NL192387B - Pure Silibinine Derivatives, Process for Their Preparation and Pharmaceutical Preparation Containing Such Derivative. - Google Patents

Pure Silibinine Derivatives, Process for Their Preparation and Pharmaceutical Preparation Containing Such Derivative.

Info

Publication number
NL192387B
NL192387B NL8503171A NL8503171A NL192387B NL 192387 B NL192387 B NL 192387B NL 8503171 A NL8503171 A NL 8503171A NL 8503171 A NL8503171 A NL 8503171A NL 192387 B NL192387 B NL 192387B
Authority
NL
Netherlands
Prior art keywords
silibinine
derivative
derivatives
pure
preparation
Prior art date
Application number
NL8503171A
Other languages
Dutch (nl)
Other versions
NL192387C (en
NL8503171A (en
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of NL8503171A publication Critical patent/NL8503171A/en
Publication of NL192387B publication Critical patent/NL192387B/en
Application granted granted Critical
Publication of NL192387C publication Critical patent/NL192387C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
NL8503171A 1984-11-22 1985-11-18 Pure Silibinine Derivatives, Process for Their Preparation and Pharmaceutical Preparation Containing Such Derivative. NL192387C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442639 1984-11-22
DE19843442639 DE3442639A1 (en) 1984-11-22 1984-11-22 FLAVOLIGNANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (3)

Publication Number Publication Date
NL8503171A NL8503171A (en) 1986-06-16
NL192387B true NL192387B (en) 1997-03-03
NL192387C NL192387C (en) 1997-07-04

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8503171A NL192387C (en) 1984-11-22 1985-11-18 Pure Silibinine Derivatives, Process for Their Preparation and Pharmaceutical Preparation Containing Such Derivative.

Country Status (29)

Country Link
JP (1) JPS61143377A (en)
KR (1) KR870001020B1 (en)
AR (1) AR240931A1 (en)
AT (1) AT393268B (en)
BE (1) BE903693A (en)
CA (1) CA1337124C (en)
CH (1) CH659473A5 (en)
CS (1) CS273610B2 (en)
DD (1) DD259191A1 (en)
DE (1) DE3442639A1 (en)
DK (1) DK164865C (en)
EG (1) EG19424A (en)
ES (1) ES8609311A1 (en)
FI (1) FI84064C (en)
FR (1) FR2573427B1 (en)
GB (1) GB2167414B (en)
HU (1) HU195503B (en)
IE (1) IE58791B1 (en)
IT (1) IT1190426B (en)
LU (1) LU86163A1 (en)
MX (1) MX168415B (en)
NL (1) NL192387C (en)
NO (1) NO160205C (en)
PL (1) PL146890B1 (en)
PT (1) PT81532B (en)
SE (1) SE465676B (en)
SU (1) SU1436875A3 (en)
YU (1) YU43689B (en)
ZA (1) ZA858951B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
RU2431634C2 (en) * 2005-03-11 2011-10-20 Говард Флори Инститьют Оф Експериментл Физиолоджи Энд Медсин Flavonoid compounds and use thereof
AU2008323156B2 (en) * 2007-11-15 2012-05-31 Madaus Gmbh Silibinin component for the treatment of hepatitis
RU2482844C2 (en) * 2007-11-15 2013-05-27 Мадаус Гмбх Silibilin component for treating hepatitis
WO2010130460A1 (en) * 2009-05-14 2010-11-18 Euromed S.A. Amorphous silibinin for the treatment of viral hepatitis
CN104427981B (en) 2012-07-05 2018-05-25 纽崔玛氏科技有限责任公司 Include sulforaphane or sulforaphane precursor and the composition of mushroom extract or powder
CN103113359B (en) * 2013-02-22 2016-01-06 西安安健药业有限公司 Silybin bis-bias succinate and pharmaceutical salts thereof
CN103172622B (en) * 2013-02-22 2015-11-04 西安安健药业有限公司 The active isomer of silybin bis-bias succinate
CN103193768B (en) * 2013-02-22 2016-03-30 西安安健药业有限公司 The silybin bis-bias succinate isomer for the treatment of hepatopathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (en) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybin esters with hepotoprotactant acti- - vity

Also Published As

Publication number Publication date
EG19424A (en) 1995-02-28
ZA858951B (en) 1986-08-27
PT81532A (en) 1985-12-01
AT393268B (en) 1991-09-25
HUT40114A (en) 1986-11-28
IT8522932A0 (en) 1985-11-21
FR2573427A1 (en) 1986-05-23
DE3442639C2 (en) 1989-08-10
FI854535A (en) 1986-05-23
ATA337185A (en) 1991-02-15
IE852808L (en) 1986-05-22
DK164865C (en) 1993-01-18
GB8528226D0 (en) 1985-12-18
FI84064C (en) 1991-10-10
YU178685A (en) 1988-02-29
DK164865B (en) 1992-08-31
PL146890B1 (en) 1989-03-31
SE465676B (en) 1991-10-14
CS273610B2 (en) 1991-03-12
MX168415B (en) 1993-05-24
NO160205B (en) 1988-12-12
CH659473A5 (en) 1987-01-30
DD259191A1 (en) 1988-08-17
KR860004056A (en) 1986-06-16
SE8505487D0 (en) 1985-11-20
NO854655L (en) 1986-05-23
DK537785D0 (en) 1985-11-21
PL256374A1 (en) 1986-12-02
ES8609311A1 (en) 1986-09-01
FI854535A0 (en) 1985-11-18
FR2573427B1 (en) 1989-03-10
JPS61143377A (en) 1986-07-01
AR240931A1 (en) 1991-03-27
DK537785A (en) 1986-05-23
PT81532B (en) 1987-11-11
GB2167414A (en) 1986-05-29
IT1190426B (en) 1988-02-16
AR240931A2 (en) 1991-03-27
SU1436875A3 (en) 1988-11-07
FI84064B (en) 1991-06-28
NL192387C (en) 1997-07-04
BE903693A (en) 1986-05-22
HU195503B (en) 1988-05-30
NL8503171A (en) 1986-06-16
CS837885A2 (en) 1990-08-14
JPH0432073B2 (en) 1992-05-28
SE8505487L (en) 1986-05-23
YU43689B (en) 1989-10-31
DE3442639A1 (en) 1986-05-22
CA1337124C (en) 1995-09-26
IE58791B1 (en) 1993-11-17
LU86163A1 (en) 1986-03-24
GB2167414B (en) 1989-01-11
NO160205C (en) 1989-03-22
KR870001020B1 (en) 1987-05-23
ES549116A0 (en) 1986-09-01

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: MADAUS AKTIENGESELLSCHAFT

V1 Lapsed because of non-payment of the annual fee

Effective date: 20020601