AR240931A2 - Process for the preparation of silibinine derivatives - Google Patents
Process for the preparation of silibinine derivativesInfo
- Publication number
- AR240931A2 AR240931A2 AR30226785A AR30226785A AR240931A2 AR 240931 A2 AR240931 A2 AR 240931A2 AR 30226785 A AR30226785 A AR 30226785A AR 30226785 A AR30226785 A AR 30226785A AR 240931 A2 AR240931 A2 AR 240931A2
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- ponderal
- preparation
- ethyl acetate
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE SILIBININA DE LA FORMULA EN LA CUAL "N" Y "M", SON O 6 1, A1K1 Y A1K2, SON RADICALES ALQUILENO Y M1 Y M2,SON H O METAL ALCALINO POR QUE A)DISOLVER UNA PARTE PONDERAL DE SILIBININA DE FORMULA II EN 1 A 2 PARTES PONDERALES DE PIRIDINA; B)HACER REACCIONAR LA SOLUCION ,CON 1 A 3 PARTES PONDERALES DE UN ANHIDRICO DE ACIDO DICARBOXILICO DE FORMULA III,EN LA CUAL A1K ES UN RADICAL A1K1 O A1K2 YA DEFINIDO; C)AGREGAR ETANOL FORMAR UNA MEZCLA HOMOGENEA; D) AGREGAR AGUA CON AGITACION INTENSIVA, PRODUCIENDO DE ESTE MODO LA HIDROLISIS DE LOS ESTERES DE LOS GRUPOS HIDROXILO AROMATICAMENTE ENLAZADOS PRESENTES; E)DILUIR LA MEZCLA CON ACETATO DE ETILO; F)LAVAR CON AGUA ACIDIFICADA QUE ES SATURADA CON ACETATO DE ETILO; H) TOMAR EL RESIDUO EN ETANOL; I) PRECIPITAR DE LA SOLUCION ETANOLICA OBTENIDA, POR EL AGREGADO DE AGUA, EL DERIVADO DE SILIBINA DE FORMULA (I), EN EL CUAL M1 Y M2 SON H.A PROCEDURE FOR THE PREPARATION OF SILIBININ DERIVATIVES FROM THE FORMULA IN WHICH "N" AND "M", ARE O 6 1, A1K1 AND A1K2, ARE ALKYLENE RADICALS AND M1 AND M2, ARE HO ALKALINE METAL WHY A) DISSOLVE A PONDERAL PART OF SILIBININ OF FORMULA II IN 1 TO 2 PONDERAL PARTS OF PIRIDINE; B) REACT THE SOLUTION, WITH 1 TO 3 WEIGHT PARTS OF A DICARBOXYLIC ACID ANHYDRIC OF FORMULA III, IN WHICH A1K IS A RADICAL A1K1 OR A1K2 ALREADY DEFINED; C) ADD ETHANOL FORM A HOMOGENOUS MIXTURE; D) ADD WATER WITH INTENSIVE AGITATION, IN THIS WAY PRODUCING THE HYDROLYSIS OF THE ESTERES OF THE AROMATICALLY LINKED HYDROXYL GROUPS PRESENT; E) DILUTE THE MIXTURE WITH ETHYL ACETATE; F) WASH WITH ACIDIFIED WATER WHICH IS SATURATED WITH ETHYL ACETATE; H) TAKE THE WASTE IN ETHANOL; I) PRECIPITATE OF THE ETHANOLIC SOLUTION OBTAINED BY THE WATER ADDED, THE DERIVATIVE OF SILIBINA OF FORMULA (I), IN WHICH M1 AND M2 ARE H.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843442639 DE3442639A1 (en) | 1984-11-22 | 1984-11-22 | FLAVOLIGNANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240931A1 AR240931A1 (en) | 1991-03-27 |
| AR240931A2 true AR240931A2 (en) | 1991-03-27 |
Family
ID=6250903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR302267A AR240931A1 (en) | 1984-11-22 | 1985-11-14 | A PROCEDURE FOR THE PREPARATION OF SILIBININ DERIVATIVES " |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS61143377A (en) |
| KR (1) | KR870001020B1 (en) |
| AR (1) | AR240931A1 (en) |
| AT (1) | AT393268B (en) |
| BE (1) | BE903693A (en) |
| CA (1) | CA1337124C (en) |
| CH (1) | CH659473A5 (en) |
| CS (1) | CS273610B2 (en) |
| DD (1) | DD259191A1 (en) |
| DE (1) | DE3442639A1 (en) |
| DK (1) | DK164865C (en) |
| EG (1) | EG19424A (en) |
| ES (1) | ES8609311A1 (en) |
| FI (1) | FI84064C (en) |
| FR (1) | FR2573427B1 (en) |
| GB (1) | GB2167414B (en) |
| HU (1) | HU195503B (en) |
| IE (1) | IE58791B1 (en) |
| IT (1) | IT1190426B (en) |
| LU (1) | LU86163A1 (en) |
| MX (1) | MX168415B (en) |
| NL (1) | NL192387C (en) |
