DE60116081T2 - Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel Download PDF

Info

Publication number
DE60116081T2
DE60116081T2 DE60116081T DE60116081T DE60116081T2 DE 60116081 T2 DE60116081 T2 DE 60116081T2 DE 60116081 T DE60116081 T DE 60116081T DE 60116081 T DE60116081 T DE 60116081T DE 60116081 T2 DE60116081 T2 DE 60116081T2
Authority
DE
Germany
Prior art keywords
compound
formula
alkyl
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60116081T
Other languages
German (de)
English (en)
Other versions
DE60116081D1 (en
Inventor
R. Jason HERR
T. Robert LUM
R. Steven SCHOW
Fanying Meng
R. Michael KOZLOWSKI
Pavel Zhichkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of DE60116081D1 publication Critical patent/DE60116081D1/de
Publication of DE60116081T2 publication Critical patent/DE60116081T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60116081T 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel Expired - Lifetime DE60116081T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
US563181 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (2)

Publication Number Publication Date
DE60116081D1 DE60116081D1 (en) 2006-01-26
DE60116081T2 true DE60116081T2 (de) 2006-08-03

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60116081T Expired - Lifetime DE60116081T2 (de) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
DE60141181T Expired - Lifetime DE60141181D1 (de) 2000-05-02 2001-05-02 Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60141181T Expired - Lifetime DE60141181D1 (de) 2000-05-02 2001-05-02 Bis-(N,N'-bis-(2-haloethyl)amino)-phosphoramidate als anti-Tumormittel

Country Status (25)

Country Link
EP (2) EP1607399B1 (https=)
JP (1) JP4249928B2 (https=)
KR (1) KR100729980B1 (https=)
CN (1) CN1182143C (https=)
AR (1) AR029072A1 (https=)
AT (2) ATE455779T1 (https=)
AU (2) AU6115301A (https=)
BR (1) BR0110553A (https=)
CA (1) CA2407606C (https=)
CZ (1) CZ20023615A3 (https=)
DE (2) DE60116081T2 (https=)
DK (2) DK1278759T3 (https=)
EA (1) EA006852B1 (https=)
ES (2) ES2337154T3 (https=)
HU (1) HUP0300688A3 (https=)
IL (2) IL152325A0 (https=)
MX (1) MXPA02010813A (https=)
NO (2) NO328854B1 (https=)
NZ (1) NZ522189A (https=)
PL (1) PL207005B1 (https=)
PT (1) PT1607399E (https=)
TW (1) TWI308569B (https=)
UA (1) UA74574C2 (https=)
WO (1) WO2001083496A1 (https=)
ZA (1) ZA200208591B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
SI2260111T1 (sl) * 2008-03-14 2015-10-30 Genentech, Inc. Genetske variante, povezane z odpornostjo proti zdravilom
KR20250052506A (ko) 2019-05-13 2025-04-18 아센타위츠 파마슈티컬즈 리미티드 플루오린 함유 화합물 및 이의 항암 의학적 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
EA006852B1 (ru) 2006-04-28
TWI308569B (en) 2009-04-11
HK1050368A1 (en) 2003-06-20
WO2001083496A1 (en) 2001-11-08
PL207005B1 (pl) 2010-10-29
KR100729980B1 (ko) 2007-06-20
NO20025240L (no) 2002-12-04
CA2407606C (en) 2008-07-15
EA200201154A1 (ru) 2003-04-24
MXPA02010813A (es) 2004-02-26
EP1607399B1 (en) 2010-01-20
PT1607399E (pt) 2010-02-02
CN1427844A (zh) 2003-07-02
AU2001261153B2 (en) 2005-04-07
KR20020094000A (ko) 2002-12-16
CN1182143C (zh) 2004-12-29
AR029072A1 (es) 2003-06-04
EP1278759B1 (en) 2005-12-21
NO20025240D0 (no) 2002-11-01
IL152325A0 (en) 2003-05-29
DK1607399T3 (da) 2010-05-10
UA74574C2 (en) 2006-01-16
IL152325A (en) 2011-04-28
CZ20023615A3 (cs) 2003-04-16
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
ATE455779T1 (de) 2010-02-15
AU6115301A (en) 2001-11-12
NZ522189A (en) 2004-04-30
EP1607399A2 (en) 2005-12-21
HK1084119A1 (en) 2006-07-21
ATE313549T1 (de) 2006-01-15
DK1278759T3 (da) 2006-02-13
BR0110553A (pt) 2003-04-01
NO20093371L (no) 2002-12-04
EP1278759A1 (en) 2003-01-29
ZA200208591B (en) 2004-03-04
DE60116081D1 (en) 2006-01-26
PL358155A1 (en) 2004-08-09
NO328854B1 (no) 2010-05-31
NO331833B1 (no) 2012-04-16
CA2407606A1 (en) 2001-11-08
HUP0300688A3 (en) 2005-02-28
DE60141181D1 (de) 2010-03-11
EP1607399A3 (en) 2006-01-04
HUP0300688A2 (hu) 2003-07-28
JP4249928B2 (ja) 2009-04-08
ES2253380T3 (es) 2006-06-01

Similar Documents

Publication Publication Date Title
AT398974B (de) Epipodophyllotoxinglucosid-4'-phosphat-derivate deren herstellung, sowie pharmazeutische zusammensetzungen hierzu
DE1057119B (de) Verfahren zur Herstellung von cyclischen Phosphorsaeure-esteramiden
DD203052A5 (de) Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben
DE2854308A1 (de) Anticholinergische substanzen mit antisekretorischer wirkung, ihre herstellung und verwendung
DE3111428C2 (https=)
DE60116081T2 (de) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
EP0099068B1 (de) Neue Glycerinderivate zur Synthese von Phospholipiden
EP1578754A2 (en) Antiprotozoal ring-substituted phospholipids
US6506739B1 (en) Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
DE69418929T2 (de) Thioxanthenone als Antitumormittel
EP0521353B1 (de) Arzneimittel mit antineoplastischer Wirkung enthaltend als Wirkstoff Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphat und Verfahren zu dessen Herstellung
DE2729165C2 (de) Phenäthylaminderivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE60023182T2 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
EP0579939A1 (de) Neue Phospholipidderivate
DE2318575A1 (de) Neue oxazolidinone
CH492738A (de) Verfahren zur Herstellung von 2-(Bis-(2-chloräthyl)aminophenyl-4- -amino)-2H-1,3,2-oxazaphosphorin-tetrahydro-2-oxid
AU2001261153A1 (en) Bis-(N,N'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
DE3245950A1 (de) Verfahren zur herstellung substituierter pyridine
DE3212387A1 (de) Glycerinphosphatide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
AT393505B (de) Arzneimittel, welche alkylphosphoamine in kombination mit einem alkylglycerin enthalten
DE60004826T2 (de) Dimere ruthenium komplexe für antimetastatische und antineoplastische arzneimittel
DE2606298A1 (de) Derivate der 2-imino- und 2-thioxo- 5-carboxyalkylbarbitursaeure, ihre salze, ihr herstellungsverfahren und pharmazeutische mittel
HK1050368B (en) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
DE3039270A1 (de) 1,5,6,11-tetrahydro-11-(1h-imidazol-1-yl)-benzo(5,6)cyclohepta(1,2-b)pyrazolo(4,3-e)pyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung bei der bekaempfung pathogener pilze und protozoen
CH447146A (de) Verfahren zur Herstellung von Adamantanderivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition