MX9602977A - Proteinas que reparan la mala union de adn humano. - Google Patents

Proteinas que reparan la mala union de adn humano.

Info

Publication number
MX9602977A
MX9602977A MX9602977A MX9602977A MX9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A
Authority
MX
Mexico
Prior art keywords
human dna
proteins
repair proteins
mismatch repair
dna mismatch
Prior art date
Application number
MX9602977A
Other languages
English (en)
Inventor
William A Haseltine
Steven M Ruben
Ying-Fei Wei
Mark D Adams
Robert D Fleischmann
Claire M Fraser
Rebeca A Fuldner
Ewen F Kirkness
Craig A Rosen
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,757 external-priority patent/US6482606B1/en
Priority claimed from US08/294,312 external-priority patent/US6380369B1/en
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of MX9602977A publication Critical patent/MX9602977A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

La presente invencion describe tres proteínas de reparacion de ADN humano y el ADN (ARN) que codifica para tales proteínas, y un procedimiento para la produccion de tales proteínas mediante técnicas recombinantes. Una de las proteínas para la reparacion del ADN humano, hMLH1, ha sido trazada en mapa al cromosoma 3, mientras que hMLH2 ha sido trazada en mapa al cromosoma 2, y hMLH3 ha sido trazada en mapa al cromosoma 7. La invencion proporciona los métodos para el diagnostico de las alteraciones en los genes hMLH1, hMLH2 y hMLH3.
MX9602977A 1994-01-27 1996-07-24 Proteinas que reparan la mala union de adn humano. MX9602977A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/187,757 US6482606B1 (en) 1994-01-27 1994-01-27 Human DNA mismatch repair polynucleotides
US08/210,143 US6620619B2 (en) 1994-01-27 1994-03-16 Human DNA mismatch repair protein
US08/294,312 US6380369B1 (en) 1994-01-27 1994-08-23 Human DNA mismatch repair proteins

Publications (1)

Publication Number Publication Date
MX9602977A true MX9602977A (es) 1998-01-31

Family

ID=27392292

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9602977A MX9602977A (es) 1994-01-27 1996-07-24 Proteinas que reparan la mala union de adn humano.

Country Status (9)

Country Link
US (3) US6416984B1 (es)
EP (1) EP0749496A4 (es)
JP (3) JP3732509B2 (es)
AU (1) AU697269B2 (es)
CA (1) CA2182206A1 (es)
IL (1) IL112453A0 (es)
MX (1) MX9602977A (es)
NZ (1) NZ281023A (es)
WO (1) WO1995020678A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7229755B1 (en) 1993-11-17 2007-06-12 Dana Farber Cancer Institute, Inc. Method for detection of alterations in the DNA mismatch repair pathway
US7396678B1 (en) 1993-11-17 2008-07-08 Dana-Farber Cancer Institute Method for detection of alterations in the DNA mismatch repair pathway
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
JP3732509B2 (ja) * 1994-01-27 2006-01-05 ヒューマン・ジェノム・サイエンシズ，インコーポレイテッド ヒト・ｄｎａミスマッチ修復蛋白
US7022472B2 (en) 1998-10-22 2006-04-04 Diadexus, Inc. Mutations in human MLH1 and human MSH2 genes useful in diagnosing colorectal cancer
US20030130215A1 (en) 2000-09-21 2003-07-10 Ryan James W. Isolated genomic polynucleotide fragments from chromosome 7
US8039602B2 (en) 2000-10-31 2011-10-18 Ryogen Llc Isolated genomic polynucleotide fragments from the p15 region of chromosome 11
EP1626991A2 (en) * 2003-05-23 2006-02-22 Morphotek, Inc. Anti alpha-folate-receptor-tetramer antibodies
US7332584B2 (en) * 2003-12-08 2008-02-19 Morphotek, Inc. Antibodies that specifically bind PMS2
EP3101034A1 (en) * 2004-02-12 2016-12-07 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
CA2600505C (en) * 2005-03-10 2016-05-03 Morphotek, Inc. Anti-mesothelin antibodies
US20060239910A1 (en) * 2005-04-22 2006-10-26 Morphotek Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
WO2008103474A1 (en) 2007-02-20 2008-08-28 Anaptysbio, Inc. Methods of generating libraries and uses thereof
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
EP3080298B1 (en) 2013-12-11 2018-10-31 AccuraGen Holdings Limited Methods for detecting rare sequence variants
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
EP3359693A4 (en) 2015-10-09 2019-03-06 Accuragen Holdings Limited METHODS AND COMPOSITIONS FOR ENRICHMENT OF AMPLIFICATION PRODUCTS
CA3024630A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
WO2018035170A1 (en) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737454A (en) 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US5124443A (en) 1989-05-16 1992-06-23 University Of Kansas cDNA clones encoding chicken egg white cystatin
CA2153480A1 (en) 1993-11-12 1995-06-01 Kenichi Matsubara Gene signature
US7229755B1 (en) 1993-11-17 2007-06-12 Dana Farber Cancer Institute, Inc. Method for detection of alterations in the DNA mismatch repair pathway
EP0730648B1 (en) 1993-12-02 2004-08-11 The Johns Hopkins University HUMAN MUTATOR GENE hMSH2 AND HEREDITARY NON POLYPOSIS COLORECTAL CANCER
US6191268B1 (en) * 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
US5922855A (en) * 1993-12-17 1999-07-13 Oregon Health Sciences University Mammalian DNA mismatch repair genes MLH1 and PMS1
JP3732509B2 (ja) * 1994-01-27 2006-01-05 ヒューマン・ジェノム・サイエンシズ，インコーポレイテッド ヒト・ｄｎａミスマッチ修復蛋白
US6380369B1 (en) * 1994-01-27 2002-04-30 Human Genome Sciences, Inc. Human DNA mismatch repair proteins

