DK529987A - Dihydropyridinderivater og fremgangsmaade til fremstilling deraf samt deres anvendelse - Google Patents
Dihydropyridinderivater og fremgangsmaade til fremstilling deraf samt deres anvendelseInfo
- Publication number
- DK529987A DK529987A DK529987A DK529987A DK529987A DK 529987 A DK529987 A DK 529987A DK 529987 A DK529987 A DK 529987A DK 529987 A DK529987 A DK 529987A DK 529987 A DK529987 A DK 529987A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl
- substituent selected
- alkoxy
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24025486 | 1986-10-09 | ||
JP24025486 | 1986-10-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK529987D0 DK529987D0 (da) | 1987-10-09 |
DK529987A true DK529987A (da) | 1988-04-10 |
DK170891B1 DK170891B1 (da) | 1996-03-04 |
Family
ID=17056752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK529987A DK170891B1 (da) | 1986-10-09 | 1987-10-09 | 1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem |
Country Status (20)
Country | Link |
---|---|
US (1) | US4772596A (da) |
EP (2) | EP0529702B1 (da) |
JP (1) | JPS63253082A (da) |
KR (1) | KR920004483B1 (da) |
CN (1) | CN1017897B (da) |
AT (2) | ATE146169T1 (da) |
AU (1) | AU600038B2 (da) |
CA (1) | CA1309098C (da) |
DE (2) | DE3751978T2 (da) |
DK (1) | DK170891B1 (da) |
ES (2) | ES2059391T3 (da) |
FI (1) | FI90543C (da) |
GR (1) | GR3022301T3 (da) |
HK (2) | HK1005727A1 (da) |
HU (1) | HU199454B (da) |
IE (1) | IE63111B1 (da) |
NO (1) | NO170084C (da) |
NZ (1) | NZ222106A (da) |
RU (1) | RU1831476C (da) |
ZA (1) | ZA877518B (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671349B1 (fr) * | 1991-01-09 | 1993-04-23 | Lafon Labor | Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant. |
US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
RU2239432C2 (ru) * | 2000-04-11 | 2004-11-10 | Санкио Компани Лимитед, Убе Индастриз, Лтд. | Стабилизированная фармацевтическая композиция, содержащая блокатор кальция |
CA2420844A1 (en) * | 2000-08-30 | 2003-02-28 | Sankyo Company, Limited | Medicinal compositions for preventing or treating heart failure |
PL375996A1 (en) * | 2002-12-24 | 2005-12-12 | Sankyo Company, Limited | Optically active dihydropyridine derivative |
JP4546726B2 (ja) * | 2002-12-24 | 2010-09-15 | 宇部興産株式会社 | 光学活性なジヒドロピリジン誘導体 |
EP1604664A4 (en) | 2003-01-31 | 2006-12-27 | Sankyo Co | MEDICAMENT FOR THE PREVENTION AND TREATMENT OF ARTERIOSCLEROSIS AND BLOOD HIGH PRESSURE |
JP4629973B2 (ja) * | 2003-09-22 | 2011-02-09 | 第一三共株式会社 | 光学活性シクロプロピルアミン誘導体およびその製造方法 |
ES2537976T3 (es) | 2003-12-12 | 2015-06-16 | Daiichi Sankyo Company, Limited | Compuestos intermedios para la producción de derivados de ciclopropilamina ópticamente activos y procedimiento para la producción de los compuestos intermedios |
JP2008543862A (ja) * | 2005-06-15 | 2008-12-04 | エラン ファーマ インターナショナル リミテッド | ナノ粒子アゼルニジピン製剤 |
JP5148296B2 (ja) * | 2005-06-27 | 2013-02-20 | 第一三共株式会社 | アンジオテンシンii受容体拮抗剤及びカルシウム拮抗剤含有医薬組成物 |
CN100352818C (zh) * | 2005-09-23 | 2007-12-05 | 四川科伦药业股份有限公司 | 一种改进的制备阿折地平的方法 |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
TWI399223B (zh) * | 2006-09-15 | 2013-06-21 | Daiichi Sankyo Co Ltd | 奧美沙坦酯及氨氯地平之固體劑型 |
JP2008290988A (ja) * | 2007-05-28 | 2008-12-04 | Ube Ind Ltd | 光学活性なジヒドロピリジン誘導体の酸付加塩を含有する医薬 |
JP2008290989A (ja) * | 2007-05-28 | 2008-12-04 | Ube Ind Ltd | ジヒドロピリジン誘導体の酸付加塩を含有する医薬 |
IT1391113B1 (it) * | 2008-09-30 | 2011-11-18 | Dipharma Francis Srl | Procedimento per la preparazione di azelnidipina cristallina |
JP5463051B2 (ja) * | 2009-02-17 | 2014-04-09 | 相模化成工業株式会社 | 1,4―ジヒドロピリジン誘導体の製造法 |
CN101863879B (zh) * | 2009-04-16 | 2012-12-19 | 四川科伦药物研究有限公司 | 一种α晶型阿折地平的制备方法 |
JP2011006379A (ja) * | 2009-05-26 | 2011-01-13 | Tokuyama Corp | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}(アゼルニジピン)の再結晶方法、アゼルニジピンのイソプロピルアルコール付加体、およびアゼルニジピンの製造方法 |
