PE20030214A1 - Procedimiento para la sintesis rapida de peptidos en solucion - Google Patents
Procedimiento para la sintesis rapida de peptidos en solucionInfo
- Publication number
- PE20030214A1 PE20030214A1 PE2002000637A PE2002000637A PE20030214A1 PE 20030214 A1 PE20030214 A1 PE 20030214A1 PE 2002000637 A PE2002000637 A PE 2002000637A PE 2002000637 A PE2002000637 A PE 2002000637A PE 20030214 A1 PE20030214 A1 PE 20030214A1
- Authority
- PE
- Peru
- Prior art keywords
- procedure
- anion
- sweeping agent
- peptides
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
QUE COMPRENDE CICLOS REPETIDOS DE LAS ETAPAS (a) - (d): a) UN ACOPLAMIENTO USANDO UN EXCESO DE UN COMPONENTE CARBOXILICO PARA ACILAR UN COMPONENTE AMINO; b) UNA EXTINCION USANDO UN AGENTE BARREDOR PARA REMOVER LAS FUNCIONES CARBOXILICAS ACTIVADAS RESIDUALES, DONDE EL AGENTE BARREDOR TAMBIEN PUEDE USARSE PARA LA DESPROTECCION DEL PEPTIDO EN CRECIMIENTO; c) UNA O MAS EXTRACCIONES ACUOSAS; Y, d) UNA ETAPA DE DESPROTECCION SEPARADA, SEGUIDA POR UNA O MAS EXTRACCIONES ACUOSAS. UNA AMINA QUE COMPRENDE UN ANION LIBRE O UN ANION LATENTE, O UN TIOL QUE COMPRENDE UN ANION LIBRE O LATENTE, SON USADOS COMO AGENTE BARREDOR DE LAS FUNCIONES CARBOXILICAS ACTIVADAS RESIDUALES. EL PROCEDIMIENTO SE EFECTUA DENTRO DE UN RANGO DE TEMPERATURAS DE 0°C A 50°C. EL PEPTIDO EN CRECIMIENTO NO NECESITA SER AISLADO HASTA QUE SE HAYA OBTENIDO LA SECUENCIA FINAL DEL PEPTIDO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202753 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030214A1 true PE20030214A1 (es) | 2003-03-17 |
Family
ID=8180656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000637A PE20030214A1 (es) | 2001-07-19 | 2002-07-17 | Procedimiento para la sintesis rapida de peptidos en solucion |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20030018164A1 (es) |
| EP (1) | EP1291356B1 (es) |
| JP (1) | JP4142907B2 (es) |
| KR (1) | KR100861031B1 (es) |
| CN (1) | CN1254483C (es) |
| AR (1) | AR034869A1 (es) |
| AT (1) | ATE302792T1 (es) |
| BR (1) | BRPI0202783B1 (es) |
| CA (1) | CA2390358C (es) |
| DE (1) | DE60205693T2 (es) |
| DK (1) | DK1291356T3 (es) |
| EC (1) | ECSP024291A (es) |
| ES (1) | ES2248485T3 (es) |
| HK (1) | HK1050904A1 (es) |
| HR (1) | HRP20020609B1 (es) |
| HU (1) | HUP0202369A2 (es) |
| IL (1) | IL150601A (es) |
| MX (1) | MXPA02006998A (es) |
| NO (1) | NO324245B1 (es) |
| PE (1) | PE20030214A1 (es) |
| PL (1) | PL205559B1 (es) |
| PT (1) | PT1291356E (es) |
| RU (1) | RU2237673C2 (es) |
| SG (1) | SG119160A1 (es) |
| TW (1) | TWI247012B (es) |
| ZA (1) | ZA200205409B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
| EP1790656A1 (en) | 2005-11-25 | 2007-05-30 | Nanokem S.A. | Solution-phase synthesis of leuprolide |
| EP1801086A1 (en) * | 2005-11-25 | 2007-06-27 | Synthacon GmbH | Synthesis of carbon acid amides |
| US20090093016A1 (en) * | 2006-01-17 | 2009-04-09 | N.V. Organon | Selective Enzymatic Hydrolysis of C-Terminal Tert-Butyl Esters of Peptides |
