DE69331265T2 - Verbindungen zur behandlung von entzündlichen erkrankungen und zur hemmung der produktion von tumornekrosefaktor - Google Patents
Verbindungen zur behandlung von entzündlichen erkrankungen und zur hemmung der produktion von tumornekrosefaktorInfo
- Publication number
- DE69331265T2 DE69331265T2 DE69331265T DE69331265T DE69331265T2 DE 69331265 T2 DE69331265 T2 DE 69331265T2 DE 69331265 T DE69331265 T DE 69331265T DE 69331265 T DE69331265 T DE 69331265T DE 69331265 T2 DE69331265 T2 DE 69331265T2
- Authority
- DE
- Germany
- Prior art keywords
- cyano
- methoxyphenyl
- cis
- trans
- cyclopentyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86211192A | 1992-04-02 | 1992-04-02 | |
| US96876192A | 1992-10-30 | 1992-10-30 | |
| PCT/US1993/002516 WO1993019751A1 (en) | 1992-04-02 | 1993-03-05 | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69331265D1 DE69331265D1 (de) | 2002-01-17 |
| DE69331265T2 true DE69331265T2 (de) | 2002-08-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69331265T Expired - Lifetime DE69331265T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen zur behandlung von entzündlichen erkrankungen und zur hemmung der produktion von tumornekrosefaktor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5605923A (enExample) |
| EP (1) | EP0636026B1 (enExample) |
| JP (1) | JP3251587B2 (enExample) |
| CN (1) | CN1094031A (enExample) |
| AU (1) | AU3924993A (enExample) |
| DE (1) | DE69331265T2 (enExample) |
| IL (1) | IL105220A0 (enExample) |
| MA (1) | MA22922A1 (enExample) |
| MX (1) | MX9301942A (enExample) |
| WO (1) | WO1993019751A1 (enExample) |
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| RO115872B1 (ro) * | 1992-04-02 | 2000-07-28 | Smithkline Beecham Corp | Derivati substituiti ai acidului fenilcarboxilic si compozitie farmaceutica ce ii contine |
| DK0710109T3 (da) * | 1993-06-18 | 2005-01-03 | Smithkline Beecham Corp | Fremgangsmåde til identifikation af en PDE IV inhibitor |
| JPH09503503A (ja) * | 1993-10-01 | 1997-04-08 | スミスクライン・ビーチャム・コーポレイション | 化合物、組成物ならびにアレルギーおよび炎症の治療 |
| GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
| US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
| US5998428A (en) * | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| ATE306260T1 (de) * | 1994-12-23 | 2005-10-15 | Smithkline Beecham Corp | Monomere der 4,4-(disubstituierten)cyclohexan-1- ole und verwandte verbindungen |
| US5777160A (en) * | 1994-12-23 | 1998-07-07 | Smithkline Beecham Corporation | 1, 4, 4-(trisubstituted) cyclohex-1-ene dimers and related compounds |
| EP0799182A4 (en) * | 1994-12-23 | 1998-03-25 | Smithkline Beecham Corp | DIMERES 3.3- (DISUBSTITUTED) CYCLOHEXAN-1-OL AND RELATED COMPOUNDS |
| ZA9510826B (en) * | 1994-12-23 | 1996-06-20 | Smithkline Beecham Corp | 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds |
| WO1996020161A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ol dimers and related compounds |
| WO1996020174A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 1,3,3-(trisubstituted)cyclohexane monomers and related compounds |
| PT828728E (pt) * | 1995-05-18 | 2003-06-30 | Altana Pharma Ag | Di-hidrobenzofuranos de fenilo |
| ES2189871T3 (es) * | 1995-05-18 | 2003-07-16 | Altana Pharma Ag | Ciclohexil-dihidro-benzofuranos. |
| AR004471A1 (es) * | 1995-05-31 | 1998-12-16 | Smithkline Beecham Corp | Compuestos de ciclohexan-1-ol-4,4-disustituidos, utiles en el tratamiento de enfermedades alergicas e inflamatorias y composiciones farmaceuticas que lascontienen |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US5891883A (en) * | 1995-12-21 | 1999-04-06 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds |
| US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| DZ3019A1 (fr) * | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| ECSP003599A (es) * | 1999-08-06 | 2002-03-25 | Smithkline Beecham Corp | Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres |
| US20040220424A1 (en) * | 1999-08-06 | 2004-11-04 | Smithkline Beecham Corporation | Process for preparing acids via alpha-chloroepoxy esters |
| CZ302882B6 (cs) | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| US6572794B1 (en) | 2000-07-24 | 2003-06-03 | Essilor International Compagnie Generale D'optique | Method of manufacturing a photochromic molded article |
| FR2816950B1 (fr) | 2000-11-17 | 2003-02-14 | Essilor Int | Procede d'obtention d'un latex photochromique |
| FR2819258B1 (fr) | 2001-01-11 | 2003-04-11 | Essilor Int | Procede d'obtention d'un latex photochromique stabilise, latex obtenu et application a l'optique ophtalmique |
| CA2868614A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| CN101745112A (zh) | 2002-07-19 | 2010-06-23 | 艾博特生物技术有限公司 | TNFα相关疾病的治疗 |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
| US20050085430A1 (en) * | 2003-07-31 | 2005-04-21 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20090274676A1 (en) * | 2003-07-31 | 2009-11-05 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
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-
1993
- 1993-03-05 EP EP93908421A patent/EP0636026B1/en not_active Expired - Lifetime
- 1993-03-05 MX MX9301942A patent/MX9301942A/es unknown
- 1993-03-05 US US08/313,093 patent/US5605923A/en not_active Expired - Lifetime
- 1993-03-05 DE DE69331265T patent/DE69331265T2/de not_active Expired - Lifetime
- 1993-03-05 WO PCT/US1993/002516 patent/WO1993019751A1/en not_active Ceased
- 1993-03-05 JP JP51749193A patent/JP3251587B2/ja not_active Expired - Lifetime
- 1993-03-05 AU AU39249/93A patent/AU3924993A/en not_active Abandoned
- 1993-03-30 IL IL10522093A patent/IL105220A0/xx unknown
- 1993-04-01 MA MA23148A patent/MA22922A1/fr unknown
- 1993-04-02 CN CN93105214A patent/CN1094031A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3924993A (en) | 1993-11-08 |
| WO1993019751A1 (en) | 1993-10-14 |
| EP0636026B1 (en) | 2001-12-05 |
| JPH07508263A (ja) | 1995-09-14 |
| MA22922A1 (fr) | 1994-04-01 |
| CN1094031A (zh) | 1994-10-26 |
| EP0636026A1 (en) | 1995-02-01 |
| EP0636026A4 (enExample) | 1995-02-22 |
| DE69331265D1 (de) | 2002-01-17 |
| MX9301942A (es) | 1994-08-31 |
| US5605923A (en) | 1997-02-25 |
| JP3251587B2 (ja) | 2002-01-28 |
| IL105220A0 (en) | 1994-08-26 |
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