CN1182143C - 双-(n,n′-双-(2-卤代乙基)氨基)氨基磷酸酯作为抗肿瘤剂 - Google Patents

双-(n,n′-双-(2-卤代乙基)氨基)氨基磷酸酯作为抗肿瘤剂 Download PDF

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Publication number
CN1182143C
CN1182143C CNB018089623A CN01808962A CN1182143C CN 1182143 C CN1182143 C CN 1182143C CN B018089623 A CNB018089623 A CN B018089623A CN 01808962 A CN01808962 A CN 01808962A CN 1182143 C CN1182143 C CN 1182143C
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China
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compound
substituted
lower alkyl
heteroaryl
aryl
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Expired - Fee Related
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CNB018089623A
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English (en)
Chinese (zh)
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CN1427844A (zh
Inventor
R��ղɭ������
R·詹森·海若
T��¬������
罗伯特·T·卢穆
R
史蒂文·R·修
R������¬��
孟繁英
ο
迈克尔·R·柯孜卢斯基
帕维尔·治克肯
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Telik Inc
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Telik Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018089623A 2000-05-02 2001-05-02 双-(n,n′-双-(2-卤代乙基)氨基)氨基磷酸酯作为抗肿瘤剂 Expired - Fee Related CN1182143C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
US09/563,181 2000-05-02

Publications (2)

Publication Number Publication Date
CN1427844A CN1427844A (zh) 2003-07-02
CN1182143C true CN1182143C (zh) 2004-12-29

Family

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Family Applications (1)

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CNB018089623A Expired - Fee Related CN1182143C (zh) 2000-05-02 2001-05-02 双-(n,n′-双-(2-卤代乙基)氨基)氨基磷酸酯作为抗肿瘤剂

Country Status (25)

Country Link
EP (2) EP1607399B1 (https=)
JP (1) JP4249928B2 (https=)
KR (1) KR100729980B1 (https=)
CN (1) CN1182143C (https=)
AR (1) AR029072A1 (https=)
AT (2) ATE455779T1 (https=)
AU (2) AU6115301A (https=)
BR (1) BR0110553A (https=)
CA (1) CA2407606C (https=)
CZ (1) CZ20023615A3 (https=)
DE (2) DE60116081T2 (https=)
DK (2) DK1278759T3 (https=)
EA (1) EA006852B1 (https=)
ES (2) ES2337154T3 (https=)
HU (1) HUP0300688A3 (https=)
IL (2) IL152325A0 (https=)
MX (1) MXPA02010813A (https=)
NO (2) NO328854B1 (https=)
NZ (1) NZ522189A (https=)
PL (1) PL207005B1 (https=)
PT (1) PT1607399E (https=)
TW (1) TWI308569B (https=)
UA (1) UA74574C2 (https=)
WO (1) WO2001083496A1 (https=)
ZA (1) ZA200208591B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
SI2260111T1 (sl) * 2008-03-14 2015-10-30 Genentech, Inc. Genetske variante, povezane z odpornostjo proti zdravilom
KR20250052506A (ko) 2019-05-13 2025-04-18 아센타위츠 파마슈티컬즈 리미티드 플루오린 함유 화합물 및 이의 항암 의학적 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
EA006852B1 (ru) 2006-04-28
DE60116081T2 (de) 2006-08-03
TWI308569B (en) 2009-04-11
HK1050368A1 (en) 2003-06-20
WO2001083496A1 (en) 2001-11-08
PL207005B1 (pl) 2010-10-29
KR100729980B1 (ko) 2007-06-20
NO20025240L (no) 2002-12-04
CA2407606C (en) 2008-07-15
EA200201154A1 (ru) 2003-04-24
MXPA02010813A (es) 2004-02-26
EP1607399B1 (en) 2010-01-20
PT1607399E (pt) 2010-02-02
CN1427844A (zh) 2003-07-02
AU2001261153B2 (en) 2005-04-07
KR20020094000A (ko) 2002-12-16
AR029072A1 (es) 2003-06-04
EP1278759B1 (en) 2005-12-21
NO20025240D0 (no) 2002-11-01
IL152325A0 (en) 2003-05-29
DK1607399T3 (da) 2010-05-10
UA74574C2 (en) 2006-01-16
IL152325A (en) 2011-04-28
CZ20023615A3 (cs) 2003-04-16
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
ATE455779T1 (de) 2010-02-15
AU6115301A (en) 2001-11-12
NZ522189A (en) 2004-04-30
EP1607399A2 (en) 2005-12-21
HK1084119A1 (en) 2006-07-21
ATE313549T1 (de) 2006-01-15
DK1278759T3 (da) 2006-02-13
BR0110553A (pt) 2003-04-01
NO20093371L (no) 2002-12-04
EP1278759A1 (en) 2003-01-29
ZA200208591B (en) 2004-03-04
DE60116081D1 (en) 2006-01-26
PL358155A1 (en) 2004-08-09
NO328854B1 (no) 2010-05-31
NO331833B1 (no) 2012-04-16
CA2407606A1 (en) 2001-11-08
HUP0300688A3 (en) 2005-02-28
DE60141181D1 (de) 2010-03-11
EP1607399A3 (en) 2006-01-04
HUP0300688A2 (hu) 2003-07-28
JP4249928B2 (ja) 2009-04-08
ES2253380T3 (es) 2006-06-01

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