ES2038751T3 - Procedimiento para preparar polimeros de superoxido dismutasa. - Google Patents

Procedimiento para preparar polimeros de superoxido dismutasa.

Info

Publication number
ES2038751T3
ES2038751T3 ES198888302244T ES88302244T ES2038751T3 ES 2038751 T3 ES2038751 T3 ES 2038751T3 ES 198888302244 T ES198888302244 T ES 198888302244T ES 88302244 T ES88302244 T ES 88302244T ES 2038751 T3 ES2038751 T3 ES 2038751T3
Authority
ES
Spain
Prior art keywords
polymers
dismutase
disoxide
procedure
prepare super
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302244T
Other languages
English (en)
Inventor
Robert A. Hallewell
Guy Mullenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ES2038751T3 publication Critical patent/ES2038751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

POLIMEROS DE SUPEROXIDO DE CU/ZN DISMUTASA (SOD) RECOMBINANTE, QUE TIENEN UNA VIDA MEDIA PROLONGADA IN VIVO, FORMADOS POR MONOMEROS SOD COMBINADOS COVALENTEMENTE ENTRE ELLOS, UN GRUPO CARBOXI TERMINAL A UN GRUPO AMINO TERMINAL, POR UN ESPACIADOR POLIPEPTIDICO TAL COMO UN FRAGMENTO DE LA REGION VISAGRA DE UNA INMUNOGLOBULINA.
ES198888302244T 1987-03-16 1988-03-15 Procedimiento para preparar polimeros de superoxido dismutasa. Expired - Lifetime ES2038751T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2614387A 1987-03-16 1987-03-16

Publications (1)

Publication Number Publication Date
ES2038751T3 true ES2038751T3 (es) 1993-08-01

Family

ID=21830149

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302244T Expired - Lifetime ES2038751T3 (es) 1987-03-16 1988-03-15 Procedimiento para preparar polimeros de superoxido dismutasa.

Country Status (7)

Country Link
EP (1) EP0283244B1 (es)
JP (1) JP2730904B2 (es)
AT (1) ATE72581T1 (es)
CA (1) CA1339777C (es)
DE (1) DE3868333D1 (es)
ES (1) ES2038751T3 (es)
GR (1) GR3004004T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2575846B2 (ja) * 1988-10-28 1997-01-29 マツダ株式会社 車両空調用制御装置
WO1990009434A1 (en) * 1989-02-13 1990-08-23 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of superoxide dismutase in pichia pastoris yeast cells
CA2072975A1 (en) * 1989-11-06 1991-05-07 Donald Andrew Beauvais Digitizer tablet system with dual-mode cursor/mouse
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
US6187564B1 (en) 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
US6242570B1 (en) 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
EP2440568B1 (en) * 2009-06-02 2015-02-25 Brandeis University Cross-linking of superoxide dismutase monomers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486493T2 (de) * 1983-10-03 2003-05-22 Chiron Corp Klonieren von Superoxiddismutase und Expression in Mikroorganismen
JPS61111690A (ja) * 1984-11-06 1986-05-29 Ube Ind Ltd 組換えｄｎａおよびその用途
ATE63757T1 (de) * 1985-03-28 1991-06-15 Chiron Corp Expression durch verwendung von fusionsgenen fuer proteinproduktion.

Also Published As

Publication number Publication date
GR3004004T3 (es) 1993-03-31
JP2730904B2 (ja) 1998-03-25
JPS6420084A (en) 1989-01-24
CA1339777C (en) 1998-03-24
EP0283244A1 (en) 1988-09-21
EP0283244B1 (en) 1992-02-12
DE3868333D1 (de) 1992-03-26
ATE72581T1 (de) 1992-02-15

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