| NO (1) | NO160205C (en) |
| PL (1) | PL146890B1 (en) |
| PT (1) | PT81532B (en) |
| SE (1) | SE465676B (en) |
| SU (1) | SU1436875A3 (en) |
| YU (1) | YU43689B (en) |
| ZA (1) | ZA858951B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8716918D0 (en) * | 1987-07-17 | 1987-08-26 | Inverni Della Beffa Spa | Soluble derivatives of silybin |
| US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
| JP5380069B2 (en) * | 2005-03-11 | 2014-01-08 | ハワード フローリー インスティチュート | Flavonoid compounds and uses thereof |
| PT2219642E (en) * | 2007-11-15 | 2011-10-18 | Madaus Gmbh | Silibinin component for the treatment of hepatitis |
| RU2482844C2 (en) * | 2007-11-15 | 2013-05-27 | Мадаус Гмбх | Silibilin component for treating hepatitis |
| US8614341B2 (en) | 2009-05-14 | 2013-12-24 | Euromed S.A. | Amorphous silibinin for the treatment of viral hepatitis |
| EP3409280B1 (en) | 2012-07-05 | 2021-04-14 | Nutramax Laboratories, Inc. | Compositions comprising a sulforaphane and milk thistle extract or powder |
| CN103193768B (en) * | 2013-02-22 | 2016-03-30 | 西安安健药业有限公司 | The silybin bis-bias succinate isomer for the treatment of hepatopathy |
| CN103113359B (en) * | 2013-02-22 | 2016-01-06 | 西安安健药业有限公司 | Silybin bis-bias succinate and pharmaceutical salts thereof |
| CN103172622B (en) * | 2013-02-22 | 2015-11-04 | 西安安健药业有限公司 | The active isomer of silybin bis-bias succinate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1963318A1 (en) * | 1969-12-17 | 1971-06-24 | Schwabe Willmar Gmbh & Co | Silybin esters with hepotoprotactant acti- - vity |
-
1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/en active Granted
-
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/en unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/en unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/en active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 FI FI854535A patent/FI84064C/en not_active IP Right Cessation
- 1985-11-18 NL NL8503171A patent/NL192387C/en not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/en not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/en not_active IP Right Cessation
- 1985-11-20 SE SE8505487A patent/SE465676B/en not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/en unknown
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-20 DD DD85283042A patent/DD259191A1/en not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/en not_active IP Right Cessation
- 1985-11-21 DK DK537785A patent/DK164865C/en not_active IP Right Cessation
- 1985-11-21 IT IT22932/85A patent/IT1190426B/en active
- 1985-11-21 NO NO854655A patent/NO160205C/en not_active IP Right Cessation
- 1985-11-21 ES ES549116A patent/ES8609311A1/en not_active Expired
- 1985-11-21 PL PL1985256374A patent/PL146890B1/en unknown
- 1985-11-21 EG EG74085A patent/EG19424A/en active
- 1985-11-21 HU HU854448A patent/HU195503B/en not_active IP Right Cessation
- 1985-11-21 ZA ZA858951A patent/ZA858951B/en unknown
- 1985-11-21 SU SU853985401A patent/SU1436875A3/en active
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/en not_active IP Right Cessation
- 1985-11-22 FR FR858517321A patent/FR2573427B1/en not_active Expired
- 1985-11-22 BE BE2/60850A patent/BE903693A/en not_active IP Right Cessation
- 1985-11-22 MX MX009022A patent/MX168415B/en unknown
- 1985-11-22 JP JP60261629A patent/JPS61143377A/en active Granted
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