BR112017001695A2 - terapia de combinação - Google Patents

terapia de combinação

Info

Publication number
BR112017001695A2
BR112017001695A2 BR112017001695A BR112017001695A BR112017001695A2 BR 112017001695 A2 BR112017001695 A2 BR 112017001695A2 BR 112017001695 A BR112017001695 A BR 112017001695A BR 112017001695 A BR112017001695 A BR 112017001695A BR 112017001695 A2 BR112017001695 A2 BR 112017001695A2
Authority
BR
Brazil
Prior art keywords
combination therapy
combination
inc280
pharmaceuticals
hydrate
Prior art date
Application number
BR112017001695A
Other languages
English (en)
Inventor
Tam Angela
Hao Huaixiang
Kasibhatla Shailaja
Huang Xizhong
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112017001695A2 publication Critical patent/BR112017001695A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente descrição refere-se a produtos farmacêuticos compreendendo uma combinação de (i) um inibidor de met que é inc280 ou um sal farmaceuticamente aceitável ou hidrato deste e (ii) um inibidor de egfr descrito aqui, que são conjuntamente ativos no tratamento de doenças proliferativas, formulações farmacêuticas correspondentes, usos, métodos, processos, embalagens comerciais e modalidades relacionadas.
BR112017001695A 2014-07-31 2015-07-29 terapia de combinação BR112017001695A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462031583P 2014-07-31 2014-07-31
PCT/IB2015/055737 WO2016016822A1 (en) 2014-07-31 2015-07-29 Combination therapy

Publications (1)

Publication Number Publication Date
BR112017001695A2 true BR112017001695A2 (pt) 2017-11-21

Family

ID=53783790

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017001695A BR112017001695A2 (pt) 2014-07-31 2015-07-29 terapia de combinação

Country Status (12)

Country Link
US (1) US10195208B2 (pt)
EP (1) EP3174869B1 (pt)
JP (1) JP6526789B2 (pt)
KR (1) KR20170036037A (pt)
CN (1) CN107207510B (pt)
AU (1) AU2015294889B2 (pt)
BR (1) BR112017001695A2 (pt)
CA (1) CA2954862A1 (pt)
ES (1) ES2831416T3 (pt)
MX (1) MX2017001461A (pt)
RU (1) RU2695230C2 (pt)
WO (1) WO2016016822A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3964513A1 (en) 2012-04-03 2022-03-09 Novartis AG Combination products with tyrosine kinase inhibitors and their use
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
TWI745824B (zh) 2019-01-03 2021-11-11 美商亞雷生物製藥股份有限公司 作為tam及met激酶抑制劑之喹啉化合物
IL296060A (en) * 2020-03-03 2022-10-01 Array Biopharma Inc Use of (r)-n-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1h-pyrazolo[3,4-b]pyridin-4-yl)oxy) phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide for cancer treatment
KR102522963B1 (ko) * 2020-11-12 2023-04-19 중앙대학교 산학협력단 캡마티닙을 포함하는 항비만 조성물

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EP3174869B1 (en) 2020-08-19
MX2017001461A (es) 2017-05-11
CN107207510A (zh) 2017-09-26
RU2695230C2 (ru) 2019-07-22
RU2017105827A (ru) 2018-08-30
RU2017105827A3 (pt) 2019-03-04
AU2015294889B2 (en) 2018-03-15
KR20170036037A (ko) 2017-03-31
CN107207510B (zh) 2019-11-29
US20170209457A1 (en) 2017-07-27
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