FI84064C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. Download PDF

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Publication number
FI84064C
FI84064C FI854535A FI854535A FI84064C FI 84064 C FI84064 C FI 84064C FI 854535 A FI854535 A FI 854535A FI 854535 A FI854535 A FI 854535A FI 84064 C FI84064 C FI 84064C
Authority
FI
Finland
Prior art keywords
silibinin
ethanol
ethyl acetate
animals
parts
Prior art date
Application number
FI854535A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI854535A (fi
FI84064B (fi
FI854535A0 (fi
Inventor
Reinhard Braatz
Klaus Goerler
Guenter Halbach
Hartwig Soicke
Karlheinz Schmidt
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of FI854535A0 publication Critical patent/FI854535A0/fi
Publication of FI854535A publication Critical patent/FI854535A/fi
Application granted granted Critical
Publication of FI84064B publication Critical patent/FI84064B/fi
Publication of FI84064C publication Critical patent/FI84064C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
FI854535A 1984-11-22 1985-11-18 Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat. FI84064C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442639 1984-11-22
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (4)

Publication Number Publication Date
FI854535A0 FI854535A0 (fi) 1985-11-18
FI854535A FI854535A (fi) 1986-05-23
FI84064B FI84064B (fi) 1991-06-28
FI84064C true FI84064C (fi) 1991-10-10

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
FI854535A FI84064C (fi) 1984-11-22 1985-11-18 Foerfarande foer framstaellning av farmakologiskt vaerdefulla silibininderivat.

Country Status (29)

Country Link
JP (1) JPS61143377A (fr)
KR (1) KR870001020B1 (fr)
AR (1) AR240931A1 (fr)
AT (1) AT393268B (fr)
BE (1) BE903693A (fr)
CA (1) CA1337124C (fr)
CH (1) CH659473A5 (fr)
CS (1) CS273610B2 (fr)
DD (1) DD259191A1 (fr)
DE (1) DE3442639A1 (fr)
DK (1) DK164865C (fr)
EG (1) EG19424A (fr)
ES (1) ES8609311A1 (fr)
FI (1) FI84064C (fr)
FR (1) FR2573427B1 (fr)
GB (1) GB2167414B (fr)
HU (1) HU195503B (fr)
IE (1) IE58791B1 (fr)
IT (1) IT1190426B (fr)
LU (1) LU86163A1 (fr)
MX (1) MX168415B (fr)
NL (1) NL192387C (fr)
NO (1) NO160205C (fr)
PL (1) PL146890B1 (fr)
PT (1) PT81532B (fr)
SE (1) SE465676B (fr)
SU (1) SU1436875A3 (fr)
YU (1) YU43689B (fr)
ZA (1) ZA858951B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
WO2006094357A1 (fr) * 2005-03-11 2006-09-14 Howard Florey Institute Of Experimental Physiology And Medicine Composes flavonoides et utilisations correspondantes
JP5349486B2 (ja) 2007-11-15 2013-11-20 マダウス ゲーエムベーハー 肝炎の治療のためのシリビニン成分
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
DK2430017T3 (en) * 2009-05-14 2016-10-03 Madaus Gmbh PROCESS FOR THE PREPARATION OF AMORPHOUS silibinin.
CA3112680C (fr) 2012-07-05 2023-07-25 Nutramax Laboratories, Inc. Compositions comprenant un sulforaphane ou un precurseur de sulforaphane et un extrait ou une poudre de chardon marie
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
EG19424A (en) 1995-02-28
SE8505487D0 (sv) 1985-11-20
DD259191A1 (de) 1988-08-17
AT393268B (de) 1991-09-25
DE3442639C2 (fr) 1989-08-10
NO160205B (no) 1988-12-12
FI854535A (fi) 1986-05-23
ES549116A0 (es) 1986-09-01
DK164865C (da) 1993-01-18
SU1436875A3 (ru) 1988-11-07
PT81532A (de) 1985-12-01
ZA858951B (en) 1986-08-27
IE852808L (en) 1986-05-22
PT81532B (pt) 1987-11-11
DE3442639A1 (de) 1986-05-22
KR870001020B1 (ko) 1987-05-23
NL192387B (nl) 1997-03-03
AR240931A1 (es) 1991-03-27
GB2167414A (en) 1986-05-29
LU86163A1 (de) 1986-03-24
ES8609311A1 (es) 1986-09-01
FR2573427B1 (fr) 1989-03-10
IT1190426B (it) 1988-02-16
GB8528226D0 (en) 1985-12-18
DK537785D0 (da) 1985-11-21
IT8522932A0 (it) 1985-11-21
DK537785A (da) 1986-05-23
YU178685A (en) 1988-02-29
HU195503B (en) 1988-05-30
NO160205C (no) 1989-03-22
PL256374A1 (en) 1986-12-02
BE903693A (fr) 1986-05-22
GB2167414B (en) 1989-01-11
JPH0432073B2 (fr) 1992-05-28
NL8503171A (nl) 1986-06-16
FI84064B (fi) 1991-06-28
JPS61143377A (ja) 1986-07-01
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
MX168415B (es) 1993-05-24
IE58791B1 (en) 1993-11-17
CH659473A5 (de) 1987-01-30
HUT40114A (en) 1986-11-28
CA1337124C (fr) 1995-09-26
CS837885A2 (en) 1990-08-14
DK164865B (da) 1992-08-31
AR240931A2 (es) 1991-03-27
ATA337185A (de) 1991-02-15
NO854655L (no) 1986-05-23
KR860004056A (ko) 1986-06-16
FR2573427A1 (fr) 1986-05-23
NL192387C (nl) 1997-07-04
FI854535A0 (fi) 1985-11-18
CS273610B2 (en) 1991-03-12

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MM Patent lapsed

Owner name: MADAUS AKTIENGESELLSCHAFT