DE69637480T2 - Bioaktive il-12 fusionsproteine - Google Patents

Bioaktive il-12 fusionsproteine Download PDF

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Publication number
DE69637480T2
DE69637480T2 DE69637480T DE69637480T DE69637480T2 DE 69637480 T2 DE69637480 T2 DE 69637480T2 DE 69637480 T DE69637480 T DE 69637480T DE 69637480 T DE69637480 T DE 69637480T DE 69637480 T2 DE69637480 T2 DE 69637480T2
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DE
Germany
Prior art keywords
subunit
linker
cells
dna
encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69637480T
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German (de)
English (en)
Other versions
DE69637480D1 (de
Inventor
Graham J. Cambridge LIESCHKE
Richard C. Lincoln MULLIGAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
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Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of DE69637480D1 publication Critical patent/DE69637480D1/de
Publication of DE69637480T2 publication Critical patent/DE69637480T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69637480T 1995-02-08 1996-02-07 Bioaktive il-12 fusionsproteine Expired - Fee Related DE69637480T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/385,335 US5891680A (en) 1995-02-08 1995-02-08 Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
PCT/US1996/001787 WO1996024676A1 (en) 1995-02-08 1996-02-07 Bioactive fusion proteins and pre-existing tumor therapy
US385335 1999-08-30

Publications (2)

Publication Number Publication Date
DE69637480D1 DE69637480D1 (de) 2008-05-15
DE69637480T2 true DE69637480T2 (de) 2009-04-09

Family

ID=23520989

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637480T Expired - Fee Related DE69637480T2 (de) 1995-02-08 1996-02-07 Bioaktive il-12 fusionsproteine

Country Status (11)

Country Link
US (1) US5891680A (es)
EP (1) EP0815245B1 (es)
JP (2) JP3919220B2 (es)
AT (1) ATE391181T1 (es)
AU (1) AU701918B2 (es)
DE (1) DE69637480T2 (es)
DK (1) DK0815245T3 (es)
ES (1) ES2302565T3 (es)
MX (1) MX9706050A (es)
PT (1) PT815245E (es)
WO (1) WO1996024676A1 (es)

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US6060284A (en) 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
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AU6094100A (en) * 1999-07-13 2001-01-30 Heska Corporation Fc epsilon receptor-luminescence inducing protein chimeric nucleic acid molecules, fusion proteins and uses thereof
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US11421010B2 (en) * 2016-10-07 2022-08-23 Board Of Regents, The University Of Texas System T cells expressing membrane-anchored IL-12 for the treatment of cancer
CN110785435B (zh) 2017-03-06 2024-01-23 艾尔特生物科技公司 与il-12和il-18的基于il-15的融合物
CN108686202A (zh) 2017-04-06 2018-10-23 张晋宇 肿瘤免疫疗法
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Also Published As

Publication number Publication date
ES2302565T3 (es) 2008-07-16
WO1996024676A1 (en) 1996-08-15
JP2006314332A (ja) 2006-11-24
EP0815245A1 (en) 1998-01-07
ATE391181T1 (de) 2008-04-15
DK0815245T3 (da) 2008-07-21
MX9706050A (es) 1997-11-29
AU701918B2 (en) 1999-02-11
EP0815245B1 (en) 2008-04-02
JP3919220B2 (ja) 2007-05-23
PT815245E (pt) 2008-07-09
DE69637480D1 (de) 2008-05-15
AU4919896A (en) 1996-08-27
JPH10513362A (ja) 1998-12-22
US5891680A (en) 1999-04-06

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