ES8609311A1 - Procedimiento para obtencion de derivados de flavolignano - Google Patents

Procedimiento para obtencion de derivados de flavolignano

Info

Publication number
ES8609311A1
ES8609311A1 ES549116A ES549116A ES8609311A1 ES 8609311 A1 ES8609311 A1 ES 8609311A1 ES 549116 A ES549116 A ES 549116A ES 549116 A ES549116 A ES 549116A ES 8609311 A1 ES8609311 A1 ES 8609311A1
Authority
ES
Spain
Prior art keywords
independently
stand
another
carbon atoms
radicals containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549116A
Other languages
English (en)
Other versions
ES549116A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Publication of ES549116A0 publication Critical patent/ES549116A0/es
Publication of ES8609311A1 publication Critical patent/ES8609311A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FLAVOLIGNANO DE FORMULA GENERAL (I), EN LA QUE ALK1 Y ALK2 REPRESENTAN RADICALES ALQUENILENICOS CON 1,4 O 2,4 ATOMOS DE CARBONO Y M1 Y M2 SON UN ATOMO DE HIDROGENO O UN ATOMO DE UN METAL ALCALINO. CONSISTE EN DISOLVER 1 A 2 PARTES EN PESO DE PIRIDINA EN 1 PARTE DE SIBILININA DE FORMULA (II) Y, EN AGITACION, HACER REACCIONAR LA SOLUCION CON UN ANHIDRIDO DICARBOXILICO A UNA TEMPERATURA ENTRE 40 Y 50JC. SE EMPLEAN EN DAÑOS POR QUEMADURAS Y EN INTOXICACIONES MICOTICAS.
ES549116A 1984-11-22 1985-11-21 Procedimiento para obtencion de derivados de flavolignano Expired ES8609311A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
ES549116A0 ES549116A0 (es) 1986-09-01
ES8609311A1 true ES8609311A1 (es) 1986-09-01

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549116A Expired ES8609311A1 (es) 1984-11-22 1985-11-21 Procedimiento para obtencion de derivados de flavolignano

Country Status (29)

Country Link
JP (1) JPS61143377A (es)
KR (1) KR870001020B1 (es)
AR (1) AR240931A1 (es)
AT (1) AT393268B (es)
BE (1) BE903693A (es)
CA (1) CA1337124C (es)
CH (1) CH659473A5 (es)
CS (1) CS273610B2 (es)
DD (1) DD259191A1 (es)
DE (1) DE3442639A1 (es)
DK (1) DK164865C (es)
EG (1) EG19424A (es)
ES (1) ES8609311A1 (es)
FI (1) FI84064C (es)
FR (1) FR2573427B1 (es)
GB (1) GB2167414B (es)
HU (1) HU195503B (es)
IE (1) IE58791B1 (es)
IT (1) IT1190426B (es)
LU (1) LU86163A1 (es)
MX (1) MX168415B (es)
NL (1) NL192387C (es)
NO (1) NO160205C (es)
PL (1) PL146890B1 (es)
PT (1) PT81532B (es)
SE (1) SE465676B (es)
SU (1) SU1436875A3 (es)
YU (1) YU43689B (es)
ZA (1) ZA858951B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
BRPI0608402B8 (pt) * 2005-03-11 2021-05-25 Armaron Bio Pty Ltd compostos de flavonóide e composições compreendendo os mesmos
CN102300570B (zh) * 2007-11-15 2015-01-14 马道斯有限责任公司 用于治疗肝炎的水飞蓟宾组分
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
CA2761656C (en) * 2009-05-14 2017-02-07 Lucio Claudio Rovati Amorphous silibinin for the treatment of viral hepatitis
AU2013286721B2 (en) 2012-07-05 2018-04-26 Nutramax Laboratories, Inc. Compositions comprising a sulforaphane or a sulforaphane precursor and milk thistle extract or powder
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
FI854535A (fi) 1986-05-23
PT81532A (de) 1985-12-01
CS273610B2 (en) 1991-03-12
IE58791B1 (en) 1993-11-17
LU86163A1 (de) 1986-03-24
GB2167414B (en) 1989-01-11
GB2167414A (en) 1986-05-29
PL256374A1 (en) 1986-12-02
BE903693A (fr) 1986-05-22
FR2573427A1 (fr) 1986-05-23
AR240931A1 (es) 1991-03-27
DK164865C (da) 1993-01-18
CS837885A2 (en) 1990-08-14
DD259191A1 (de) 1988-08-17
NO160205B (no) 1988-12-12
FI854535A0 (fi) 1985-11-18
NL192387B (nl) 1997-03-03
DK537785A (da) 1986-05-23
FI84064B (fi) 1991-06-28
IE852808L (en) 1986-05-22
HUT40114A (en) 1986-11-28
SU1436875A3 (ru) 1988-11-07
ES549116A0 (es) 1986-09-01
YU178685A (en) 1988-02-29
IT8522932A0 (it) 1985-11-21
CH659473A5 (de) 1987-01-30
IT1190426B (it) 1988-02-16
DE3442639C2 (es) 1989-08-10
FI84064C (fi) 1991-10-10
FR2573427B1 (fr) 1989-03-10
ZA858951B (en) 1986-08-27
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
DK164865B (da) 1992-08-31
DE3442639A1 (de) 1986-05-22
GB8528226D0 (en) 1985-12-18
ATA337185A (de) 1991-02-15
EG19424A (en) 1995-02-28
NL192387C (nl) 1997-07-04
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
AT393268B (de) 1991-09-25
PT81532B (pt) 1987-11-11
DK537785D0 (da) 1985-11-21
SE8505487D0 (sv) 1985-11-20
HU195503B (en) 1988-05-30
NO854655L (no) 1986-05-23
MX168415B (es) 1993-05-24
NL8503171A (nl) 1986-06-16
JPS61143377A (ja) 1986-07-01
NO160205C (no) 1989-03-22
AR240931A2 (es) 1991-03-27
KR870001020B1 (ko) 1987-05-23
JPH0432073B2 (es) 1992-05-28
KR860004056A (ko) 1986-06-16
CA1337124C (en) 1995-09-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102