DE3751978T2 - Dihydropyridin-Derivate, ihre Herstellung und ihre Anwendung - Google Patents

Dihydropyridin-Derivate, ihre Herstellung und ihre Anwendung

Info

Publication number
DE3751978T2
DE3751978T2 DE3751978T DE3751978T DE3751978T2 DE 3751978 T2 DE3751978 T2 DE 3751978T2 DE 3751978 T DE3751978 T DE 3751978T DE 3751978 T DE3751978 T DE 3751978T DE 3751978 T2 DE3751978 T2 DE 3751978T2
Authority
DE
Germany
Prior art keywords
group
alkyl
substituent selected
alkoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751978T
Other languages
English (en)
Other versions
DE3751978D1 (de
Inventor
Hiroyuki Koike
Masafumi Yoshimoto
Hiroshi Nishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE3751978D1 publication Critical patent/DE3751978D1/de
Publication of DE3751978T2 publication Critical patent/DE3751978T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3751978T 1986-10-09 1987-10-09 Dihydropyridin-Derivate, ihre Herstellung und ihre Anwendung Expired - Lifetime DE3751978T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24025486 1986-10-09

Publications (2)

Publication Number Publication Date
DE3751978D1 DE3751978D1 (de) 1997-01-23
DE3751978T2 true DE3751978T2 (de) 1997-07-03

Family

ID=17056752

Family Applications (2)

Application Number Title Priority Date Filing Date
DE87308976T Expired - Lifetime DE3787346T2 (de) 1986-10-09 1987-10-09 Dihydropyridin-Derivate, ihre Herstellung und ihre Verwendung.
DE3751978T Expired - Lifetime DE3751978T2 (de) 1986-10-09 1987-10-09 Dihydropyridin-Derivate, ihre Herstellung und ihre Anwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE87308976T Expired - Lifetime DE3787346T2 (de) 1986-10-09 1987-10-09 Dihydropyridin-Derivate, ihre Herstellung und ihre Verwendung.

Country Status (20)

