AR065865A1 - Liposoma para la administracion pulmonar para controlar el suministro de la droga - Google Patents

Liposoma para la administracion pulmonar para controlar el suministro de la droga

Info

Publication number
AR065865A1
AR065865A1 ARP080101281A ARP080101281A AR065865A1 AR 065865 A1 AR065865 A1 AR 065865A1 AR P080101281 A ARP080101281 A AR P080101281A AR P080101281 A ARP080101281 A AR P080101281A AR 065865 A1 AR065865 A1 AR 065865A1
Authority
AR
Argentina
Prior art keywords
pulmonary administration
liposoma
control drug
drug supply
liposome
Prior art date
Application number
ARP080101281A
Other languages
English (en)
Inventor
Hidekazu Toyobuku
Koji Nakano
Hirofumi Takeuchi
Original Assignee
Hirofumi Takeuchi
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hirofumi Takeuchi, Otsuka Pharma Co Ltd filed Critical Hirofumi Takeuchi
Publication of AR065865A1 publication Critical patent/AR065865A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/10—Vectors comprising a non-peptidic targeting moiety

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Proveer un liposoma para el control del suministro intrapulmonar de drogas o genes y que es adecuado para la administracion pulmonar. Al modificar la superficie de un liposoma que emplea un alcohol polivinílico hidrofobizado terminal y/o quitosanaes posible modular de un modo adecuado la retencion de las drogas o de los genes encapsulados en el liposoma sobre la superficie de tejido pulmonar y transferir las drogas o los genes hacia el tejido pulmonar o las células superficiales delpulmon.
ARP080101281A 2007-03-30 2008-03-28 Liposoma para la administracion pulmonar para controlar el suministro de la droga AR065865A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007090874 2007-03-30

Publications (1)

Publication Number Publication Date
AR065865A1 true AR065865A1 (es) 2009-07-08

Family

ID=39808316

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101281A AR065865A1 (es) 2007-03-30 2008-03-28 Liposoma para la administracion pulmonar para controlar el suministro de la droga

Country Status (20)

