MX9706050A - Proteinas de fusion bioactivas y terapia de tumores pre-existentes. - Google Patents

Proteinas de fusion bioactivas y terapia de tumores pre-existentes.

Info

Publication number
MX9706050A
MX9706050A MX9706050A MX9706050A MX9706050A MX 9706050 A MX9706050 A MX 9706050A MX 9706050 A MX9706050 A MX 9706050A MX 9706050 A MX9706050 A MX 9706050A MX 9706050 A MX9706050 A MX 9706050A
Authority
MX
Mexico
Prior art keywords
fusion proteins
bioactive
tumor therapy
existing tumor
bioactive fusion
Prior art date
Application number
MX9706050A
Other languages
English (en)
Inventor
Graham J Lieschke
Richard C Mulligan
Original Assignee
Whitehead Biomedical Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst filed Critical Whitehead Biomedical Inst
Publication of MX9706050A publication Critical patent/MX9706050A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describen proteínas de fusion, tales como un polipéptido IL-12 bioactivo, que comprenden al menos dos monomeros polipéptidos (cadenas de aminoácidos) unidos a través de un aglutinante polipéptido heterologo y que son bioactivos, así como sus productos. De igual modo, se describen células tumorosas transducidas para expresar las proteínas de fusion, y métodos para tratar enfermedades caracterizadas por tumores establecidos.
MX9706050A 1995-02-08 1996-02-07 Proteinas de fusion bioactivas y terapia de tumores pre-existentes. MX9706050A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/385,335 US5891680A (en) 1995-02-08 1995-02-08 Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
PCT/US1996/001787 WO1996024676A1 (en) 1995-02-08 1996-02-07 Bioactive fusion proteins and pre-existing tumor therapy

Publications (1)

Publication Number Publication Date
MX9706050A true MX9706050A (es) 1997-11-29

Family

ID=23520989

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706050A MX9706050A (es) 1995-02-08 1996-02-07 Proteinas de fusion bioactivas y terapia de tumores pre-existentes.

Country Status (11)

Country Link
US (1) US5891680A (es)
EP (1) EP0815245B1 (es)
JP (2) JP3919220B2 (es)
AT (1) ATE391181T1 (es)
AU (1) AU701918B2 (es)
DE (1) DE69637480T2 (es)
DK (1) DK0815245T3 (es)
ES (1) ES2302565T3 (es)
MX (1) MX9706050A (es)
PT (1) PT815245E (es)
WO (1) WO1996024676A1 (es)

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Also Published As

Publication number Publication date
PT815245E (pt) 2008-07-09
DE69637480D1 (de) 2008-05-15
AU701918B2 (en) 1999-02-11
AU4919896A (en) 1996-08-27
JP3919220B2 (ja) 2007-05-23
JP2006314332A (ja) 2006-11-24
WO1996024676A1 (en) 1996-08-15
JPH10513362A (ja) 1998-12-22
DE69637480T2 (de) 2009-04-09
EP0815245B1 (en) 2008-04-02
ATE391181T1 (de) 2008-04-15
EP0815245A1 (en) 1998-01-07
DK0815245T3 (da) 2008-07-21
ES2302565T3 (es) 2008-07-16
US5891680A (en) 1999-04-06

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