Country Link
US (1) US4772596A (de)
EP (2) EP0529702B1 (de)
JP (1) JPS63253082A (de)
KR (1) KR920004483B1 (de)
CN (1) CN1017897B (de)
AT (2) ATE146169T1 (de)
AU (1) AU600038B2 (de)
CA (1) CA1309098C (de)
DE (2) DE3787346T2 (de)
DK (1) DK170891B1 (de)
ES (2) ES2097859T3 (de)
FI (1) FI90543C (de)
GR (1) GR3022301T3 (de)
HK (2) HK1005727A1 (de)
HU (1) HU199454B (de)
IE (1) IE63111B1 (de)
NO (1) NO170084C (de)
NZ (1) NZ222106A (de)
RU (1) RU1831476C (de)
ZA (1) ZA877518B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
AU2001246883B2 (en) * 2000-04-11 2004-08-12 Sankyo Company, Limited Stabilized pharmaceutical compositions containing calcium channel blockers
CA2420844A1 (en) * 2000-08-30 2003-02-28 Sankyo Company, Limited Medicinal compositions for preventing or treating heart failure
KR101008871B1 (ko) * 2002-12-24 2011-01-17 우베 고산 가부시키가이샤 광학 활성 디히드로피리딘 유도체
JP4546726B2 (ja) * 2002-12-24 2010-09-15 宇部興産株式会社 光学活性なジヒドロピリジン誘導体
NZ541454A (en) 2003-01-31 2008-04-30 Daiichi Sankyo Co Ltd Medicine for prevention of and treatment for arteriosclerosis and hypertension
JP4629973B2 (ja) * 2003-09-22 2011-02-09 第一三共株式会社 光学活性シクロプロピルアミン誘導体およびその製造方法
HUE025625T2 (en) 2003-12-12 2016-04-28 Daiichi Sankyo Co Ltd Intermediates for the preparation of optically active cyclopropylamine derivatives and a process for the preparation of intermediates
CA2612384A1 (en) * 2005-06-15 2006-12-28 Elan Pharma International, Limited Nanoparticulate azelnidipine formulations
WO2007001066A1 (en) * 2005-06-27 2007-01-04 Daiichi Sankyo Company, Limited Pharmaceutical preparation containing an angiotensin ii receptor antagonist and a calcium channel blocker
CN100352818C (zh) * 2005-09-23 2007-12-05 四川科伦药业股份有限公司 一种改进的制备阿折地平的方法
TW200806648A (en) 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
JP2008290988A (ja) * 2007-05-28 2008-12-04 Ube Ind Ltd 光学活性なジヒドロピリジン誘導体の酸付加塩を含有する医薬
JP2008290989A (ja) * 2007-05-28 2008-12-04 Ube Ind Ltd ジヒドロピリジン誘導体の酸付加塩を含有する医薬
IT1391113B1 (it) * 2008-09-30 2011-11-18 Dipharma Francis Srl Procedimento per la preparazione di azelnidipina cristallina
JP5463051B2 (ja) * 2009-02-17 2014-04-09 相模化成工業株式会社 １，４―ジヒドロピリジン誘導体の製造法
CN101863879B (zh) * 2009-04-16 2012-12-19 四川科伦药物研究有限公司 一种α晶型阿折地平的制备方法
JP2011006379A (ja) * 2009-05-26 2011-01-13 Tokuyama Corp ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝（アゼルニジピン）の再結晶方法、アゼルニジピンのイソプロピルアルコール付加体、およびアゼルニジピンの製造方法
JP2011105649A (ja) * 2009-11-18 2011-06-02 Daito Kk アゼルニジピンの結晶
JP5637710B2 (ja) * 2010-03-24 2014-12-10 株式会社トクヤマ ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
JP2012020970A (ja) * 2010-07-15 2012-02-02 Tokuyama Corp ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
EP2703398B1 (de) * 2011-04-29 2017-12-13 Xuanzhu Pharma Co., Ltd. 1,4-dihydropyridin-3,5-dicarboxylatderivate sowie herstellungsverfahren dafür und anwendungen davon
JP5917034B2 (ja) * 2011-07-15 2016-05-11 ニプロ株式会社 カルシウムブロッカーを含有する固形医薬組成物
AU2012303683B2 (en) 2011-08-26 2016-09-08 Wockhardt Limited Methods for treating cardiovascular disorders
CN102329259B (zh) * 2011-10-21 2013-09-18 南京工业大学 (1-二苯甲基-3-吖丁啶醇)氰基乙酸酯的制备方法
CN102382104A (zh) * 2011-11-21 2012-03-21 山东新华制药股份有限公司 α晶型阿折地平的制备方法
CN103319457B (zh) * 2012-03-20 2016-01-27 北京晶润宏达医药科技有限公司 阿折地平γ晶型的制备方法
WO2017063307A1 (zh) * 2015-10-13 2017-04-20 山东轩竹医药科技有限公司 1，4-二氢吡啶-3，5-二羧酸酯衍生物的制备方法及中间体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
US3935223A (en) * 1972-03-06 1976-01-27 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
GB1455502A (en) * 1973-02-20 1976-11-10 Yamanouchi Pharma Co Ltd 1,4-dihydropyridine derivatives
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
EP0125803A3 (de) * 1983-04-27 1987-01-21 FISONS plc Pharmazeutisch aktive Dihydropyridine
GB8314744D0 (en) * 1983-05-27 1983-07-06 Fujisawa Pharmaceutical Co 2 6-disubstituted-1 4-dihydropyridine derivative
US4603135A (en) * 1983-10-17 1986-07-29 Takeda Chemical Industries, Ltd. Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
ES8708211A1 (es) * 1985-06-14 1987-10-01 Sankyo Co Un procedimiento para la preparacion de nuevos derivados de 4-(fenil sustituido)-1,4-dihidropiridina.

Also Published As

Publication number Publication date
NO874219L (no) 1988-04-11
KR880005078A (ko) 1988-06-27
DK170891B1 (da) 1996-03-04
ATE94162T1 (de) 1993-09-15
NZ222106A (en) 1989-12-21
HUT47268A (en) 1989-02-28
GR3022301T3 (en) 1997-04-30
DK529987A (da) 1988-04-10
NO874219D0 (no) 1987-10-09
KR920004483B1 (ko) 1992-06-05
JPS63253082A (ja) 1988-10-20
EP0266922B1 (de) 1993-09-08
DE3751978D1 (de) 1997-01-23
IE872706L (en) 1988-04-09
ES2059391T3 (es) 1994-11-16
DK529987D0 (da) 1987-10-09
CN1017897B (zh) 1992-08-19
AU600038B2 (en) 1990-08-02
IE63111B1 (en) 1995-03-22
FI90543B (fi) 1993-11-15
EP0266922A1 (de) 1988-05-11
DE3787346T2 (de) 1994-04-21
FI874451A (fi) 1988-04-10
CN87107150A (zh) 1988-05-04
AU7953787A (en) 1988-04-14
CA1309098C (en) 1992-10-20
HU199454B (en) 1990-02-28
RU1831476C (ru) 1993-07-30
HK1005726A1 (en) 1999-01-22
FI90543C (fi) 1994-02-25
EP0529702B1 (de) 1996-12-11
HK1005727A1 (en) 1999-01-22
NO170084B (no) 1992-06-01
FI874451A0 (fi) 1987-10-09
DE3787346D1 (de) 1993-10-14
NO170084C (no) 1992-09-09
ZA877518B (en) 1989-06-28
US4772596A (en) 1988-09-20
ES2097859T3 (es) 1997-04-16
ATE146169T1 (de) 1996-12-15
JPH0331715B2 (de) 1991-05-08
EP0529702A1 (de) 1993-03-03

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Legal Events

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