ATE80617T1 - Mittel zur ortsspezifischen alkylierung. - Google Patents
Mittel zur ortsspezifischen alkylierung.Info
- Publication number
- ATE80617T1 ATE80617T1 AT87304442T AT87304442T ATE80617T1 AT E80617 T1 ATE80617 T1 AT E80617T1 AT 87304442 T AT87304442 T AT 87304442T AT 87304442 T AT87304442 T AT 87304442T AT E80617 T1 ATE80617 T1 AT E80617T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- substituted
- hydrogen
- unsubstituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868612218A GB8612218D0 (en) | 1986-05-20 | 1986-05-20 | Site specific alkylating agents |
EP87304442A EP0246868B1 (de) | 1986-05-20 | 1987-05-19 | Mittel zur ortsspezifischen Alkylierung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE80617T1 true ATE80617T1 (de) | 1992-10-15 |
Family
ID=10598117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT87304442T ATE80617T1 (de) | 1986-05-20 | 1987-05-19 | Mittel zur ortsspezifischen alkylierung. |
Country Status (27)
Country | Link |
---|---|
US (1) | US5017599A (de) |
EP (1) | EP0246868B1 (de) |
JP (1) | JPH0623193B2 (de) |
KR (1) | KR950011408B1 (de) |
AT (1) | ATE80617T1 (de) |
AU (1) | AU597659B2 (de) |
BG (1) | BG60531B2 (de) |
BR (1) | BR1101017A (de) |
CA (1) | CA1314551C (de) |
CS (1) | CS413791A3 (de) |
DE (1) | DE3781716T2 (de) |
DK (1) | DK254587A (de) |
ES (1) | ES2046202T3 (de) |
FI (1) | FI86543C (de) |
GB (1) | GB8612218D0 (de) |
GR (1) | GR3006163T3 (de) |
HK (1) | HK31993A (de) |
HU (1) | HU201336B (de) |
IE (1) | IE60198B1 (de) |
IL (1) | IL82553A (de) |
MX (1) | MX9203122A (de) |
NZ (1) | NZ220361A (de) |
PT (1) | PT84896B (de) |
SG (1) | SG3793G (de) |
SU (1) | SU1528316A3 (de) |
UA (1) | UA5928A1 (de) |
ZA (1) | ZA873593B (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85103908A (zh) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4′-表多克索红菌素的新方法 |
GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
IT1262921B (it) * | 1992-01-10 | 1996-07-22 | Federico Arcamone | Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono |
IT1271456B (it) * | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
US5821258A (en) * | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
EP0750913A3 (de) * | 1995-06-30 | 1997-11-05 | Takeda Chemical Industries, Ltd. | Disaccharide enthaltende gefriergetrocknete Zubereitung für pharmazeutische Verwendung |
GB9514993D0 (en) * | 1995-07-21 | 1995-09-20 | Pharmacia Spa | Site specific phenyl nitrogen mustards |
US5808087A (en) * | 1995-11-29 | 1998-09-15 | Mitsui Chemicals, Inc. | Sulfonium salts of pyrrolylbenzimidazoles |
CA2244139C (en) * | 1996-02-02 | 2005-06-07 | Pharmacia & Upjohn S.P.A. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
US6555692B1 (en) | 1996-02-26 | 2003-04-29 | California Institute Of Technology | Preparation and use of bifunctional molecules having DNA sequence binding specificity |
EP1023288A1 (de) | 1996-02-26 | 2000-08-02 | California Institute Of Technology | Stereochemische kontrolle der dna-bindungsaffinität, sequenz-spezifität und orientierungspräferenz von chiralen hairinpolyamiden an den kleinen graben |
US6143901A (en) * | 1996-07-31 | 2000-11-07 | Genesoft, Inc. | Complex formation between dsDNA and pyrrole imidazole polyamides |
EP0968186A1 (de) | 1996-02-26 | 2000-01-05 | California Institute Of Technology | Polyamide zum binden an den kleinen graben von doppelsträngiger dna |
US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
US6506906B1 (en) | 1996-02-26 | 2003-01-14 | California Institute Of Technology | Preparation and use of bifunctional molecules having DNA sequence binding specificity |
US6090947A (en) | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
