DE60205693T2 - Verfahren zur schnellen Synthese von Peptiden in Lösung - Google Patents

Verfahren zur schnellen Synthese von Peptiden in Lösung Download PDF

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Publication number
DE60205693T2
DE60205693T2 DE60205693T DE60205693T DE60205693T2 DE 60205693 T2 DE60205693 T2 DE 60205693T2 DE 60205693 T DE60205693 T DE 60205693T DE 60205693 T DE60205693 T DE 60205693T DE 60205693 T2 DE60205693 T2 DE 60205693T2
Authority
DE
Germany
Prior art keywords
peptides
solution
rapid synthesis
synthesis
rapid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60205693T
Other languages
German (de)
English (en)
Other versions
DE60205693D1 (de
Inventor
Ivo Franci Eggen
Kortenaar Paulus Bernardus Ten
Cornelis Albert Gruso Haasnoot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE60205693D1 publication Critical patent/DE60205693D1/de
Publication of DE60205693T2 publication Critical patent/DE60205693T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60205693T 2001-07-19 2002-07-15 Verfahren zur schnellen Synthese von Peptiden in Lösung Expired - Lifetime DE60205693T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202753 2001-07-19

Publications (2)

Publication Number Publication Date
DE60205693D1 DE60205693D1 (de) 2005-09-29
DE60205693T2 true DE60205693T2 (de) 2006-06-14

Family

ID=8180656

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60205693T Expired - Lifetime DE60205693T2 (de) 2001-07-19 2002-07-15 Verfahren zur schnellen Synthese von Peptiden in Lösung

Country Status (25)

Country Link
US (4) US20030018164A1 (enExample)
EP (1) EP1291356B1 (enExample)
JP (1) JP4142907B2 (enExample)
KR (1) KR100861031B1 (enExample)
CN (1) CN1254483C (enExample)
AR (1) AR034869A1 (enExample)
AT (1) ATE302792T1 (enExample)
BR (1) BRPI0202783B1 (enExample)
CA (1) CA2390358C (enExample)
DE (1) DE60205693T2 (enExample)
DK (1) DK1291356T3 (enExample)
EC (1) ECSP024291A (enExample)
ES (1) ES2248485T3 (enExample)
HR (1) HRP20020609B1 (enExample)
HU (1) HUP0202369A2 (enExample)
IL (1) IL150601A (enExample)
MX (1) MXPA02006998A (enExample)
NO (1) NO324245B1 (enExample)
PE (1) PE20030214A1 (enExample)
PL (1) PL205559B1 (enExample)
PT (1) PT1291356E (enExample)
RU (1) RU2237673C2 (enExample)
SG (1) SG119160A1 (enExample)
TW (1) TWI247012B (enExample)
ZA (1) ZA200205409B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
EP1790656A1 (en) * 2005-11-25 2007-05-30 Nanokem S.A. Solution-phase synthesis of leuprolide
EP1801086A1 (en) * 2005-11-25 2007-06-27 Synthacon GmbH Synthesis of carbon acid amides
DK1979370T3 (da) * 2006-01-17 2010-06-28 Organon Nv Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider
EP1995254B1 (en) 2006-03-01 2019-04-03 Kaneka Corporation Method of producing peptides
ES2359121T3 (es) * 2007-06-25 2011-05-18 N.V. Organon Proceso para la conversión de ésteres o ácidos peptídicos c-terminales en amidas empleando subtilisina en presencia de sales de amonio.
US8124372B2 (en) 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides
CA2753224C (en) * 2008-12-30 2018-04-17 Gkl-Biotec Ag Peptide combination
KR101032399B1 (ko) * 2010-02-11 2011-05-03 주식회사 이너트론 밴드패스필터의 철재하우징 및 그 제조방법
EP2409982A3 (en) * 2010-02-25 2012-02-08 Corning Incorporated Chemical processes generating solid(s) carried out continuously within microreactors
JP6136934B2 (ja) 2011-12-15 2017-05-31 味の素株式会社 Ｆｍｏｃ基の除去方法
EP3266792B1 (en) 2015-03-04 2020-12-30 Jitsubo Co., Ltd. Peptide synthesis method
ES2924473T3 (es) 2015-12-21 2022-10-07 Univ Texas Tech System Sistema y procedimiento de síntesis de péptidos GAP en fase de solución
DK3778621T5 (da) 2018-04-13 2024-08-19 Jitsubo Co Ltd Peptidsyntesefremgangsmåde
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
FR3090636B1 (fr) * 2018-12-24 2021-01-01 Strainchem Procédé de synthèse de peptides
US11827660B2 (en) 2019-02-01 2023-11-28 Sederma Synthesis strategy for gap protecting group
EP4023661B1 (en) * 2019-08-30 2024-09-04 Nissan Chemical Corporation Method for producing peptide compound
JP7709920B2 (ja) 2019-12-27 2025-07-17 中外製薬株式会社 ペプチド化合物の合成法
CN115362144A (zh) * 2020-03-27 2022-11-18 株式会社钟化 含酰胺键化合物的制造方法
JP7063408B1 (ja) 2021-07-02 2022-05-09 ペプチスター株式会社 液相ペプチド製造方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1991A (en) * 1841-02-23 Manner of fastening bedsteads
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis
US5101059A (en) * 1989-12-05 1992-03-31 Research Corporation Technologies, Inc. Amino acid protecting groups
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5516892A (en) * 1992-12-28 1996-05-14 Indiana University Foundation Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids
US6310180B1 (en) * 1993-06-21 2001-10-30 Vanderbilt University Method for synthesis of proteins
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
US5698676A (en) * 1995-11-30 1997-12-16 Abbott Laboratories Use of propylene oxide as an acid scavenger in peptide synthesis
US5849954A (en) * 1996-01-18 1998-12-15 Research Corporation Technologies, Inc. Method of peptide synthesis
AU737428B2 (en) * 1996-05-03 2001-08-16 Warner-Lambert Company Rapid purification by polymer supported quench
US6121488A (en) * 1997-09-24 2000-09-19 Warner-Lambert Company Quenching reagents for solution phase synthesis
JPH11217397A (ja) * 1997-11-27 1999-08-10 Saburo Aimoto ペプチドチオールエステルの製造方法
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
CA2373816A1 (en) * 1999-05-26 2000-11-30 Abbott Laboratories Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents
US20020127219A1 (en) * 1999-12-30 2002-09-12 Okkels Jens Sigurd Lysosomal enzymes and lysosomal enzyme activators
TW200628612A (en) * 2000-07-19 2006-08-16 Pharmacia & Up John Company Substrates and assays for β-secretase activity
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
TWI243826B (en) * 2001-07-19 2005-11-21 Akzo Nobel Nv Process for the preparation of peptides
US20060287477A1 (en) * 2005-06-17 2006-12-21 Crawford Emmett D Greenhouses comprising polyester compositions formed from 2,2,4,4-tetramethyl-1,3-cyclobutanediol and 1,4- cyclohexanedimethanol