| WO2007099656A1 (ja) | 2006-03-01 | 2007-09-07 | Kaneka Corporation | ペプチドの製造方法 |
| US8124372B2 (en) | 2007-06-25 | 2012-02-28 | N.V. Organon | Selective enzymatic amidation of C-terminal esters or acids of peptides |
| DK2167673T3 (da) * | 2007-06-25 | 2011-04-18 | Organon Nv | Fremgangsmåde til omdannelse af C-terminale peptidestere eller -syrer til amider under anvendelse af subtilisin i tilstedeværelsen af ammoniumsalte |
| EP2235038B1 (de) * | 2008-12-30 | 2019-06-05 | GKL-Biotec AG | Tetrapeptidkombination |
| KR101032399B1 (ko) * | 2010-02-11 | 2011-05-03 | 주식회사 이너트론 | 밴드패스필터의 철재하우징 및 그 제조방법 |
| EP2409982A3 (en) * | 2010-02-25 | 2012-02-08 | Corning Incorporated | Chemical processes generating solid(s) carried out continuously within microreactors |
| WO2013089241A1 (ja) | 2011-12-15 | 2013-06-20 | 味の素株式会社 | Ｆｍｏｃ基の除去方法 |
| DK3266792T3 (da) | 2015-03-04 | 2021-02-01 | Jitsubo Co Ltd | Fremgangsmåde til peptidsyntese |
| DK3778621T3 (da) | 2018-04-13 | 2023-09-25 | Jitsubo Co Ltd | Peptidsyntesefremgangsmåde |
| FR3090636B1 (fr) * | 2018-12-24 | 2021-01-01 | Strainchem | Procédé de synthèse de peptides |
| EP3917937A4 (en) | 2019-02-01 | 2022-11-23 | Sederma | SYNTHETIC STRATEGY FOR A SPLIT PROTECTION GROUP |
| WO2021132545A1 (ja) * | 2019-12-27 | 2021-07-01 | 中外製薬株式会社 | ペプチド化合物の合成法 |
| JPWO2021192488A1 (es) * | 2020-03-27 | 2021-09-30 | ||
| JP7063408B1 (ja) | 2021-07-02 | 2022-05-09 | ペプチスター株式会社 | 液相ペプチド製造方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1991A (en) * | 1841-02-23 | Manner of fastening bedsteads | ||
| US5221754A (en) * | 1989-06-09 | 1993-06-22 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
| US5101059A (en) * | 1989-12-05 | 1992-03-31 | Research Corporation Technologies, Inc. | Amino acid protecting groups |
| US5877278A (en) * | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
| US5516892A (en) * | 1992-12-28 | 1996-05-14 | Indiana University Foundation | Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids |
| US6310180B1 (en) * | 1993-06-21 | 2001-10-30 | Vanderbilt University | Method for synthesis of proteins |
| US5516639A (en) * | 1993-07-22 | 1996-05-14 | Mayo Foundation For Medical Education And Research | Antibodies specific for human prostate glandular kallkrein |
| US6001966A (en) * | 1995-10-19 | 1999-12-14 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
| US5698676A (en) * | 1995-11-30 | 1997-12-16 | Abbott Laboratories | Use of propylene oxide as an acid scavenger in peptide synthesis |
| US5849954A (en) * | 1996-01-18 | 1998-12-15 | Research Corporation Technologies, Inc. | Method of peptide synthesis |
| CA2251700A1 (en) * | 1996-05-03 | 1997-11-13 | Warner-Lambert Company | Rapid purification by polymer supported quench |
| US6121488A (en) * | 1997-09-24 | 2000-09-19 | Warner-Lambert Company | Quenching reagents for solution phase synthesis |
| JPH11217397A (ja) * | 1997-11-27 | 1999-08-10 | Saburo Aimoto | ペプチドチオールエステルの製造方法 |
