BRPI9711079B1 - Humanized immunoglobulin or antigen-binding fragment thereof, isolated nucleic acid, expression vector, humanized heavy chain immunoglobulin or antigen-binding fragment thereof, method for preparing a humanized light chain immunoglobulin, pharmaceutical composition and use of an immunoglobulin humanized or antigen-binding fragment thereof - Google Patents
Humanized immunoglobulin or antigen-binding fragment thereof, isolated nucleic acid, expression vector, humanized heavy chain immunoglobulin or antigen-binding fragment thereof, method for preparing a humanized light chain immunoglobulin, pharmaceutical composition and use of an immunoglobulin humanized or antigen-binding fragment thereof Download PDFInfo
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- BRPI9711079B1 BRPI9711079B1 BRPI9711079-5A BR9711079A BRPI9711079B1 BR PI9711079 B1 BRPI9711079 B1 BR PI9711079B1 BR 9711079 A BR9711079 A BR 9711079A BR PI9711079 B1 BRPI9711079 B1 BR PI9711079B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/700,737 | 1996-08-15 | ||
| US08/700,737 US7147851B1 (en) | 1996-08-15 | 1996-08-15 | Humanized immunoglobulin reactive with α4β7 integrin |
| PCT/US1997/013884 WO1998006248A2 (en) | 1996-08-15 | 1997-08-06 | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9711079A BR9711079A (pt) | 2000-06-06 |
| BRPI9711079B1 true BRPI9711079B1 (pt) | 2017-06-20 |
| BRPI9711079B8 BRPI9711079B8 (enExample) | 2021-05-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9711079-5A BRPI9711079B1 (pt) | 1996-08-15 | 1997-08-06 | Humanized immunoglobulin or antigen-binding fragment thereof, isolated nucleic acid, expression vector, humanized heavy chain immunoglobulin or antigen-binding fragment thereof, method for preparing a humanized light chain immunoglobulin, pharmaceutical composition and use of an immunoglobulin humanized or antigen-binding fragment thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7147851B1 (enExample) |
| EP (2) | EP1710314A1 (enExample) |
| JP (3) | JP4171071B2 (enExample) |
| CN (1) | CN100406562C (enExample) |
| AT (1) | ATE321788T1 (enExample) |
| AU (1) | AU730326C (enExample) |
| BE (1) | BE2014C068I2 (enExample) |
| BR (1) | BRPI9711079B1 (enExample) |
| CA (1) | CA2263106C (enExample) |
| DE (1) | DE69735596T3 (enExample) |
| DK (1) | DK0918797T4 (enExample) |
| ES (1) | ES2262186T5 (enExample) |
| IL (3) | IL128052A0 (enExample) |
| LT (1) | LTC0918797I2 (enExample) |
| LU (1) | LU92596I2 (enExample) |
| NZ (1) | NZ334226A (enExample) |
| PT (1) | PT918797E (enExample) |
| SI (1) | SI0918797T2 (enExample) |
| WO (1) | WO1998006248A2 (enExample) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| AU2011226857B2 (en) * | 1998-05-13 | 2013-09-19 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| US7090845B2 (en) * | 1998-05-13 | 2006-08-15 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| CA2352963A1 (en) * | 1998-11-25 | 2000-06-02 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Antagonists of the alpha e beta 7 integrin as therapeutic agents for inflammatory diseases |
| CA2370814C (en) * | 1999-04-22 | 2010-07-06 | Biogen, Inc. | Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit |
| US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| AU2006220426B2 (en) * | 2000-04-14 | 2008-10-30 | Genentech Inc. | Method of administering an antibody |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| CA2470643C (en) * | 2001-12-17 | 2011-10-18 | Bryan Paul Morgan | Cleavable reagents for specific delivery to disease sites |
| EP2048154B2 (en) | 2002-02-05 | 2015-06-03 | Genentech, Inc. | Protein purification |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| WO2003102132A2 (en) | 2002-04-26 | 2003-12-11 | Genetech, Inc. | Non-affinity purification of proteins |
| GB0210121D0 (en) * | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| BR122019027974B1 (pt) | 2002-05-02 | 2022-06-14 | Wyeth Holdings Corporation | Composição compreendendo conjugado monomérico de derivado de caliqueamicina/anticorpo anti-cd22 e seu uso |
| ES2897506T3 (es) * | 2003-01-09 | 2022-03-01 | Macrogenics Inc | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos |
| JP2006516639A (ja) * | 2003-02-01 | 2006-07-06 | ニユーララブ・リミテツド | 可溶性Ａ−βに対する抗体を生成させるための能動免疫 |
| CA2531595C (en) | 2003-07-28 | 2015-12-08 | Genentech, Inc. | Reducing protein a leaching during protein a affinity chromatography |
| ES2622522T3 (es) | 2003-08-26 | 2017-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas |
| EP2135619A1 (en) | 2003-12-10 | 2009-12-23 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| PL2177537T3 (pl) | 2004-01-09 | 2012-06-29 | Pfizer | Przeciwciała przeciw MadCAM |
| US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| ES2690079T3 (es) | 2004-09-03 | 2018-11-19 | Genentech, Inc. | Antagonistas anti-beta7 humanizados y utilizaciones para los mismos |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| EP1838348B1 (en) | 2004-12-15 | 2013-06-26 | Janssen Alzheimer Immunotherapy | Humanized amyloid beta antibodies for use in improving cognition |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| WO2007007151A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Use of anti-mad-cam antibody for the treatment of emphysema |
| WO2007007160A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat fever |
| WO2007061679A1 (en) * | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
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