DE4410997A1 - Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen - Google Patents

Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen

Info

Publication number
DE4410997A1
DE4410997A1 DE4410997A DE4410997A DE4410997A1 DE 4410997 A1 DE4410997 A1 DE 4410997A1 DE 4410997 A DE4410997 A DE 4410997A DE 4410997 A DE4410997 A DE 4410997A DE 4410997 A1 DE4410997 A1 DE 4410997A1
Authority
DE
Germany
Prior art keywords
stimulators
nitrogen monoxide
compounds
guanylate cyclase
endothelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4410997A
Other languages
German (de)
English (en)
Inventor
Eike Albrecht Noack
Georg Dr Rer Nat Kojda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Puren Pharma GmbH and Co KG
Original Assignee
Isis Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharma GmbH filed Critical Isis Pharma GmbH
Priority to DE4410997A priority Critical patent/DE4410997A1/de
Priority to EP95914275A priority patent/EP0752858A1/de
Priority to CZ962836A priority patent/CZ283696A3/cs
Priority to HU9602671A priority patent/HU220165B/hu
Priority to AU21345/95A priority patent/AU698359C/en
Priority to DE19580261T priority patent/DE19580261D2/de
Priority to CN95193401A priority patent/CN1150387A/zh
Priority to SK1218-96A priority patent/SK121896A3/sk
Priority to PCT/DE1995/000421 priority patent/WO1995026725A1/de
Priority to JP7525343A priority patent/JPH09510979A/ja
Priority to SI9520047A priority patent/SI9520047A/sl
Priority to CA002186783A priority patent/CA2186783A1/en
Priority to EE9600139A priority patent/EE9600139A/xx
Priority to PL95316528A priority patent/PL316528A1/xx
Priority to MX9604434A priority patent/MX9604434A/es
Publication of DE4410997A1 publication Critical patent/DE4410997A1/de
Priority to LVP-96-378A priority patent/LV11666B/lv
Priority to IS4365A priority patent/IS4365A/is
Priority to FI963883A priority patent/FI963883A/fi
Priority to NO964102A priority patent/NO964102D0/no
Priority to US08/721,465 priority patent/US5973011A/en
Priority to LT96-148A priority patent/LT4310B/lt
Priority to BG100930A priority patent/BG63073B1/bg
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE4410997A 1994-03-30 1994-03-30 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen Withdrawn DE4410997A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4410997A DE4410997A1 (de) 1994-03-30 1994-03-30 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
HU9602671A HU220165B (hu) 1994-03-30 1995-03-28 Endoteliális zavarok megelőzésére és kezelésére alkalmas gyógyászati készítmények
SI9520047A SI9520047A (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
CA002186783A CA2186783A1 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicinal substances for the prevention and treatment of endothelial dysfunctions
AU21345/95A AU698359C (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicinal substances for the prevention and treatment of endothelial dysfunctions
DE19580261T DE19580261D2 (de) 1994-03-30 1995-03-28 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktion
CN95193401A CN1150387A (zh) 1994-03-30 1995-03-28 防治内皮机能不良的药物及药物制剂
SK1218-96A SK121896A3 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
PCT/DE1995/000421 WO1995026725A1 (de) 1994-03-30 1995-03-28 Pharmazeutische zubereitingen und arzneistoffe zur prävention und behandlung endothelialer dysfunktion
JP7525343A JPH09510979A (ja) 1994-03-30 1995-03-28 内皮性機能障害の予防および治療用医薬製剤および医薬品
PL95316528A PL316528A1 (en) 1994-03-30 1995-03-28 Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders
EP95914275A EP0752858A1 (de) 1994-03-30 1995-03-28 Pharmazeutische zubereitingen und arzneistoffe zur prävention und behandlung endothelialer dysfunktion
EE9600139A EE9600139A (et) 1994-03-30 1995-03-28 Farmatseutilised preparaadid ja ravimid endoteelsete düsfunktsioonide vältimiseks ja raviks
CZ962836A CZ283696A3 (cs) 1994-03-30 1995-03-28 Farmaceutické prostředky a léčivo pro prevenci a léčení endotheliálních dysfunkcí
MX9604434A MX9604434A (es) 1994-03-30 1995-03-28 Productos farmaceuticos y medicamentos para la prevencion y el tratamiento de disfunciones endoteliales.
LVP-96-378A LV11666B (en) 1994-03-30 1996-09-19 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
IS4365A IS4365A (is) 1994-03-30 1996-09-25 Lyfjablöndur og lyf til að hindra og meðhöndla starfstruflun í innanþekju (endothelial dysfunctions)
FI963883A FI963883A (fi) 1994-03-30 1996-09-27 Farmaseuttisia valmisteita ja lääkeaineita endoteelin toimintahäiriön ehkäisemiseksi ja hoitamiseksi
US08/721,465 US5973011A (en) 1994-03-30 1996-09-27 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
NO964102A NO964102D0 (no) 1994-03-30 1996-09-27 Farmasöytiske preparater og medikamenter for forebyggelse og behandling av endotheliale dysfunksjoner
LT96-148A LT4310B (lt) 1994-03-30 1996-10-22 Farmaciniai preparatai ir vaistai endotelio disfunkcijų profilaktikai ir gydymui
BG100930A BG63073B1 (bg) 1994-03-30 1996-10-22 Фармацевтични състави и лекарствени средства за профилактика и лечение на ендотелиални нарушения

