BE903693A - Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes. - Google Patents

Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes.

Info

Publication number
BE903693A
BE903693A BE2/60850A BE2060850A BE903693A BE 903693 A BE903693 A BE 903693A BE 2/60850 A BE2/60850 A BE 2/60850A BE 2060850 A BE2060850 A BE 2060850A BE 903693 A BE903693 A BE 903693A
Authority
BE
Belgium
Prior art keywords
flavolignan
derivatives
compounds
processes
preparation
Prior art date
Application number
BE2/60850A
Other languages
English (en)
Inventor
R Braatz
K Gorler
G Halbach
H Soicke
K Schmidt
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of BE903693A publication Critical patent/BE903693A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)

Abstract

Les dérivés de la silibinine répondant à la formule générale ci-dessous, dans laquelle n et m = O ou 1; Alk1 et Alk2 = alcoylène en C1-C4 ou alcènylène en C2-C4 et M1 et M2 = H ou métal alcalin, sont des médicaments utiles notamment pour le traitement des lésions par brulures, des cirrhoses du foie et d'autres troubles toxiques-métaboliques du foie ainsi que des empoisonnements par des champignons.
BE2/60850A 1984-11-22 1985-11-22 Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes. BE903693A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
BE903693A true BE903693A (fr) 1986-05-22

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2/60850A BE903693A (fr) 1984-11-22 1985-11-22 Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes.

Country Status (29)

Country Link
JP (1) JPS61143377A (fr)
KR (1) KR870001020B1 (fr)
AR (1) AR240931A1 (fr)
AT (1) AT393268B (fr)
BE (1) BE903693A (fr)
CA (1) CA1337124C (fr)
CH (1) CH659473A5 (fr)
CS (1) CS273610B2 (fr)
DD (1) DD259191A1 (fr)
DE (1) DE3442639A1 (fr)
DK (1) DK164865C (fr)
EG (1) EG19424A (fr)
ES (1) ES8609311A1 (fr)
FI (1) FI84064C (fr)
FR (1) FR2573427B1 (fr)
GB (1) GB2167414B (fr)
HU (1) HU195503B (fr)
IE (1) IE58791B1 (fr)
IT (1) IT1190426B (fr)
LU (1) LU86163A1 (fr)
MX (1) MX168415B (fr)
NL (1) NL192387C (fr)
NO (1) NO160205C (fr)
PL (1) PL146890B1 (fr)
PT (1) PT81532B (fr)
SE (1) SE465676B (fr)
SU (1) SU1436875A3 (fr)
YU (1) YU43689B (fr)
ZA (1) ZA858951B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
NZ560633A (en) * 2005-03-11 2011-08-26 Neuprotect Pty Ltd Flavonoid compounds and uses thereof
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
MX2010005107A (es) * 2007-11-15 2010-05-27 Madaus Gmbh Componente de silibinina para tratamiento contra hepatitis.
CA2761656C (fr) 2009-05-14 2017-02-07 Lucio Claudio Rovati Silibinine amorphe pour le traitement d'une hepatite virale
CN108355136B (zh) 2012-07-05 2021-12-07 纽崔玛氏科技有限责任公司 包含莱菔硫烷或莱菔硫烷前体和蕈类提取物或粉末的组合物
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
ZA858951B (en) 1986-08-27
YU178685A (en) 1988-02-29
PT81532B (pt) 1987-11-11
FI854535A0 (fi) 1985-11-18
DK537785D0 (da) 1985-11-21
NL192387B (nl) 1997-03-03
DK164865C (da) 1993-01-18
SE8505487D0 (sv) 1985-11-20
LU86163A1 (de) 1986-03-24
CS273610B2 (en) 1991-03-12
EG19424A (en) 1995-02-28
FR2573427A1 (fr) 1986-05-23
IE58791B1 (en) 1993-11-17
CS837885A2 (en) 1990-08-14
PT81532A (de) 1985-12-01
CH659473A5 (de) 1987-01-30
IE852808L (en) 1986-05-22
SE8505487L (sv) 1986-05-23
CA1337124C (fr) 1995-09-26
NO160205C (no) 1989-03-22
AT393268B (de) 1991-09-25
FR2573427B1 (fr) 1989-03-10
KR860004056A (ko) 1986-06-16
NL192387C (nl) 1997-07-04
ATA337185A (de) 1991-02-15
GB2167414A (en) 1986-05-29
HU195503B (en) 1988-05-30
DK537785A (da) 1986-05-23
HUT40114A (en) 1986-11-28
IT1190426B (it) 1988-02-16
ES8609311A1 (es) 1986-09-01
GB8528226D0 (en) 1985-12-18
MX168415B (es) 1993-05-24
NO160205B (no) 1988-12-12
YU43689B (en) 1989-10-31
ES549116A0 (es) 1986-09-01
DD259191A1 (de) 1988-08-17
NO854655L (no) 1986-05-23
NL8503171A (nl) 1986-06-16
PL256374A1 (en) 1986-12-02
DE3442639A1 (de) 1986-05-22
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
SU1436875A3 (ru) 1988-11-07
IT8522932A0 (it) 1985-11-21
JPS61143377A (ja) 1986-07-01
FI84064B (fi) 1991-06-28
KR870001020B1 (ko) 1987-05-23
GB2167414B (en) 1989-01-11
AR240931A1 (es) 1991-03-27
FI854535A (fi) 1986-05-23
FI84064C (fi) 1991-10-10
AR240931A2 (es) 1991-03-27
DE3442639C2 (fr) 1989-08-10
JPH0432073B2 (fr) 1992-05-28
DK164865B (da) 1992-08-31

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: DR. MADAUS G.M.B.H. & CO.

Effective date: 20011130