DE69519093D1 - Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind - Google Patents

Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind

Info

Publication number
DE69519093D1
DE69519093D1 DE69519093T DE69519093T DE69519093D1 DE 69519093 D1 DE69519093 D1 DE 69519093D1 DE 69519093 T DE69519093 T DE 69519093T DE 69519093 T DE69519093 T DE 69519093T DE 69519093 D1 DE69519093 D1 DE 69519093D1
Authority
DE
Germany
Prior art keywords
clavulanates
preparation
water
polymer film
based polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69519093T
Other languages
English (en)
Other versions
DE69519093T2 (de
Inventor
Creighton Pierce Conley
Nigel Philip Davidson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10754044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69519093(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE69519093D1 publication Critical patent/DE69519093D1/de
Publication of DE69519093T2 publication Critical patent/DE69519093T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE69519093T 1994-04-23 1995-04-19 Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind Expired - Fee Related DE69519093T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408117A GB9408117D0 (en) 1994-04-23 1994-04-23 Pharmaceutical formulations

Publications (2)

Publication Number Publication Date
DE69519093D1 true DE69519093D1 (de) 2000-11-16
DE69519093T2 DE69519093T2 (de) 2001-07-19

Family

ID=10754044

Family Applications (5)

Application Number Title Priority Date Filing Date
DE69519093T Expired - Fee Related DE69519093T2 (de) 1994-04-23 1995-04-19 Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind
DE29522153U Expired - Lifetime DE29522153U1 (de) 1994-04-23 1995-04-19 Polymerbeschichtete Tablette umfassend Amoxycillin und Clavulanat
DE69521799T Expired - Lifetime DE69521799T2 (de) 1994-04-23 1995-04-19 Polymer umhüllte tablette enthaltend amoxicillin und clavulanat
DE69528608T Revoked DE69528608T2 (de) 1994-04-23 1995-04-19 Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind
DE69528204T Expired - Lifetime DE69528204T2 (de) 1994-04-23 1995-04-19 Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerüberzug versehen sind

Family Applications After (4)

Application Number Title Priority Date Filing Date
DE29522153U Expired - Lifetime DE29522153U1 (de) 1994-04-23 1995-04-19 Polymerbeschichtete Tablette umfassend Amoxycillin und Clavulanat
DE69521799T Expired - Lifetime DE69521799T2 (de) 1994-04-23 1995-04-19 Polymer umhüllte tablette enthaltend amoxicillin und clavulanat
DE69528608T Revoked DE69528608T2 (de) 1994-04-23 1995-04-19 Verfahren zur Herstellung von Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerfilm auf Wasserbasis versehen sind
DE69528204T Expired - Lifetime DE69528204T2 (de) 1994-04-23 1995-04-19 Tabletten enthaltend Amoxicillin und Clavulanate, die mit einem Polymerüberzug versehen sind

Country Status (35)

Country Link
US (1) US6051255A (de)
EP (5) EP0761218B1 (de)
JP (1) JP3622975B2 (de)
CN (1) CN1134258C (de)
AP (2) AP564A (de)
AT (6) ATE223706T1 (de)
AU (1) AU684949B2 (de)
BG (1) BG62842B1 (de)
BR (1) BR9507502A (de)
CA (1) CA2188496A1 (de)
CZ (2) CZ11376U1 (de)
DE (5) DE69519093T2 (de)
DK (4) DK1093813T3 (de)
DZ (1) DZ1876A1 (de)
ES (4) ES2152485T3 (de)
FI (1) FI964249A0 (de)
GB (1) GB9408117D0 (de)
GR (2) GR3035031T3 (de)
HK (5) HK1050992A1 (de)
HU (1) HU228399B1 (de)
IL (1) IL113433A (de)
MA (1) MA23528A1 (de)
MY (1) MY115351A (de)
NO (1) NO310703B1 (de)
NZ (1) NZ285080A (de)
OA (1) OA10377A (de)
PL (1) PL316966A1 (de)
PT (4) PT978276E (de)
RO (1) RO116997B1 (de)
RU (1) RU2152213C1 (de)
SA (1) SA95160343B1 (de)
SI (1) SI0758235T1 (de)
SK (1) SK282594B6 (de)
WO (1) WO1995028927A1 (de)
ZA (1) ZA953236B (de)

