HUP9900391A2 - Rapamicineket tartalmazó gyógyszerkészítmények - Google Patents
Rapamicineket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9900391A2 HUP9900391A2 HU9900391A HUP9900391A HUP9900391A2 HU P9900391 A2 HUP9900391 A2 HU P9900391A2 HU 9900391 A HU9900391 A HU 9900391A HU P9900391 A HUP9900391 A HU P9900391A HU P9900391 A2 HUP9900391 A2 HU P9900391A2
- Authority
- HU
- Hungary
- Prior art keywords
- rapamycins
- pharmaceutical compositions
- compositions containing
- solid dispersion
- rapamycin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000007962 solid dispersion Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- 229920001187 thermosetting polymer Polymers 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát szilárd diszperzió főrmájú rapamicinekettartalmazó gyógyszerkészítmények képezik, amelyek őrális adagőlásraalkalmasak. A szilárd diszperzióban a rapamicin vagy származékai amőrfállapőtúak, és fizikai kötéssel kötődnek a hőrdőzóközeghez. ŕ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514397.0A GB9514397D0 (en) | 1995-07-14 | 1995-07-14 | Organic compounds |
GBGB9515025.6A GB9515025D0 (en) | 1995-07-21 | 1995-07-21 | Organic compounds |
PCT/EP1996/003066 WO1997003654A2 (en) | 1995-07-14 | 1996-07-12 | Pharmaceutical compositions |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9900391A2 true HUP9900391A2 (hu) | 1999-06-28 |
HUP9900391A3 HUP9900391A3 (en) | 2001-08-28 |
HU226774B1 HU226774B1 (en) | 2009-09-28 |
Family
ID=26307397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900391A HU226774B1 (en) | 1995-07-14 | 1996-07-12 | Pharmaceutical compositions in the form of a solid dispersion containing rapamycins |
Country Status (31)
Country | Link |
---|---|
US (5) | US6004973A (hu) |
EP (2) | EP0839028B1 (hu) |
JP (4) | JPH11509223A (hu) |
KR (1) | KR100352943B1 (hu) |
CN (1) | CN1080120C (hu) |
AT (2) | ATE258429T1 (hu) |
AU (1) | AU706174B2 (hu) |
BE (1) | BE1009856A5 (hu) |
BR (1) | BR9609537A (hu) |
CA (2) | CA2225960C (hu) |
CL (1) | CL2003002715A1 (hu) |
CY (2) | CY2603B2 (hu) |
CZ (1) | CZ291305B6 (hu) |
DE (2) | DE69631422T2 (hu) |
DK (2) | DK0839028T3 (hu) |
ES (2) | ES2215195T3 (hu) |
FR (1) | FR2736550B1 (hu) |
HK (1) | HK1016081A1 (hu) |
HU (1) | HU226774B1 (hu) |
IL (2) | IL122905A (hu) |
IT (1) | IT1284871B1 (hu) |
NO (2) | NO314924B1 (hu) |
NZ (1) | NZ313633A (hu) |
PL (1) | PL191933B1 (hu) |
PT (1) | PT839028E (hu) |
RU (1) | RU2159107C2 (hu) |
SI (2) | SI1281400T1 (hu) |
SK (2) | SK283572B6 (hu) |
TR (1) | TR199800045T1 (hu) |
UY (1) | UY25896A1 (hu) |
WO (1) | WO1997003654A2 (hu) |
Families Citing this family (152)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
BE1009856A5 (fr) | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
CA2230748C (en) * | 1997-03-14 | 2010-08-03 | American Home Products Corporation | Rapamycin formulations for oral administration |
BRPI9909201B8 (pt) * | 1998-03-26 | 2021-05-25 | Astellas Pharma Inc | formulação de composto de macrolídeo de liberação controlada |
JP3718341B2 (ja) | 1998-05-12 | 2005-11-24 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロースとその製造方法 |
US20060240070A1 (en) * | 1998-09-24 | 2006-10-26 | Cromack Keith R | Delivery of highly lipophilic agents via medical devices |
AU2003200370B2 (en) * | 1998-12-07 | 2005-10-27 | Novartis Ag | Stabilization of macrolides |
GB9826882D0 (en) | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
ATE474590T1 (de) | 1999-05-10 | 2010-08-15 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
EP1054019A1 (en) * | 1999-05-18 | 2000-11-22 | Shin-Etsu Chemical Co., Ltd. | Low-substituted hydroxypropyl cellulose |
US6593292B1 (en) | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6680069B1 (en) | 1999-11-09 | 2004-01-20 | Shin-Etsu Chemical Co., Ltd. | Low-substituted hydroxypropyl cellulose and process for manufacturing the same |
WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
JP3552160B2 (ja) | 2000-01-14 | 2004-08-11 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース粒子の形成方法 |
IL134701A0 (en) | 2000-02-23 | 2001-04-30 | J P M E D Ltd | Homogeneous solid matrix containing vegetable proteins |
DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
JP2005512946A (ja) * | 2001-05-09 | 2005-05-12 | ノバルティス アクチエンゲゼルシャフト | 選択的免疫調節法 |
US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
GB0123400D0 (en) * | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
AU2006218279B2 (en) * | 2001-09-28 | 2009-12-10 | Novartis Ag | Pharmaceutical compositions comprising colloidal silicon dioxide |
