YU43689B - Process for preparing derivatives of silibinine - Google Patents

Process for preparing derivatives of silibinine

Info

Publication number
YU43689B
YU43689B YU1786/85A YU178685A YU43689B YU 43689 B YU43689 B YU 43689B YU 1786/85 A YU1786/85 A YU 1786/85A YU 178685 A YU178685 A YU 178685A YU 43689 B YU43689 B YU 43689B
Authority
YU
Yugoslavia
Prior art keywords
silibinine
preparing derivatives
derivatives
preparing
Prior art date
Application number
YU1786/85A
Other languages
English (en)
Other versions
YU178685A (en
Inventor
R Braatz
K Goerler
G Halbach
H Soicke
K Schmidt
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Priority to SI8511786A priority Critical patent/SI8511786A8/sl
Publication of YU178685A publication Critical patent/YU178685A/xx
Publication of YU43689B publication Critical patent/YU43689B/xx
Priority to HRP-1786/85A priority patent/HRP950126B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
YU1786/85A 1984-11-22 1985-11-14 Process for preparing derivatives of silibinine YU43689B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8511786A SI8511786A8 (sl) 1984-11-22 1985-11-14 Postopek za pripravo derivatov silibinina
HRP-1786/85A HRP950126B1 (en) 1984-11-22 1995-03-16 Process for the preparation of silibinine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
YU178685A YU178685A (en) 1988-02-29
YU43689B true YU43689B (en) 1989-10-31

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1786/85A YU43689B (en) 1984-11-22 1985-11-14 Process for preparing derivatives of silibinine

Country Status (29)

Country Link
JP (1) JPS61143377A (fr)
KR (1) KR870001020B1 (fr)
AR (1) AR240931A1 (fr)
AT (1) AT393268B (fr)
BE (1) BE903693A (fr)
CA (1) CA1337124C (fr)
CH (1) CH659473A5 (fr)
CS (1) CS273610B2 (fr)
DD (1) DD259191A1 (fr)
DE (1) DE3442639A1 (fr)
DK (1) DK164865C (fr)
EG (1) EG19424A (fr)
ES (1) ES8609311A1 (fr)
FI (1) FI84064C (fr)
FR (1) FR2573427B1 (fr)
GB (1) GB2167414B (fr)
HU (1) HU195503B (fr)
IE (1) IE58791B1 (fr)
IT (1) IT1190426B (fr)
LU (1) LU86163A1 (fr)
MX (1) MX168415B (fr)
NL (1) NL192387C (fr)
NO (1) NO160205C (fr)
PL (1) PL146890B1 (fr)
PT (1) PT81532B (fr)
SE (1) SE465676B (fr)
SU (1) SU1436875A3 (fr)
YU (1) YU43689B (fr)
ZA (1) ZA858951B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
NZ560633A (en) * 2005-03-11 2011-08-26 Neuprotect Pty Ltd Flavonoid compounds and uses thereof
CN102300570B (zh) * 2007-11-15 2015-01-14 马道斯有限责任公司 用于治疗肝炎的水飞蓟宾组分
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
AU2010247716B2 (en) * 2009-05-14 2015-11-05 Madaus Gmbh Amorphous silibinin for the treatment of viral hepatitis
US20150174213A1 (en) 2012-07-05 2015-06-25 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
JPH0432073B2 (fr) 1992-05-28
BE903693A (fr) 1986-05-22
FI84064C (fi) 1991-10-10
PT81532B (pt) 1987-11-11
LU86163A1 (de) 1986-03-24
DK537785A (da) 1986-05-23
PL256374A1 (en) 1986-12-02
KR860004056A (ko) 1986-06-16
GB8528226D0 (en) 1985-12-18
AR240931A1 (es) 1991-03-27
IT8522932A0 (it) 1985-11-21
IE852808L (en) 1986-05-22
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
FI854535A (fi) 1986-05-23
DE3442639C2 (fr) 1989-08-10
FR2573427A1 (fr) 1986-05-23
GB2167414A (en) 1986-05-29
NL192387B (nl) 1997-03-03
FR2573427B1 (fr) 1989-03-10
CH659473A5 (de) 1987-01-30
NO854655L (no) 1986-05-23
CS273610B2 (en) 1991-03-12
SE8505487L (sv) 1986-05-23
SU1436875A3 (ru) 1988-11-07
IT1190426B (it) 1988-02-16
EG19424A (en) 1995-02-28
DK164865B (da) 1992-08-31
NL8503171A (nl) 1986-06-16
AT393268B (de) 1991-09-25
ZA858951B (en) 1986-08-27
IE58791B1 (en) 1993-11-17
HUT40114A (en) 1986-11-28
KR870001020B1 (ko) 1987-05-23
NO160205B (no) 1988-12-12
DE3442639A1 (de) 1986-05-22
NL192387C (nl) 1997-07-04
PT81532A (de) 1985-12-01
DD259191A1 (de) 1988-08-17
JPS61143377A (ja) 1986-07-01
YU178685A (en) 1988-02-29
HU195503B (en) 1988-05-30
FI854535A0 (fi) 1985-11-18
FI84064B (fi) 1991-06-28
GB2167414B (en) 1989-01-11
CS837885A2 (en) 1990-08-14
ES8609311A1 (es) 1986-09-01
NO160205C (no) 1989-03-22
MX168415B (es) 1993-05-24
AR240931A2 (es) 1991-03-27
ES549116A0 (es) 1986-09-01
DK537785D0 (da) 1985-11-21
DK164865C (da) 1993-01-18
SE8505487D0 (sv) 1985-11-20
CA1337124C (fr) 1995-09-26
ATA337185A (de) 1991-02-15

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