DE60329277D1 - Oligonukleotidzusammensetzungen mit verbesserter effizienz - Google Patents

Oligonukleotidzusammensetzungen mit verbesserter effizienz

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Publication number
DE60329277D1
DE60329277D1 DE60329277T DE60329277T DE60329277D1 DE 60329277 D1 DE60329277 D1 DE 60329277D1 DE 60329277 T DE60329277 T DE 60329277T DE 60329277 T DE60329277 T DE 60329277T DE 60329277 D1 DE60329277 D1 DE 60329277D1
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Germany
Prior art keywords
improved efficiency
compositions
oligonucleotide compositions
making
antisense oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329277T
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English (en)
Inventor
Tod M Woolf
Margaret F Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Life Technologies Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41112152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60329277(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
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Expired - Lifetime legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11022—Cyclin-dependent kinase (2.7.11.22)
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering N.A.
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2320/00—Applications; Uses
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
DE60329277T 2002-02-01 2003-02-03 Oligonukleotidzusammensetzungen mit verbesserter effizienz Expired - Lifetime DE60329277D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35338102P 2002-02-01 2002-02-01
US35320302P 2002-02-01 2002-02-01
US43623802P 2002-12-23 2002-12-23
US43860803P 2003-01-07 2003-01-07
PCT/US2003/003208 WO2003064625A2 (en) 2002-02-01 2003-02-03 Oligonucleotide compositions with enhanced efficiency

Publications (1)

Publication Number Publication Date
DE60329277D1 true DE60329277D1 (de) 2009-10-29

Family

ID=41112152

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DE60329277T Expired - Lifetime DE60329277D1 (de) 2002-02-01 2003-02-03 Oligonukleotidzusammensetzungen mit verbesserter effizienz
DE60337040T Expired - Lifetime DE60337040D1 (de) 2002-02-01 2003-02-03 Oligonukleotid-Zusammensetzungen mit verbesserter Wirksamkeit

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DE60337040T Expired - Lifetime DE60337040D1 (de) 2002-02-01 2003-02-03 Oligonukleotid-Zusammensetzungen mit verbesserter Wirksamkeit

Country Status (9)

Country Link
US (9) US20040014956A1 (de)
EP (10) EP3415625A1 (de)
JP (2) JP2005515780A (de)
AT (4) ATE443133T1 (de)
CA (2) CA2474910A1 (de)
DE (2) DE60329277D1 (de)
DK (1) DK2128248T4 (de)
HK (1) HK1147515A1 (de)
WO (2) WO2003064625A2 (de)

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