GB991602A - Antibiotics and their purification - Google Patents

Antibiotics and their purification

Info

Publication number
GB991602A
GB991602A GB895761A GB895761A GB991602A GB 991602 A GB991602 A GB 991602A GB 895761 A GB895761 A GB 895761A GB 895761 A GB895761 A GB 895761A GB 991602 A GB991602 A GB 991602A
Authority
GB
United Kingdom
Prior art keywords
polymyxin
antibiotics
purification
polymyxins
sulphates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB895761A
Inventor
Walter Mark Duffin
Raymond Weddle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB895761A priority Critical patent/GB991602A/en
Priority to CH279762A priority patent/CH399479A/en
Priority to ES0275328A priority patent/ES275328A1/en
Priority to SE263562A priority patent/SE316570B/xx
Priority to BR13702462A priority patent/BR6237024D0/en
Publication of GB991602A publication Critical patent/GB991602A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A polymyxin is purified by a process which comprises treating an aqueous solution of the polymyxin with a permanganate at a pH not above pH 8.0. Examples describe the treatment of solutions of polymyxin B hydrochloride and of the sulphates of polymyxins A, B and E.
GB895761A 1961-03-10 1961-03-10 Antibiotics and their purification Expired GB991602A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB895761A GB991602A (en) 1961-03-10 1961-03-10 Antibiotics and their purification
CH279762A CH399479A (en) 1961-03-10 1962-03-08 Process for purifying polymyxins
ES0275328A ES275328A1 (en) 1961-03-10 1962-03-09 Antibiotics and their purification
SE263562A SE316570B (en) 1961-03-10 1962-03-09
BR13702462A BR6237024D0 (en) 1961-03-10 1962-03-09 PROCESS FOR PURIFICATION OF AN ANTIBIOTIC POLYMIXIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB895761A GB991602A (en) 1961-03-10 1961-03-10 Antibiotics and their purification

Publications (1)

Publication Number Publication Date
GB991602A true GB991602A (en) 1965-05-12

Family

ID=9862573

Family Applications (1)

Application Number Title Priority Date Filing Date
GB895761A Expired GB991602A (en) 1961-03-10 1961-03-10 Antibiotics and their purification

Country Status (5)

Country Link
BR (1) BR6237024D0 (en)
CH (1) CH399479A (en)
ES (1) ES275328A1 (en)
GB (1) GB991602A (en)
SE (1) SE316570B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007142611A1 (en) * 2006-06-02 2007-12-13 Biotika A.S. Method of polymyxin b recovery from fermentation broth
WO2010058427A2 (en) 2008-11-24 2010-05-27 Reliance Life Sciences Pvt. Ltd. Process for production and purification of polymyxin b sulfate
US8119371B2 (en) 2006-06-15 2012-02-21 Biotika A.S. Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa
RU2492180C2 (en) * 2011-12-07 2013-09-10 Учреждение Российской академии наук Центр "Биоинженерия" РАН Method of producing pharmaceutical substance polymyxin b
CN104327167A (en) * 2014-09-28 2015-02-04 河北圣雪大成制药有限责任公司 Technology for extracting polymyxin B through precipitation method

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007142611A1 (en) * 2006-06-02 2007-12-13 Biotika A.S. Method of polymyxin b recovery from fermentation broth
US7951913B2 (en) 2006-06-02 2011-05-31 Biotika A.S. Method of polymyxin B recovery from fermentation broth
US8119371B2 (en) 2006-06-15 2012-02-21 Biotika A.S. Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa
WO2010058427A2 (en) 2008-11-24 2010-05-27 Reliance Life Sciences Pvt. Ltd. Process for production and purification of polymyxin b sulfate
RU2492180C2 (en) * 2011-12-07 2013-09-10 Учреждение Российской академии наук Центр "Биоинженерия" РАН Method of producing pharmaceutical substance polymyxin b
CN104327167A (en) * 2014-09-28 2015-02-04 河北圣雪大成制药有限责任公司 Technology for extracting polymyxin B through precipitation method

Also Published As

Publication number Publication date
ES275328A1 (en) 1962-05-16
CH399479A (en) 1965-09-30
BR6237024D0 (en) 1973-05-24
SE316570B (en) 1969-10-27

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