DE3740595A1 - Neue prostacycline - Google Patents

Neue prostacycline

Info

Publication number
DE3740595A1
DE3740595A1 DE19873740595 DE3740595A DE3740595A1 DE 3740595 A1 DE3740595 A1 DE 3740595A1 DE 19873740595 DE19873740595 DE 19873740595 DE 3740595 A DE3740595 A DE 3740595A DE 3740595 A1 DE3740595 A1 DE 3740595A1
Authority
DE
Germany
Prior art keywords
compounds
formula
compounds according
hydrogen
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873740595
Other languages
German (de)
English (en)
Inventor
George William Holland
Hans Maag
Perry Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE3740595A1 publication Critical patent/DE3740595A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE19873740595 1986-12-01 1987-11-30 Neue prostacycline Withdrawn DE3740595A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93652286A 1986-12-01 1986-12-01

Publications (1)

Publication Number Publication Date
DE3740595A1 true DE3740595A1 (de) 1988-06-16

Family

ID=25468757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19873740595 Withdrawn DE3740595A1 (de) 1986-12-01 1987-11-30 Neue prostacycline

Country Status (14)

Country Link
JP (1) JPS63145275A (ja)
AT (1) AT391697B (ja)
AU (1) AU597128B2 (ja)
BE (1) BE1001271A5 (ja)
CH (1) CH674363A5 (ja)
DE (1) DE3740595A1 (ja)
DK (1) DK627787A (ja)
FR (1) FR2607501A1 (ja)
GB (1) GB2198130B (ja)
IT (1) IT1223390B (ja)
NL (1) NL8702855A (ja)
NZ (1) NZ222723A (ja)
SE (1) SE8704770L (ja)
ZA (1) ZA878947B (ja)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
US4558142A (en) * 1981-03-11 1985-12-10 Hoffmann-La Roche Inc. 7-Fluoro-prostacyclin analogs
JPS5867682A (ja) * 1981-10-16 1983-04-22 Teijin Ltd フルオロｐｇｉ↓２類の製法
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) * 1983-06-10 1984-12-21 Asahi Glass Co Ltd ７−フルオロプロスタグランジン類の製造方法
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GB-Z: Tetrahedron, 39 (22), 1983, S. 3807-3819 *
JP-Z: Chem.Pharm. Bull. 32 (3), 1984, S.1248-1251 *
US-Z: Chem.Abstr. 99, 1983, Ref. 87.908t *
US-Z: Chemical Abstr. 100, 1984, Ref.85.494 *

Also Published As

Publication number Publication date
IT8722814A0 (it) 1987-11-30
JPS63145275A (ja) 1988-06-17
GB2198130A (en) 1988-06-08
IT1223390B (it) 1990-09-19
DK627787A (da) 1988-06-02
BE1001271A5 (fr) 1989-09-12
FR2607501A1 (fr) 1988-06-03
GB2198130B (en) 1990-08-08
NL8702855A (nl) 1988-07-01
AU8190787A (en) 1988-06-02
ZA878947B (en) 1988-06-01
AU597128B2 (en) 1990-05-24
AT391697B (de) 1990-11-12
CH674363A5 (ja) 1990-05-31
GB8727991D0 (en) 1988-01-06
SE8704770D0 (sv) 1987-11-30
NZ222723A (en) 1990-11-27
DK627787D0 (da) 1987-11-30
ATA313887A (de) 1990-05-15
SE8704770L (sv) 1988-06-02

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Legal Events

Date Code Title Description
8101 Request for examination as to novelty
8105 Search report available
8127 New person/name/address of the applicant

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8128 New person/name/address of the agent

Representative=s name: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDER

8139 Disposal/non-payment of the annual fee