ES2097859T3 - Derivados de dihidropiridina, su preparacion y su utilizacion. - Google Patents
Derivados de dihidropiridina, su preparacion y su utilizacion.Info
- Publication number
- ES2097859T3 ES2097859T3 ES92202251T ES92202251T ES2097859T3 ES 2097859 T3 ES2097859 T3 ES 2097859T3 ES 92202251 T ES92202251 T ES 92202251T ES 92202251 T ES92202251 T ES 92202251T ES 2097859 T3 ES2097859 T3 ES 2097859T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- substituent selected
- alkoxy
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I): EN LA QUE: AR REPRESENTA UN GRUPO DE FENILO QUE TIENE AL MENOS UN SUBSTITUYENTE SELECCIONADO DE NITRO, HALOALQUILO C1-C4, HALOALKOXI C1-C4 Y GRUPOS DE CIANO Y ATOMOS HALOGENOS; R REPRESENTA UN GRUPO ALQUILO C1-C16, UN GRUPO CICLOALQUILO C3C6, UN GRUPO ALQUILO C1-C4 QUE TIENE UN SUBSTITUYENTE DE CICLOALQUILO C3-C6, UN GRUPO ALQUENILO C2-C4, UN GRUPO CINAMILO O UN GRUPO ALQUILO C1-C16 QUE TIENE AL MENOS UN SUBSTITUYENTE SELECCIONADO DE HIDROXI, ALCOXI C1-C4 Y GRUPOS DE ALQUILTIO C1C4; R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-C3; R2A Y R2B SON IGUALES O DIFERENTES Y CADA UNO REPRESENTA UN GRUPO DE FENILO NO SUSTITUIDO O UN GRUPO DE FENILO SUSTITUIDO QUE TIENE AL MENOS UN SUSTITUYENTE SELECCIONADO DE ALQUILO C1-C4, ALCOXI C1-C4 Y GRUPOS HALOALQUILOS C1-C4 Y ATOMOS HALOGENOS; UNO DE R3 Y R4 REPRESENTA UN GRUPO DE METILO Y EL OTRO REPRESENTA UN GRUPO AMINO; Y N ES UN ENTERO DE 1 A 3; ESTOS COMPUESTOS TIENEN UNA VARIEDAD DE ACTIVIDADES ESTIMABLES, QUE INCLUYEN ACTIVIDADES HIPERTENSORAS Y DE BLOQUEO CA++, DIRIGIENDOSE SU USO PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIAS Y CIRCULATORIAS. SE PUEDEN PREPARAR POR CONDENSACION DE ESTERES DE ACIDO BENCILIDENEACETOACETICO SUSTITUIDOS APROPIADOS CON ESTERES DE ACIDO AMIDINOACETICO APROPIADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24025486 | 1986-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097859T3 true ES2097859T3 (es) | 1997-04-16 |
Family
ID=17056752
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92202251T Expired - Lifetime ES2097859T3 (es) | 1986-10-09 | 1987-10-09 | Derivados de dihidropiridina, su preparacion y su utilizacion. |
ES87308976T Expired - Lifetime ES2059391T3 (es) | 1986-10-09 | 1987-10-09 | Derivados de dihidropiridina, su preparacion y su uso. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87308976T Expired - Lifetime ES2059391T3 (es) | 1986-10-09 | 1987-10-09 | Derivados de dihidropiridina, su preparacion y su uso. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4772596A (es) |
EP (2) | EP0266922B1 (es) |
JP (1) | JPS63253082A (es) |
KR (1) | KR920004483B1 (es) |
CN (1) | CN1017897B (es) |
AT (2) | ATE146169T1 (es) |
AU (1) | AU600038B2 (es) |
CA (1) | CA1309098C (es) |
DE (2) | DE3751978T2 (es) |
DK (1) | DK170891B1 (es) |
ES (2) | ES2097859T3 (es) |
FI (1) | FI90543C (es) |
GR (1) | GR3022301T3 (es) |
HK (2) | HK1005727A1 (es) |
HU (1) | HU199454B (es) |
IE (1) | IE63111B1 (es) |
