PE20170694A1 - Compuestos anti-tnf - Google Patents

Compuestos anti-tnf

Info

Publication number
PE20170694A1
PE20170694A1 PE2017000552A PE2017000552A PE20170694A1 PE 20170694 A1 PE20170694 A1 PE 20170694A1 PE 2017000552 A PE2017000552 A PE 2017000552A PE 2017000552 A PE2017000552 A PE 2017000552A PE 20170694 A1 PE20170694 A1 PE 20170694A1
Authority
PE
Peru
Prior art keywords
refers
compound
oligonucleotides
molecular species
glycol
Prior art date
Application number
PE2017000552A
Other languages
English (en)
Inventor
Christopher C Mader
Tiffany L Halo
Sergei Gryaznov
Richard Kang
Weston Daniel
Original Assignee
Exicure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55653658&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20170694(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exicure Inc filed Critical Exicure Inc
Publication of PE20170694A1 publication Critical patent/PE20170694A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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    • C12N2310/3517—Marker; Tag
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Abstract

Se refiere a oligonucleotidos anti TNF-alfa que tiene una longitud de 18 nucleotidos, el cual comprende, en uno o ambos extremos, una especie molecular tal como un espaciador, un lipido, un esterol, colesterol, entre otros, donde dicha especie molecular esta conectada directamente al compuesto a traves de un enlace tal como enlaces fosfodiester, fosforotioato, entre otros; o se encuentra conectada indirectamente al compuesto a traves de un enlazador tal como un enlazador no nucleotidico seleccionado de restos abasicos, un oligoetilenglicol tal como trietilenglicol o hexaetilenglicol y un alcanodiol tal como butanodiol. Tambien se refiere a una composicion farmaceutica y a una nanoestructura de autoensamblaje estable. Dichos oligonucleotidos son utiles en el tratamiento de enfermedades autoinmunes, enfermedades infecciosas, entre otras
PE2017000552A 2014-10-06 2015-10-06 Compuestos anti-tnf PE20170694A1 (es)

Applications Claiming Priority (1)

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US201462060424P 2014-10-06 2014-10-06

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PE20170694A1 true PE20170694A1 (es) 2017-05-26

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US (3) US10208310B2 (es)
EP (1) EP3204499A4 (es)
JP (1) JP6741673B2 (es)
KR (1) KR20170063949A (es)
CN (1) CN107002081A (es)
AU (1) AU2015328242A1 (es)
BR (1) BR112017007012A2 (es)
CA (1) CA2963931A1 (es)
CL (1) CL2017000806A1 (es)
CO (1) CO2017004314A2 (es)
CR (1) CR20170181A (es)
EA (1) EA201790802A1 (es)
IL (1) IL251508A0 (es)
MX (1) MX2017004448A (es)
PE (1) PE20170694A1 (es)
PH (1) PH12017500601A1 (es)
SG (1) SG11201702656WA (es)
WO (1) WO2016057549A1 (es)

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PE20170694A1 (es) 2014-10-06 2017-05-26 Exicure Inc Compuestos anti-tnf
CN107106493A (zh) 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
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