) * | 2022-11-23 | 2024-02-09 | 华中农业大学 | 一种重组融合蛋白纳米颗粒及其制备方法 |
| CN116218889A (zh) * | 2022-12-13 | 2023-06-06 | 浙江大学 | 一种表达猫细小病毒VP2蛋白的mRNA疫苗及其制备方法 |
| CN116121282B (zh) * | 2023-01-10 | 2023-09-22 | 浙江大学 | 一种表达猫疱疹病毒蛋白的mRNA疫苗及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631154A (en) * | 1988-06-10 | 1997-05-20 | Therion Biologics, Incorporated | Self assembled, defective, non-self-propagating lentivirus particles |
| HUT54733A (en) * | 1989-07-12 | 1991-03-28 | Duphar Int Res | Process for producing new, antigenically active proteins and peptides, as well as feline infectious peritonitis virus (fipv) vaccines |
| ATE119545T1 (de) * | 1989-07-21 | 1995-03-15 | Upjohn Co | Felincalicivirus-capsid-protein und nukleotidsequenz. |
| US5665362A (en) * | 1990-09-25 | 1997-09-09 | Cantab Pharmaceuticals Research Limited | Viral vaccines |
| WO1993015762A1 (en) * | 1992-02-18 | 1993-08-19 | Parhelion Corporation | Feline infectious peritonitis vaccine and method of preparation |
| JPH08501452A (ja) * | 1992-09-21 | 1996-02-20 | ビアジーン,インコーポレイティド | Felv及び/又はfivに対する組換レトロウィルスベクター |
| GB2316681B (en) * | 1993-09-16 | 1998-04-15 | Dimminaco Ag Sa Ltd | Antigenically active proteins/polypeptides and coronavirus vaccines containing the same |
| US6348449B1 (en) * | 1993-09-21 | 2002-02-19 | The Trustees Of The University Of Pennsylvania | Methods of inducing mucosal immunity |
| TW377373B (en) * | 1993-09-22 | 1999-12-21 | Wyeth Corp | Recombinant raccoon pox viruses and their use as an effective vaccine against feline infectious peritonitis virus disease |
| DE69536091D1 (de) * | 1994-01-27 | 2010-09-09 | Univ Massachusetts Medical | Immunisierung durch Impfung von DNS Transkriptionseinheit |
| US5529780A (en) * | 1994-03-30 | 1996-06-25 | Virogenetics Corporation | Nucleotide and amino acid sequences of canine herpesvirus gB and gC |
| DE69535125T2 (de) * | 1994-04-29 | 2007-08-30 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Impfstoff gegen felines immunodefizienz-virus |
| FR2724385B1 (fr) * | 1994-08-29 | 1996-12-13 | Rhone Merieux | Vaccin de la peritonite infectieuse feline. |
-
1996
- 1996-07-19 FR FR9609337A patent/FR2751223B1/fr not_active Expired - Lifetime
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1997
- 1997-07-11 AR ARP970103110A patent/AR007861A1/es active IP Right Grant
- 1997-07-15 WO PCT/FR1997/001315 patent/WO1998003660A1/fr not_active Ceased
- 1997-07-15 DE DE69736185T patent/DE69736185T2/de not_active Expired - Lifetime
- 1997-07-15 EP EP97933746A patent/EP0934416B1/fr not_active Expired - Lifetime
- 1997-07-15 AU AU36992/97A patent/AU3699297A/en not_active Abandoned
- 1997-07-15 PL PL331247A patent/PL191551B1/pl unknown
- 1997-07-15 CA CA2261345A patent/CA2261345C/en not_active Expired - Lifetime
- 1997-07-15 JP JP10506629A patent/JP2001500112A/ja not_active Ceased
- 1997-07-15 BR BRPI9710497-3A patent/BR9710497B1/pt not_active IP Right Cessation
- 1997-07-15 CZ CZ20070505A patent/CZ304126B6/cs not_active IP Right Cessation
- 1997-07-15 BR BRPI9715228-5A patent/BR9715228B1/pt not_active IP Right Cessation
- 1997-07-15 NZ NZ333781A patent/NZ333781A/xx not_active IP Right Cessation
- 1997-07-15 CZ CZ0015999A patent/CZ298613B6/cs not_active IP Right Cessation
- 1997-07-15 KR KR1019980710909A patent/KR100687509B1/ko not_active Expired - Lifetime
- 1997-07-16 ZA ZA976286A patent/ZA976286B/xx unknown
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1999
- 1999-01-15 US US09/232,278 patent/US6348196B1/en not_active Expired - Lifetime
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2001
- 2001-08-30 US US09/943,443 patent/US7534559B2/en not_active Expired - Fee Related
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2002
- 2002-12-05 RU RU2002132832/13A patent/RU2312676C2/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69736185D1 (de) | 2006-08-03 |
| US6348196B1 (en) | 2002-02-19 |
| CA2261345A1 (en) | 1998-01-29 |
| PL331247A1 (en) | 1999-07-05 |
| KR20000065257A (ko) | 2000-11-06 |
| ZA976286B (en) | 1999-01-19 |
| CZ298613B6 (cs) | 2007-11-21 |
| US7534559B2 (en) | 2009-05-19 |
| RU2002132832A (ru) | 2005-01-20 |
| BR9710497B1 (pt) | 2011-04-05 |
| NZ333781A (en) | 2000-09-29 |
| CZ15999A3 (cs) | 1999-06-16 |
| BR9710497A (pt) | 1999-08-17 |
| FR2751223B1 (fr) | 1998-12-04 |
| CA2261345C (en) | 2010-09-14 |
| RU2312676C2 (ru) | 2007-12-20 |
| FR2751223A1 (fr) | 1998-01-23 |
| US20030017172A1 (en) | 2003-01-23 |
| CZ304126B6 (cs) | 2013-11-06 |
| EP0934416B1 (fr) | 2006-06-21 |
| BR9715228B1 (pt) | 2011-10-04 |
| JP2001500112A (ja) | 2001-01-09 |
| KR100687509B1 (ko) | 2007-10-12 |
| EP0934416A1 (fr) | 1999-08-11 |
| AU3699297A (en) | 1998-02-10 |
| PL191551B1 (pl) | 2006-06-30 |
| AR007861A1 (es) | 1999-11-24 |
| WO1998003660A1 (fr) | 1998-01-29 |
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