| FR2780061B1 (fr) * | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| MXPA01012082A (es) * | 1999-05-26 | 2002-07-22 | Abbott Lab | Proceso de sintesis de peptidos de aislamiento minimo, usando resinas de intercambio de iones como agentes depuradores. |
| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| IL153943A0 (en) * | 2000-07-19 | 2003-07-31 | Upjohn Co | SUBSTRATES AND ASSAYS FOR beta-SECRETASE ACTIVITY |
| TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
| TWI243826B (en) * | 2001-07-19 | 2005-11-21 | Akzo Nobel Nv | Process for the preparation of peptides |
| US7510768B2 (en) * | 2005-06-17 | 2009-03-31 | Eastman Chemical Company | Thermoplastic articles comprising cyclobutanediol having a decorative material embedded therein |
-
2002
- 2002-07-04 TW TW091114832A patent/TWI247012B/zh not_active IP Right Cessation
- 2002-07-04 IL IL150601A patent/IL150601A/en active IP Right Grant
- 2002-07-05 ZA ZA200205409A patent/ZA200205409B/xx unknown
- 2002-07-05 JP JP2002197550A patent/JP4142907B2/ja not_active Expired - Lifetime
- 2002-07-15 EP EP02077830A patent/EP1291356B1/en not_active Expired - Lifetime
- 2002-07-15 SG SG200204298A patent/SG119160A1/en unknown
- 2002-07-15 AT AT02077830T patent/ATE302792T1/de active
- 2002-07-15 DE DE60205693T patent/DE60205693T2/de not_active Expired - Lifetime
- 2002-07-15 ES ES02077830T patent/ES2248485T3/es not_active Expired - Lifetime
- 2002-07-15 PT PT02077830T patent/PT1291356E/pt unknown
- 2002-07-15 DK DK02077830T patent/DK1291356T3/da active
- 2002-07-17 PE PE2002000637A patent/PE20030214A1/es not_active Application Discontinuation
- 2002-07-17 MX MXPA02006998A patent/MXPA02006998A/es active IP Right Grant
- 2002-07-18 NO NO20023446A patent/NO324245B1/no not_active IP Right Cessation
- 2002-07-18 KR KR1020020041898A patent/KR100861031B1/ko not_active IP Right Cessation
- 2002-07-18 CA CA002390358A patent/CA2390358C/en not_active Expired - Lifetime
- 2002-07-18 HU HU0202369A patent/HUP0202369A2/hu unknown
- 2002-07-18 RU RU2002119630/04A patent/RU2237673C2/ru not_active IP Right Cessation
- 2002-07-18 BR BRPI0202783A patent/BRPI0202783B1/pt active IP Right Grant
- 2002-07-18 CN CNB021261911A patent/CN1254483C/zh not_active Expired - Lifetime
- 2002-07-18 AR ARP020102687A patent/AR034869A1/es active IP Right Grant
- 2002-07-19 HR HR20020609A patent/HRP20020609B1/xx not_active IP Right Cessation
- 2002-07-19 US US10/199,805 patent/US20030018164A1/en not_active Abandoned
- 2002-07-19 PL PL355125A patent/PL205559B1/pl not_active IP Right Cessation
- 2002-07-19 EC EC2002004291A patent/ECSP024291A/es unknown
-
2003
- 2003-04-29 HK HK03103037A patent/HK1050904A1/xx not_active IP Right Cessation
- 2003-10-22 US US10/692,354 patent/US20040082760A1/en not_active Abandoned
- 2003-10-23 US US10/693,123 patent/US20060063918A1/en not_active Abandoned
- 2003-10-23 US US10/693,802 patent/US7435791B2/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |