DE3442639A1 - Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten - Google Patents
Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthaltenInfo
- Publication number
- DE3442639A1 DE3442639A1 DE19843442639 DE3442639A DE3442639A1 DE 3442639 A1 DE3442639 A1 DE 3442639A1 DE 19843442639 DE19843442639 DE 19843442639 DE 3442639 A DE3442639 A DE 3442639A DE 3442639 A1 DE3442639 A1 DE 3442639A1
- Authority
- DE
- Germany
- Prior art keywords
- alk
- silibinin
- ethyl acetate
- independently
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Compounds (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843442639 DE3442639A1 (de) | 1984-11-22 | 1984-11-22 | Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten |
IE280885A IE58791B1 (en) | 1984-11-22 | 1985-11-11 | Flavolignan derivatives and pharmaceutical compositions containing them |
LU86163A LU86163A1 (de) | 1984-11-22 | 1985-11-13 | Flavolignanderivate,verfahren zu deren herstellung und arzneimittel,die diese verbindungen enthalten |
YU1786/85A YU43689B (en) | 1984-11-22 | 1985-11-14 | Process for preparing derivatives of silibinine |
AR302267A AR240931A1 (es) | 1984-11-22 | 1985-11-14 | Un procedimiento para la preparacion de derivados de silibinina" |
SI8511786A SI8511786A8 (sl) | 1984-11-22 | 1985-11-14 | Postopek za pripravo derivatov silibinina |
GB08528226A GB2167414B (en) | 1984-11-22 | 1985-11-15 | Flavolignan derivatives and pharmaceutical compositions containing them |
NL8503171A NL192387C (nl) | 1984-11-22 | 1985-11-18 | Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat. |
FI854535A FI84064C (fi) | 1984-11-22 | 1985-11-18 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. |
CH4935/85A CH659473A5 (de) | 1984-11-22 | 1985-11-19 | Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten. |
AT3371/85A AT393268B (de) | 1984-11-22 | 1985-11-19 | Verfahren zur herstellung neuer flavolignanderivate |
CA000495804A CA1337124C (en) | 1984-11-22 | 1985-11-20 | Flavolignan derivatives, processes for the preparation thereof and pharmaceutical compositions containing these compounds |
SE8505487A SE465676B (sv) | 1984-11-22 | 1985-11-20 | Flavolignanderivat, saett att framstaella detta och ett farmaceutiskt medel |
CS837885A CS273610B2 (en) | 1984-11-22 | 1985-11-20 | Method of silibinene's new derivatives production |
DD85283042A DD259191A1 (de) | 1984-11-22 | 1985-11-20 | Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten |
NO854655A NO160205C (no) | 1984-11-22 | 1985-11-21 | Fremgangsmaate ved fremstilling av silibininderivater. |
ZA858951A ZA858951B (en) | 1984-11-22 | 1985-11-21 | Flavolignane derivatives,process for preparation thereof and pharmaceuticals,which contain these combinations |
DK537785A DK164865C (da) | 1984-11-22 | 1985-11-21 | Silibininderivater, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende silibininderivaterne |
SU853985401A SU1436875A3 (ru) | 1984-11-22 | 1985-11-21 | Способ получени производных силибинина |
ES549116A ES8609311A1 (es) | 1984-11-22 | 1985-11-21 | Procedimiento para obtencion de derivados de flavolignano |
IT22932/85A IT1190426B (it) | 1984-11-22 | 1985-11-21 | Derivati del flavolignano,procedimento per la loro preparazione e medicinali che contengono questi composti |
PL1985256374A PL146890B1 (en) | 1984-11-22 | 1985-11-21 | Process for preparing novel derivatives of silibinin |
EG74085A EG19424A (en) | 1984-11-22 | 1985-11-21 | Flavolignan derivatives, process for their preparation. |
HU854448A HU195503B (en) | 1984-11-22 | 1985-11-21 | Process for preparing flavolignane derivatives and pharmaceutical compositions containing them |
PT81532A PT81532B (pt) | 1984-11-22 | 1985-11-21 | Processo para a preparacao de derivados da flavolignana e de composicoes farmaceuticas que os contem |
JP60261629A JPS61143377A (ja) | 1984-11-22 | 1985-11-22 | シリビニン誘導体、その製法及びこれを含有する火傷、肝臓障害及びキノコ毒の治療剤 |
FR858517321A FR2573427B1 (fr) | 1984-11-22 | 1985-11-22 | Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes |
KR1019850008733A KR870001020B1 (ko) | 1984-11-22 | 1985-11-22 | 실리비닌 유도체의 제조방법 |
BE2/60850A BE903693A (fr) | 1984-11-22 | 1985-11-22 | Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes. |
MX009022A MX168415B (es) | 1984-11-22 | 1985-11-22 | Procedimiento para la preparacion de derivados de silibinina |
HRP-1786/85A HRP950126B1 (en) | 1984-11-22 | 1995-03-16 | Process for the preparation of silibinine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843442639 DE3442639A1 (de) | 1984-11-22 | 1984-11-22 | Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3442639A1 true DE3442639A1 (de) | 1986-05-22 |
DE3442639C2 DE3442639C2 (ru) | 1989-08-10 |
Family
ID=6250903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19843442639 Granted DE3442639A1 (de) | 1984-11-22 | 1984-11-22 | Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten |
Country Status (29)