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US20030109503A1 (en) * 1995-06-06 2003-06-12 Smithkline Beecham P.L.C. Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
ATE208618T1 (de) * 1995-09-07 2001-11-15 Smithkline Beecham Corp Verwendung einer amoxicillin und clavulanat enthaltenden paediatrischen pharmazeutischen formulierung
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TWI225402B (en) 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
GB9613470D0 (en) 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
GB9616536D0 (en) 1996-08-06 1996-09-25 Quadrant Holdings Cambridge Co-amoxiclav dosage form
GB9617780D0 (en) * 1996-08-24 1996-10-02 Smithkline Beecham Plc Method of treatment
WO1998034598A2 (en) * 1997-02-07 1998-08-13 Gist-Brocades B.V. Homogeneous granulated formulations for dose sipping technology
US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
ATE243516T1 (de) * 1997-02-14 2003-07-15 Glaxosmithkline Lab Sas Amoxicillin und clavulanat enthaltende arzneizubereitungen
EP1023065A1 (de) * 1997-08-29 2000-08-02 Dsm N.V. Zusatzfreie granulate
WO1999022769A1 (en) 1997-10-31 1999-05-14 Monsanto Company Gellan gum tablet coating
AU3817300A (en) 1999-04-01 2000-08-01 Dsm N.V. Agglomerates by crystallisation
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US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US20040038948A1 (en) * 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
GB9930578D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Pharmaceutical formulations
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US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
EP1330236A2 (de) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Amoxicillinhaltige arzneizusammensetzungen
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
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US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
WO2003066053A1 (en) * 2002-02-07 2003-08-14 Rutgers, The State University Antibiotic polymers
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US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
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CL2008003230A1 (es) * 2007-11-01 2009-11-27 Sanofi Aventis Healthcare Pty Ltd Composicion de recubrimiento de tableta que comprende polimero celulosico, plastificante, edulcorante y composicion de sabor en polvo la que comprende saborizante asociado con portador solido; fluido de recubrimiento de tableta que comprende dicha composicion; tableta farmaceutica; proceso de preparacion de dicha tableta.
EP2477611B1 (de) * 2009-09-18 2017-04-05 Sanofi (z)-2-cyano-3-hydroxy-but-2-enolsäure-(4'- trifluormethylphenyl)-amidtablettenformulierungen mit verbesserter stabilität
TR200909787A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Üçüncü kuşak bir sefalosporin ve klavulanik asit içeren farmasötik formülasyonlar.
TR201000687A1 (tr) 2010-01-29 2011-08-22 Bi̇lgi̇ç Mahmut Aktif madde olarak sefiksim ve klavulanik asit içeren efervesan formülasyonlar
TR201000686A1 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@
TR201000688A2 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar.
JP6041591B2 (ja) * 2011-09-13 2016-12-14 大日本住友製薬株式会社 イルベサルタンとアムロジピンまたはその塩を含有する安定化された医薬組成物
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair

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DE3266580D1 (en) * 1981-12-02 1985-10-31 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
CN100382782C (zh) * 1999-04-13 2008-04-23 比彻姆药品(Pte)有限公司 一种释放改良型药用制剂
EP1330236A2 (de) * 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Amoxicillinhaltige arzneizusammensetzungen

