DE69735596T3 - Humanisiertes immunglobulin gegen den alpha4beta7-integrin - Google Patents
Humanisiertes immunglobulin gegen den alpha4beta7-integrin Download PDFInfo
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- DE69735596T3 DE69735596T3 DE69735596.9T DE69735596T DE69735596T3 DE 69735596 T3 DE69735596 T3 DE 69735596T3 DE 69735596 T DE69735596 T DE 69735596T DE 69735596 T3 DE69735596 T3 DE 69735596T3
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- humanized immunoglobulin
- heavy chain
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
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- Chemical & Material Sciences (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US700737 | 1996-08-15 | ||
| US08/700,737 US7147851B1 (en) | 1996-08-15 | 1996-08-15 | Humanized immunoglobulin reactive with α4β7 integrin |
| EP97937148.1A EP0918797B2 (en) | 1996-08-15 | 1997-08-06 | Humanized immunoglobulin reactive with alpha4beta7 integrin |
| PCT/US1997/013884 WO1998006248A2 (en) | 1996-08-15 | 1997-08-06 | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69735596D1 DE69735596D1 (de) | 2006-05-18 |
| DE69735596T2 DE69735596T2 (de) | 2006-12-21 |
| DE69735596T3 true DE69735596T3 (de) | 2016-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735596.9T Expired - Lifetime DE69735596T3 (de) | 1996-08-15 | 1997-08-06 | Humanisiertes immunglobulin gegen den alpha4beta7-integrin |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7147851B1 (enExample) |
| EP (2) | EP0918797B2 (enExample) |
| JP (3) | JP4171071B2 (enExample) |
| CN (1) | CN100406562C (enExample) |
| AT (1) | ATE321788T1 (enExample) |
| AU (1) | AU730326C (enExample) |
| BE (1) | BE2014C068I2 (enExample) |
| BR (1) | BRPI9711079B1 (enExample) |
| CA (1) | CA2263106C (enExample) |
| DE (1) | DE69735596T3 (enExample) |
| DK (1) | DK0918797T4 (enExample) |
| ES (1) | ES2262186T5 (enExample) |
| IL (3) | IL128052A0 (enExample) |
| LT (1) | LTC0918797I2 (enExample) |
| LU (1) | LU92596I2 (enExample) |
| NZ (1) | NZ334226A (enExample) |
| PT (1) | PT918797E (enExample) |
| SI (1) | SI0918797T2 (enExample) |
| WO (1) | WO1998006248A2 (enExample) |
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| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7090845B2 (en) * | 1998-05-13 | 2006-08-15 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| AU2011226857B2 (en) * | 1998-05-13 | 2013-09-19 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| CA2352963A1 (en) * | 1998-11-25 | 2000-06-02 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Antagonists of the alpha e beta 7 integrin as therapeutic agents for inflammatory diseases |
| DE60020955T2 (de) * | 1999-04-22 | 2006-05-11 | Biogen Idec Ma Inc., Cambridge | Verfahren zur behandlung einer fibrose unter verwendung eines antagonisten der integrin alpha-4 untereinheit |
| AU2006220426B2 (en) * | 2000-04-14 | 2008-10-30 | Genentech Inc. | Method of administering an antibody |
| US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| ATE457741T1 (de) * | 2001-12-17 | 2010-03-15 | Univ Cardiff | Enzymatische spaltbare reagenzien zum spezifischen targeting von krankheitsherden |
| CA2473144C (en) | 2002-02-05 | 2013-05-28 | Genentech, Inc. | Protein purification |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| HUE025101T2 (en) | 2002-04-26 | 2016-02-29 | Genentech Inc | Purification of proteins other than affinity purification |
| PT2371392E (pt) * | 2002-05-02 | 2015-10-07 | Wyeth Holdings Llc | Conjugados de derivado da caliqueamicina - transportador |
| GB0210121D0 (en) * | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| CA2512729C (en) * | 2003-01-09 | 2014-09-16 | Macrogenics, Inc. | Identification and engineering of antibodies with variant fc regions and methods of using same |
| UA87453C2 (ru) * | 2003-02-01 | 2009-07-27 | Вайет | Применения фрагмента ав для лечения болезни альцгеймера |
| JP4599355B2 (ja) | 2003-07-28 | 2010-12-15 | ジェネンテック， インコーポレイテッド | プロテインａアフィニティークロマトグラフィーの間のプロテインａの浸出の低減 |
| JP2007504144A (ja) | 2003-08-26 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド ア ボディー コーポレイト | セリンプロテアーゼ活性阻害因子、ならびに細菌感染の治療法および組成物におけるその使用方法 |
| EP2135619A1 (en) | 2003-12-10 | 2009-12-23 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| EP1709080B1 (en) | 2004-01-09 | 2011-03-09 | Pfizer Inc. | ANTIBODIES TO MAdCAM |
| US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| EP1784426B1 (en) | 2004-09-03 | 2011-11-23 | Genentech, Inc. | Humanized anti-beta7 antagonists and uses therefor |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
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