DE69631422D1 - Feste dispersion von rapamycin - Google Patents

Feste dispersion von rapamycin

Info

Publication number
DE69631422D1
DE69631422D1 DE69631422T DE69631422T DE69631422D1 DE 69631422 D1 DE69631422 D1 DE 69631422D1 DE 69631422 T DE69631422 T DE 69631422T DE 69631422 T DE69631422 T DE 69631422T DE 69631422 D1 DE69631422 D1 DE 69631422D1
Authority
DE
Germany
Prior art keywords
rapamycin
fixed dispersion
dispersion
fixed
ascomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631422T
Other languages
English (en)
Other versions
DE69631422T2 (de
Inventor
Patrice Guitard
Barbara Haeberlin
Rainer Link
Friedrich Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26307397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69631422(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9514397.0A external-priority patent/GB9514397D0/en
Priority claimed from GBGB9515025.6A external-priority patent/GB9515025D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE69631422D1 publication Critical patent/DE69631422D1/de
Publication of DE69631422T2 publication Critical patent/DE69631422T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DE69631422T 1995-07-14 1996-07-12 Feste dispersion von rapamycin Expired - Lifetime DE69631422T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9514397 1995-07-14
GBGB9514397.0A GB9514397D0 (en) 1995-07-14 1995-07-14 Organic compounds
GBGB9515025.6A GB9515025D0 (en) 1995-07-21 1995-07-21 Organic compounds
GB9515025 1995-07-21
PCT/EP1996/003066 WO1997003654A2 (en) 1995-07-14 1996-07-12 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE69631422D1 true DE69631422D1 (de) 2004-03-04
DE69631422T2 DE69631422T2 (de) 2004-11-04

Family

ID=26307397

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69635499T Expired - Fee Related DE69635499T2 (de) 1995-07-14 1996-07-12 Arzneizusammensetzungen enthaltend Ascomyzinderivate
DE69631422T Expired - Lifetime DE69631422T2 (de) 1995-07-14 1996-07-12 Feste dispersion von rapamycin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69635499T Expired - Fee Related DE69635499T2 (de) 1995-07-14 1996-07-12 Arzneizusammensetzungen enthaltend Ascomyzinderivate

Country Status (31)

Country Link
US (5) US6004973A (de)
EP (2) EP0839028B1 (de)
JP (4) JPH11509223A (de)
KR (1) KR100352943B1 (de)
CN (1) CN1080120C (de)
AT (2) ATE310519T1 (de)
AU (1) AU706174B2 (de)
BE (1) BE1009856A5 (de)
BR (1) BR9609537A (de)
CA (2) CA2426956C (de)
CL (1) CL2003002715A1 (de)
CY (2) CY2603B2 (de)
CZ (1) CZ291305B6 (de)
DE (2) DE69635499T2 (de)
DK (2) DK0839028T3 (de)
ES (2) ES2215195T3 (de)
FR (1) FR2736550B1 (de)
HK (1) HK1016081A1 (de)
HU (1) HU226774B1 (de)
IL (2) IL144684A (de)
IT (1) IT1284871B1 (de)
NO (2) NO314924B1 (de)
NZ (1) NZ313633A (de)
PL (1) PL191933B1 (de)
PT (1) PT839028E (de)
RU (1) RU2159107C2 (de)
SI (2) SI1281400T1 (de)
SK (2) SK283571B6 (de)
TR (1) TR199800045T1 (de)
UY (1) UY25896A1 (de)
WO (1) WO1997003654A2 (de)