NO (1) | NO170084C (es) |
NZ (1) | NZ222106A (es) |
RU (1) | RU1831476C (es) |
ZA (1) | ZA877518B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671349B1 (fr) * | 1991-01-09 | 1993-04-23 | Lafon Labor | Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant. |
US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
CA2405046C (en) * | 2000-04-11 | 2009-06-23 | Sankyo Company, Limited | Stabilized pharmaceutical compositions comprising a calcium blocker and an alkaline material |
EP1314425A4 (en) * | 2000-08-30 | 2004-06-02 | Sankyo Co | MEDICINAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE |
JP4546726B2 (ja) * | 2002-12-24 | 2010-09-15 | 宇部興産株式会社 | 光学活性なジヒドロピリジン誘導体 |
WO2004058745A1 (ja) | 2002-12-24 | 2004-07-15 | Sankyo Company,Limited | 光学活性なジヒドロピリジン誘導体 |
EP3045174A1 (en) | 2003-01-31 | 2016-07-20 | Daiichi Sankyo Company, Limited | Medicine for prevention of and treatment for arteriosclerosis and hypertension |
JP4629973B2 (ja) * | 2003-09-22 | 2011-02-09 | 第一三共株式会社 | 光学活性シクロプロピルアミン誘導体およびその製造方法 |
HUE025625T2 (en) * | 2003-12-12 | 2016-04-28 | Daiichi Sankyo Co Ltd | Intermediates for the preparation of optically active cyclopropylamine derivatives and a process for the preparation of intermediates |
CA2612384A1 (en) * | 2005-06-15 | 2006-12-28 | Elan Pharma International, Limited | Nanoparticulate azelnidipine formulations |
KR20130135994A (ko) * | 2005-06-27 | 2013-12-11 | 다이이찌 산쿄 가부시키가이샤 | 안지오텐신 ⅱ 수용체 길항제 및 칼슘 채널 차단제를 함유한 약학 제제 |
CN100352818C (zh) * | 2005-09-23 | 2007-12-05 | 四川科伦药业股份有限公司 | 一种改进的制备阿折地平的方法 |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
TWI399223B (zh) * | 2006-09-15 | 2013-06-21 | Daiichi Sankyo Co Ltd | 奧美沙坦酯及氨氯地平之固體劑型 |
JP2008290988A (ja) * | 2007-05-28 | 2008-12-04 | Ube Ind Ltd | 光学活性なジヒドロピリジン誘導体の酸付加塩を含有する医薬 |
JP2008290989A (ja) * | 2007-05-28 | 2008-12-04 | Ube Ind Ltd | ジヒドロピリジン誘導体の酸付加塩を含有する医薬 |
IT1391113B1 (it) * | 2008-09-30 | 2011-11-18 | Dipharma Francis Srl | Procedimento per la preparazione di azelnidipina cristallina |
JP5463051B2 (ja) * | 2009-02-17 | 2014-04-09 | 相模化成工業株式会社 | 1,4―ジヒドロピリジン誘導体の製造法 |
CN101863879B (zh) * | 2009-04-16 | 2012-12-19 | 四川科伦药物研究有限公司 | 一种α晶型阿折地平的制备方法 |
JP2011006379A (ja) * | 2009-05-26 | 2011-01-13 | Tokuyama Corp | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}(アゼルニジピン)の再結晶方法、アゼルニジピンのイソプロピルアルコール付加体、およびアゼルニジピンの製造方法 |
JP2011105649A (ja) * | 2009-11-18 | 2011-06-02 | Daito Kk | アゼルニジピンの結晶 |
JP5637710B2 (ja) * | 2010-03-24 | 2014-12-10 | 株式会社トクヤマ | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
JP2012020970A (ja) * | 2010-07-15 | 2012-02-02 | Tokuyama Corp | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
JP5859115B2 (ja) * | 2011-04-29 | 2016-02-10 | 山東軒竹医薬科技有限公司 | 1,4−ジヒドロピリジン−3,5−ジカルボキシラート誘導体、その調製方法及びその使用 |
JP5917034B2 (ja) * | 2011-07-15 | 2016-05-11 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
BR112014004370A2 (pt) | 2011-08-26 | 2017-03-21 | Wockhardt Ltd | métodos para tratar distúrbios cardiovasculares |