Also Published As

Publication number Publication date
DK0761218T3 (da) 2000-12-18
EP0761218A1 (de) 1997-03-12
PT1093813E (pt) 2003-02-28
CA2188496A1 (en) 1995-11-02
DE69528608T2 (de) 2003-06-26
HK1027024A1 (en) 2001-01-05
DK1093813T3 (da) 2003-02-17
HUT76335A (en) 1997-08-28
ATE223706T1 (de) 2002-09-15
SK282594B6 (sk) 2002-10-08
US6051255A (en) 2000-04-18
MY115351A (en) 2003-05-31
CZ11376U1 (cs) 2001-07-12
GR3036844T3 (en) 2002-01-31
FI964249A (fi) 1996-10-22
NO964488D0 (no) 1996-10-22
PT978276E (pt) 2003-01-31
GB9408117D0 (en) 1994-06-15
EP1093813A2 (de) 2001-04-25
HK1009936A1 (en) 1999-06-11
CZ309096A3 (en) 1997-04-16
PT761218E (pt) 2001-03-30
EP1093813B1 (de) 2002-10-16
NZ285080A (en) 1998-05-27
NO964488L (no) 1996-12-17
HU228399B1 (en) 2013-03-28
IL113433A (en) 2003-06-24
AP564A (en) 1996-11-21
DK0978276T3 (da) 2003-01-20
CN1134258C (zh) 2004-01-14
HK1050992A1 (zh) 2003-07-18
ES2161288T3 (es) 2001-12-01
DE69519093T2 (de) 2001-07-19
SI0758235T1 (en) 2001-10-31
ZA953236B (en) 1995-12-27
DK0758235T3 (da) 2001-10-29
EP0761218B1 (de) 2000-10-11
PL316966A1 (en) 1997-03-03
EP0978276A2 (de) 2000-02-09
GR3035031T3 (en) 2001-03-30
HK1036404A1 (en) 2002-01-04
PT758235E (pt) 2001-10-31
DE69528204D1 (de) 2002-10-17
EP1093813A3 (de) 2001-05-30
DE69528204T2 (de) 2003-08-07
RO116997B1 (ro) 2001-09-28
DE69528608D1 (de) 2002-11-21
HU9602922D0 (en) 1996-12-30
HK1021860A1 (en) 2000-07-07
AP9600868A0 (en) 1996-10-31
MA23528A1 (fr) 1995-12-31
AT5349U1 (de) 2002-06-25
AU684949B2 (en) 1998-01-08
SA95160343B1 (ar) 2005-05-04
OA10377A (en) 2001-11-21
DE29522153U1 (de) 2000-04-06
EP1243267A3 (de) 2002-10-30
EP0978276B1 (de) 2002-09-11
FI964249A0 (fi) 1996-10-22
JP3622975B2 (ja) 2005-02-23
ATE226074T1 (de) 2002-11-15
ES2180251T3 (es) 2003-02-01
EP0758235A1 (de) 1997-02-19
EP0978276A3 (de) 2000-04-12
AU2406895A (en) 1995-11-16
BG100933A (en) 1997-07-31
SK135496A3 (en) 1997-05-07
BR9507502A (pt) 1997-09-02
IL113433A0 (en) 1995-07-31
EP1243267A2 (de) 2002-09-25
AT5350U1 (de) 2002-06-25
ES2152485T3 (es) 2001-02-01
AP9500733A0 (en) 1995-04-30
ATE203161T1 (de) 2001-08-15
CZ294168B6 (cs) 2004-10-13
ATE196845T1 (de) 2000-10-15
ES2182754T3 (es) 2003-03-16
NO310703B1 (no) 2001-08-20
DZ1876A1 (fr) 2002-02-17
JPH09512027A (ja) 1997-12-02
EP0758235B1 (de) 2001-07-18
BG62842B1 (bg) 2000-09-29
RU2152213C1 (ru) 2000-07-10
DE69521799D1 (de) 2001-08-23
WO1995028927A1 (en) 1995-11-02
CN1149829A (zh) 1997-05-14
DE69521799T2 (de) 2002-06-13

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