JP2011105649A (ja) * | 2009-11-18 | 2011-06-02 | Daito Kk | アゼルニジピンの結晶 |
JP5637710B2 (ja) * | 2010-03-24 | 2014-12-10 | 株式会社トクヤマ | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
JP2012020970A (ja) * | 2010-07-15 | 2012-02-02 | Tokuyama Corp | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
EP2703398B1 (en) * | 2011-04-29 | 2017-12-13 | Xuanzhu Pharma Co., Ltd. | 1,4-dihydropyridine -3,5-dicarboxylate derivatives, preparation methods and uses thereof |
JP5917034B2 (ja) * | 2011-07-15 | 2016-05-11 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
CA2846387C (en) | 2011-08-26 | 2016-02-09 | Wockhardt Limited | Methods for treating cardiovascular disorders |
CN102329259B (zh) * | 2011-10-21 | 2013-09-18 | 南京工业大学 | (1-二苯甲基-3-吖丁啶醇)氰基乙酸酯的制备方法 |
CN102382104A (zh) * | 2011-11-21 | 2012-03-21 | 山东新华制药股份有限公司 | α晶型阿折地平的制备方法 |
CN103319457B (zh) * | 2012-03-20 | 2016-01-27 | 北京晶润宏达医药科技有限公司 | 阿折地平γ晶型的制备方法 |
WO2017063307A1 (zh) * | 2015-10-13 | 2017-04-20 | 山东轩竹医药科技有限公司 | 1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备方法及中间体 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2003146A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
US3935223A (en) * | 1972-03-06 | 1976-01-27 | Bayer Aktiengesellschaft | 2-Amino-1,4-dihydropyridine derivatives |
GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS5970666A (ja) * | 1982-10-15 | 1984-04-21 | Kyowa Hakko Kogyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
GB8314744D0 (en) * | 1983-05-27 | 1983-07-06 | Fujisawa Pharmaceutical Co | 2 6-disubstituted-1 4-dihydropyridine derivative |
US4603135A (en) * | 1983-10-17 | 1986-07-29 | Takeda Chemical Industries, Ltd. | Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates |
JPS6289662A (ja) * | 1985-06-14 | 1987-04-24 | Sankyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
-
1987
- 1987-10-05 US US07/105,388 patent/US4772596A/en not_active Expired - Lifetime
- 1987-10-06 KR KR1019870011142A patent/KR920004483B1/ko not_active IP Right Cessation
- 1987-10-07 ZA ZA877518A patent/ZA877518B/xx unknown
- 1987-10-08 RU SU874203529A patent/RU1831476C/ru active
- 1987-10-08 JP JP62254085A patent/JPS63253082A/ja active Granted
- 1987-10-09 NZ NZ222106A patent/NZ222106A/xx unknown
- 1987-10-09 IE IE270687A patent/IE63111B1/en not_active IP Right Cessation
- 1987-10-09 CN CN87107150A patent/CN1017897B/zh not_active Expired
- 1987-10-09 AT AT92202251T patent/ATE146169T1/de not_active IP Right Cessation
- 1987-10-09 ES ES87308976T patent/ES2059391T3/es not_active Expired - Lifetime
- 1987-10-09 AT AT87308976T patent/ATE94162T1/de not_active IP Right Cessation
- 1987-10-09 DE DE3751978T patent/DE3751978T2/de not_active Expired - Lifetime
- 1987-10-09 HU HU874578A patent/HU199454B/hu unknown
- 1987-10-09 EP EP92202251A patent/EP0529702B1/en not_active Expired - Lifetime
- 1987-10-09 DK DK529987A patent/DK170891B1/da not_active IP Right Cessation
- 1987-10-09 NO NO874219A patent/NO170084C/no unknown
- 1987-10-09 DE DE87308976T patent/DE3787346T2/de not_active Expired - Lifetime
- 1987-10-09 CA CA000548953A patent/CA1309098C/en not_active Expired - Lifetime
- 1987-10-09 AU AU79537/87A patent/AU600038B2/en not_active Expired
- 1987-10-09 FI FI874451A patent/FI90543C/fi not_active IP Right Cessation
- 1987-10-09 ES ES92202251T patent/ES2097859T3/es not_active Expired - Lifetime
- 1987-10-09 EP EP87308976A patent/EP0266922B1/en not_active Expired - Lifetime
-
1997
- 1997-01-16 GR GR970400061T patent/GR3022301T3/el unknown
-
1998
- 1998-06-03 HK HK98104825A patent/HK1005727A1/xx not_active IP Right Cessation
- 1998-06-03 HK HK98104824A patent/HK1005726A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |