CA1337124C - Derives de flavolignane; methode pour les preparer; compositions pharmaceutiques a base de ces derives - Google Patents

Derives de flavolignane; methode pour les preparer; compositions pharmaceutiques a base de ces derives

Info

Publication number
CA1337124C
CA1337124C CA000495804A CA495804A CA1337124C CA 1337124 C CA1337124 C CA 1337124C CA 000495804 A CA000495804 A CA 000495804A CA 495804 A CA495804 A CA 495804A CA 1337124 C CA1337124 C CA 1337124C
Authority
CA
Canada
Prior art keywords
silibinin
independently selected
alk2
alk1
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000495804A
Other languages
English (en)
Inventor
Reinhard Braatz
Klaus Gorler
Gunter Halbach
Hartwig Soicke
Karlheinz Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Madaus AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus AG filed Critical Madaus AG
Application granted granted Critical
Publication of CA1337124C publication Critical patent/CA1337124C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
CA000495804A 1984-11-22 1985-11-20 Derives de flavolignane; methode pour les preparer; compositions pharmaceutiques a base de ces derives Expired - Fee Related CA1337124C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
DEP3442639 1984-11-22

Publications (1)

Publication Number Publication Date
CA1337124C true CA1337124C (fr) 1995-09-26

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000495804A Expired - Fee Related CA1337124C (fr) 1984-11-22 1985-11-20 Derives de flavolignane; methode pour les preparer; compositions pharmaceutiques a base de ces derives

Country Status (29)

Country Link
JP (1) JPS61143377A (fr)
KR (1) KR870001020B1 (fr)
AR (1) AR240931A1 (fr)
AT (1) AT393268B (fr)
BE (1) BE903693A (fr)
CA (1) CA1337124C (fr)
CH (1) CH659473A5 (fr)
CS (1) CS273610B2 (fr)
DD (1) DD259191A1 (fr)
DE (1) DE3442639A1 (fr)
DK (1) DK164865C (fr)
EG (1) EG19424A (fr)
ES (1) ES8609311A1 (fr)
FI (1) FI84064C (fr)
FR (1) FR2573427B1 (fr)
GB (1) GB2167414B (fr)
HU (1) HU195503B (fr)
IE (1) IE58791B1 (fr)
IT (1) IT1190426B (fr)
LU (1) LU86163A1 (fr)
MX (1) MX168415B (fr)
NL (1) NL192387C (fr)
NO (1) NO160205C (fr)
PL (1) PL146890B1 (fr)
PT (1) PT81532B (fr)
SE (1) SE465676B (fr)
SU (1) SU1436875A3 (fr)
YU (1) YU43689B (fr)
ZA (1) ZA858951B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014008361A2 (fr) 2012-07-05 2014-01-09 Nutramax Laboratories, Inc. Compositions comprenant un sulforaphane ou un précurseur de sulforaphane et un extrait ou une poudre de chardon marie

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
ES2552108T3 (es) * 2005-03-11 2015-11-25 Howard Florey Institute Pty Ltd Compuestos flavonoides y usos de los mismos
JP5349486B2 (ja) 2007-11-15 2013-11-20 マダウス ゲーエムベーハー 肝炎の治療のためのシリビニン成分
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
AU2010247716B2 (en) * 2009-05-14 2015-11-05 Madaus Gmbh Amorphous silibinin for the treatment of viral hepatitis
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014008361A2 (fr) 2012-07-05 2014-01-09 Nutramax Laboratories, Inc. Compositions comprenant un sulforaphane ou un précurseur de sulforaphane et un extrait ou une poudre de chardon marie
EP3409280A1 (fr) 2012-07-05 2018-12-05 Nutramax Laboratories, Inc. Compositions comprenant un sulforaphane et un extrait ou poudre de chardon-marie
EP3821895A1 (fr) 2012-07-05 2021-05-19 Nutramax Laboratories, Inc. Compositions comprenant du sulforaphane ou un extrait de brocoli et un extrait ou une poudre de chardon-marie

Also Published As

Publication number Publication date
CS837885A2 (en) 1990-08-14
JPH0432073B2 (fr) 1992-05-28
GB8528226D0 (en) 1985-12-18
DK537785D0 (da) 1985-11-21
NL192387C (nl) 1997-07-04
DE3442639A1 (de) 1986-05-22
AT393268B (de) 1991-09-25
PT81532A (de) 1985-12-01
FI854535A (fi) 1986-05-23
NO854655L (no) 1986-05-23
SE8505487D0 (sv) 1985-11-20
ES549116A0 (es) 1986-09-01
LU86163A1 (de) 1986-03-24
IE58791B1 (en) 1993-11-17
ZA858951B (en) 1986-08-27
FI84064C (fi) 1991-10-10
MX168415B (es) 1993-05-24
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
KR860004056A (ko) 1986-06-16
CH659473A5 (de) 1987-01-30
YU43689B (en) 1989-10-31
JPS61143377A (ja) 1986-07-01
IE852808L (en) 1986-05-22
DK164865C (da) 1993-01-18
FI84064B (fi) 1991-06-28
DK164865B (da) 1992-08-31
GB2167414B (en) 1989-01-11
NO160205C (no) 1989-03-22
PL256374A1 (en) 1986-12-02
HU195503B (en) 1988-05-30
FR2573427B1 (fr) 1989-03-10
HUT40114A (en) 1986-11-28
FR2573427A1 (fr) 1986-05-23
DE3442639C2 (fr) 1989-08-10
PT81532B (pt) 1987-11-11
ES8609311A1 (es) 1986-09-01
BE903693A (fr) 1986-05-22
KR870001020B1 (ko) 1987-05-23
DK537785A (da) 1986-05-23
IT8522932A0 (it) 1985-11-21
SU1436875A3 (ru) 1988-11-07
AR240931A2 (es) 1991-03-27
EG19424A (en) 1995-02-28
ATA337185A (de) 1991-02-15
NL8503171A (nl) 1986-06-16
IT1190426B (it) 1988-02-16
FI854535A0 (fi) 1985-11-18
NL192387B (nl) 1997-03-03
DD259191A1 (de) 1988-08-17
GB2167414A (en) 1986-05-29
AR240931A1 (es) 1991-03-27
NO160205B (no) 1988-12-12
SE8505487L (sv) 1986-05-23
CS273610B2 (en) 1991-03-12
YU178685A (en) 1988-02-29

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