CS837885A2 - Method of silibinene's new derivatives production - Google Patents

Method of silibinene's new derivatives production

Info

Publication number
CS837885A2
CS837885A2 CS858378A CS837885A CS837885A2 CS 837885 A2 CS837885 A2 CS 837885A2 CS 858378 A CS858378 A CS 858378A CS 837885 A CS837885 A CS 837885A CS 837885 A2 CS837885 A2 CS 837885A2
Authority
CS
Czechoslovakia
Prior art keywords
silibinene
new derivatives
derivatives production
production
new
Prior art date
Application number
CS858378A
Other languages
Czech (cs)
Other versions
CS273610B2 (en
Inventor
Reinhard Dr Braatz
Klaus Dr Gorler
Gunter Dr Halbach
Hartwig Dr Soicke
Karlheinz Prof Dr Dr Schmidt
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of CS837885A2 publication Critical patent/CS837885A2/en
Publication of CS273610B2 publication Critical patent/CS273610B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
CS837885A 1984-11-22 1985-11-20 Method of silibinene's new derivatives production CS273610B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (en) 1984-11-22 1984-11-22 FLAVOLIGNANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (2)

Publication Number Publication Date
CS837885A2 true CS837885A2 (en) 1990-08-14
CS273610B2 CS273610B2 (en) 1991-03-12

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
CS837885A CS273610B2 (en) 1984-11-22 1985-11-20 Method of silibinene's new derivatives production

Country Status (29)

Country Link
JP (1) JPS61143377A (en)
KR (1) KR870001020B1 (en)
AR (1) AR240931A1 (en)
AT (1) AT393268B (en)
BE (1) BE903693A (en)
CA (1) CA1337124C (en)
CH (1) CH659473A5 (en)
CS (1) CS273610B2 (en)
DD (1) DD259191A1 (en)
DE (1) DE3442639A1 (en)
DK (1) DK164865C (en)
EG (1) EG19424A (en)
ES (1) ES8609311A1 (en)
FI (1) FI84064C (en)
FR (1) FR2573427B1 (en)
GB (1) GB2167414B (en)
HU (1) HU195503B (en)
IE (1) IE58791B1 (en)
IT (1) IT1190426B (en)
LU (1) LU86163A1 (en)
MX (1) MX168415B (en)
NL (1) NL192387C (en)
NO (1) NO160205C (en)
PL (1) PL146890B1 (en)
PT (1) PT81532B (en)
SE (1) SE465676B (en)
SU (1) SU1436875A3 (en)
YU (1) YU43689B (en)
ZA (1) ZA858951B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
US8017649B2 (en) * 2005-03-11 2011-09-13 Howard Florey Institute Of Experimental Physiology And Medicine Flavonoid compounds and uses thereof
EP2392326B9 (en) * 2007-11-15 2018-09-05 Madaus GmbH Silibinin component for the treatment of hepatitis
RU2482844C2 (en) * 2007-11-15 2013-05-27 Мадаус Гмбх Silibilin component for treating hepatitis
US8614341B2 (en) 2009-05-14 2013-12-24 Euromed S.A. Amorphous silibinin for the treatment of viral hepatitis
EP3409280B1 (en) 2012-07-05 2021-04-14 Nutramax Laboratories, Inc. Compositions comprising a sulforaphane and milk thistle extract or powder
CN103172622B (en) * 2013-02-22 2015-11-04 西安安健药业有限公司 The active isomer of silybin bis-bias succinate
CN103193768B (en) * 2013-02-22 2016-03-30 西安安健药业有限公司 The silybin bis-bias succinate isomer for the treatment of hepatopathy
CN103113359B (en) * 2013-02-22 2016-01-06 西安安健药业有限公司 Silybin bis-bias succinate and pharmaceutical salts thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (en) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybin esters with hepotoprotactant acti- - vity