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4410997A DE4410997A1 (de) 1994-03-30 1994-03-30 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen

Publications (1)

Publication Number Publication Date
DE4410997A1 true DE4410997A1 (de) 1995-10-26

Family

ID=6514213

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4410997A Withdrawn DE4410997A1 (de) 1994-03-30 1994-03-30 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
DE19580261T Expired - Lifetime DE19580261D2 (de) 1994-03-30 1995-03-28 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktion

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19580261T Expired - Lifetime DE19580261D2 (de) 1994-03-30 1995-03-28 Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktion

Country Status (19)

Country Link
EP (1) EP0752858A1 (fi)
JP (1) JPH09510979A (fi)
CN (1) CN1150387A (fi)
BG (1) BG63073B1 (fi)
CA (1) CA2186783A1 (fi)
CZ (1) CZ283696A3 (fi)
DE (2) DE4410997A1 (fi)
EE (1) EE9600139A (fi)
FI (1) FI963883A (fi)
HU (1) HU220165B (fi)
IS (1) IS4365A (fi)
LT (1) LT4310B (fi)
LV (1) LV11666B (fi)
MX (1) MX9604434A (fi)
NO (1) NO964102D0 (fi)
PL (1) PL316528A1 (fi)
SI (1) SI9520047A (fi)
SK (1) SK121896A3 (fi)
WO (1) WO1995026725A1 (fi)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604361A1 (de) * 1996-02-07 1997-08-14 Sanol Arznei Schwarz Gmbh Pharmazeutische Zusammensetzung
DE19726812A1 (de) * 1997-06-25 1999-01-07 Isis Pharma Gmbh Neue Derivate des Pentaerythrits, deren Herstellung und Verwendung sowie Intermediate zur Synthese derselben
DE19745622A1 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Neue Salpetersäureester des Pentaerythrits
WO1999018930A2 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Pharmazeutische zubereitungen
RU2467748C1 (ru) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее эндотелиопротекторной активностью

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
DE19654895C2 (de) * 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh Detektionsverfahren
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
DE69830069T3 (de) * 1997-10-17 2012-02-09 Ark Therapeutics Ltd. Verwendung von hemmern des renin-angiotensin systems zur behandlung von hypoxie oder verringertem stoffwechsel
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
EP1087926A2 (de) * 1998-06-24 2001-04-04 Alpharma-Isis GmbH & Co. KG Analytische substrate und antioxidative mittel
US6465463B1 (en) 1999-09-08 2002-10-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
WO2001035961A1 (en) 1999-10-29 2001-05-25 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
WO2008124505A2 (en) * 2007-04-05 2008-10-16 Ironwood Pharmaceuticals,Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
MA34330B1 (fr) * 2010-05-27 2013-06-01 Merck Sharp & Dohme Activateurs de guanylate cyclase soluble
JP5360939B2 (ja) * 2011-09-28 2013-12-04 国立大学法人徳島大学 ニトロソニフェジピン誘導体を有効成分とする動脈硬化症治療剤