Also Published As

Publication number Publication date
JP3732509B2 (ja) 2006-01-05
CA2182206A1 (en) 1995-08-03
IL112453A0 (en) 1995-03-30
JP2002325588A (ja) 2002-11-12
EP0749496A4 (en) 1999-03-03
US6610477B1 (en) 2003-08-26
JP3752457B2 (ja) 2006-03-08
US20030027177A1 (en) 2003-02-06
JPH09508280A (ja) 1997-08-26
NZ281023A (en) 1998-04-27
EP0749496A1 (en) 1996-12-27
JP2005323601A (ja) 2005-11-24
US6416984B1 (en) 2002-07-09
AU697269B2 (en) 1998-10-01
AU1733095A (en) 1995-08-15
WO1995020678A1 (en) 1995-08-03

Similar Documents

Publication Publication Date Title
MX9602977A (es) Proteinas que reparan la mala union de adn humano.
EP1439230A3 (en) Human transmembrane protein TMP-2 gene
DK0939767T3 (da) Procin faktor VIII og hybrider deraf
AU2681497A (en) Novel agouti-related gene
MX9606013A (es) Lacasas purificadas de myceliophthora y acidos nucleicos que codifican para las mismas.
EP2284189A3 (en) Nucleic acid molecules encoding fibroblast growth factor-like (FGF-like) polypeptides
DE69130506D1 (de) Nukleotidsequenzen kodierend für ein humanes protein mit angiogenetisch-regulatorischen eigenschaften
HU9601448D0 (en) Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof
DE69637856D1 (en) Interleukin-19.
AU3802595A (en) Tripeptidyl aminopeptidase
ES8609475A1 (es) Procedimiento para preparar peptidos de interferon
EP0546087A4 (es)
EP0801657A4 (en) POLYPEPTIDES AND RELATED MOLECULES AND METHODS INTERACTING WITH RETENOID X-RECEPTOR
AU3162097A (en) Retinoid metabolizing protein
DE69619808D1 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
DE69533626D1 (de) Tioredioxine h aus zwig und hart-weizen und ähnliche proteine, diese kodierende dna-fragmente und verfahren zu ihrer herstellung
GR3034725T3 (en) Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy.
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
AUPM772494A0 (en) Improvements in production of proteins in host cells
DK0977859T3 (da) Den neurotrofiske faktor NNT-1
DE69637429D1 (de) Gene, die für lymphocyte spezifischen interferon-regulationsfaktor (lsirf) polypeptide kodiert
TW342413B (en) Novel toxins isolated from Bracon Hebetor
MX9800507A (es) Ctla-8 humana y usos de proteinas relacionadas con la ctla-8.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal