FR2607501A1 - Nouveaux esters en 11,15 de 7-fluoro-11,15-dihydro pgi2 utiles comme medicaments et procede pour leur preparation - Google Patents

Nouveaux esters en 11,15 de 7-fluoro-11,15-dihydro pgi2 utiles comme medicaments et procede pour leur preparation Download PDF

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Publication number
FR2607501A1
FR2607501A1 FR8716485A FR8716485A FR2607501A1 FR 2607501 A1 FR2607501 A1 FR 2607501A1 FR 8716485 A FR8716485 A FR 8716485A FR 8716485 A FR8716485 A FR 8716485A FR 2607501 A1 FR2607501 A1 FR 2607501A1
Authority
FR
France
Prior art keywords
compounds according
formula
compounds
fluoro
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8716485A
Other languages
English (en)
French (fr)
Inventor
George William Holland
Hans Maag
Perry Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2607501A1 publication Critical patent/FR2607501A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
FR8716485A 1986-12-01 1987-11-27 Nouveaux esters en 11,15 de 7-fluoro-11,15-dihydro pgi2 utiles comme medicaments et procede pour leur preparation Pending FR2607501A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93652286A 1986-12-01 1986-12-01

Publications (1)

Publication Number Publication Date
FR2607501A1 true FR2607501A1 (fr) 1988-06-03

Family

ID=25468757

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8716485A Pending FR2607501A1 (fr) 1986-12-01 1987-11-27 Nouveaux esters en 11,15 de 7-fluoro-11,15-dihydro pgi2 utiles comme medicaments et procede pour leur preparation

Country Status (14)

Country Link
JP (1) JPS63145275A (ja)
AT (1) AT391697B (ja)
AU (1) AU597128B2 (ja)
BE (1) BE1001271A5 (ja)
CH (1) CH674363A5 (ja)
DE (1) DE3740595A1 (ja)
DK (1) DK627787A (ja)
FR (1) FR2607501A1 (ja)
GB (1) GB2198130B (ja)
IT (1) IT1223390B (ja)
NL (1) NL8702855A (ja)
NZ (1) NZ222723A (ja)
SE (1) SE8704770L (ja)
ZA (1) ZA878947B (ja)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2088856A (en) * 1980-10-27 1982-06-16 Chinoin Gyogyszer Es Vegyeszet 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
JPS5867682A (ja) * 1981-10-16 1983-04-22 Teijin Ltd フルオロｐｇｉ↓２類の製法
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
EP0148953A1 (en) * 1983-06-10 1985-07-24 Asahi Glass Company Ltd. 7-fluoroprostaglandins and process for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558142A (en) * 1981-03-11 1985-12-10 Hoffmann-La Roche Inc. 7-Fluoro-prostacyclin analogs
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2088856A (en) * 1980-10-27 1982-06-16 Chinoin Gyogyszer Es Vegyeszet 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
JPS5867682A (ja) * 1981-10-16 1983-04-22 Teijin Ltd フルオロｐｇｉ↓２類の製法
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
EP0148953A1 (en) * 1983-06-10 1985-07-24 Asahi Glass Company Ltd. 7-fluoroprostaglandins and process for their preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 11, 12 mars 1984, page 525, résumé no. 85494v, Columbus, Ohio, US; & JP-A-58 150 583 (TEIJIN LTD) 07-09-1983 *
CHEMICAL ABSTRACTS, vol. 99, no. 11, 12 septembre 1983, page 543, résumé no. 87908t, Columbus, Ohio, US; & JP-A-58 67 682 (TEIJIN LTD) 22-04-1983 *
TETRAHEDRON, vol. 39, no. 22, 1983, pages 3807-3819, Pergamon Press Ltd, Oxford, GB; K. BANNAI et al.: "Synthesis of chemically stable prostacyclin analog" *

Also Published As

Publication number Publication date
DE3740595A1 (de) 1988-06-16
ATA313887A (de) 1990-05-15
JPS63145275A (ja) 1988-06-17
AU8190787A (en) 1988-06-02
BE1001271A5 (fr) 1989-09-12
SE8704770L (sv) 1988-06-02
ZA878947B (en) 1988-06-01
GB8727991D0 (en) 1988-01-06
AU597128B2 (en) 1990-05-24
SE8704770D0 (sv) 1987-11-30
NL8702855A (nl) 1988-07-01
GB2198130A (en) 1988-06-08
DK627787D0 (da) 1987-11-30
IT8722814A0 (it) 1987-11-30
NZ222723A (en) 1990-11-27
IT1223390B (it) 1990-09-19
DK627787A (da) 1988-06-02
CH674363A5 (ja) 1990-05-31
GB2198130B (en) 1990-08-08
AT391697B (de) 1990-11-12

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