GB9610079D0 (en) * | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB9816653D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-{〔1-(1,3-벤조디옥솔-5-일메틸-1h-이미다졸-5-일〕메틸}-4-(1-나프틸)-1h-피롤-3-일〕(4-메틸-1-피페라지닐)메타논의 약학적 조성물 |
US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
JP2003529609A (ja) * | 2000-03-16 | 2003-10-07 | ジーンソフト インコーポレイティッド | 核酸結合部分を含む荷電した化合物およびその利用法 |
US7078536B2 (en) * | 2001-03-14 | 2006-07-18 | Genesoft Pharmaceuticals, Inc. | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
US7122626B2 (en) * | 2001-04-26 | 2006-10-17 | Genesoft Pharmceuticals, Inc. | Halogen-substitued thienyl compounds |
US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
EP1562931A2 (de) * | 2002-10-25 | 2005-08-17 | Genesoft Pharmaceuticals, Inc. | Biarylverbindungen mitantiinfektionswirkung |
AU2003297822A1 (en) * | 2002-12-10 | 2004-06-30 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
GB202114032D0 (en) * | 2021-09-30 | 2021-11-17 | Univ Strathclyde | Antivirals |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR86210E (de) * | 1963-04-04 | 1966-03-23 | ||
BR6461040D0 (pt) * | 1963-07-26 | 1973-08-02 | Farmaceutici Italia | Processo para preparar novos derivados de pirrol |
DE1795539A1 (de) * | 1963-07-26 | 1972-01-13 | Farmaceutici Italia | Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen |
FR141F (de) * | 1963-07-26 | |||
NL130086C (de) * | 1964-07-14 | 1970-06-15 | ||
CN85103908A (zh) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4′-表多克索红菌素的新方法 |
GB8517922D0 (en) * | 1985-07-16 | 1985-08-21 | Erba Farmitalia | Carboxamido derivatives |
-
1986
- 1986-05-20 GB GB868612218A patent/GB8612218D0/en active Pending
-
1987
- 1987-05-14 HU HU872168A patent/HU201336B/hu not_active IP Right Cessation
- 1987-05-18 IE IE129287A patent/IE60198B1/en not_active IP Right Cessation
- 1987-05-18 IL IL82553A patent/IL82553A/xx unknown
- 1987-05-18 FI FI872173A patent/FI86543C/fi not_active IP Right Cessation
- 1987-05-18 AU AU73163/87A patent/AU597659B2/en not_active Ceased
- 1987-05-18 UA UA4202591A patent/UA5928A1/uk unknown
- 1987-05-18 SU SU874202591A patent/SU1528316A3/ru active
- 1987-05-19 AT AT87304442T patent/ATE80617T1/de not_active IP Right Cessation
- 1987-05-19 DK DK254587A patent/DK254587A/da not_active Application Discontinuation
- 1987-05-19 ZA ZA873593A patent/ZA873593B/xx unknown
- 1987-05-19 CA CA000537338A patent/CA1314551C/en not_active Expired - Fee Related
- 1987-05-19 ES ES198787304442T patent/ES2046202T3/es not_active Expired - Lifetime
- 1987-05-19 PT PT84896A patent/PT84896B/pt not_active IP Right Cessation
- 1987-05-19 NZ NZ220361A patent/NZ220361A/en unknown
- 1987-05-19 DE DE8787304442T patent/DE3781716T2/de not_active Expired - Fee Related
- 1987-05-19 EP EP87304442A patent/EP0246868B1/de not_active Expired - Lifetime
- 1987-05-19 KR KR1019870004929A patent/KR950011408B1/ko not_active IP Right Cessation
- 1987-05-19 JP JP62122375A patent/JPH0623193B2/ja not_active Expired - Lifetime
-
1990
- 1990-02-21 US US07/485,847 patent/US5017599A/en not_active Expired - Fee Related
-
1991
- 1991-12-30 CS CS914137A patent/CS413791A3/cs unknown
-
1992
- 1992-06-22 MX MX9203122A patent/MX9203122A/es unknown
- 1992-11-05 GR GR920402483T patent/GR3006163T3/el unknown
-
1993
- 1993-01-08 SG SG37/93A patent/SG3793G/en unknown
- 1993-04-01 HK HK319/93A patent/HK31993A/xx not_active IP Right Cessation
-
1994
- 1994-02-22 BG BG098518A patent/BG60531B2/bg unknown
-
1997
- 1997-05-14 BR BR1101017-7A patent/BR1101017A/pt active IP Right Grant
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner | ||
EEFA | Change of the company name | ||
REN | Ceased due to non-payment of the annual fee |