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ATE464900T1 (de) * 1998-03-26 2010-05-15 Astellas Pharma Inc Retardpräparat mit makroliden wie tacrolimus
JP3718341B2 (ja) 1998-05-12 2005-11-24 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロースとその製造方法
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GB9826882D0 (en) * 1998-12-07 1999-01-27 Novartis Ag Organic compounds
AU2003200370B2 (en) * 1998-12-07 2005-10-27 Novartis Ag Stabilization of macrolides
AU4565000A (en) 1999-05-10 2000-11-21 Novartis Ag Organic compounds
EP1054019A1 (de) * 1999-05-18 2000-11-22 Shin-Etsu Chemical Co., Ltd. Niedersubstituierte Hydroxypropylcellulose
EP1210121A2 (de) 1999-08-24 2002-06-05 Cellgate Inc. Verbesserung der verabreichung von medikamenten durch und in epitheliale gewebe durch verwendung von oligoarginine-gruppen
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6680069B1 (en) 1999-11-09 2004-01-20 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropyl cellulose and process for manufacturing the same
ATE329579T1 (de) 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
JP3552160B2 (ja) 2000-01-14 2004-08-11 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース粒子の形成方法
IL134701A0 (en) 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
CA2442969A1 (en) * 2001-05-09 2002-11-14 Novartis Ag Methods for selective immunomodulation using pimecrolimus
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
AU2006218279B2 (en) * 2001-09-28 2009-12-10 Novartis Ag Pharmaceutical compositions comprising colloidal silicon dioxide
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US7682387B2 (en) * 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
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DE69631422T2 (de) 2004-11-04
CN1080120C (zh) 2002-03-06
KR100352943B1 (ko) 2003-03-06
US6197781B1 (en) 2001-03-06
ATE310519T1 (de) 2005-12-15
HU226774B1 (en) 2009-09-28
AU6615296A (en) 1997-02-18
US20060115533A1 (en) 2006-06-01
US6956043B2 (en) 2005-10-18
IL144684A0 (en) 2002-06-30
EP1281400B1 (de) 2005-11-23
BR9609537A (pt) 1999-02-23
EP1281400A2 (de) 2003-02-05
US20030211160A1 (en) 2003-11-13
NO317702B1 (no) 2004-12-06
ITRM960501A1 (it) 1998-01-12
NO20025089L (no) 1998-01-18
JPH11509223A (ja) 1999-08-17
ITRM960501A0 (de) 1996-07-12
US6599535B2 (en) 2003-07-29
FR2736550B1 (fr) 1998-07-24
SI1281400T1 (sl) 2006-06-30
CA2225960C (en) 2004-05-11
DE69635499D1 (de) 2005-12-29
HUP9900391A2 (hu) 1999-06-28
US6004973A (en) 1999-12-21
UY25896A1 (es) 2001-10-25
IL122905A0 (en) 1998-08-16
NZ313633A (en) 1999-05-28
DK0839028T3 (da) 2004-06-01
DE69635499T2 (de) 2006-08-03
EP1281400A3 (de) 2003-11-05
PL191933B1 (pl) 2006-07-31
KR19990028942A (ko) 1999-04-15
PT839028E (pt) 2004-05-31
TR199800045T1 (xx) 1998-05-21
CL2003002715A1 (es) 2005-05-20
EP0839028B1 (de) 2004-01-28
BE1009856A5 (fr) 1997-10-07
IL122905A (en) 2003-07-06
NO980081L (no) 1998-01-08
SI0839028T1 (en) 2004-06-30
IT1284871B1 (it) 1998-05-22
FR2736550A1 (fr) 1997-01-17
NO314924B1 (no) 2003-06-16
SK4498A3 (en) 1998-05-06
HUP9900391A3 (en) 2001-08-28
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US20030008835A1 (en) 2003-01-09
NO20025089D0 (no) 2002-10-23
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JP2004002457A (ja) 2004-01-08
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ATE258429T1 (de) 2004-02-15
PL324502A1 (en) 1998-05-25
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EP0839028A2 (de) 1998-05-06
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AU706174B2 (en) 1999-06-10
NO980081D0 (no) 1998-01-08
JP5522901B2 (ja) 2014-06-18
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JP2012082217A (ja) 2012-04-26
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CA2426956A1 (en) 1997-02-06
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CY2571B1 (en) 2008-07-02
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CN1195289A (zh) 1998-10-07
ES2215195T3 (es) 2004-10-01
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SK283572B6 (sk) 2003-09-11
IL144684A (en) 2007-03-08

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