UA6043A1 - Способ получения производных хлорамбуцила (его варианты) - Google Patents

Способ получения производных хлорамбуцила (его варианты)

Info

Publication number
UA6043A1
UA6043A1 UA2804752A UA2804752A UA6043A1 UA 6043 A1 UA6043 A1 UA 6043A1 UA 2804752 A UA2804752 A UA 2804752A UA 2804752 A UA2804752 A UA 2804752A UA 6043 A1 UA6043 A1 UA 6043A1
Authority
UA
Ukraine
Prior art keywords
chloroambucyl
derivatives
producing
variants
reacted
Prior art date
Application number
UA2804752A
Other languages
English (en)
Ukrainian (uk)
Inventor
Асано Кіро
Тамура Хуміо
Володимир Hіканорович Молотков
Єномото Сатору
Original Assignee
Куреха Кагаку Когіо Кабусікі Кайся
Куреха Кагаку Когио Кабусики Кайся
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Куреха Кагаку Когіо Кабусікі Кайся, Куреха Кагаку Когио Кабусики Кайся filed Critical Куреха Кагаку Когіо Кабусікі Кайся
Publication of UA6043A1 publication Critical patent/UA6043A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Предметом изобретения является способ получения производных хлорамбуцила. Эстрадиол или его ацилированное производное подвергаются взаимодействию со связывающим агентом - монобромуксусной кислотой или монобромацетилбромидом в присутствии органического растворителя. Модифицированный эстрадиол или его ацилированное производное подвергаются взаимодействию с карбоксильной группой хлорамбуцила в органическом растворителе с последующим выделением целевого продукта.
UA2804752A 1978-08-14 1979-08-13 Способ получения производных хлорамбуцила (его варианты) UA6043A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53098795A JPS5810393B2 (ja) 1978-08-14 1978-08-14 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤

Publications (1)

Publication Number Publication Date
UA6043A1 true UA6043A1 (ru) 1994-12-29

Family

ID=14229286

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2804752A UA6043A1 (ru) 1978-08-14 1979-08-13 Способ получения производных хлорамбуцила (его варианты)

Country Status (8)

Country Link
JP (1) JPS5810393B2 (ru)
BE (1) BE878186A (ru)
CS (1) CS242856B2 (ru)
GE (1) GEP19960478B (ru)
HU (1) HU180002B (ru)
SU (1) SU1001860A3 (ru)
UA (1) UA6043A1 (ru)
YU (1) YU41345B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2169900B (en) * 1984-06-27 1988-02-17 Onkologi N Ct Ak Med V Derivatives of steroids of androstane series

Also Published As

Publication number Publication date
CS556679A2 (en) 1985-08-15
BE878186A (fr) 1980-02-11
JPS5527121A (en) 1980-02-27
SU1001860A3 (ru) 1983-02-28
GEP19960478B (en) 1996-08-29
HU180002B (en) 1983-01-28
CS242856B2 (en) 1986-05-15
YU41345B (en) 1987-02-28
JPS5810393B2 (ja) 1983-02-25
YU198179A (en) 1983-01-21

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