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR984523A (fr) * 1949-02-10 1951-07-06 Phosphate de trinitro-triéthanolamine et procédé de préparation
DE2221080A1 (de) * 1971-04-29 1972-11-09 American Home Prod 1,4 : 3,6-Dianhydro-D-Glucitolmononitratester,Verfahren zu ihrer Herstellung und ihreVerwendung
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
DE2623800B2 (de) * 1976-05-28 1978-03-23 Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf Übersättigte wässerige Isosorbiddinitrat-Lösung, Herstellungsverfahren und Verwendung
DE1695897B2 (de) * 1966-07-04 1978-04-20 Takeda Chemical Industries Ltd N-Acyl-sydnonimine deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2532124B2 (de) * 1975-07-18 1978-08-10 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Verfahren zur Herstellung von 4-Amino-morpholin
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE2903927C2 (de) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat
EP0045076A1 (de) * 1980-07-30 1982-02-03 Roche Diagnostics GmbH Verfahren zur Herstellung von 1,4:3,6-Dianhydro-D-glucit-5-nitrat (Isosorbid-5-nitrat)
EP0057847A1 (de) * 1981-01-29 1982-08-18 Heinrich Mack Nachf. Verfahren zur Herstellung von Isosorbid-5-nitrat
EP0059664A1 (fr) * 1981-02-27 1982-09-08 Societe Nationale Des Poudres Et Explosifs Procédé de synthèse des mononitrates d'isosorbide
EP0064194A2 (de) * 1981-05-05 1982-11-10 CASSELLA Aktiengesellschaft Verfahren zur Herstellung von Isosorbid-5-nitrat
EP0067964A2 (de) * 1981-06-22 1982-12-29 Heinrich Mack Nachf. Verfahren zur Herstellung von Isosorbid-2-nitrat
JPS5910513A (ja) * 1982-07-12 1984-01-20 Nitto Electric Ind Co Ltd 医薬製剤
DE3325652A1 (de) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung
DE3328094A1 (de) * 1983-08-04 1985-02-21 H. Trommsdorff GmbH & Co, 5110 Alsdorf Phlegmatisierte pharmazeutische zubereitung von explosionsfaehigen salpetersaeureestern
EP0143507A1 (en) * 1983-11-25 1985-06-05 TOSHIN CHEMICAL CO., Ltd. A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof
DD244980A1 (de) * 1985-12-18 1987-04-22 Isis Chemie Zwickau Veb Verfahren zur herstellung von n-morpholinoaminoacetonitril und dessen hydrochlorid
DD293492A5 (de) * 1987-11-26 1991-09-05 Isis-Chemie Gmbh,De Verfahren zur herstellung einer glyceroltrinitrat-arzneiform mit gleichmaessig verzoegerter arzneistofffreisetzung
DE4007705C1 (fi) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4038203A1 (de) * 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen
WO1992018002A1 (en) * 1991-04-10 1992-10-29 Brigham And Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof

