DE602007008877D1 - Verfahren zur rückgewinnung von polymyxin b aus einer fermentationsbrühe - Google Patents

Verfahren zur rückgewinnung von polymyxin b aus einer fermentationsbrühe

Info

Publication number
DE602007008877D1
DE602007008877D1 DE602007008877T DE602007008877T DE602007008877D1 DE 602007008877 D1 DE602007008877 D1 DE 602007008877D1 DE 602007008877 T DE602007008877 T DE 602007008877T DE 602007008877 T DE602007008877 T DE 602007008877T DE 602007008877 D1 DE602007008877 D1 DE 602007008877D1
Authority
DE
Germany
Prior art keywords
polymyxine
recovery
fermentation broth
till
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007008877T
Other languages
English (en)
Inventor
Ivan Varga
Maria Bobalova
Eva Michalkova
Maria Jakubcova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotika AS
Original Assignee
Biotika AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotika AS filed Critical Biotika AS
Publication of DE602007008877D1 publication Critical patent/DE602007008877D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE602007008877T 2006-06-02 2007-05-11 Verfahren zur rückgewinnung von polymyxin b aus einer fermentationsbrühe Active DE602007008877D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SK83-2006A SK287315B6 (sk) 2006-06-02 2006-06-02 Spôsob izolácie polymyxínu B z vyfermentovanej pôdy
PCT/SK2007/050009 WO2007142611A1 (en) 2006-06-02 2007-05-11 Method of polymyxin b recovery from fermentation broth

Publications (1)

Publication Number Publication Date
DE602007008877D1 true DE602007008877D1 (de) 2010-10-14

Family

ID=38342659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007008877T Active DE602007008877D1 (de) 2006-06-02 2007-05-11 Verfahren zur rückgewinnung von polymyxin b aus einer fermentationsbrühe

Country Status (9)

Country Link
US (1) US7951913B2 (de)
EP (1) EP2021355B1 (de)
AT (1) ATE479703T1 (de)
DE (1) DE602007008877D1 (de)
ES (1) ES2350865T3 (de)
PL (1) PL2021355T3 (de)
SI (1) SI2021355T1 (de)
SK (1) SK287315B6 (de)
WO (1) WO2007142611A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010058427A2 (en) 2008-11-24 2010-05-27 Reliance Life Sciences Pvt. Ltd. Process for production and purification of polymyxin b sulfate
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
CN101974075A (zh) * 2010-10-12 2011-02-16 山东鲁抗医药股份有限公司 从发酵技术培养物中提取多粘菌素b、e的方法
CN103130875B (zh) * 2011-11-25 2015-06-24 上海医药工业研究院 一种从发酵液中提取多粘菌素b的方法
RU2492180C2 (ru) * 2011-12-07 2013-09-10 Учреждение Российской академии наук Центр "Биоинженерия" РАН Способ получения фармацевтической субстанции полимиксина в
EP2679302A1 (de) 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Selektives Sorptionsmittel für die extrakorporale Blutreinigung
CN102718842B (zh) * 2012-07-16 2013-09-11 河北圣雪大成制药有限责任公司 沉淀法提取硫酸粘菌素的工艺
CN102775477A (zh) * 2012-07-19 2012-11-14 浙江钱江生物化学股份有限公司 一种改善硫酸黏菌素后提取树脂吸附液质量的方法
CN103044529B (zh) * 2012-12-06 2018-01-30 山东鲁抗医药股份有限公司 一种在硫酸多粘菌素b中提取b1单组份的方法
TWI634213B (zh) * 2014-12-18 2018-09-01 財團法人工業技術研究院 誘發微藻細胞自解之活性物質的製造方法、由此方法所獲得之誘發微藻細胞自解之活性物質以及誘發微藻細胞自解的方法
WO2018032505A1 (zh) * 2016-08-19 2018-02-22 湖北瑞昊安科医药科技发展有限公司 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法
JP2019531339A (ja) * 2016-08-19 2019-10-31 湖北瑞昊安科医薬科技発展有限公司 ポリミキシンｂ硫酸塩結晶及びその製造方法
CN116284254B (zh) * 2023-02-28 2023-08-04 黄石曼菲特生物科技有限公司 一种从发酵液中提取高纯度高含量硫酸多粘菌素b单组分的方法

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Also Published As

Publication number Publication date
EP2021355B1 (de) 2010-09-01
SK287315B6 (sk) 2010-06-07
SK832006A3 (sk) 2008-02-05
EP2021355A1 (de) 2009-02-11
US20090253894A1 (en) 2009-10-08
ATE479703T1 (de) 2010-09-15
WO2007142611A1 (en) 2007-12-13
ES2350865T3 (es) 2011-01-27
SI2021355T1 (sl) 2011-01-31
PL2021355T3 (pl) 2011-02-28
US7951913B2 (en) 2011-05-31

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