CN102329259B (zh) * | 2011-10-21 | 2013-09-18 | 南京工业大学 | (1-二苯甲基-3-吖丁啶醇)氰基乙酸酯的制备方法 |
CN102382104A (zh) * | 2011-11-21 | 2012-03-21 | 山东新华制药股份有限公司 | α晶型阿折地平的制备方法 |
CN103319457B (zh) * | 2012-03-20 | 2016-01-27 | 北京晶润宏达医药科技有限公司 | 阿折地平γ晶型的制备方法 |
WO2017063307A1 (zh) * | 2015-10-13 | 2017-04-20 | 山东轩竹医药科技有限公司 | 1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备方法及中间体 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2003146A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
US3935223A (en) * | 1972-03-06 | 1976-01-27 | Bayer Aktiengesellschaft | 2-Amino-1,4-dihydropyridine derivatives |
GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS5970666A (ja) * | 1982-10-15 | 1984-04-21 | Kyowa Hakko Kogyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
GB8314744D0 (en) * | 1983-05-27 | 1983-07-06 | Fujisawa Pharmaceutical Co | 2 6-disubstituted-1 4-dihydropyridine derivative |
US4603135A (en) * | 1983-10-17 | 1986-07-29 | Takeda Chemical Industries, Ltd. | Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates |
JPS6289662A (ja) * | 1985-06-14 | 1987-04-24 | Sankyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
-
1987
- 1987-10-05 US US07/105,388 patent/US4772596A/en not_active Expired - Lifetime
- 1987-10-06 KR KR1019870011142A patent/KR920004483B1/ko not_active IP Right Cessation
- 1987-10-07 ZA ZA877518A patent/ZA877518B/xx unknown
- 1987-10-08 RU SU874203529A patent/RU1831476C/ru active
- 1987-10-08 JP JP62254085A patent/JPS63253082A/ja active Granted
- 1987-10-09 NZ NZ222106A patent/NZ222106A/xx unknown
- 1987-10-09 AT AT92202251T patent/ATE146169T1/de not_active IP Right Cessation
- 1987-10-09 EP EP87308976A patent/EP0266922B1/en not_active Expired - Lifetime
- 1987-10-09 DE DE3751978T patent/DE3751978T2/de not_active Expired - Lifetime
- 1987-10-09 DK DK529987A patent/DK170891B1/da not_active IP Right Cessation
- 1987-10-09 EP EP92202251A patent/EP0529702B1/en not_active Expired - Lifetime
- 1987-10-09 IE IE270687A patent/IE63111B1/en not_active IP Right Cessation
- 1987-10-09 NO NO874219A patent/NO170084C/no unknown
- 1987-10-09 ES ES92202251T patent/ES2097859T3/es not_active Expired - Lifetime
- 1987-10-09 AU AU79537/87A patent/AU600038B2/en not_active Expired
- 1987-10-09 DE DE87308976T patent/DE3787346T2/de not_active Expired - Lifetime
- 1987-10-09 CN CN87107150A patent/CN1017897B/zh not_active Expired
- 1987-10-09 AT AT87308976T patent/ATE94162T1/de not_active IP Right Cessation
- 1987-10-09 FI FI874451A patent/FI90543C/fi not_active IP Right Cessation
- 1987-10-09 HU HU874578A patent/HU199454B/hu unknown
- 1987-10-09 CA CA000548953A patent/CA1309098C/en not_active Expired - Lifetime
- 1987-10-09 ES ES87308976T patent/ES2059391T3/es not_active Expired - Lifetime
-
1997
- 1997-01-16 GR GR970400061T patent/GR3022301T3/el unknown
-
1998
- 1998-06-03 HK HK98104825A patent/HK1005727A1/xx not_active IP Right Cessation
- 1998-06-03 HK HK98104824A patent/HK1005726A1/xx not_active IP Right Cessation
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