Patent Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR984523A (fr) * 1949-02-10 1951-07-06 Phosphate de trinitro-triéthanolamine et procédé de préparation
DE1695897B2 (de) * 1966-07-04 1978-04-20 Takeda Chemical Industries Ltd N-Acyl-sydnonimine deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2221080A1 (de) * 1971-04-29 1972-11-09 American Home Prod 1,4 : 3,6-Dianhydro-D-Glucitolmononitratester,Verfahren zu ihrer Herstellung und ihreVerwendung
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
DE2532124B2 (de) * 1975-07-18 1978-08-10 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Verfahren zur Herstellung von 4-Amino-morpholin
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE2623800B2 (de) * 1976-05-28 1978-03-23 Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf Übersättigte wässerige Isosorbiddinitrat-Lösung, Herstellungsverfahren und Verwendung
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
DE2751934A1 (de) * 1977-02-24 1978-08-31 American Home Prod Verfahren zur herstellung von 1,4 zu 3,6-dianhydro-d-glucit-2-nitrat
DE2903927C2 (de) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat
EP0045076A1 (de) * 1980-07-30 1982-02-03 Roche Diagnostics GmbH Verfahren zur Herstellung von 1,4:3,6-Dianhydro-D-glucit-5-nitrat (Isosorbid-5-nitrat)
DE3028873A1 (de) * 1980-07-30 1982-02-11 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von 1,4 zu 3,6-dianhydro-d-glucit-5-nitrat (isosorbid-5-nitrat)
US4431829A (en) * 1980-07-30 1984-02-14 Boehringer Mannheim Gmbh Process for the preparation of 1,4:3,6-dianhydro-D glucitol 5-nitrate
EP0057847A1 (de) * 1981-01-29 1982-08-18 Heinrich Mack Nachf. Verfahren zur Herstellung von Isosorbid-5-nitrat
DE3102947A1 (de) * 1981-01-29 1982-09-02 Heinrich Mack Nachf., 7918 Illertissen Verfahren zur herstellung von isosorbid-5-nitrat
EP0059664A1 (fr) * 1981-02-27 1982-09-08 Societe Nationale Des Poudres Et Explosifs Procédé de synthèse des mononitrates d'isosorbide
EP0064194A2 (de) * 1981-05-05 1982-11-10 CASSELLA Aktiengesellschaft Verfahren zur Herstellung von Isosorbid-5-nitrat
EP0067964A2 (de) * 1981-06-22 1982-12-29 Heinrich Mack Nachf. Verfahren zur Herstellung von Isosorbid-2-nitrat
DE3124410A1 (de) * 1981-06-22 1983-01-05 Heinrich Mack Nachf., 7918 Illertissen Verfahren zur herstellung von isosorbid-2-nitrat
US4417065A (en) * 1981-06-22 1983-11-22 Heinrich Mack Nachf. Chem.-Pharmazeutische Fabrik Process for the preparation of isosorbide 2-nitrate
JPS5910513A (ja) * 1982-07-12 1984-01-20 Nitto Electric Ind Co Ltd 医薬製剤
DE3325652A1 (de) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung
DE3328094A1 (de) * 1983-08-04 1985-02-21 H. Trommsdorff GmbH & Co, 5110 Alsdorf Phlegmatisierte pharmazeutische zubereitung von explosionsfaehigen salpetersaeureestern
EP0143507A1 (en) * 1983-11-25 1985-06-05 TOSHIN CHEMICAL CO., Ltd. A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof
DD244980A1 (de) * 1985-12-18 1987-04-22 Isis Chemie Zwickau Veb Verfahren zur herstellung von n-morpholinoaminoacetonitril und dessen hydrochlorid
DD293492A5 (de) * 1987-11-26 1991-09-05 Isis-Chemie Gmbh,De Verfahren zur herstellung einer glyceroltrinitrat-arzneiform mit gleichmaessig verzoegerter arzneistofffreisetzung
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4007705C1 (fi) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4038203A1 (de) * 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen
WO1992018002A1 (en) * 1991-04-10 1992-10-29 Brigham And Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
Brunton, Lancet 97(1867) *
FEELISCH, et.al.: Biochem. Pharmacol. 44(1992), S. 1149-1157 *
GOLDBERG, L.: Acta Physiol. Scand. 15(1948), S. 173 *
HARRISON, et.al.: Circulation 87(1993), S. 1461-1467 *
JGNARRO, et.al.: Proc. Natl. Acad. Sci. 84 *
KARCZEWSLEI, et.al.: Z. Kardiol. 79(Supp. 1), 1990, S. 212 *
KOJDA, et.al.: Endothelium 1(Supp.) Abstract 299, S. 76(1993) *
MEDARD, Mem.Poudres 35(1953), S. 113 *
NOACK und FEELISCH: "Endothelial Meclanisms of Vasomotor Control", Hrsg. Drexler, et.al., Steintzopff, Darmstadt, 1991, S. 37-50 *
NOACK, et.al.: Neuroprotocols 1(1992), S. 133-139 *
NOACK: Nitroglycerin VII, W.de Gruyter + Co, Berlin 1991, S. 23-28 *
PALMER, et.al.: Nature 327(1987), S. 524-526 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604361A1 (de) * 1996-02-07 1997-08-14 Sanol Arznei Schwarz Gmbh Pharmazeutische Zusammensetzung
DE19604361C2 (de) * 1996-02-07 1999-01-14 Sanol Arznei Schwarz Gmbh Verwendung gasdichter Primärpackmittel für pharmazeutische Zusammensetzungen
DE19726812A1 (de) * 1997-06-25 1999-01-07 Isis Pharma Gmbh Neue Derivate des Pentaerythrits, deren Herstellung und Verwendung sowie Intermediate zur Synthese derselben
DE19745622A1 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Neue Salpetersäureester des Pentaerythrits
WO1999018930A2 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Pharmazeutische zubereitungen
WO1999020638A1 (de) * 1997-10-16 1999-04-29 Isis Pharma Gmbh Neue salpetersäureester des pentaerythrits
WO1999018930A3 (de) * 1997-10-16 1999-10-07 Isis Pharma Gmbh Pharmazeutische zubereitungen
CZ301265B6 (cs) * 1997-10-16 2009-12-23 Actavis Deutschland Gmbh & Co. Kg Farmaceutický prípravek obsahující pentaerythrityltetra-, -tri-, -di- nebo -mononitrát, zpusob jeho prípravy a použití
RU2467748C1 (ru) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее эндотелиопротекторной активностью

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