Also Published As

Publication number Publication date
AT393268B (en) 1991-09-25
DD259191A1 (en) 1988-08-17
FR2573427B1 (en) 1989-03-10
CH659473A5 (en) 1987-01-30
DK164865C (en) 1993-01-18
JPS61143377A (en) 1986-07-01
ATA337185A (en) 1991-02-15
NL192387B (en) 1997-03-03
KR870001020B1 (en) 1987-05-23
YU178685A (en) 1988-02-29
ES8609311A1 (en) 1986-09-01
EG19424A (en) 1995-02-28
PL146890B1 (en) 1989-03-31
SE465676B (en) 1991-10-14
AR240931A1 (en) 1991-03-27
CS273610B2 (en) 1991-03-12
MX168415B (en) 1993-05-24
ES549116A0 (en) 1986-09-01
FI854535A0 (en) 1985-11-18
SE8505487D0 (en) 1985-11-20
NL8503171A (en) 1986-06-16
DK537785A (en) 1986-05-23
BE903693A (en) 1986-05-22
ZA858951B (en) 1986-08-27
IE852808L (en) 1986-05-22
SU1436875A3 (en) 1988-11-07
FR2573427A1 (en) 1986-05-23
PL256374A1 (en) 1986-12-02
IT8522932A0 (en) 1985-11-21
JPH0432073B2 (en) 1992-05-28
FI84064C (en) 1991-10-10
IE58791B1 (en) 1993-11-17
CA1337124C (en) 1995-09-26
PT81532A (en) 1985-12-01
AR240931A2 (en) 1991-03-27
LU86163A1 (en) 1986-03-24
YU43689B (en) 1989-10-31
DE3442639C2 (en) 1989-08-10
DK164865B (en) 1992-08-31
GB2167414A (en) 1986-05-29
FI854535A (en) 1986-05-23
NO160205C (en) 1989-03-22
GB2167414B (en) 1989-01-11
HUT40114A (en) 1986-11-28
FI84064B (en) 1991-06-28
PT81532B (en) 1987-11-11
SE8505487L (en) 1986-05-23
DK537785D0 (en) 1985-11-21
HU195503B (en) 1988-05-30
DE3442639A1 (en) 1986-05-22
GB8528226D0 (en) 1985-12-18
NO160205B (en) 1988-12-12
IT1190426B (en) 1988-02-16
NL192387C (en) 1997-07-04
KR860004056A (en) 1986-06-16
NO854655L (en) 1986-05-23

Similar Documents

Publication Publication Date Title
CS747588A2 (en) Method of 5-deoxy-5-fluorcytidine's new derivatives production
PL256983A1 (en) Method of obtaining novel derivatives of cyclohexanodione-1,3
PL256985A1 (en) Method of obtaining novel derivatives of cyclohexanodione-1,3
PL265523A1 (en) Method of obtaining novel derivatives of allanilproline
PL256984A1 (en) Method of obtaining novel derivatives of cyclohexanodione-1,3
CS8605412A2 (en) Method of poly-4-aminopyrrole-2-amides' derivatives production
CS837985A2 (en) Method of isosilybine-free silybine production
CS392785A2 (en) Method of 1,3-oxazolidine-2-onane's derivatives preparation
CS837885A2 (en) Method of silibinene's new derivatives production
CS554387A2 (en) Method of pyrimidine's new derivatives production
CS523687A2 (en) Method of pyrimidine's new derivatives production
CS872287A2 (en) Method of new triazine's derivatives production
CS597887A2 (en) Method of new lensofuran-2 ylimidazol derivatives production
PL255499A1 (en) Method of obtaining novel derivatives of quinazolinodione
PL253089A1 (en) Method of obtaining novel derivatives of iminotriazolidine
CS960486A2 (en) Method of pregnale-21-acid's 16,17-acetal-substituted derivatives production
PL257564A1 (en) Method of obtaining novel derivatives of thiocyanopyrimidine
CS520584A2 (en) Method of 1-sulpho-2-azetidinone's derivatives production
CS311786A2 (en) Method of mitomycin's n7-amidino-substituted derivatives production
CS504086A2 (en) Method of benzamide's derivatives production
PL254117A1 (en) Method of obtaining novel derivatives of oxycames
CS910288A2 (en) Method of dioxazocine's derivatives production
GB2165836B (en) Process of producing guanidinothiazole derivatives
CS810187A2 (en) Method of 2-guanidinothiazole's derivative production
CS252841B2 (en) Method of 3-phenyl-2-propenamine's new derivatives production