Country Link
US (2) US8658204B2 (es)
EP (2) EP2656858B1 (es)
JP (2) JP5191478B2 (es)
KR (2) KR101476167B1 (es)
CN (2) CN101646462A (es)
AR (1) AR065865A1 (es)
AU (2) AU2008233656B2 (es)
BR (1) BRPI0809852A2 (es)
CA (2) CA2885621C (es)
CO (1) CO6260108A2 (es)
ES (2) ES2618457T3 (es)
IL (1) IL201172A0 (es)
MX (1) MX2009010479A (es)
NZ (1) NZ579881A (es)
PH (1) PH12014502430A1 (es)
RU (1) RU2493874C2 (es)
TW (1) TW200902085A (es)
UA (1) UA100375C2 (es)
WO (1) WO2008120736A1 (es)
ZA (1) ZA200906742B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300556B (zh) * 2008-12-26 2015-04-29 株式会社三养生物制药 含有阴离子药物的药物组合物及其制备方法
JP2011246464A (ja) * 2010-04-28 2011-12-08 Wakamoto Pharmaceutical Co Ltd ジクロフェナクナトリウムを封入した後眼部到達用ポリマーコーティングリポソーム
KR101601035B1 (ko) * 2013-02-28 2016-03-08 주식회사 종근당 키토산 및 액상결정 형성 물질을 포함하는 유전자 전달용 조성물
US10894963B2 (en) 2013-07-25 2021-01-19 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
CN106535876B (zh) 2014-06-04 2020-09-11 埃克西奎雷股份有限公司 免疫调节剂通过脂质体球形核酸的多价递送以用于预防或治疗应用
AU2015328242A1 (en) 2014-10-06 2017-04-27 Exicure, Inc. Anti-TNF compounds
CN104922068B (zh) * 2015-05-22 2017-10-13 江苏凯基生物技术股份有限公司 一种Decoy核酸阳离子脂质体载体及其制备方法
CN108137694B (zh) 2015-09-18 2022-08-12 慕尼黑工业大学 整合素αvβ6的配体及其合成和应用
US9732303B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Microcapsules formed from phosphate esters and compositions containing same
US9730867B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Methods of forming a slurry with microcapsules formed from phosphate esters
US10154947B2 (en) 2016-01-06 2018-12-18 The Procter & Gamble Company Antiperspirant composition
US20200297867A1 (en) * 2016-02-01 2020-09-24 Exicure, Inc. Surface functionalization of liposomes and liposomal spherical nucleic acids (snas)
EP3452598A4 (en) 2016-05-06 2020-04-29 Exicure, Inc. LIPOSOMAL SPHERIC NUCLEIC ACID (SNA) CONSTRUCTS WITH ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC KNOCKDOWN OF INTERLEUKIN-17 RECEPTOR MRNA
TWI754659B (zh) * 2016-08-08 2022-02-11 台灣微脂體股份有限公司 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組
WO2018167295A1 (en) 2017-03-17 2018-09-20 Technische Universität München LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
TWI734987B (zh) * 2019-05-23 2021-08-01 國立陽明交通大學 單醣標記之奈米脂質體藥物遞送系統，其製法及其作為藥物靶定遞送載體之應用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
RU2130771C1 (ru) 1998-06-01 1999-05-27 Автушенко Сергей Сергеевич Способ получения липосомальных препаратов
AU757121B2 (en) * 1998-11-18 2003-02-06 University Of Florida Methods for preparing coated drug particles and pharmaceutical formulations thereof
JP2003504321A (ja) 1999-07-08 2003-02-04 オーランド・ハン リポソーム被包カンナビノイドの肺送達
WO2001072283A1 (en) 2000-03-29 2001-10-04 Aradigm Corporation Cationic liposomes
US20030096774A1 (en) * 2001-11-21 2003-05-22 Igor Gonda Compositions of nucleic acids and cationic aminoglycosides and methods of using and preparing the same
DE10214983A1 (de) 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
EP1506032A1 (en) * 2002-05-20 2005-02-16 Research Development Foundation Aerosol drug inhibition of lung metastases
RU2238091C2 (ru) 2002-12-15 2004-10-20 Закрытое акционерное общество "АИП-Наука" Способ лечения туберкулеза у человека
CA2527625A1 (en) * 2003-05-30 2004-12-23 Alza Corporation Method of pulmonary administration of an agent
JP4503953B2 (ja) 2003-08-11 2010-07-14 テルモ株式会社 プレフィルドシリンジの製造方法
JP4669665B2 (ja) * 2004-04-12 2011-04-13 正彦 阿部 細胞毒性のないポリカチオン修飾リポソームおよびその製造方法
CN100356919C (zh) * 2004-05-31 2007-12-26 上海医药工业研究院 羟基喜树碱脂质体及其制备方法
KR20070057932A (ko) * 2004-09-15 2007-06-07 오츠카 세이야쿠 가부시키가이샤 경점막용 조성물, 및 경점막 흡수의 향상 방법

Also Published As

Publication number Publication date
US9750694B2 (en) 2017-09-05
JP5191478B2 (ja) 2013-05-08
CO6260108A2 (es) 2011-03-22
MX2009010479A (es) 2009-10-19
EP2656858A1 (en) 2013-10-30
US8658204B2 (en) 2014-02-25
AU2014204483A1 (en) 2014-08-07
WO2008120736A1 (ja) 2008-10-09
US20100112043A1 (en) 2010-05-06
CA2682376A1 (en) 2008-10-09
ZA200906742B (en) 2010-12-29
EP2133097B1 (en) 2017-01-25
UA100375C2 (ru) 2012-12-25
NZ579881A (en) 2012-10-26
US20140105968A1 (en) 2014-04-17
JPWO2008120736A1 (ja) 2010-07-15
ES2618457T3 (es) 2017-06-21
IL201172A0 (en) 2010-05-17
CA2885621A1 (en) 2008-10-09
BRPI0809852A2 (pt) 2014-09-23
ES2643938T3 (es) 2017-11-27
JP5674831B2 (ja) 2015-02-25
CN103356482A (zh) 2013-10-23
RU2009140058A (ru) 2011-05-10
TW200902085A (en) 2009-01-16
AU2008233656B2 (en) 2014-05-22
RU2493874C2 (ru) 2013-09-27
EP2133097A1 (en) 2009-12-16
EP2656858B1 (en) 2017-08-16
CA2885621C (en) 2016-01-05
KR101476167B1 (ko) 2014-12-24
JP2013100332A (ja) 2013-05-23
PH12014502430A1 (en) 2015-09-07
KR20090128491A (ko) 2009-12-15
AU2008233656A1 (en) 2008-10-09
CN101646462A (zh) 2010-02-10
KR20140136047A (ko) 2014-11-27
CA2682376C (en) 2015-10-06
EP2133097A4 (en) 2013-01-16

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