Country | Link |
---|---|
JP (1) | JPS61143377A (ru) |
KR (1) | KR870001020B1 (ru) |
AR (1) | AR240931A1 (ru) |
AT (1) | AT393268B (ru) |
BE (1) | BE903693A (ru) |
CA (1) | CA1337124C (ru) |
CH (1) | CH659473A5 (ru) |
CS (1) | CS273610B2 (ru) |
DD (1) | DD259191A1 (ru) |
DE (1) | DE3442639A1 (ru) |
DK (1) | DK164865C (ru) |
EG (1) | EG19424A (ru) |
ES (1) | ES8609311A1 (ru) |
FI (1) | FI84064C (ru) |
FR (1) | FR2573427B1 (ru) |
GB (1) | GB2167414B (ru) |
HU (1) | HU195503B (ru) |
IE (1) | IE58791B1 (ru) |
IT (1) | IT1190426B (ru) |
LU (1) | LU86163A1 (ru) |
MX (1) | MX168415B (ru) |
NL (1) | NL192387C (ru) |
NO (1) | NO160205C (ru) |
PL (1) | PL146890B1 (ru) |
PT (1) | PT81532B (ru) |
SE (1) | SE465676B (ru) |
SU (1) | SU1436875A3 (ru) |
YU (1) | YU43689B (ru) |
ZA (1) | ZA858951B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8716918D0 (en) * | 1987-07-17 | 1987-08-26 | Inverni Della Beffa Spa | Soluble derivatives of silybin |
US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
ES2552108T3 (es) * | 2005-03-11 | 2015-11-25 | Howard Florey Institute Pty Ltd | Compuestos flavonoides y usos de los mismos |
JP5349486B2 (ja) | 2007-11-15 | 2013-11-20 | マダウス ゲーエムベーハー | 肝炎の治療のためのシリビニン成分 |
RU2482844C2 (ru) * | 2007-11-15 | 2013-05-27 | Мадаус Гмбх | Силибининовый компонент для лечения гепатита |
AU2010247716B2 (en) * | 2009-05-14 | 2015-11-05 | Madaus Gmbh | Amorphous silibinin for the treatment of viral hepatitis |
WO2014008353A2 (en) | 2012-07-05 | 2014-01-09 | Nutramax Laboratories, Inc. | Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder |
CN103172622B (zh) * | 2013-02-22 | 2015-11-04 | 西安安健药业有限公司 | 水飞蓟宾二偏琥珀酸酯的活性异构体 |
CN103193768B (zh) * | 2013-02-22 | 2016-03-30 | 西安安健药业有限公司 | 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体 |
CN103113359B (zh) * | 2013-02-22 | 2016-01-06 | 西安安健药业有限公司 | 水飞蓟宾二偏琥珀酸酯及其药用盐 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1963318B (de) * | Dr Willmar Schwabe GmbH, 7500 Karls ruhe Durlach | Süybinhalbestersauren des Süybins mit 1 und bzw oder 2 Mol und deren Salze mit pharmakologisch vertraglichen anorga nischen oder organischen Basen, und Arznei mittel |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1963318A1 (de) * | 1969-12-17 | 1971-06-24 | Schwabe Willmar Gmbh & Co | Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten |
-
1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/de active Granted
-
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/de unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/xx unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/es active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 NL NL8503171A patent/NL192387C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854535A patent/FI84064C/fi not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/de not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/de not_active IP Right Cessation
- 1985-11-20 DD DD85283042A patent/DD259191A1/de not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/cs unknown
- 1985-11-20 SE SE8505487A patent/SE465676B/sv not_active IP Right Cessation
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-21 DK DK537785A patent/DK164865C/da not_active IP Right Cessation
- 1985-11-21 EG EG74085A patent/EG19424A/xx active
- 1985-11-21 IT IT22932/85A patent/IT1190426B/it active
- 1985-11-21 NO NO854655A patent/NO160205C/no not_active IP Right Cessation
- 1985-11-21 HU HU854448A patent/HU195503B/hu not_active IP Right Cessation
- 1985-11-21 ZA ZA858951A patent/ZA858951B/xx unknown
- 1985-11-21 PL PL1985256374A patent/PL146890B1/pl unknown
- 1985-11-21 ES ES549116A patent/ES8609311A1/es not_active Expired
- 1985-11-21 PT PT81532A patent/PT81532B/pt not_active IP Right Cessation
- 1985-11-21 SU SU853985401A patent/SU1436875A3/ru active
- 1985-11-22 MX MX009022A patent/MX168415B/es unknown
- 1985-11-22 FR FR858517321A patent/FR2573427B1/fr not_active Expired
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/ko not_active IP Right Cessation
- 1985-11-22 JP JP60261629A patent/JPS61143377A/ja active Granted
- 1985-11-22 BE BE2/60850A patent/BE903693A/fr not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1963318B (de) * | Dr Willmar Schwabe GmbH, 7500 Karls ruhe Durlach | Süybinhalbestersauren des Süybins mit 1 und bzw oder 2 Mol und deren Salze mit pharmakologisch vertraglichen anorga nischen oder organischen Basen, und Arznei mittel |
Non-Patent Citations (4)
Title |
---|
Arch. Pharm. 316, 1983, S.385-394 * |
Arzneimittel-Forsch./Drug Res. 30, (1), 1980, S.452-454 * |
Arzneimittelforschung 24 (4), 1974, S. 466-471 * |
J. Chem. Soc., Chem. Comm. 16, 1979, S. 696-697 * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
D2 | Grant after examination | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MADAUS AG, 5000 KOELN, DE |
|
8364 | No opposition during term of opposition |