KR100861031B1 - 펩티드의 급속 용액 합성 방법 - Google Patents

펩티드의 급속 용액 합성 방법 Download PDF

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Publication number
KR100861031B1
KR100861031B1 KR1020020041898A KR20020041898A KR100861031B1 KR 100861031 B1 KR100861031 B1 KR 100861031B1 KR 1020020041898 A KR1020020041898 A KR 1020020041898A KR 20020041898 A KR20020041898 A KR 20020041898A KR 100861031 B1 KR100861031 B1 KR 100861031B1
Authority
KR
South Korea
Prior art keywords
scavenger
extraction
protecting group
anion
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020020041898A
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English (en)
Korean (ko)
Other versions
KR20030009188A (ko
Inventor
에겐이보프란시
텐코르테나르파울러스베르나르더스윌헬머스
하스누트코르넬리스알버트그루손
Original Assignee
엔.브이.오가논
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Publication date
Application filed by 엔.브이.오가논 filed Critical 엔.브이.오가논
Publication of KR20030009188A publication Critical patent/KR20030009188A/ko
Application granted granted Critical
Publication of KR100861031B1 publication Critical patent/KR100861031B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020020041898A 2001-07-19 2002-07-18 펩티드의 급속 용액 합성 방법 Expired - Fee Related KR100861031B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202753.8 2001-07-19
EP01202753 2001-07-19

Publications (2)

Publication Number Publication Date
KR20030009188A KR20030009188A (ko) 2003-01-29
KR100861031B1 true KR100861031B1 (ko) 2008-10-01

Family

ID=8180656

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020020041898A Expired - Fee Related KR100861031B1 (ko) 2001-07-19 2002-07-18 펩티드의 급속 용액 합성 방법

Country Status (25)

Country Link
US (4) US20030018164A1 (enExample)
EP (1) EP1291356B1 (enExample)
JP (1) JP4142907B2 (enExample)
KR (1) KR100861031B1 (enExample)
CN (1) CN1254483C (enExample)
AR (1) AR034869A1 (enExample)
AT (1) ATE302792T1 (enExample)
BR (1) BRPI0202783B1 (enExample)
CA (1) CA2390358C (enExample)
DE (1) DE60205693T2 (enExample)
DK (1) DK1291356T3 (enExample)
EC (1) ECSP024291A (enExample)
ES (1) ES2248485T3 (enExample)
HR (1) HRP20020609B1 (enExample)
HU (1) HUP0202369A2 (enExample)
IL (1) IL150601A (enExample)
MX (1) MXPA02006998A (enExample)
NO (1) NO324245B1 (enExample)
PE (1) PE20030214A1 (enExample)
PL (1) PL205559B1 (enExample)
PT (1) PT1291356E (enExample)
RU (1) RU2237673C2 (enExample)
SG (1) SG119160A1 (enExample)
TW (1) TWI247012B (enExample)
ZA (1) ZA200205409B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
EP1801086A1 (en) * 2005-11-25 2007-06-27 Synthacon GmbH Synthesis of carbon acid amides
EP1790656A1 (en) * 2005-11-25 2007-05-30 Nanokem S.A. Solution-phase synthesis of leuprolide
ES2340885T3 (es) * 2006-01-17 2010-06-10 N.V. Organon Hidrolisis enzimatica selectiva de esteres terc-butilicos c terminal de peptidos.
ES2729197T3 (es) * 2006-03-01 2019-10-30 Kaneka Corp Método de producción de péptidos
WO2009000814A1 (en) * 2007-06-25 2008-12-31 N.V. Organon Process for the conversion of c-terminal peptide esters or acids to amides employing subtilisin in the presence of ammonium salts
US8124372B2 (en) 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides
EP2235038B1 (de) * 2008-12-30 2019-06-05 GKL-Biotec AG Tetrapeptidkombination
KR101032399B1 (ko) * 2010-02-11 2011-05-03 주식회사 이너트론 밴드패스필터의 철재하우징 및 그 제조방법
EP2409982A3 (en) * 2010-02-25 2012-02-08 Corning Incorporated Chemical processes generating solid(s) carried out continuously within microreactors
JP6136934B2 (ja) 2011-12-15 2017-05-31 味の素株式会社 Ｆｍｏｃ基の除去方法
WO2016140232A1 (ja) 2015-03-04 2016-09-09 Jitsubo株式会社 ペプチド合成方法
CN108697770B (zh) 2015-12-21 2023-08-01 得克萨斯技术大学联合体 用于溶液相gap肽合成的系统和方法
EP3778621B1 (en) 2018-04-13 2023-08-23 Jitsubo Co., Ltd. Peptide synthesis method
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
FR3090636B1 (fr) * 2018-12-24 2021-01-01 Strainchem Procédé de synthèse de peptides
US11827660B2 (en) 2019-02-01 2023-11-28 Sederma Synthesis strategy for gap protecting group
US12466850B2 (en) * 2019-08-30 2025-11-11 Nissan Chemical Corporation Method for producing peptide compound
WO2021132545A1 (ja) * 2019-12-27 2021-07-01 中外製薬株式会社 ペプチド化合物の合成法
WO2021192488A1 (ja) * 2020-03-27 2021-09-30 株式会社カネカ アミド結合含有化合物の製造方法
JP7063408B1 (ja) 2021-07-02 2022-05-09 ペプチスター株式会社 液相ペプチド製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001569A1 (en) * 2005-06-17 2007-01-04 Eastman Chemical Company Polyester compositions containing high amounts of cyclobutanediol and articles made therefrom