Also Published As

Publication number Publication date
CN1254483C (zh) 2006-05-03
PL355125A1 (en) 2003-01-27
KR20030009188A (ko) 2003-01-29
ZA200205409B (en) 2002-09-05
PT1291356E (pt) 2005-11-30
IL150601A0 (en) 2003-02-12
HK1050904A1 (en) 2003-07-11
NO20023446L (no) 2003-01-20
JP2003055396A (ja) 2003-02-26
CA2390358C (en) 2004-12-21
RU2002119630A (ru) 2004-01-20
PL205559B1 (pl) 2010-05-31
IL150601A (en) 2010-06-30
DE60205693D1 (de) 2005-09-29
HU0202369D0 (enExample) 2002-09-28
ATE302792T1 (de) 2005-09-15
ECSP024291A (es) 2002-09-27
DK1291356T3 (da) 2005-12-19
US20030018164A1 (en) 2003-01-23
BRPI0202783B1 (pt) 2016-07-05
SG119160A1 (en) 2006-02-28
US7435791B2 (en) 2008-10-14
EP1291356A2 (en) 2003-03-12
PE20030214A1 (es) 2003-03-17
RU2237673C2 (ru) 2004-10-10
CA2390358A1 (en) 2003-01-19
BR0202783A (pt) 2003-06-10
NO324245B1 (no) 2007-09-17
HRP20020609B1 (en) 2005-06-30
JP4142907B2 (ja) 2008-09-03
US20040082760A1 (en) 2004-04-29
EP1291356A3 (en) 2004-01-02
ES2248485T3 (es) 2006-03-16
HRP20020609A2 (en) 2003-02-28
MXPA02006998A (es) 2005-02-17
KR100861031B1 (ko) 2008-10-01
NO20023446D0 (no) 2002-07-18
TWI247012B (en) 2006-01-11
US20060063918A1 (en) 2006-03-23
AR034869A1 (es) 2004-03-24
CN1398876A (zh) 2003-02-26
HUP0202369A2 (en) 2006-08-28
EP1291356B1 (en) 2005-08-24
US20040087768A1 (en) 2004-05-06

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