MX168415B - Procedimiento para la preparacion de derivados de silibinina - Google Patents

Procedimiento para la preparacion de derivados de silibinina

Info

Publication number
MX168415B
MX168415B MX009022A MX902285A MX168415B MX 168415 B MX168415 B MX 168415B MX 009022 A MX009022 A MX 009022A MX 902285 A MX902285 A MX 902285A MX 168415 B MX168415 B MX 168415B
Authority
MX
Mexico
Prior art keywords
independently
ethyl acetate
weight
ethanol
alkali metal
Prior art date
Application number
MX009022A
Other languages
English (en)
Spanish (es)
Inventor
Hartwig Soicke
Karlheinz Schmidt
Reinhard Braatz
Klaus Gorler
Gunter Halbach
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of MX168415B publication Critical patent/MX168415B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
MX009022A 1984-11-22 1985-11-22 Procedimiento para la preparacion de derivados de silibinina MX168415B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
MX168415B true MX168415B (es) 1993-05-24

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
MX009022A MX168415B (es) 1984-11-22 1985-11-22 Procedimiento para la preparacion de derivados de silibinina

Country Status (29)

Country Link
JP (1) JPS61143377A (ru)
KR (1) KR870001020B1 (ru)
AR (1) AR240931A1 (ru)
AT (1) AT393268B (ru)
BE (1) BE903693A (ru)
CA (1) CA1337124C (ru)
CH (1) CH659473A5 (ru)
CS (1) CS273610B2 (ru)
DD (1) DD259191A1 (ru)
DE (1) DE3442639A1 (ru)
DK (1) DK164865C (ru)
EG (1) EG19424A (ru)
ES (1) ES8609311A1 (ru)
FI (1) FI84064C (ru)
FR (1) FR2573427B1 (ru)
GB (1) GB2167414B (ru)
HU (1) HU195503B (ru)
IE (1) IE58791B1 (ru)
IT (1) IT1190426B (ru)
LU (1) LU86163A1 (ru)
MX (1) MX168415B (ru)
NL (1) NL192387C (ru)
NO (1) NO160205C (ru)
PL (1) PL146890B1 (ru)
PT (1) PT81532B (ru)
SE (1) SE465676B (ru)
SU (1) SU1436875A3 (ru)
YU (1) YU43689B (ru)
ZA (1) ZA858951B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
CN101137639B (zh) * 2005-03-11 2012-05-23 霍华德弗洛里生理医学实验研究所 类黄酮化合物及其用途
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
PL2392326T3 (pl) * 2007-11-15 2018-07-31 Madaus Gmbh Składnik sylibininowy do leczenia zapalenia wątroby
TWI529167B (zh) * 2009-05-14 2016-04-11 歐羅梅德股份有限公司 用於治療病毒性肝炎之非晶型水飛薊賓
WO2014008366A2 (en) 2012-07-05 2014-01-09 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
PT81532A (de) 1985-12-01
EG19424A (en) 1995-02-28
LU86163A1 (de) 1986-03-24
FR2573427A1 (fr) 1986-05-23
AT393268B (de) 1991-09-25
FI84064C (fi) 1991-10-10
CS837885A2 (en) 1990-08-14
IE58791B1 (en) 1993-11-17
JPH0432073B2 (ru) 1992-05-28
GB8528226D0 (en) 1985-12-18
NO854655L (no) 1986-05-23
NL192387B (nl) 1997-03-03
HUT40114A (en) 1986-11-28
HU195503B (en) 1988-05-30
IT8522932A0 (it) 1985-11-21
KR860004056A (ko) 1986-06-16
NL8503171A (nl) 1986-06-16
AR240931A1 (es) 1991-03-27
BE903693A (fr) 1986-05-22
SU1436875A3 (ru) 1988-11-07
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
GB2167414B (en) 1989-01-11
FI854535A (fi) 1986-05-23
NO160205B (no) 1988-12-12
NL192387C (nl) 1997-07-04
DK537785D0 (da) 1985-11-21
CA1337124C (en) 1995-09-26
KR870001020B1 (ko) 1987-05-23
ES8609311A1 (es) 1986-09-01
PT81532B (pt) 1987-11-11
GB2167414A (en) 1986-05-29
YU178685A (en) 1988-02-29
SE8505487D0 (sv) 1985-11-20
DE3442639C2 (ru) 1989-08-10
FI854535A0 (fi) 1985-11-18
CS273610B2 (en) 1991-03-12
NO160205C (no) 1989-03-22
DK164865C (da) 1993-01-18
JPS61143377A (ja) 1986-07-01
DE3442639A1 (de) 1986-05-22
PL256374A1 (en) 1986-12-02
CH659473A5 (de) 1987-01-30
DK164865B (da) 1992-08-31
ZA858951B (en) 1986-08-27
IT1190426B (it) 1988-02-16
FR2573427B1 (fr) 1989-03-10
IE852808L (en) 1986-05-22
ES549116A0 (es) 1986-09-01
DD259191A1 (de) 1988-08-17
AR240931A2 (es) 1991-03-27
FI84064B (fi) 1991-06-28
DK537785A (da) 1986-05-23
ATA337185A (de) 1991-02-15

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