Family Cites Families (19)

* Cited by examiner, † Cited by third party
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US1991A (en) * 1841-02-23 Manner of fastening bedsteads
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis
US5101059A (en) * 1989-12-05 1992-03-31 Research Corporation Technologies, Inc. Amino acid protecting groups
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5516892A (en) * 1992-12-28 1996-05-14 Indiana University Foundation Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids
US6310180B1 (en) * 1993-06-21 2001-10-30 Vanderbilt University Method for synthesis of proteins
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
US5698676A (en) * 1995-11-30 1997-12-16 Abbott Laboratories Use of propylene oxide as an acid scavenger in peptide synthesis
US5849954A (en) * 1996-01-18 1998-12-15 Research Corporation Technologies, Inc. Method of peptide synthesis
NZ332116A (en) * 1996-05-03 2000-06-23 Warner Lambert Co Rapid purification of synthetic intermediates and products by polymer supported quench reagents
US6121488A (en) * 1997-09-24 2000-09-19 Warner-Lambert Company Quenching reagents for solution phase synthesis
JPH11217397A (ja) * 1997-11-27 1999-08-10 Saburo Aimoto ペプチドチオールエステルの製造方法
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
MXPA01012082A (es) * 1999-05-26 2002-07-22 Abbott Lab Proceso de sintesis de peptidos de aislamiento minimo, usando resinas de intercambio de iones como agentes depuradores.
US20020127219A1 (en) * 1999-12-30 2002-09-12 Okkels Jens Sigurd Lysosomal enzymes and lysosomal enzyme activators
TW200628612A (en) * 2000-07-19 2006-08-16 Pharmacia & Up John Company Substrates and assays for β-secretase activity
TWI243826B (en) * 2001-07-19 2005-11-21 Akzo Nobel Nv Process for the preparation of peptides
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001569A1 (en) * 2005-06-17 2007-01-04 Eastman Chemical Company Polyester compositions containing high amounts of cyclobutanediol and articles made therefrom

Also Published As

Publication number Publication date
JP4142907B2 (ja) 2008-09-03
EP1291356A3 (en) 2004-01-02
NO20023446D0 (no) 2002-07-18
DE60205693T2 (de) 2006-06-14
NO324245B1 (no) 2007-09-17
NO20023446L (no) 2003-01-20
JP2003055396A (ja) 2003-02-26
PE20030214A1 (es) 2003-03-17
IL150601A (en) 2010-06-30
RU2002119630A (ru) 2004-01-20
PT1291356E (pt) 2005-11-30
DK1291356T3 (da) 2005-12-19
CN1254483C (zh) 2006-05-03
HRP20020609B1 (en) 2005-06-30
IL150601A0 (en) 2003-02-12
SG119160A1 (en) 2006-02-28
CA2390358C (en) 2004-12-21
US20030018164A1 (en) 2003-01-23
US20040082760A1 (en) 2004-04-29
KR20030009188A (ko) 2003-01-29
EP1291356B1 (en) 2005-08-24
ECSP024291A (es) 2002-09-27
PL205559B1 (pl) 2010-05-31
DE60205693D1 (de) 2005-09-29
ES2248485T3 (es) 2006-03-16
EP1291356A2 (en) 2003-03-12
ZA200205409B (en) 2002-09-05
CN1398876A (zh) 2003-02-26
RU2237673C2 (ru) 2004-10-10
HRP20020609A2 (en) 2003-02-28
PL355125A1 (en) 2003-01-27
US7435791B2 (en) 2008-10-14
ATE302792T1 (de) 2005-09-15
TWI247012B (en) 2006-01-11
AR034869A1 (es) 2004-03-24
BRPI0202783B1 (pt) 2016-07-05
HUP0202369A2 (en) 2006-08-28
CA2390358A1 (en) 2003-01-19
MXPA02006998A (es) 2005-02-17
US20040087768A1 (en) 2004-05-06
BR0202783A (pt) 2003-06-10
US20060063918A1 (en) 2006-03-23
HK1050904A1 (en) 2003-07-11
HU0202369D0 (enExample) 2002-09-28

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