US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
WO2003063831A2 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Immediate release dosage forms containing solid drug dispersions |
ATE395044T1 (de) * | 2002-02-01 | 2008-05-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
JP3956114B2 (ja) * | 2002-06-28 | 2007-08-08 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 表示制御方法、これを用いたプログラム、情報処理装置及び光学式文字読み取り装置 |
KR20050086648A (ko) * | 2002-11-15 | 2005-08-30 | 노파르티스 아게 | 약물 전달 시스템 |
AR043504A1 (es) * | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
US7160867B2 (en) | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
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-
1996
- 1996-07-11 BE BE9600631A patent/BE1009856A5/fr active
- 1996-07-11 FR FR9608705A patent/FR2736550B1/fr not_active Expired - Lifetime
- 1996-07-12 IT IT96RM000501A patent/IT1284871B1/it active IP Right Grant
- 1996-07-12 EP EP96925741A patent/EP0839028B1/en not_active Expired - Lifetime
- 1996-07-12 DK DK96925741T patent/DK0839028T3/da active
- 1996-07-12 CA CA002225960A patent/CA2225960C/en not_active Expired - Lifetime
- 1996-07-12 BR BR9609537A patent/BR9609537A/pt not_active Application Discontinuation
- 1996-07-12 ES ES96925741T patent/ES2215195T3/es not_active Expired - Lifetime
- 1996-07-12 CZ CZ199891A patent/CZ291305B6/cs not_active IP Right Cessation
- 1996-07-12 CN CN96196788A patent/CN1080120C/zh not_active Expired - Lifetime
- 1996-07-12 SK SK186-2002A patent/SK283572B6/sk not_active IP Right Cessation
- 1996-07-12 DE DE69631422T patent/DE69631422T2/de not_active Expired - Lifetime
- 1996-07-12 NZ NZ313633A patent/NZ313633A/xx not_active IP Right Cessation
- 1996-07-12 HU HU9900391A patent/HU226774B1/hu unknown
- 1996-07-12 SK SK44-98A patent/SK283571B6/sk not_active IP Right Cessation
- 1996-07-12 DK DK02023033T patent/DK1281400T3/da active
- 1996-07-12 US US08/981,952 patent/US6004973A/en not_active Expired - Lifetime
- 1996-07-12 PL PL324502A patent/PL191933B1/pl unknown
- 1996-07-12 EP EP02023033A patent/EP1281400B1/en not_active Expired - Lifetime
- 1996-07-12 TR TR1998/00045T patent/TR199800045T1/xx unknown
- 1996-07-12 RU RU98102855/14A patent/RU2159107C2/ru active Protection Beyond IP Right Term
- 1996-07-12 DE DE69635499T patent/DE69635499T2/de not_active Expired - Fee Related
- 1996-07-12 IL IL12290596A patent/IL122905A/xx active Protection Beyond IP Right Term
- 1996-07-12 SI SI9630730T patent/SI1281400T1/sl unknown
- 1996-07-12 IL IL144684A patent/IL144684A/en not_active IP Right Cessation
- 1996-07-12 KR KR10-1998-0700244A patent/KR100352943B1/ko not_active IP Right Cessation
- 1996-07-12 AT AT96925741T patent/ATE258429T1/de active
- 1996-07-12 WO PCT/EP1996/003066 patent/WO1997003654A2/en active IP Right Grant
- 1996-07-12 ES ES02023033T patent/ES2250566T3/es not_active Expired - Lifetime
- 1996-07-12 JP JP9506264A patent/JPH11509223A/ja not_active Withdrawn
- 1996-07-12 AU AU66152/96A patent/AU706174B2/en not_active Expired
- 1996-07-12 AT AT02023033T patent/ATE310519T1/de not_active IP Right Cessation
- 1996-07-12 SI SI9630671T patent/SI0839028T1/xx unknown
- 1996-07-12 CA CA002426956A patent/CA2426956C/en not_active Expired - Fee Related
- 1996-07-12 PT PT96925741T patent/PT839028E/pt unknown
-
1998
- 1998-01-08 NO NO19980081A patent/NO314924B1/no not_active IP Right Cessation
-
1999
- 1999-03-29 HK HK99101280A patent/HK1016081A1/xx not_active IP Right Cessation
- 1999-08-13 US US09/374,899 patent/US6197781B1/en not_active Expired - Lifetime
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2000
- 2000-01-13 UY UY25896A patent/UY25896A1/es not_active Application Discontinuation
-
2002
- 2002-07-12 US US10/194,826 patent/US6599535B2/en not_active Expired - Fee Related
- 2002-10-23 NO NO20025089A patent/NO317702B1/no not_active IP Right Cessation
-
2003
- 2003-06-04 US US10/454,017 patent/US6956043B2/en not_active Expired - Fee Related
- 2003-07-11 JP JP2003273402A patent/JP2004002457A/ja not_active Withdrawn
- 2003-12-22 CL CL200302715A patent/CL2003002715A1/es unknown
-
2005
- 2005-07-26 CY CY0500043A patent/CY2603B2/xx unknown
- 2005-10-21 US US11/255,359 patent/US20060115533A1/en not_active Abandoned
-
2007
- 2007-02-09 CY CY0700003A patent/CY2571B1/xx unknown
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2008
- 2008-02-29 JP JP2008049742A patent/JP5522901B2/ja not_active Expired - Lifetime
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2011
- 2011-12-22 JP JP2011281577A patent/JP2012082217A/ja active Pending
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